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Concurrent EEG- and fMRI-derived functional connectomes exhibit linked dynamics [article]

Jonathan Wirsich, Anne-Lise Giraud, Sepideh Sadaghiani
2018 bioRxiv   pre-print
Acknowledgements We thank Katia Lehongre and Benjamin Morillon (primary dataset) and Fani Deligianni and Jonathan Clayden (generalization dataset) for generously sharing their data.  ... 
doi:10.1101/464438 fatcat:dponfjiz2jak5ia37d6r232cwe

Safety and data quality of simultaneous EEG-fMRI using multi-band fMRI imaging [article]

Maximillian Kirichenko Egan, Ryan Larsen, Jonathan Wirsich, Brad P. Sutton, Sepideh Sadaghiani
2020 bioRxiv   pre-print
Purpose Simultaneously recorded electroencephalography and functional magnetic resonance imaging (EEG-fMRI) is highly informative yet technically challenging. Until recently, there has been little information about the data quality and safety when used with newer multi-band (MB) fMRI sequences. Here, we assessed heating-related safety of a MB protocol on a phantom, then evaluated EEG quality recorded concurrently with the MB protocol on humans. Materials and Methods We compared radiofrequency
more » ... F)-related heating and magnetic field magnitude (B1+RMS), of a fast MB fMRI sequence with whole-brain coverage (TR=440ms, MB factor=4) against a previously recommended, safe single-band (SB) sequence using a phantom outfitted with a 64-channel EEG cap. Temperatures were recorded at the ECG and TP7 electrodes using a fluoroptic thermometer. Next, 6 human subjects underwent eyes-closed resting state EEG-fMRI with the MB sequence. EEG data quality was assessed by the ability to remove gradient and cardioballistic artifacts and a clean spectrogram. Results RF induced heating was lower at both electrodes in the MB sequence compared to the SB sequence at ratios of 0.7 and 0.8, respectively. These ratios are slightly greater than the ratio of RF power deposition of the sequences, which is 0.64. However, our results are consistent with the use of RF power deposition, characterized by B1+RMS, in predicting less heating in the MB sequence than the SB sequence. In the resting state EEG data, gradient and cardioballistic artifacts were successfully removed using traditional template subtraction. All subjects showed an individual alpha peak in the spectrogram with a posterior topography characteristic of eyes-closed EEG. Conclusions Our study shows that B1+RMS is a useful indication of the relative heating of fMRI protocols. This observation indicates that simultaneous EEG-fMRI recordings using this MB sequence can be safe in terms of RF-related heating, and that EEG data recorded using this sequence is of acceptable quality.
doi:10.1101/2020.08.19.256974 fatcat:2el677omgzdrroypdgoagolley

Intrinsic connectome organization across temporal scales: New insights from cross-modal approaches

Sepideh Sadaghiani, Jonathan Wirsich
2019 Network Neuroscience  
Jonathan Wirsich: Writing -Original Draft; Writing -Review & Editing.  ...  Both Wirsich et al. (2017b) and Deligianni et al. (2016) further assessed the relation to structural connectivity as discussed in section 4.  ... 
doi:10.1162/netn_a_00114 pmid:32043042 pmcid:PMC7006873 fatcat:v7bmzpajqvb7hh4lgkczluj3hi

Multi-timescale hybrid components of the functional brain connectome: A bimodal EEG-fMRI decomposition [article]

Jonathan Wirsich, Enrico Amico, Maxime Guye, Jean-Philippe Ranjeva, Anne-Lise Giraud, Joaquin Goni, Sepideh Sadaghiani
2019 bioRxiv   pre-print
Concurrent electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) bridge brain connectivity across timescales. During concurrent EEG-fMRI resting-state recordings, whole-brain functional connectivity (FC) strength is spatially correlated across modalities. However, cross-modal investigations have commonly remained correlational, and joint analysis of EEG-fMRI connectivity is largely unexplored. Here we investigated if there exist (spatially) independent FC networks linked
more » ... between modalities. We applied the recently proposed hybrid connectivity independent component analysis (connICA) framework to two concurrent EEG-fMRI resting state datasets (total 40 subjects). Two robust components were found across both datasets. The first component has a uniformly distributed EEG-frequency fingerprint linked mainly to intrinsic connectivity networks (ICNs) in both modalities. Conversely, the second component is sensitive to different EEG-frequencies and is primarily linked to intra-ICN connectivity in fMRI but to inter-ICN connectivity in EEG. The first hybrid component suggests that connectivity dynamics within well-known ICNs span timescales, from millisecond-range in all canonical frequencies of FCEEG to second-range of FCfMRI. Conversely, the second component additionally exposes linked but spatially divergent neuronal processing at the two timescales. This work reveals the existence of joint spatially independent components, suggesting that parts of resting-state connectivity are co-expressed in a linked manner across EEG and fMRI over individuals.
doi:10.1101/800797 fatcat:qsjvy2ybhvfttn2lzua64atqja

