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Reconstruction of the nipple-areola complex is the final step in surgical restoration of the breast. Nipple-areola reconstruction was previously done after an interval of several months using variable techniques, often resulting in low projection and flattened breast mound over time. We present algorithm of simultaneous nipple reconstruction (SNR) that leaves adequate residual projection and naturally shaped breast mound. Forty patients underwent a skin-sparing mastectomy and nipple excisiondoi:10.21037/gs-21-338 pmid:34804884 pmcid:PMC8575712 fatcat:acl3ers4qnd37ovccts5fcrkkm
more »... ween October 2016 and December 2020. In the control group, 21 patients underwent delayed nipple reconstruction for 6 months after breast reconstruction. The experimental group of 19 patients underwent nipple and breast reconstruction simultaneously. We collected relevant information and photographs of nipple profiles of both groups in the preoperative, postoperative 6-month, and postoperative 1-year time periods. We also examined the ratio between the reconstructed and contralateral nipples. Scores regarding patient satisfaction questionnaire averaged higher in experimental groups to every category. The control group's scores gradually declined over time and the experimental group showed lesser decline. At the 1-year postoperative follow-up, the mean projection of the immediately reconstructed nipple was approximately the same as the contralateral nipple at 91%, whereas the delayed reconstructed nipple resulted in a 77% ratio. Nipple reconstruction should no longer be considered as a secondary complement to immediate breast reconstruction. The nipple appears to be essential component of breast reconstruction for patient. SNR with immediate breast reconstruction is a simple and reliable technique, giving stable aesthetic results over time.
subunit interface of their deoxy forms. 1 H NMR spectroscopy has been shown to be an excellent tool to investigate the tertiary and quaternary structural features of Hb (Ho, 1992) . ... The resonance at ~14 ppm from DSS of the Hb A has been assigned to the intersubunit hydrogen bond between α42Tyr and β99Asp (Fung and Ho, 1975) , and is a key marker for the deoxy-quaternary structure ...doi:10.5483/bmbrep.2005.38.1.115 pmid:15715956 fatcat:xaycuko6pzeahauf54packkote
Prior studies examining predictors of favorable clinical outcomes after upper limb robot-assisted therapy (RT) have many shortcomings. Therefore, the aim of this study was to identify meaningful predictors and a prediction model for clinically significant motor improvement in upper limb impairment after RT for each stroke phase. This retrospective, single-center study enrolled patients with stroke who received RT using InMotion2 along with conventional therapy (CT) from January 2015 todoi:10.3389/fneur.2021.668923 doaj:f5585d7715d14aff850cc67bf43c8b9f fatcat:yoczie6nivf2zg7hh3ixggne5u
more »... 2019. Demographic characteristics, clinical measures, and robotic kinematic measures were evaluated. The primary outcome measure was the Fugl-Meyer Assessment-Upper Extremity (FMA-UE) and we classified patients with improvement more than the minimal clinically important difference as responders for each stroke phase. Univariable and multivariable logistic regression analyses were performed to assess the relationship between potential predictors and RT responders and determine meaningful predictors. Subsequently, meaningful predictors were included in the final prediction model. One hundred forty-four patients were enrolled. The Hand Movement Scale and time since onset were significant predictors of clinically significant improvement in upper limb impairment (P = 0.045 and 0.043, respectively), as represented by the FMA-UE score after RT along with CT, in patients with subacute stroke. These variables were also meaningful predictors with borderline statistical significance in patients with chronic stroke (P = 0.076 and 0.066, respectively). Better hand movement and a shorter time since onset can be used as realistic predictors of clinically significant motor improvement in upper limb impairment after RT with InMotion2 alongside CT in patients with subacute and chronic stroke. This information may help healthcare professionals discern optimal patients for RT and accurately inform patients and caregivers about outcomes of RT.
