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Tiotropium in asthma: From bench to bedside

Lyndon Mansfield, Jonathan A. Bernstein
2019 Respiratory Medicine  
Tiotropium is a long-acting muscarinic antagonist approved for maintenance treatment of asthma in children, adolescents, and adults in the United States, and recommended as add-on treatment for uncontrolled asthma despite treatment with inhaled corticosteroids and/or long-acting beta-2 agonists. This review traces the journey of tiotropium from its historical origins through early preclinical testing to human clinical trials and real-life studies.
doi:10.1016/j.rmed.2019.06.008 pmid:31212121 fatcat:g2zn6hfjh5bxnofrpkewqccuc4

Repeated Bleach Sanitization Effects on Medical Exam Glove Mechanical Properties

Samuel A. Mansfield, Jonathan Patterson, John Cuadros Olave, Robert N. Phalen, Youssef K. Hamidi
2021 Zenodo  
Since the mass outbreak of COVID-19 globally, the unique challenges of the pandemic have demanded the global economy, governments, and scientific community adapt in unprecedented ways. Despite pre-existing federal stockpiles of personal protective equipment (PPE) in countries such as the United States, rising shortages and resource constraints have compounded the complexity of curbing the spread of the pandemic and treating patients. To face such shortages, healthcare workers in different parts
more » ... of the world have been reusing PPE, especially personal protective gloves, and possibly sanitizing them through more cost-effective means such as a simple bleach and water solution. To preserve current and future PPE resources, this study investigates the effect of repeated diluted bleach treatment on mechanical properties of representative gloves to determine if reuse is an acceptable practice. This study aims to determine how bleach sanitization may affect material degradation of gloves when used in working environments. To this end, tensile tests were performed on elastomeric exam gloves with and without bleach sanitization treatments. Control data were prepared for both non-conditioned and humidity conditioned glove samples. Additional glove samples were subjected to ten repetitions of bleach exposure as outlined by Centers for Disease Control and Prevention US (CDC US) guidelines. Subsequently, all glove samples were tensile tested, and mechanical properties were determined. A statistically significant (p ≤ 0.05) loss of stiffness was observed for some of the tested samples, ranging as high as a 90% loss in stiffness. This research could serve to inform medical professionals as to whether sanitization through bleach treatments is acceptable and if so, at how many repetitions this treatment could potentially compromise the glove's ability to function as intended.
doi:10.5281/zenodo.5817219 fatcat:3jkfbmjjcjgspp5gmn6t6vft3y

Repeated Bleach Sanitization Effects on Medical Exam Glove Mechanical Properties

Samuel A. Mansfield, Jonathan Patterson, John Cuadros Olave, Robert N. Phalen, Youssef K. Hamidi
2021 Zenodo  
Since the mass outbreak of COVID-19 globally, the unique challenges of the pandemic have demanded the global economy, governments, and scientific community adapt in unprecedented ways. Despite pre-existing federal stockpiles of personal protective equipment (PPE) in countries such as the United States, rising shortages and resource constraints have compounded the complexity of curbing the spread of the pandemic and treating patients. To face such shortages, healthcare workers in different parts
more » ... of the world have been reusing PPE, especially personal protective gloves, and possibly sanitizing them through more cost-effective means such as a simple bleach and water solution. To preserve current and future PPE resources, this study investigates the effect of repeated diluted bleach treatment on mechanical properties of representative gloves to determine if reuse is an acceptable practice. This study aims to determine how bleach sanitization may affect material degradation of gloves when used in working environments. To this end, tensile tests were performed on elastomeric exam gloves with and without bleach sanitization treatments. Control data were prepared for both non-conditioned and humidity conditioned glove samples. Additional glove samples were subjected to ten repetitions of bleach exposure as outlined by Centers for Disease Control and Prevention US (CDC US) guidelines. Subsequently, all glove samples were tensile tested, and mechanical properties were determined. A statistically significant (p ≤ 0.05) loss of stiffness was observed for some of the tested samples, ranging as high as a 90% loss in stiffness. This research could serve to inform medical professionals as to whether sanitization through bleach treatments is acceptable and if so, at how many repetitions this treatment could potentially compromise the glove's ability to function as intended.
doi:10.5281/zenodo.5112641 fatcat:tyk2oe2i4zebrff2g6y4ouzzny

