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Synthesis and anti-HIV-1 activities of new pyrimido[5,4-b]indoles

Isidro Merino, Antonio Monge, Marı́a Font, Juan José Martı́nez de Irujo, Elena Alberdi, Esteban Santiago, Isidro Prieto, Juan José Lasarte, Pablo Sarobe, Francisco Borrás
1999 Il Farmaco  
The Gobierno Foral de Navarra (Spain) granted a scholarship to Isidro Merino.  ... 
doi:10.1016/s0014-827x(99)00035-x pmid:10384720 fatcat:6qm6g7a34fchpfqhzj6kzfpseq

Estados fallidos. La quiebra del Estado Nacional y la desestabilización de la seguridad regional

Isidro Sepúlveda
2013 Revista Científica General José María Córdova  
Y LA DESESTABILIZACIÓN DE LA SEGURIDDAD REGIONAL Revista Colombiana sobre investigación en el campo militar REVISTA CIENTÍFICA "GENERAL JOSÉ MARÍA CÓRDOVA" ; Fragile States Strategy, 2005; Investing  ...  Y LA DESESTABILIZACIÓN DE LA SEGURIDDAD REGIONAL Revista Colombiana sobre investigación en el campo militar REVISTA CIENTÍFICA "GENERAL JOSÉ MARÍA CÓRDOVA" •Los países vecinos a la crisis y las potencias  ... 
doi:10.21830/19006586.204 fatcat:gelvwoip3vdnzluuepa7cggybi

Summing over Spacetime Dimensions in Quantum Gravity

Erik Curiel, Felix Finster, Jose Maria Isidro
2020 Symmetry  
quantum-gravity corrections (in the form of a minimal length) to the Feynman propagator for a free scalar particle in R D are shown to be the result of summing over all dimensions D ′ ≥ D of R D ′ , each summand taken in the absence of quantum gravity.
doi:10.3390/sym12010138 fatcat:cisscf6fwnfj3j24ljcujw63dy

Cambio institucional en la atención de la enfermedad mental en el Hospital Psiquiátrico San Isidro (1955-1970)

María Del Carmen Castrillón-Valderrutén, José Fernando Sánchez-Salcedo
2019 Revista CS  
Este artículo busca indagar, a través de una revisión cualitativa de 24 historias clínicas del Hospital Psiquiátrico San Isidro de Cali, los modos de diagnosticar y los tratamientos que llevaron a cabo  ...  M Reacción maniaco depresiva Tuvo un ingreso previo en la Clínica Psiquiátrica San José.  ...  En esta suerte de isomorfismo, se creó el archivo de historias clínicas del Hospital Psiquiátrico San Isidro. De esta manera, y con el apoyo del doctor Carlos León, se 9.  ... 
doi:10.18046/recs.i28.2838 fatcat:73z4uf4stjgzlmve5nz6zuxjsu

Advanced systemic amyloidosis secondary to metastatic renal cell carcinoma

Maria Asunción Algarra, Maria José Juan Fita, Sergio Sandiego, Héctor Augusto Aguilar, Pablo Álvarez, Mateo Quispe, Antonio Salvador, Adoración Egido, Javier Lavernia, Isidro Machado, José Rubio-Briones, Miguel Ángel Climent
2020 ecancermedicalscience  
Secondary amyloidosis is a rare complex complication related to chronic inflammatory disease. This complication is sparsely associated to malignant neoplasms. Renal cell carcinoma (RCC) is the most common solid organ malignancy related with this paraneoplastic syndrome. Some case reports have described stabilisation or even remission of amyloidosis with cytoreductive nephrectomy. Majority of those reports were based on locally advanced RCC. We report the first case of early aggressive systemic
more » ... econdary amyloidosis in high-volume metastatic RCC. The subject was diagnosed with metastatic RCC within 6 months of secondary amyloidosis; on month 5 of initiation of targeted therapy (pazopanib) developed nephrotic syndrome with a heavy proteinuria (>18 g/day), severe hypoalbuminaemia (1.53 g/dL), intense and progressive oedema, severe pancolitis and mild dyspnoea with hypotension. A colon biopsy and the immunohistochemistry confirmed the histological diagnosis of a secondary amyloidosis. The multidisciplinary tumour board decided to perform cytoreductive nephrectomy in order to reduce the pro-inflammatory status. Pathology report showed a complete resection of clear cell RCC plus renal amyloid deposits. The patient died within 4 days of surgery due to multiorgan failure.
doi:10.3332/ecancer.2020.1156 pmid:33574901 pmcid:PMC7864688 fatcat:xuebhqdlsrbbfmsiqnmclic3we