Lee et al. studied deformed nuclei within the RMF with various parameter sets  . We have used the same numerical methods and parameter sets for our calculation here. ...arXiv:nucl-th/9903001v1 fatcat:2dpuo5r3l5auzpnavl6prgnihm
Verrucous carcinoma is an unusual, non-metastasizing, distinct variant of squamous cell carcinoma composed of four subtypes according to the site of occurrence: oral type, anogenital type, plantar type, and other cutaneous sites. Oral type verrucous carcinoma usually shows slow progression with a low incidence of metastases. Treatment of verrcous carcinoma is challenging; multiple medical and surgical therapies are often attempted, with limited success. We reported on 2 cases of verrucousdoi:10.5021/ad.2011.23.s1.s68 pmid:22028577 pmcid:PMC3199427 fatcat:rjifbxyku5aqjk2ltlb7ewjggi
more »... oma of the lip treated with topical imiquimod and debulking therapy. (Ann Dermatol 23(S1) S68∼S71, 2011)
Ho w e v e r, t he m e c h a n is m ha s no t b e e n c le a rly u nd e rs t o o d . ... 2000 C h a n g e s in G a llb la d d e r M o t ilit y in G a s t r e ct o m iz e d P a t ie n t s J o o n s o o Ha h m , J o o ny o n g Pa rk , Yu nj u C h o , Ch a n g s o o Eu n , Yo n gw o o k Le e , Ho ... A ND MET HO DS 1. ...doi:10.3904/kjim.2000.15.1.19 pmid:10714087 pmcid:PMC4531745 fatcat:yl2d34ujxbfbllgzyjlsss6ydm
doi:10.5021/ad.2011.23.s1.s53 pmid:22028573 pmcid:PMC3199423 fatcat:mbpw5qpk2zfplpkaqaujzfjnwy
Argyria is a rare cutaneous discoloration caused by the intake of silver or various compounds containing silver. We report a case of argyria in a 73-year-old male following ingestion of colloidal silver as an alternative medicine over 5 years. He had a diffuse, slate gray discoloration of his face and hands. A biopsy specimen from the face revealed brown-black extracellular granules in the upper dermis and between collagen bundles. We also found silver particles in the mucous of the colon. Thedoi:10.5021/ad.2009.21.3.308 pmid:20523812 pmcid:PMC2861249 fatcat:naei7ieekfbsjf46mlgjacbubm
more »... ngestion of colloidal silver appears to be increasing among patients using alternative health practices. We report this case to bring people's attention to the problems associated with the ingestion of colloidal silver. (Ann Dermatol 21(3) 308∼310, 2009) -Keywords-Argyria, Colloidal silver
O b j e c t i v e: Occupational medicine specialists in the Busan, Ulsan and Kyung-Nam areas established an area-based occupational disease surveillance system and used this system to collected case information for the purpose of preventing occupational diseases Methods: 11 hospitals participated in this system. The authors selected five main diseases, which were hand-arm vibration syndrome (HAVS), work-related musculoskeletal disorder 대한산업의학회지 제 16 권 제 1 호 ( 2 0 0 4년 3월)doi:10.35371/kjoem.2004.16.1.1 fatcat:6n42wylxafc6faeb5yqjjtkroi
The advantage of HOS analysis is detection of statistical deviations from Gaussian distribution. ... The higher order statistics (HOS) technique has been applied to natural frequency extraction    . ...doi:10.1049/iet-rsn.2019.0005 fatcat:mqugjpc5evhmdavusncookbtba
Nuclear receptor related-1 protein (Nurr1) serves important roles in hippocampal-dependent cognitive process. In the present study, the protein expression of Nurr1 was compared in the hippocampi of young [postnatal month 3 (PM 3)], adult (PM 12) and aged (PM 24) gerbils using western blot analysis and immunohistochemistry. Results indicated that the protein level of Nurr1 was significantly and gradually decreased in the gerbil hippocampus with increasing age. In addition, strong Nurr1doi:10.3892/br.2018.1094 pmid:29904610 pmcid:PMC5996841 fatcat:t3rjnqfe7jbo7khjhupeef6xli
more »... tivity was primarily observed in pyramidal neurons and granule cells of the hippocampus in the young group, which was determined to be reduced in the adult group and to a greater extent in the aged group. Collectively the data demonstrated that Nurr1 immunoreactivity was gradually and markedly decreased during normal aging. These results indicate that gradual decrease of Nurr1 expression in the hippocampus may be associated with the normal aging process and a decline in hippocampus-dependent cognitive function.