Feature congestion

Ruth Rosenholtz, Yuanzhen Li, Jonathan Mansfield, Zhenlan Jin
2005 Proceedings of the SIGCHI conference on Human factors in computing systems - CHI '05  
Management of clutter is an important factor in the design of user interfaces and information visualizations, allowing improved usability and aesthetics. However, clutter is not a well defined concept. In this paper, we present the Feature Congestion measure of display clutter. This measure is based upon extensive modeling of the saliency of elements of a display, and upon a new operational definition of clutter. The current implementation is based upon two features: color and luminance
more » ... . We have tested this measure on maps that observers ranked by perceived clutter. Results show good agreement between the observers' rankings and our measure of clutter. Furthermore, our measure can be used to make design suggestions in an automated UI critiquing tool.
doi:10.1145/1054972.1055078 dblp:conf/chi/RosenholtzLMJ05 fatcat:abql43on7nccljl3qkp5x2dtuu

Evolutionary quantitative genomics of Populus trichocarpa [article]

Ilga Porth, Jaroslav Klapste, Athena D McKown, Jonathan La Mantia, Robert D Guy, Paer K Ingvarsson, Richard Hamelin, Shawn D Mansfield, Juergen Ehlting, Carl J Douglas, Yousry A El-Kassaby
2015 bioRxiv   pre-print
Forest trees generally show high levels of local adaptation and efforts focusing on understanding adaptation to climate will be crucial for species survival and management. Merging quantitative genetics and population genomics, we studied the molecular basis of climate adaptation in 433 Populus trichocarpa (black cottonwood) genotypes originating across western North America. Variation in 74 field-assessed traits (growth, ecophysiology, phenology, leaf stomata, wood, and disease resistance) was
more » ... investigated for signatures of selection (comparing QST -FST) using clustering of individuals by climate of origin. 29,354 SNPs were investigated employing three different outlier detection methods. Narrow-sense QST for 53% of distinct field traits was significantly divergent from expectations of neutrality (indicating adaptive trait variation); 2,855 SNPs showed signals of diversifying selection, and of these, 118 SNPs (within 81 genes) were associated with adaptive traits (based on significant QST). Many SNPs were putatively pleiotropic for functionally uncorrelated adaptive traits, such as autumn phenology, height, and disease resistance. Evolutionary quantitative genomics in P. trichocarpa provides an enhanced understanding regarding the molecular basis of climate-driven selection in forest trees. We highlight that important loci underlying adaptive trait variation also show relationship to climate of origin.
doi:10.1101/026021 fatcat:acq4sxjlhngjjk4wkx5tcd3cpq

Introduction: A Journal of Law in the Service of Human Needs

Jonathan D. Libby, Todd David Muhlstock, Emily Barnes Cole, Anthony H. Mansfield
1996 CUNY Law Review  
INTRODUCTION: A JOURNAL OF LAW IN THE SERVICE OF HUMAN NEEDS Jonathan D. Libby Todd David Muhlstock Emily Barnes Cole Anthony H.  ...  Mansfield On behalf of the editors and staff of the New York City Law Review, we would like to extend a warm welcome to our readers.  ... 
doi:10.31641/clr010101 fatcat:buahbnczlbe2dorrcle3dz3fay

Supplementary_Info - Preferences of Type 1 Diabetic Patients on Devices for Islet Transplantation

