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Joshua T. Johnstone and Stephen Collins are the employees of Biscayne Neurotherapeutics, Inc. ... Steven Schachter is the inventor on a patent for the use of Huperzine A for treatment of epilepsy, which is licensed by Harvard Medical School to Biscayne Neurotherapeutics, Inc., in which he holds less ...doi:10.1089/neu.2017.5258 pmid:29054135 pmcid:PMC5784790 fatcat:rg2mrlvenzho7es3qjz3vr6qni
doi:10.1172/jci16242 pmid:12464671 pmcid:PMC151634 fatcat:m22mh5ruyffpxk3v7mcjl4qsoq
doi:10.1172/jci0216242 pmid:12464671 pmcid:PMC151634 fatcat:lmczdyjkcfasxd2og57fleh75m
Uveal melanoma is the most common primary intraocular malignancy in adults with no effective systemic treatment option in the metastatic setting. Selumetinib (AZD6244, ARRY-142886) is an oral, potent, and selective MEK1/2 inhibitor with a short half-life, which demonstrated single-agent activity in patients with metastatic uveal melanoma in a randomized phase II trial. Methods The Selumetinib (AZD6244: ARRY-142886) (Hyd-Sulfate) in Metastatic Uveal Melanoma (SUMIT) study was a phase III,doi:10.1200/jco.2017.74.1090 pmid:29528792 fatcat:4thfftqk7bgrbjtmo7atf2zrlu
more »... blind trial (ClinicalTrial.gov identifier: NCT01974752) in which patients with metastatic uveal melanoma and no prior systemic therapy were randomly assigned (3:1) to selumetinib (75 mg twice daily) plus dacarbazine (1,000 mg/m 2 intravenously on day 1 of every 21day cycle) or placebo plus dacarbazine. The primary end point was progression-free survival (PFS) by blinded independent central radiologic review. Secondary end points included overall survival and objective response rate. Results A total of 129 patients were randomly assigned to receive selumetinib plus dacarbazine (n = 97) or placebo plus dacarbazine (n = 32). In the selumetinib plus dacarbazine group, 82 patients (85%) experienced a PFS event, compared with 24 (75%) in the placebo plus dacarbazine group (median, 2.8 v 1.8 months); the hazard ratio for PFS was 0.78 (95% CI, 0.48 to 1.27; two-sided P = .32). The objective response rate was 3% with selumetinib plus dacarbazine and 0% with placebo plus dacarbazine (two-sided P = .36). At 37% maturity (n = 48 deaths), analysis of overall survival gave a hazard ratio of 0.75 (95% CI, 0.39 to 1.46; two-sided P = .40). The most frequently reported adverse events (selumetinib plus dacarbazine v placebo plus dacarbazine) were nausea (62% v 19%), rash (57% v 6%), fatigue (44% v 47%), diarrhea (44% v 22%), and peripheral edema (43% v 6%). Conclusion In patients with metastatic uveal melanoma, the combination of selumetinib plus dacarbazine had a tolerable safety profile but did not significantly improve PFS compared with placebo plus dacarbazine.
Seven genome-wide association studies (GWAS) have been published in AIDS, and only associations in the HLA region on chromosome 6 and CXCR6 have passed genome-wide significance. Methods: We reanalyzed the data from 3 previously published GWAS, targeting specifically low-frequency SNPs (minor allele frequency ,5%). Two groups composed of 365 slow progressors and 147 rapid progressors from Europe and the United States were compared with a control group of 1394 seronegative individuals usingdoi:10.1097/qai.0b013e318204982b pmid:21107268 pmcid:PMC3386792 fatcat:7kifiv6eobfunc6onihnxwidta
more »... trat corrections. Results: Of the 8584 SNPs with minor allele frequency ,5% in cases and controls (Bonferroni threshold = 5.8 3 10 26 ), 4 SNPs showed statistical evidence of association with the slow progressor phenotype. The best result was for HCP5 rs2395029 [P = 8.54 3 10 215 , odds ratio (OR) = 3.41] in the HLA locus, in partial linkage disequilibrium with 2 additional chromosome 6 associations in C6orf48 (P = 3.03 3 10 210 , OR = 2.9) and NOTCH4 (9.08 3 10 207 , OR = 2.32). The fourth association corresponded to rs2072255 located in RICH2 (P = 3.30 3 10 206 , OR = 0.43) in chromosome 17. Using HCP5 rs2395029 as a covariate, the C6orf48 and NOTCH4 signals disappeared, but the RICH2 signal still remained significant. Conclusions: Besides the already known chromosome 6 associations, the analysis of low-frequency SNPs brought up a new association in the RICH2 gene. Interestingly, RICH2 interacts with BST-2 known to be a major restriction factor for HIV-1 infection. Our study has thus identified a new candidate gene for AIDS molecular etiology and confirms the interest of singling out low-frequency SNPs to exploit GWAS data.