Microstructural Effects of Sulphate Attack in Sustainable Grouts for Micropiles

José Ortega Álvarez, María Esteban Pérez, Raúl Rodríguez Escribano, José Pastor Navarro, Isidro Sánchez Martín
2016 Materials  
Nowadays, the use of micropiles has undergone a great development. In general, they are made with cement grout, reinforced with steel tubing. In Spain, these grouts are prepared using OPC, although the standards do not forbid the use of other cements, like sustainable ones. Micropiles are in contact with soils and groundwater, in which the presence of sulphates is common. Their deleterious effects firstly affect to the microstructure. Then, the aim of this research is to study the effects of
more » ... phate attack in the microstructure of micropiles grouts, prepared with OPC, fly ash and slag commercial cements, compared to their behaviour when they are exposed to an optimum hardening condition. The microstructure evolution has been studied with the non-destructive impedance spectroscopy technique, which has never been used for detecting the effects of sulphate attack when slag and fly ash cements are used. Its results have been contrasted with mercury intrusion porosimetry and "Wenner" resistivity ones. The 28-day compressive strength of grouts has been also determined. The results of microstructure characterization techniques are in agreement, although impedance spectroscopy is the most sensitive for following the changes in the porous network of grouts. The results showed that micropiles made using fly ash and slag cements could have a good performance in contact with aggressive sodium sulphate media, even better than OPC ones. Materials 2016, 9, 905 2 of 23 other types of cements, like sustainable ones. These sustainable cements in most cases contain active additions, like fly ash and ground granulated blast furnace slag. The use of these cements shows many advantages [5] [6] [7] [8] [9] . On the one hand, these cements contribute to reduce CO 2 emissions produced by the cement industry, because the additions replace a proportion of clinker, so less quantity of this product is needed. Furthermore, the most used active additions are wastes of other industrial processes, and their reuse in cement manufacture constitutes in itself an environmental benefit. On the other hand, the most common active additions improve the properties of cement-based materials and their effects are still now a topic of study [5, [10] [11] [12] . Among the different active additions, in this research cements that incorporate fly ash and ground granulated blast furnace slag have been studied. Regarding blast furnace slag, the development of their hydration reactions entails the formation of additional CSH phases, increasing the microstructure refinement [13] , which improves the service properties of cement-based materials [14, 15] . On the other hand, fly ash has a similar effect in the microstructure and properties of these materials, although this admixture is able to react with portlandite [11] , which is formed during the clinker hydration. As products of these pozzolanic reactions, new hydrated phases are produced, which densify the pore network of the material [5, 11] . Therefore, both additions have good performance for many applications [5], particularly for marine structures [7, [16] [17] [18] . Despite that, cements containing fly ash or slag are not used for making cement grouts for micropiles. With respect to the durability of micropiles, it is important to emphasize the abovementioned fact that the reinforcement elements of this type of special foundation are embedded in cement grouts (pastes), instead of concrete, as happens in the majority of civil engineering structures. Then, it could entail a different behaviour of these elements against the attack of aggressive substances, especially if sustainable cements are used. One of the most important aggressive attacks to which micropiles can be exposed is that produced by sulphate, because this aggressive is commonly present in soils and groundwater. The sulphate attack is produced by a complex mechanism, which involves different chemical reactions between components of cement paste microstructure and sulphate ions [19] . First of all, the effect of sulphate attack produces a gradual dissolution of portlandite and decomposition of the CSH phases [19, 20] and whenever the attack is being developing, more and more ettringite crystals are formed in the pore network [21] . These crystals are expansive, and when the pores are filled enough, they start to cause volumetric strains in the hardened material, which brings microcracking and a loss of pore refinement [20, 22] . Moreover, as consequence of those damages in the microstructure, it is also produced a loss of strength and durability in the cement-based materials exposed to sulphate attack [22] . In relation to mineral admixtures, several studies have shown that they reduce the degree of damage produced by sulphate attack [19, [23] [24] [25] . In general, this better behaviour has been related to the higher microstructure refinement, less C3A availability and additional formation of CSH phases [19, 25] produced by the addition of fly ash and slag. Besides, for fly ash cements, the lower presence of portlandite due to their consumption during pozzolanic reactions [19, 26] also favours their better sulphate resistance. Nevertheless, it has been observed that the performance against sulphate attack of sustainable cements depends on the kind of active addition used, and the degree of substitution of clinker by admixture [25, [27] [28] [29] [30] [31] [32] . As has been previously mentioned, the microstructure of cement-based materials is directly related to their service properties [13, 33] , especially their durability. Nowadays, the use of non-destructive techniques for characterizing the microstructure of cement-based materials has become an important research field [34] [35] [36] [37] [38] [39] . Among these techniques, impedance spectroscopy has experienced a great development during the last years. This technique is based on the possibility of correlating dielectric and mechanical properties of a solid material [40] . Recently, impedance spectroscopy has been successfully used for studying the microstructure of cement-based materials [41] [42] [43] [44] [45] , although there is no experience of using this technique for detecting the effects of sulphate attack when cements which incorporate fly ash and slag are used. However, it has been demonstrated that impedance spectroscopy can be useful for detecting the appearance of microcracking [45] . One of the effects of the expansive
doi:10.3390/ma9110905 pmid:28774026 pmcid:PMC5457211 fatcat:xyotmgsbx5hfzeqz7nc2vrqpme