M. Rezaa Mohammadi, Farideh Dehkordi-Vakil, Joni Ricks-Oddie, Robert Mansfield, Himala Kashimiri, Mark Daniels, Weian Zhao, Jonathan RT Lakey
2020 Figshare  
Rezaa Mohammadi, Farideh Dehkordi-Vakil, Joni Ricks-Oddie, Robert Mansfield, Himala Kashimiri, Mark Daniels, Weian Zhao and Jonathan RT Lakey in Cell Transplantation  ... 
doi:10.25384/sage.13066841.v1 fatcat:l4oxkmf7sza3xmhyxcjuzwtfym

Mechanical Performance of Latex and Nitrile Medical Exam Gloves Under Repeated Soap and Water Treatment

Jonathan Patterson, Samuel A. Mansfield, John Cuadros Olave, Robert N. Phalen, Youssef K. Hamidi
2021 Zenodo  
The human cost of the COVID-19 pandemic has taken a great toll, and led, around the globe, to a shortage in personal protective equipment (PPE) such as medical exam gloves. To face this shortage and keep themselves and patients safe, many front-line healthcare providers have been overextending the life of PPE. Though not ideal, one pragmatic solution often used is the practice of sanitization and extended use of existing PPE. The data produced by these experiments should help determine an
more » ... able reusability window of PPE in a working environment, by which the effective use time may be extended and justified. The effect of repeated sanitization, using soap and water, on the mechanical performance was investigated for latex and nitrile elastomeric medical exam gloves. Tensile tests were performed for various manufacturer brands commonly used in the United States (Glovepak Europa, Polymed and Sempersure) and India (Surgiglove). Tensile test samples were prepared for each studied glove and treatment combination. Nitrile gloves were observed to be more uniformly affected by the application of soap and water sanitization than latex gloves. Glovepak Europa nitrile gloves saw significant changes (p≤0.001) in elastic modulus after 5, 10 and 20 treatments losing 31.5%, 42.7% and 49.7%, respectively. Sempersure nitrile gloves also saw significant changes (p≤0.05) in elastic modulus at 5, 10 and 20 treatments losing 44.2%, 34.3% and 45.9%, respectively. Surgiglove nitrile gloves saw a significant loss in elastic modulus of 42.0% (p≤0.001) after 10 treatments. Surgiglove powder free latex showed no significant (p>0.05) change after 10 or 20 repeated treatments using soap and water. Polymed powder free latex showed no significant (p>0.05) change after 10 treatments, but did show a significant (p≤0.05) decrease in elastic modulus by 24.2% after 5 treatments and 25.5% after 20 treatments. Surgiglove powdered latex showed a significant (p≤0.05) increase in elastic modulus by 19.9% after 5 treatments and 15.8% after 10 t [...]
doi:10.5281/zenodo.5112602 fatcat:podotquih5a4neqsqhqlbnqkka

S-matrix equivalence restored

Chih-Hao Fu, Jonathan Fudger, Paul R.W Mansfield, Tim R Morris, Zhiguang Xiao
2009 Journal of High Energy Physics  
Acknowlegements Tim and Xiao thank STFC, and Jonathan thanks the Richard Newitt bursary scheme, for financial support.  ... 
doi:10.1088/1126-6708/2009/06/035 fatcat:gifwejliwvbk3kdrj3t2hz6yui

Efficacy and safety of fluticasone/formoterol combination therapy in patients with moderate-to-severe asthma

Jonathan Corren, Lyndon E. Mansfield, Tetyana Pertseva, Viktor Blahzko, Kirsten Kaiser
2013 Respiratory Medicine  
Conflict of interest statement Jonathan Corren, Lyndon Mansfield, Tetyana Pertseva and Viktor Blahzko had no proprietary interest in the tested product which was the subject of this study nor did they  ... 
doi:10.1016/j.rmed.2012.10.025 pmid:23273405 fatcat:cby23iew3zghfmxnhhvlqnt2qu

