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Divergence of species responses to climate change

Songlin Fei, Johanna M. Desprez, Kevin M. Potter, Insu Jo, Jonathan A. Knott, Christopher M. Oswalt
2017 Science Advances  
P la ta n u s o c c id e n ta li s M a g n o li a v ir g in ia n a M a g n o li a a c u m in a ta In summary, trees in the eastern United States have experienced prominent westward and northward shifts  ...  ic in a A b ie s b a ls a m e a T s u g a c a n a d e n s is J u n ip e ru s v ir g in ia n a T h u ja o c c id e n ta lis Ta xo di um di st ic hu m Tax odi um asc end ens Ac er neg und o Ac er ru br um  ... 
doi:10.1126/sciadv.1603055 pmid:28560343 pmcid:PMC5435420 fatcat:of6idoibgbb3fbzgvhio3vxdt4

Optogenetic feedback control of neural activity

Jonathan P Newman, Ming-fai Fong, Daniel C Millard, Clarissa J Whitmire, Garrett B Stanley, Steve M Potter
2015 eLife  
Acknowledgements We thank M LaPlaca for providing tissue and JT Shoemaker for performing tissue harvests. JPN  ...  The resulting mixture was returned to the culturing well and pipetted up and down 5 times to arrive at a final concentration of 20 μM CNQX, 50 μM AP5, or 20 μM bicuculline.  ...  The culturing well of each MEA was sealed with a fluorinated ethylene-propylene membrane (Potter and DeMarse, 2001) .  ... 
doi:10.7554/elife.07192 pmid:26140329 pmcid:PMC4490717 fatcat:mtqfozry65ectftquptfoy4nda

Amplitude modulated photostimulation for probing neuronal network dynamics

Jonathan P Newman, Tatjana Tchumatchenko, Ming-fai Fong, Steve M Potter
2012 BMC Neuroscience  
doi:10.1186/1471-2202-13-s1-p71 pmcid:PMC3403645 fatcat:6gx3yemvh5gv7jy6dyu62smwqi

Upward synaptic scaling is dependent on neurotransmission rather than spiking

Ming-fai Fong, Jonathan P. Newman, Steve M. Potter, Peter Wenner
2015 Nature Communications  
Homeostatic plasticity encompasses a set of mechanisms that are thought to stabilize firing rates in neural circuits. The most widely studied form of homeostatic plasticity is upward synaptic scaling (upscaling), characterized by a multiplicative increase in the strength of excitatory synaptic inputs to a neuron as a compensatory response to chronic reductions in firing rate. While reduced spiking is thought to trigger upscaling, an alternative possibility is that reduced glutamatergic
more » ... ion generates this plasticity directly. However, spiking and neurotransmission are tightly coupled, so it has been difficult to determine their independent roles in the scaling process. Here we combined chronic multielectrode recording, closed-loop optogenetic stimulation, and pharmacology to show that reduced glutamatergic transmission directly triggers cell-wide synaptic upscaling. This work highlights the importance of synaptic activity in initiating signalling cascades that mediate upscaling. Moreover, our findings challenge the prevailing view that upscaling functions to homeostatically stabilize firing rates.
doi:10.1038/ncomms7339 pmid:25751516 pmcid:PMC4355957 fatcat:ewbqd2lb3zhtnezxlpihhlwk6y

Delivery of continuously-varying stimuli using channelrhodopsin-2

Tatjana Tchumatchenko, Jonathan P. Newman, Ming-fai Fong, Steve M. Potter
2013 Frontiers in Neural Circuits  
Additionally, this work was supported by NSF GRFP Fellowship 08-593 to Jonathan P. Newman, NSF GRFP Fellowship 09-603 to Ming-fai Fong, and NSF IGERT Fellowship DGE-0333411 to Jonathan P.  ...  We thank M. LaPlaca for providing tissue and J. T. Shoemaker for performing tissue harvests. We thank N. Laxpati, and the Kaplan Lab for assistance with virus production. We thank P.  ...  All experiments were performed in the presence of 40 μM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), 50 μM (2R)-amino-5-phosphonovaleric acid (AP5), 20 μM bicuculline in order to prevent synaptic transmission  ... 
doi:10.3389/fncir.2013.00184 pmid:24367294 pmcid:PMC3853882 fatcat:xjmxvc3v2jdk5juv5eiu22p5xm