Background. The compilation of previous genomewide association studies of AIDS shows a major polymorphism in the HCP5 gene associated with both control of the viral load and long-term nonprogression (LTNP) to AIDS. Methods. To look for genetic variants that affect LTNP without necessary control of the viral load, we reanalyzed the genomewide data of the unique LTNP Genomics of Resistance to Immunodeficiency Virus (GRIV) cohort by excluding "elite controller" patients, who were controlling thedoi:10.1086/655782 pmid:20704485 pmcid:PMC3601691 fatcat:gpszbmoahfgunoofu63ldz4gui
more »... ral load at very low levels (!100 copies/mL). Results. The rs2234358 polymorphism in the CXCR6 gene was the strongest signal ( ; odds ratio, Ϫ7 P p 2.5 ϫ 10 1.85) obtained for the genomewide association study comparing the 186 GRIV LTNPs who were not elite controllers with 697 uninfected control subjects. This association was replicated in 3 additional independent European studies, reaching genomewide significance of . This association with LTNP is independent of the Ϫ10 P p 9.7 ϫ 10 combined CCR2-CCR5 locus and the HCP5 polymorphisms. Conclusions. The statistical significance, the replication, and the magnitude of the association demonstrate that CXCR6 is likely involved in the molecular etiology of AIDS and, in particular, in LTNP, emphasizing the power of extreme-phenotype cohorts. CXCR6 is a chemokine receptor that is known as a minor coreceptor in human immunodeficiency virus type 1 infection but could participate in disease progression through its role as a mediator of inflammation. Previous genomewide association studies (GWASs) of AIDS have revealed a major association involving a genetic polymorphism within the human leukocyte antigen region, the rs2395029 HCP5 single-nucleotide polymorphism (SNP), which tracks HLA-B*5701. This
Schachter, Vice-Chairman Henry C. Lee Mabel B. Tichy VETERANS COMMITTEE Leo J. Cahill, Chairman William R. Gubbin, Vice-Chairman Vincent P. Vivirito L. ... Mascari ENTERTAINMENT Joshua S. Vission, Chairman Harry L. Brown J. C. Schmitt Arthur D. Tessler PROGRAM Harry L. Rubens, Chairman Fred N. Bazola, Vice-Chairman Michael A. ...
Schachter William J. Serritella William D. Walden SPORTS Alvin J. Sells, Chairman Joshua S. Vission, Vice-Chairman O. V. Anderson Sylvester S. Metcalf George D. Muriella RELIEF Carl J. ... Kropik FORUM ENTERTAINMENT Joshua S. Vission, Chairman Louis Postilion, Vice-Chairman Joseph A. Josh Howard L. Rosen Alvin J. Sells William O. Sutcher George Tourek James J. ...
Rabbi Schachter-Shalomi and his wife, Eve Ilsen, opened the event. The symposium was videotaped and broadcast on the CU Libraries YouTube channel. 12 ... Several accessions of additional materials from Schachter-Shalomi's home followed, including a complete set of books he authored, translations from Yiddish to English of Abraham Joshua Heschel's poetry ... "The Transcendental Experience", a talk recorded in 1967 entitled "The Jewish Mystical Experience and LSD", a talk from 1976 titled "Kabalah: The New Liturgy", and recordings of Ram Dass and Abraham Joshua ...doi:10.14263/2330-2976.1144 fatcat:ygdpfpeg2bdkfgd7wp365aeiru
Schachter, Vice-Chairman Charles G. Fortelka William J. Kaiser E. H. Vanoucek Lincoln O. Wistain J. L. Zieff DENTAL EDUCATION Howard 1. Michener, Chairman Robert K. Baxter, Vice-Chairman B. A. ... Shimandlc Joshua S. Vission Lester Wiman ENTERTAINMENT Edward J. Rus, Chairman Leo J. Cahill, Vice-Chairman Otto H. Glantz Louis K. Holzman Joseph A. Josh George L. Slad Theodore Stein George F. ...
blisha Reynolds, Jennifer Rice, Prudence Riles, Annelise Robb, John Roberts, John Rodriguez- Alegria, Enrique Rogers, Susan Carol Roitman, Janct Roland, Kaita Rommen, lim Rosa, Jonathan Rossen, Jack Roth, Joshua ... Rudiak-Gould, Peter Rudrappa, Sharmila Rudzvik, Alanna Rutherford, Blair Sacthre, Lirik Salomon, Frank Samet, Robert Sangaramoorthy, Thurka Sargent, Carolyn Saturno, William Scarborough, Vern Scelza, Brooke Schachter ...
Abraham Joshua Heschel (ö. 1972), Hasidik dünyanın kalbi olan Polonya'nın Varşova şehrinde dünyaya gelmiştir ve aileden zaddikim sülalesine aittir. ... Özet Abraham Joshua Heschel (ö. 1972), Hasidik dünyanın kalbi olan Polonya'nın Varşova şehrinde dünyaya gelmiştir ve aileden zaddikim sülalesine aittir. ... , 2020) 21 Zalman Schachter-Shalomi (ö. 2014) (A Biography of Zalman Schachter-Shalomi, 2020) 22 ve Arthur Green (1941-) (Arthur Green Biography, 2020) 23 gibi bir kısmı Avrupa ve bir kısmı da Amerikan ...doi:10.15869/itobiad.728929 fatcat:bmwto2ityncezfgnk5vie24ilq
., 32785 Ryland, David, 35023 salio, R 35639 bez Eucles 35385 , Teresa Chandler, 34461 Sacco, Joshua, 34105 Sacco, L., 32926 Sachnoff, Elaine A., 34916 S., 35209 Sack, Robert L., 33508 Safonova, T. ... , Jacquelyn, 35554 Schachter-Shalomi, Zalman M., 35058 Schachtman, Todd R., 33225 Schacter, Daniel ‘.. 34795 Schafe, Glenn E., 33359 Scharfetter,, 34200 Scheff, Stephen W., 33326 Scheffers, Marten K., ...
The analysis was therefore designed in both content and mode of delivery to resonate with ideas from Schachter-Shalomi and the community. ... The analysis was first delivered in a public forum involving members of a local Jewish community and Zalman Schachter-Shalomi, an influential rabbi who recalled the niggun from his family in Vienna before ... ACKNOWLEDGEMENTS I am grateful to David Shneer for his invitation to participate in the Embodied Judaism Symposium, to Rabbi Zalman Schachter-Shalomi of blessed memory for his teachings and interest in ...doaj:ce38db86b5e54b239ddb0c66ffd9547c fatcat:fstahqdydbcundzwwc4wymayj4
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