Exploiting Natural Variation to Uncover an Alkene Biosynthetic Enzyme in Poplar

Eliana Gonzales-Vigil, Charles A. Hefer, Michelle E. von Loessl, Jonathan La Mantia, Shawn D. Mansfield
2017 The Plant Cell  
Alkenes are linear hydrocarbons with one or more double bonds. Despite their potential as biofuels and precursors for specialty chemicals, the underlying biochemistry and genetics of alkene biosynthesis in plants remain elusive. Here, we report on a screen of natural accessions of poplar (Populus trichocarpa) revealing that the leaf cuticular waxes are predominantly composed of alkanes and alkenes. Interestingly, the accumulation of alkenes increases with leaf development, is limited to the
more » ... ial side of the leaf, and is impaired in a few accessions. Among other genes, a β-ketoacyl CoA synthase gene (PotriKCS1) was downregulated in leaves from non-alkene-producing accessions. We demonstrated biochemically that PotriKCS1 elongates monounsaturated fatty acids and is responsible for the recruitment of unsaturated substrates to the cuticular wax. Moreover, we found significant associations between the presence of alkenes and tree growth and resistance to leaf spot. These findings highlight the crucial role of cuticular waxes as the first point of contact with the environment, and they provide a foundation for engineering long-chain monounsaturated oils in other species.
doi:10.1105/tpc.17.00338 pmid:28729404 pmcid:PMC5590506 fatcat:dttuevindfbr5amtkrytslb44u

Preferences of Type 1 Diabetic Patients on Devices for Islet Transplantation

M. Rezaa Mohammadi, Farideh Dehkordi-Vakil, Joni Ricks-Oddie, Robert Mansfield, Himala Kashimiri, Mark Daniels, Weian Zhao, Jonathan RT Lakey
2020 Cell Transplantation  
Transplantation of pancreatic islets within a biomaterial device is currently under investigation in clinical trials for the treatment of patients with type 1 diabetes (T1D). Patients' preferences on such implants could guide the designs of next-generation implantable devices; however, such information is not currently available. We surveyed the preferences of 482 patients with T1D on the size, shape, visibility, and transplantation site of islet containing implants. More than 83% of
more » ... s were willing to receive autologous stem cells, and there was no significant association between implant fabricated by one's own stem cell with gender ( χ 2 (1, n = 468) = 0.28; P = 0.6) or with age ( χ 2 (4, n = 468) = 2.92; P = 0.6). Preferred location for islet transplantation within devices was under the skin (52.7%). 48.3% preferred microscopic disks, and 32.3% preferred a thin device (like a credit card). Moreover, 58.4% preferred the implant to be as small as possible, 25.4% did not care about visibility, and 16.2% preferred their implants not to be visible. Among female participants, 81% cared about the implant visibility, whereas this number was 64% for male respondents ( χ 2 test (1, n = 468) = 16.34; P < 0.0001). 22% of those younger than 50 years of age and 30% of those older than 50 did not care about the visibility of implant ( χ 2 test (4, n = 468) = 23.69; P < 0.0001). These results suggest that subcutaneous sites and micron-sized devices are preferred choices among patients with T1D who participated in our survey.
doi:10.1177/0963689720952343 pmid:33023311 fatcat:rkfniw6dbfhx3dtp6jczg336w4

Exfoliated transition metal dichalcogenide nanosheets for supercapacitor and sodium ion battery applications