Canonizar a un santo medieval en la Roma de la Contrarreforma: Isidro Labrador, patrón de Madrid

María-José Del-Río-Barredo
2020 Anuario de Historia de la Iglesia  
En el contexto del Madrid postridentino convertido en sede permanente de la Corte, este artículo se centra en los rasgos de san Isidro como santo local y antiguo, decisivos para el desarrollo y resultado  ...  MARÍA JOSÉ DEL RÍO BARREDO de España, Sessa respondió tajante que «por ser tan santo [Isidro] y estar en la corte de España se había de dar lugar» 31 .  ...  AHIg 29 / 2020 MARÍA JOSÉ DEL RÍO BARREDO En el libro de Alonso de Villegas, que la cofradía de san Isidro costeó en 1592, se seguía de cerca el texto medieval, aunque con la incorporación de detalles,  ... 
doi:10.15581/007.29.010 fatcat:ojhekiceqjbtbkkjkuquo3upua

Integral Involving Bessel Functions Arising in Propagation Phenomena

Yuri L. Ratis, Pedro Fernández de Córdoba, José María Isidro, Ramón Jaime
2019 Mathematics  
An new integral identity involving the product of two modified Bessel functions K 0 and K 1 , previously unreported, is presented and proved.
doi:10.3390/math7050434 fatcat:gksbsxkixretxdrt32vugfzs6m


Isidro José Pacheco Carrión, María Yolanda Jiménez Rubio
2020 Edetania. Estudios y propuestas socioeducativas  
Actualmente, existe en el mercado un gran número de plataformas informáticas que permiten automatizar los diferentes procesos relacionados con la gestión de una institución educativa: pasar lista, horarios de los profesores, introducir notas, generación de calendarios comunes, envío de correos entre los distintos estamentos, comunicaciones con las familias, etc. Desde los colegios, se invierte una gran cantidad de esfuerzos, tanto económicos como personales, para que dichas aplicaciones sean
more » ... ptadas de forma masiva por todos los componentes de la institución, ya que, obviamente, una vez seleccionada una solución u otra, se deben introducir los datos (nombres de alumnos, de profesores, encargados de dirección, etc.) y se debe, además, formar a los profesores en el uso de la herramienta, con la consiguiente adaptación tanto de su metodología didáctica, como de su forma de trabajar. En el presente documento, se describe el proceso seguido para la creación e implantación de una plataforma propia de gestión de un colegio, creada a partir de las necesidades observadas en el día a día de los docentes.
doi:10.46583/edetania_2019.56.474 fatcat:3ebr2drtzja4jkqzgidgvj6hoe

Plan de Fomento del Alojamiento de Sevilla, 1929

Dr. Vicente Flores-Alés, Dra. María De los Reyes Abad Flores, Dr. Isidro Cortés Albalá, Dr. José María Calama Rodríguez
2019 Revista de Arquitectura  
MARÍA DE LOS REYES ABAD FLORES · Depto. Construcciones Arquitectónicas II, Universidad de Sevilla · DR. ISIDRO CORTÉS ALBALÁ · Depto.  ...  JOSÉ MARÍA CALAMA RODRÍGUEZ · Depto. Construcciones Arquitectónicas II, Universidad de Sevilla · Fecha de recepción: 15 de marzo 2019 · Fecha de aceptación: 30 de abril 2019 Tabla 1.  ... 
doi:10.5354/0719-5427.2019.53769 fatcat:6k4znmpdcfemdc4x5evvblqc3i

Improvements on marker-free images alignment for electron tomography [article]

Carlos Oscar S Sorzano, Federico de Isidro-Gomez, Estrella Fernandez-Gimenez, David Herreros, Sergio Marco, Jose Maria Carazo, Cedric Messaoudi
2020 bioRxiv   pre-print
Electron tomography is a technique to obtain three-dimensional structural information of samples. However, the technique is limited by shifts occurring during acquisition that need to be corrected before the reconstruction process. In 2009, we proposed an approach for post-acquisition alignment of tilt series images. This approach was marker-free, based on patch tracking and integrated in free software. Here, we present improvements to the method to make it more reliable, stable and accurate.
more » ... addition, we modified the image formation model underlying the alignment procedure to include different deformations occurring during acquisition. We propose a new way to correct these computed deformations to obtain reconstructions with reduced artifacts. The new approach has demonstrated to improve the quality of the final 3D reconstruction, giving access to better defined structures for different transmission electron tomography methods: resin embedded STEM-tomography and cryo-TEM tomography. The method is freely available in TomoJ software.
doi:10.1101/2020.05.22.110445 fatcat:cfwtsdj7zncihhwhc5pgcwjb2e