Lower extremity combat-related amputations

Scott M Tintle, Jonathan Agner Forsberg, John J Keeling, Scott B Shawen, Benjamin Kyle Potter
2010 Journal of Surgical Orthopaedic Advances  
Since the onset of combat activity in Iraq and Afghanistan, there have been over 1100 major limb amputations among United States service members. With a sustained military presence in the Middle East, continued severe lower extremity trauma is inevitable. For this reason, combat surgeons must understand the various amputation levels as well as the anatomic and technical details that enable an optimal functional outcome. These amputations are unique and usually result from blast mechanisms and
more » ... e complicated by broad zones of injury with severe contamination and ongoing infection. The combat servicemen are young, previously healthy, and have the promising potential to rehabilitate to very high levels of activity. Therefore, every practical effort should be made to perform sound initial and definitive trauma-related amputations so that these casualties may return to their highest possible level of function.
pmid:20371005 fatcat:aksgjpxgvjhvvcydq2evcjrjkq

Does test-enhanced learning transfer for triple associates?

Steven C. Pan, Carol M. Wong, Zachary E. Potter, Jonathan Mejia, Timothy C. Rickard
2015 Memory & Cognition  
The mean for those test items overall (M = .23, SE = .023) was approximately the same as that for both tested-identical and tested-inverted items from triplets that were incorrectly solved on the initial  ... 
doi:10.3758/s13421-015-0547-x pmid:26324093 fatcat:myrhg5tfqvelni4cmzgsrj2bki

The flexibility of industrial additive manufacturing systems

Daniel R. Eyers, Andrew T. Potter, Jonathan Gosling, Mohamed M. Naim
2018 International Journal of Operations & Production Management  
Flexibility assessment procedure We based our assessment on the four components of IAMS identified by Eyers and Potter (2015) : 1. Design.  ...  Zhang, Q., Vonderembse, M. A. and Lim, J.  ... 
doi:10.1108/ijopm-04-2016-0200 fatcat:f7yjqcxnnjbrngy7pfuq4omoee

Scientific Drilling

John W. Shervais, Douglas R. Schmitt, Dennis Nielson, James P. Evans, Eric H. Christiansen, Lisa Morgan, W. C. Pat Shanks, Alexander A. Prokopenko, Thomas Lachmar, Lee M. Liberty, David D. Blackwell, Jonathan M. Glen (+3 others)
2013 Scientific Drilling  
., 2012; Champion and Duncan, 2012; Potter et al., 2012) .  ...  Potter et al. (2011) have documented 557 basalt flow units in this section, based on natural gamma logs, neutron logs, and the recovered core, with a total thickness of 1803 m.  ... 
doi:10.2204/iodp.sd.15.06.2013 fatcat:65pistli7fa3thl7qw7px6epnq

Stimulus-evoked high frequency oscillations are present in neuronal networks on microelectrode arrays

Chadwick M. Hales, Riley Zeller-Townson, Jonathan P. Newman, James T. Shoemaker, Nathan J. Killian, Steve M. Potter
2012 Frontiers in Neural Circuits  
As with in vivo studies, activity is isolated to a single electrode, however, the MEA provides improved spatial resolution with no spread of the oscillation to adjacent electrodes 200 μm away.  ...  ACKNOWLEDGMENTS Chadwick M. Hales wrote the paper, designed, and conducted all experiments. Steve M. Potter edited the paper and contributed to experimental design.  ...  Research was supported by the Clinical Research Training Fellowship from the American Academy of Neurology Foundation (Chadwick M. Hales) and NSF EFRI (0836017) (Steve M. Potter).  ... 
doi:10.3389/fncir.2012.00029 pmid:22615686 pmcid:PMC3351760 fatcat:uhb5uevznbbwvknob67foia3da