Journal of Stroke
and Purpose Health-related quality of life (HRQoL) is a multidimensional concept that signifies a subjective evaluation of perceived health; hence, it has gained wide acceptance in geriatrics. However, its application has not been tested in patients with post-stroke cognitive impairment with no dementia (PSCIND). We investigated whether PSCIND interferes with HRQoL measured by EQ-5D, compared the findings to those of healthy people with normal cognition, and evaluated the influence of eachdoi:10.5853/jos.2013.15.1.49 pmid:24324939 pmcid:PMC3779672 fatcat:rykkccg3snb3hmde5m55gzanzq
more »... tive domain on this score. Methods In total, 1,528 subjects were identified who had undergone neuropsychological assessment using the 60-min protocol of the Korean version of Vascular Cognitive Impairment Harmonization Standards, EQ-5D, and magnetic resonance imaging at the stroke prevention clinic. Fifty PSCIND patients were matched to 50 post-stroke dementia (PSD) patients and 50 normal age-( ± 3 years) and sex-matched controls. The effects of PSCIND, PSD, and control groups upon the EQ-5Dindex score were tested by generalized estimating equation modeling. Results Estimated means ± standard errors of EQ-5Dindex scores were as follows: 0.94 ± 0.06 (control group), 0.86 ± 0.08 (PSCIND group), and 0.61 ± 0.32 (PSD group); and the difference among the three groups was statistically significant (P < 0.0001). Pairwise comparisons showed that EQ-5Dindex scores in the PSCIND group differed from those in the PSD and control groups (both P < 0.01). No cognitive domain was specifically associated with EQ-5Dindex scores after adjusting for functional status. Conclusions This study shows that PSCIND may interfere with the quality of life in stroke victims.
Cord blood transplantation (CBT) is a valuable alternative to bone marrow transplantation in adults without readily available donors. We conducted this study to investigate the feasibility of CBT for adult patients with acute leukemia with regards to impact of different conditioning and graft-versus-host disease (GVHD) prophylaxis regimens on clinical outcomes. From 16 centers in Korea, 41 acute myeloid leukemia (AML) and 29 ALL (acute lymphoblastic leukemia) patients undergoing CBT weredoi:10.3390/jcm9072310 pmid:32708168 fatcat:5i3bs3rl4ng6rofbdlitq6eplq
more »... d. For AML patients, the neutrophil engraftment was observed in 87.5% of reduced intensity conditioning (RIC) and 72.0% of myeloablative conditioning (MAC) (p = 0.242). The median RFS was 5 months and OS 7 months. Conditioning regimen did not affect relapse free survival (RFS) or overall survival (OS). GVHD prophylaxis using calcineurin inhibitors (CNI) plus methotrexate was associated with better RFS compared to CNI plus ATG (p = 0.032). For ALL patients, neutrophil engraftment was observed in 55.6% of RIC and 90.0% of MAC (p = 0.034). The median RFS was 5 months and OS 19 months. MAC regimens, especially total body irradiation (TBI)-based regimen, were associated with both longer RFS and OS compared to other conditioning regimens. In conclusion, individualized conditioning regimens will add value in terms of enhancing safety and efficacy of CBT.
Ganglion cyst of the lumbar facet joint is a rare elsion. We have experienced a patient who had right leg radiating pain and he was diagnosed with ganglion cyst in the lumbar facet joint. On the MRI images, an 0.8cm sized round mass was located on the anterior aspect of the right side facet joint between the 4th and 5th lumbar vertebra. It was compressing the right 4th spinal root. After surgical excision, his symptoms were disappeared. Ganglion cyst of the spine occurs most commonly in thedoi:10.4184/jkss.2006.13.2.138 fatcat:zqjnf5bcpbaxnlmqjdcsbaamxm
more »... t joint between the 4th and 5th lumbar vertebra, which is the most mobile back joint. It must be considered as part of the differential diagnosis of herniated lumbar intervertebral disc.
Hepatocellular carcinoma (HCC) is a cytotoxic chemotherapy-resistant tumor and most HCCs arise in a background of liver cirrhosis of various causes. Although the IMBrave150 trial showed remarkable advancements in the treatment of unresectable HCC with atezolizumab plus bevacizumab (AteBeva), therapeutic outcomes were unsatisfactory in more than half of the patients. Accordingly, many ongoing trials combine conventional modalities with new drugs such as immune checkpoint inhibitors for betterdoi:10.17998/jlc.2022.03.04 fatcat:kivsujejp5dhddt2ywnukpikza
more »... atment outcomes, and they are expected to benefit patients with limited responses to conventional treatment. Here, two patients with advanced stage HCC with preserved liver function and good performance status showed partial response after treatment with combination or sequential therapy of AteBeva, hepatic arterial infusion chemotherapy, radiation therapy, and transarterial chemoembolization. These findings indicate the efficacy of multidisciplinary treatment against advanced HCC. Additional studies are required to establish optimal treatment strategies.
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