Síndrome moyamoya en paciente con síndrome de Down y déficit de antitrombina III

Marta Hernández Ch, Isidro Huete L, María-José Concha G, José I Méndez C, Nicolás Sánchez D, María-Carolina Cuéllar G, Eva Retamal R, Tomás Mesa L
2009 Revista médica de Chile (Impresa)  
Moyamoya disease is a unique chronic progressive cerebrovascular disease characterized by bilateral stenosis or occlusion of the arteries around the circle of Willis with prominent arterial collateral circulation. It can be primary or secondary to genetic syndromes such as Down syndrome. We report a seven year-old girl with a Down syndrome that presented with a disturbance of consciousness, seizures and a right hemiparesia at the age of five. Magnetic resonance imaging showed old cortical
more » ... ic lesions in both cerebral hemispheres and a recent infarction in the territory of the left middle cerebral artery. Brain angiography showed a proximal stenosis of both medial cerebral arteries and a net of collateral vessels, consistent with the diagnosis of moyamoya syndrome. The patient had also an antithrombin III deficiency. Aspirin was indicated and a surgical correction was recommended. However, prior to the procedure, the patient had a new infarction in the territory of the right middle cerebral artery, which caused a severe disability (Rev Méd Chile 2009; 137: 1066-70). (
doi:10.4067/s0034-98872009000800011 fatcat:c6hx3g3zeferzdhhf6exhvgnxe

The oldest human fossil in Europe, from Orce (Spain)

Isidro Toro-Moyano, Bienvenido Martínez-Navarro, Jordi Agustí, Caroline Souday, José María Bermúdez de Castro, María Martinón-Torres, Beatriz Fajardo, Mathieu Duval, Christophe Falguères, Oriol Oms, Josep Maria Parés, Pere Anadón (+6 others)
2013 Journal of Human Evolution  
The Orce region, which is known in the literature as the Spanish Olduvai, has one of the best Late Pliocene and Early Pleistocene continental paleobiological records of Europe. It is situated in the northeastern sector of the intramontane Guadix-Baza Basin (Granada, Andalusia, southern Spain). Here we describe a new fossil hominin tooth from the site of Barranco León, dated to ~1.4 Ma by a combination of Electron Spin Resonance (ESR), paleomagnetic and biochronologic methods. This is, at the moment, the oldest human remain from Western Europe.
doi:10.1016/j.jhevol.2013.01.012 pmid:23481345 fatcat:r556v2nmyvghddeylyctuf2ytu

Neuronal Induction of the Immunoproteasome in Huntington's Disease

Miguel Díaz-Hernández, Félix Hernández, Ester Martín-Aparicio, Pilar Gómez-Ramos, María A. Morán, José G. Castaño, Isidro Ferrer, Jesús Avila, José J. Lucas
2003 Journal of Neuroscience  
Huntington's disease (HD) inclusions are stained with anti-ubiquitin and anti-proteasome antibodies. This, together with proteasome activity studies on transfected cells, suggest that an impairment of the ubiquitin-proteasome system (UPS) may be key in HD pathogenesis. To test whether proteasome activity is impaired in vivo, we performed enzymatic assays for the three peptidase activities of the proteasome in brain extracts from the HD94 conditional mouse model of HD. We found no inhibition of
more » ... ny of the activities, suggesting that if UPS impairment happens in vivo, it is not at the level of the proteasome catalytic core. Intriguingly, the chymotrypsin-and trypsin-like activities increased selectively in the affected and aggregate-containing regions: cortex and striatum. Western blot analysis revealed no difference in total proteasome content whereas an increase in the interferon-inducible subunits of the immunoproteasome, LMP2 and LMP7, was observed. These subunits confer to the proteasome catalytic properties that are optimal for MHC-I peptide presentation. Immunohistochemistry in control mouse brain revealed LMP2 and LMP7 mainly in neurons. Accordingly, their increase in HD94 mice predominantly took place in neurons, and 5% of the ubiquitin-positive cortical aggregates were also LMP2-positive. Ultrastructural analysis of neurons with high level of immunoproteasome subunits revealed signs of neurodegeneration like nuclear indentation or fragmentation and dark cell appearance. The neuronal induction of LMP2 and LMP7 and the associated signs of neurodegeneration were also found in HD postmortem brains. Our results indicate that LMP2 and LMP7 participate in normal neuronal physiology and suggest a role in HD neurodegeneration.
doi:10.1523/jneurosci.23-37-11653.2003 pmid:14684867 fatcat:z2rmmjvayzhbphrbklbsn2osny
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