Investigating Novice and Expert Conceptions of Genetically Modified Organisms

Lisa M. Potter, Sarah A. Bissonnette, Jonathan D. Knight, Kimberly D. Tanner, Diane K. O'Dowd
2017 CBE - Life Sciences Education  
The aspiration of biology education is to give students tools to apply knowledge learned in the classroom to everyday life. Genetic modification is a real-world biological concept that relies on an in-depth understanding of the molecular behavior of DNA and proteins. This study investigated undergraduate biology students' conceptions of genetically modified organisms (GMOs) when probed with real-world, molecular and cellular, and essentialist cues, and how those conceptions compared across
more » ... gy expertise. We developed a novel written assessment tool and administered it to 120 non-biology majors, 154 entering biology majors, 120 advanced biology majors (ABM), and nine biology faculty. Results indicated that undergraduate biology majors rarely included molecular and cellular rationales in their initial explanations of GMOs. Despite ABM demonstrating that they have much of the biology knowledge necessary to understand genetic modification, they did not appear to apply this knowledge to explaining GMOs. Further, this study showed that all undergraduate student populations exhibited evidence of essentialist thinking while explaining GMOs, regardless of their level of biology training. Finally, our results suggest an association between scientifically accurate ideas and the application of molecular and cellular rationales, as well as an association between misconceptions and essentialist rationales.
doi:10.1187/cbe.16-11-0333 pmid:28821537 pmcid:PMC5589432 fatcat:etsxpck7grdx5nhozygkds2v24

Networks of face-to-face social contacts in Niakhar, Senegal

Gail E. Potter, Jimmy Wong, Jonathan Sugimoto, Aldiouma Diallo, John C. Victor, Kathleen Neuzil, M. Elizabeth Halloran, Kin On Kwok
2019 PLoS ONE  
Baguelin M, Van Hoek AJ, Jit M, Flasche S, White PJ, Edmunds WJ. Vaccination against pandemic influenza A/H1N1v in England: a real-time economic evaluation.  ...  Hens N, Ayele GM, Goeyvaerts N, Aerts M, Mossong J, Edmunds JW, et al.  ... 
doi:10.1371/journal.pone.0220443 pmid:31386686 pmcid:PMC6684077 fatcat:6skngyzv6rgedaykhdldzntfcq

Introducing the national COPD resources and outcomes project

Robert A Stone, Brian DW Harrison, Derek Lowe, Rhona J Buckingham, Nancy A Pursey, Harold SR Hosker, Jonathan M Potter, C Michael Roberts
2009 BMC Health Services Research  
We report baseline data on the organisation of COPD care in UK NHS hospitals participating in the National COPD Resources and Outcomes Project (NCROP). Methods: We undertook an initial survey of participating hospitals in 2007, looking at organisation and performance indicators in relation to general aspects of care, provision of non-invasive ventilation (NIV), pulmonary rehabilitation, early discharge schemes, and oxygen. We compare, where possible, against the national 2003 audit. Results:
more » ... hospitals participated. These were typically larger sized Units. Many aspects of COPD care had improved since 2003. Areas for further improvement include organisation of acute care, staff training, end-of-life care, organisation of oxygen services and continuation of pulmonary rehabilitation. Conclusion: Key Points: positive change occurs over time and repeated audit seems to deliver some improvement in services. It is necessary to assess interventions such as the Peer Review used in the NCROP to achieve more comprehensive and rapid change.
doi:10.1186/1472-6963-9-173 pmid:19778416 pmcid:PMC2761897 fatcat:wejnvix5jbfndjbmas6bq7ru2e

Immobilization of active human carboxylesterase 1 in biomimetic silica nanoparticles

Jonathan S. Edwards, Amar Kumbhar, Adam Roberts, Andrew C. Hemmert, Carol C. Edwards, Philip M. Potter, Matthew R. Redinbo
2011 Biotechnology progress (Print)  
Furthermore, hCE1 in silica exhibited a slightly reduced efficiency (k cat /K m = 3.1 × 10 4 s −1 M −1 ) relative to free enzyme (k cat /K m = 1.9 × 10 4 s −1 M −1 ).  ...  k cat /K m (s −1 M −1 ) 6.09 × 10 4 3.85 × 10 4 Biotechnol Prog.  ... 
doi:10.1002/btpr.604 pmid:21509954 pmcid:PMC3670151 fatcat:aipx3hpxcnapfdvtbaytsbwmee

What Risk Factors Predict Recurrence of Heterotopic Ossification After Excision in Combat-related Amputations?