Santanu Mukherjee, Jonathan Turnley, Elisabeth Mansfield, Jason Holm, Davi Soares, Lamuel David, Gurpreet Singh
2019 Royal Society Open Science  
Growing concerns regarding the safety, flammability and hazards posed by Li-ion systems have led to research on alternative rechargeable metal-ion electrochemical storage technologies. Among the most notable of these are Na-ion supercapacitors and batteries, motivated, in part, by the similar electrochemistry of Li and Na ions. However, sodium ion batteries (SIBs) come with their own set of issues, especially the large size of the Na+ ion, its relatively sluggish kinetics and low energy
more » ... s. This makes the development of novel materials and appropriate electrode architecture of absolute significance. Transition metal dichalcogenides (TMDs) have attracted a lot of attention in this regard due to their relative ease of exfoliation, diverse morphologies and architectures with superior electronic properties. Here, we study the electrochemical performance of Mo-based two-dimensional (2D) layered TMDs (e.g. MoS2, MoSe2 and MoTe2), exfoliated in a superacid, for battery and supercapacitor applications. The exfoliated TMD flakes were interfaced with reduced graphene oxide (rGO) to be used as composite electrodes. Electron microscopy, elemental mapping and Raman spectra were used to analyse the exfoliated material and confirm the formation of 2D TMD/rGO layer morphology. For supercapacitor applications in aqueous electrolyte, the sulfide-based TMD (MoS2) exhibited the best performance, providing an areal capacitance of 60.25 mF cm-2. For SIB applications, TMD electrodes exhibited significantly higher charge capacities than the neat rGO electrode. The initial desodiation capacities for the composite electrodes are 468.84 mAh g-1 (1687.82 C g-1), 399.10 mAh g-1 (1436.76 C g-1) and 387.36 mAh g-1 (1394.49 C g-1) for MoS2, MoSe2 and MoTe2, respectively. Also, the MoS2 and MoSe2 composite electrodes provided a coulombic efficiency of near 100 % after a few initial cycles.
doi:10.1098/rsos.190437 pmid:31598243 pmcid:PMC6731721 fatcat:easlylhrnzdanbcv4k52fvjqwy

Evolutionary Quantitative Genomics of Populus trichocarpa

Ilga Porth, Jaroslav Klápště, Athena D. McKown, Jonathan La Mantia, Robert D. Guy, Pär K. Ingvarsson, Richard Hamelin, Shawn D. Mansfield, Jürgen Ehlting, Carl J. Douglas, Yousry A. El-Kassaby, Björn Hamberger
2015 PLoS ONE  
PLOS ONE |
doi:10.1371/journal.pone.0142864 pmid:26599762 pmcid:PMC4658102 fatcat:x2reewkjwreipcym2k7qr5gspy

Association Analysis Identifies Melampsora ×columbiana Poplar Leaf Rust Resistance SNPs

Jonathan La Mantia, Jaroslav Klápště, Yousry A. El-Kassaby, Shofiul Azam, Robert D. Guy, Carl J. Douglas, Shawn D. Mansfield, Richard Hamelin, Ivan Baxter
2013 PLoS ONE  
Populus species are currently being domesticated through intensive time-and resource-dependent programs for utilization in phytoremediation, wood and paper products, and conversion to biofuels. Poplar leaf rust disease can greatly reduce wood volume. Genetic resistance is effective in reducing economic losses but major resistance loci have been race-specific and can be readily defeated by the pathogen. Developing durable disease resistance requires the identification of non-racespecific loci.
more » ... the presented study, area under the disease progress curve was calculated from natural infection of Melampsora 6columbiana in three consecutive years. Association analysis was performed using 412 P. trichocarpa clones genotyped with 29,355 SNPs covering 3,543 genes. We found 40 SNPs within 26 unique genes significantly associated (permutated P,0.05) with poplar rust severity. Moreover, two SNPs were repeated in all three years suggesting non-racespecificity and three additional SNPs were differentially expressed in other poplar rust interactions. These five SNPs were found in genes that have orthologs in Arabidopsis with functionality in pathogen induced transcriptome reprogramming, Ca 2+ /calmodulin and salicylic acid signaling, and tolerance to reactive oxygen species. The additive effect of non-R gene functional variants may constitute high levels of durable poplar leaf rust resistance. Therefore, these findings are of significance for speeding the genetic improvement of this long-lived, economically important organism.
doi:10.1371/journal.pone.0078423 pmid:24236018 pmcid:PMC3827267 fatcat:i7ujepn6gze2lge5t4bx2mutiu
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