Multi-timescale hybrid components of the functional brain connectome: A bimodal EEG-fMRI decomposition

Jonathan Wirsich, Enrico Amico, Anne-Lise Giraud, Joaquín Goñi, Sepideh Sadaghiani
2020 Network Neuroscience  
., 2018; Wirsich et al., 2017) .  ...  Data was segmented into 3.6-s segments (according to one TR of the fMRI sequence and equivalent to Wirsich et al., 2017) .  ... 
doi:10.1162/netn_a_00135 pmid:32885120 pmcid:PMC7462430 fatcat:gyh6wq5vxzbdnlfmrk6oqvqvcy

EEG and fMRI connectomes are reliably related: a simultaneous EEG-fMRI study from 1.5T to 7T [article]

Jonathan Wirsich, Joao Jorge, Giannina R Iannotti, Elhum A Shamshiri, Frederic Grouiller, Rodolfo Abreu, Francois Lazeyras, Anne-Lise Giraud, Rolf Gruetter, Sepideh Sadaghiani, Serge Vulliemoz
2020 biorxiv/medrxiv   pre-print
Acknowledgments We thank Katia Lehongre, Benjamin Morillon (64Ch-3T dataset) and Fani Deligianni and Jonathan Clayden (64Ch-1.5T dataset) for generously sharing their data.  ...  This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ ) Table 3 3 Jonathan Wirsich : Wirsich Conceptualization, Methodology, Software, Formal analysis  ...  ., 2016 ; Wirsich et al., 2017 ) .  ... 
doi:10.1101/2020.06.16.154625 fatcat:ktgkxfrawnafnng7rrt6eg4qg4

Impact of Zika Virus on adult human brain structure and functional organization

Richard Bido-Medina, Jonathan Wirsich, Minelly Rodríguez, Jairo Oviedo, Isidro Miches, Pamela Bido, Luis Tusen, Peter Stoeter, Sepideh Sadaghiani
2018 Annals of Clinical and Translational Neurology  
Objective: To determine the impact of Zika virus (ZIKV) infection on brain structure and functional organization of severely affected adult patients with neurological complications that extend beyond Guillain-Barr e Syndrome (GBS)-like manifestations and include symptoms of the central nervous system (CNS). Methods: In this first case-control neuroimaging study, we obtained structural and functional magnetic resonance images in nine rare adult patients in the subacute phase, and healthy age-and
more » ... sex-matched controls. ZIKV patients showed atypical descending and rapidly progressing peripheral nervous system (PNS) manifestations, and importantly, additional CNS presentations such as perceptual deficits. Voxel-based morphometry was utilized to evaluate gray matter volume, and resting state functional connectivity and Network Based Statistics were applied to assess the functional organization of the brain. Results: Gray matter volume was decreased bilaterally in motor areas (supplementary motor cortex, specifically Frontal Eye Fields) and beyond (left inferior frontal sulcus). Additionally, gray matter volume increased in right middle frontal gyrus. Functional connectivity increased in a widespread network within and across temporal lobes. Interpretation: We provide preliminary evidence for a link between ZIKV neurological complications and changes in adult human brain structure and functional organization, comprising both motor-related regions potentially secondary to prolonged PNS weakness, and nonsomatomotor regions indicative of PNS-independent alternations. The latter included the temporal lobes, particularly vulnerable in a range of neurological conditions. While future studies into the ZIKV-related neuroinflammatory mechanisms in adults are urgently needed, this study indicates that ZIKV infection can lead to an impact on the brain. and its potential to cause neural damage. 3 Surprisingly, the causal association of the virus with clinically relevant neurological manifestations is recent. In consonance with the increased rate of microcephaly associated with ZIKV in pregnant women, 4 the majority of efforts have been devoted to understanding such unfortunate developmental disruptions. ZIKV-related neurological complications in adults have been overlooked, and the understanding of such a nosological entity remains significantly limited. 752
doi:10.1002/acn3.575 pmid:29928658 pmcid:PMC5989769 fatcat:asgp6kt25ngste7lgv4id3asrq

Whole-brain analytic measures of network communication reveal increased structure-function correlation in right temporal lobe epilepsy