Gabriel J. Pavey, Elizabeth M. Polfer, Kyle E. Nappo, Scott M. Tintle, Jonathan A. Forsberg, Benjamin K. Potter
2015 Clinical Orthopaedics and Related Research  
Heterotopic ossification (HO) is common after combat-related amputations and surgical excision remains the only definitive treatment for persistently symptomatic HO. There is no consensus in the literature regarding the timing of surgery, and recurrence frequency, reexcision, and complications have not been reported in large numbers of patients. Questions/purposes (1) What are the rates of symptomatic recurrence resulting in reexcision and other complications resulting in reoperation in
more » ... with HO? (2) Is either radiographic or symptomatic recurrence dependent on timing and type of initial surgery, the experience of the surgeon in performing the procedure, the severity of preexcision HO, the presence of concomitant neurologic injury, or the use of postoperative HO prophylaxis? Methods Between March 2005 and March 2013 our institution treated 994 patients with 1377 combat-related major extremity amputations; of those, 172 amputations underwent subsequent excision of symptomatic HO. The mechanism of injury resulting in nearly all amputations (n = 168) was blast-related trauma. We reviewed medical records and radiographs to collect initial grade of HO, radiographic recurrence, complete compared with partial excision, concomitant neurologic injury, timing to initial surgery, surgeon experience, and use of postexcision prophylaxis with our primary study outcome being a return to the operating room (OR) for repeat excision of symptomatic HO. All 172 combat-related amputations were considered for this study irrespective of followup, which was noted to be robust, with 157 (91%) amputations having Each author certifies that he or she, or a member of his or her immediate family, has no funding or commercial associations (eg, consultancies, stock ownership, equity interest, patent/licensing arrangements, etc) that might pose a conflict of interest in connection with the submitted article. at least 6 months clinical followup by an orthopaedic surgeon or physiatrist (median, 20 months; range, 0-88 months). Results Eleven of 172 patients (6.5%) underwent reexcision of HO, and 67 complications resulting in return to the OR occurred in 53 patients (31%) of patients. Multivariate analysis of our primary outcome measure showed more frequent symptomatic recurrences requiring reexcision when initial excision was performed as a partial excision (p = 0.03; odds ratio [OR], 5.0; 95% confidence interval [CI], 1.2-29.6) or when the initial excision was performed within 180 days of injury (p = 0.047; OR, 4.1; 95% CI, 1.02-16.6). There was no association between symptomatic recurrence and HO grade, central nervous system injury, experience of the attending surgeon, or postoperative prophylaxis. Radiographic recurrence was observed when partial excisions (eight of 30 [27%]) were done compared with complete excisions (five of 77 [7%]; p = 0.008). Conclusions HO is common after combat-related amputations, and patients undergoing surgical excision of HO for this indication often have complications that result in repeat surgical procedures. Partial excisions of immature lesions more often resulted in both symptomatic and radiographic recurrence. The likelihood of a patient undergoing reexcision can be minimized by performing a complete excision at least 180 days from injury to surgery with no evidence of a reduced risk of reexcision by waiting longer than 270 days. Level of Evidence Level III, therapeutic study. * Statistically significant difference; HO = heterotopic ossification; OR = odds ratio; CI = confidence interval; CNS = central nervous system; WR = Walter Reed; NSAIDs = nonsteroidal antiinflammatory drugs; XRT = external beam radiation.
doi:10.1007/s11999-015-4266-1 pmid:25832006 pmcid:PMC4523520 fatcat:pn2q7ias3fhm7om4v3ncecpes4
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