Jonathan Wirsich, Alistair Perry, Ben Ridley, Timothée Proix, Mathieu Golos, Christian Bénar, Jean-Philippe Ranjeva, Fabrice Bartolomei, Michael Breakspear, Viktor Jirsa, Maxime Guye
2016 NeuroImage: Clinical  
The in vivo structure-function relationship is key to understanding brain network reorganization due to pathologies. This relationship is likely to be particularly complex in brain network diseases such as temporal lobe epilepsy, in which disturbed large-scale systems are involved in both transient electrical events and long-lasting functional and structural impairments. Herein, we estimated this relationship by analyzing the correlation between structural connectivity and functional
more » ... y in terms of analytical network communication parameters. As such, we targeted the gradual topological structure-function reorganization caused by the pathology not only at the whole brain scale but also both in core and peripheral regions of the brain. We acquired diffusion (dMRI) and resting-state fMRI (rsfMRI) data in seven right-lateralized TLE (rTLE) patients and fourteen healthy controls and analyzed the structure-function relationship by using analytical network communication metrics derived from the structural connectome. In rTLE patients, we found a widespread hypercorrelated functional network. Network communication analysis revealed greater unspecific branching of the shortest path (search information) in the structural connectome and a higher global correlation between the structural and functional connectivity for the patient group. We also found evidence for a preserved structural rich-club in the patient group. In sum, global augmentation of structure-function correlation might be linked to a smaller functional repertoire in rTLE patients, while sparing the central core of the brain which may represent a pathway that facilitates the spread of seizures.
doi:10.1016/j.nicl.2016.05.010 pmid:27330970 pmcid:PMC4909094 fatcat:jojee7yrrraxjb7gedg2iimvna

Alien Hand, Restless Brain: Salience Network and Interhemispheric Connectivity Disruption Parallel Emergence and Extinction of Diagonistic Dyspraxia

Ben Ridley, Marion Beltramone, Jonathan Wirsich, Arnaud Le Troter, Eve Tramoni, Sandrine Aubert, Sophie Achard, Jean-Philippe Ranjeva, Maxime Guye, Olivier Felician
2016 Frontiers in Human Neuroscience  
Ridley et al. Longitudinal Changes in Alien Hand Connectomics This also raises the possibility that changes to large-scale functional architecture revealed by resting-state functional magnetic resonance imaging (fMRI) (rs-fMRI) may provide relevant information on the evolution of behavioral syndromes in addition to that provided by structural and task-based functional imaging.
doi:10.3389/fnhum.2016.00307 pmid:27378896 pmcid:PMC4913492 fatcat:kxnnuxeswjg77b6a5hn55s3nj4

Modular slowing of resting-state dynamic Functional Connectivity as a marker of cognitive dysfunction induced by sleep deprivation [article]

Diego Lombardo, Catherine Casse-Perrot, Jean-Philippe Ranjeva, Arnaud Le Troter, Maxime Guye, Jonathan Wirsich, Pierre Payoux, David Bartres-Faz, Regis Bordet, Jill C Richardson, Olivier Felician, Viktor Jirsa (+3 others)
2020 biorxiv/medrxiv   pre-print
., 2010; Wirsich et al., 2018) .  ...  For more details, see Wirsich et al. (2018) and Chan Kwong et al. (2020) .  ... 
doi:10.1101/2020.01.17.910810 fatcat:btohiuclbfb4jmdimzhzp2u7yq

Simultaneous Intracranial EEG-fMRI Shows Inter-Modality Correlation in Time-Resolved Connectivity Within Normal Areas but Not Within Epileptic Regions

Ben Ridley, Jonathan Wirsich, Gaelle Bettus, Roman Rodionov, Teresa Murta, Umair Chaudhary, David Carmichael, Rachel Thornton, Serge Vulliemoz, Andrew McEvoy, Fabrice Wendling, Fabrice Bartolomei (+3 others)
2017 Brain Topography  
For the first time in research in humans, we used simultaneous icEEG-fMRI to examine the link between connectivity in haemodynamic signals during the resting-state (rs) and connectivity derived from electrophysiological activity in terms of the inter-modal
doi:10.1007/s10548-017-0551-5 pmid:28194612 fatcat:6abpgyc5lzc3vjmyjvjrx467qe

Safety and data quality of EEG recorded simultaneously with multi-band fMRI

Maximillian K Egan, Ryan Larsen, Jonathan Wirsich, Brad P Sutton, Sepideh Sadaghiani
2021
Egan, Ryan Larsen, Jonathan Wirsich, Brad P. Sutton, Sepideh Sadaghiani.  ...  Egan, Ryan Larsen, Jonathan Wirsich, Brad P. Sutton, Sepideh Sadaghiani. Data curation: Maximillian K. Egan, Ryan Larsen. Formal analysis: Maximillian K. Egan, Ryan Larsen.  ... 
doi:10.1371/journal.pone.0238485 pmid:34214093 pmcid:PMC8253410 fatcat:mesmn2djgvhv3ir3doxxbiib4e

Arbeit vs. Muße [chapter]

2021 Nichtstun als politische Praxis  
Dies ergibt sich aus einer Begegnung mit dem ehemals bei Tobler angestellten Herr Wirsich.  ...  Jonathan B. Wight. Petersfield: Harriman House (2007), 293. 77 Baudrillard: Der Symbolische Tausch, 23. 78 Pierre Bourdieu u. Jean-Claude Passeron: Die Erben. Studenten, Bildung und Kultur.  ... 
doi:10.1515/9783839457399-006 fatcat:7d5dpx57zravhachut5mfsoytm