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Chronology Protection Implementation in Analogue Gravity
[article]
2022
arXiv
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Analogue gravity systems offer many insights into gravitational phenomena, both at the classical and at the semiclassical level. The existence of an underlying Minkowskian structure (or Galilean in the non-relativistic limit) in the laboratory has been argued to directly forbid the simulation of geometries with Closed Timelike Curves (CTCs) within analogue systems. We will show that this is not strictly the case. In principle, it is possible to simulate spacetimes with CTCs whenever this does
arXiv:2201.11072v1
fatcat:uklartu7izd5hc3bdkgovfjxxa
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... t entail the presence of a chronological horizon separating regions with CTCs from regions that do not have CTCs. We find an Analogue-gravity Chronology protection mechanism very similar in spirit to Hawking's Chronology Protection hypothesis. We identify the universal behaviour of analogue systems near the formation of such horizons and discuss the further implications that this analysis has from an emergent gravity perspective. Furthermore, we build explicit geometries containing CTCs, for instance spacetimes constructed from two warp-drive configurations, that might be useful for future analysis, both from a theoretical and an experimental point of view.
fREX
2016
Proceedings of the 8th International Workshop on Modeling in Software Engineering - MiSE '16
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Reverse engineering is still a challenging process, notably because of the growing number, heterogeneity, complexity, and size of software applications. While the analysis of their structural elements has been intensively investigated, there is much less work covering the reverse engineering of their behavioral aspects. To further stimulate research on this topic, we propose fREX as an open framework for reverse engineering of executable behaviors from existing software code bases. fREX
doi:10.1145/2896982.2896984
dblp:conf/icse/BergmayrBCGMW16
fatcat:vsyjkwdd7rezbd56dh5x3mfsce
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... y provides model discovery support for behavior embedded in Java code, employs the OMG's fUML standard language as executable pivot format for dynamic analysis, and uses model transformations to bridge Java and fUML. Thus, fREX also aims at contributing to explore the relationship between programming languages (e.g., Java) and executable modeling languages (e.g., fUML). In this paper, we describe the proposed fREX framework and its current reverse engineering support covering some core Java features. In addition we discuss how the framework can be used for performing different kinds of dynamic analysis on existing software, as well as how it could be extended in the future.
EMF Views: A View Mechanism for Integrating Heterogeneous Models
[chapter]
2015
Lecture Notes in Computer Science
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Modeling complex systems involves dealing with several heterogeneous and interrelated models defined using a variety of languages (UML, ER, BPMN, DSLs, etc.). These models must be frequently combined in different cross-domain perspectives to provide stakeholders the view of the system they need to best perform their tasks. Several model composition approaches have already been proposed addressing this problem. Nevertheless, they present some important limitations concerning efficiency,
doi:10.1007/978-3-319-25264-3_23
fatcat:qihuuqnacjedhmfg3qsmzdtali
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... ability and synchronization between the base models and the composed ones. As an alternative we introduce EMF Views, an approach coming with a dedicated language and tooling for defining views on potentially heterogeneous models. Similarly to views in databases, model views are not materialized but instead redirect all model access and manipulation requests to the base models from which they are obtained. This is realized in a transparent way for both the modeler and the other modeling tools using the concerned (meta)models.
Overexpression of COL11A1 by Cancer-Associated Fibroblasts: Clinical Relevance of a Stromal Marker in Pancreatic Cancer
2013
PLoS ONE
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The collagen11A1 (COL11A1) gene is overexpressed in pancreatic cancer. The expression of COL11A1 protein could be involved in desmoplastic events in pancreatic cancer, but an antibody that specifically stains the COL11A1 protein is not currently available. Methods and findings: A total of 54 pancreatic ductal adenocarcinomas (PDAC), 23 chronic pancreatitis (CP) samples, and cultured peritumoral stromal cells of PDAC (passages 3-6) were studied. Normal human pancreas tissue samples were obtained
doi:10.1371/journal.pone.0078327
pmid:24194920
pmcid:PMC3808536
fatcat:v6wvhfgijrghpirdr2ieyhstui
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... through a cadaveric organ donation program. 1) Validation of COL11A1 gene overexpression by q-RT-PCR. Findings: the expression of COL11A1 gene is significantly increased in PDAC samples vs. normal and CP samples. 2) Analysis of COL11A1 by immunohistochemistry using highly specific anti-proCOL11A1 antibodies. Findings: anti-proCOL11A1 stains stromal cells/cancer-associated fibroblasts (CAFs) of PDAC but it does not stain chronic benign condition (chronic pancreatitis) stromal cells, epithelial cells, or normal fibroblasts. 3) Evaluation of the discrimination ability of the antibody. Findings: anti-proCOL11A1 immunostaining accurately discriminates between PDAC and CP (AUC 0.936, 95% CI 0.851, 0.981). 4) Phenotypic characterization of proCOL11A1+ stromal cells co-staining with mesenchymal, epithelial and stellate cell markers on pancreatic tissue samples and cultured peritumoral pancreatic cancer stromal cells. Findings: ProCOL11A1+ cells present co-staining with mesenchymal, stellate and epithelial markers (EMT phenotype) in different proportions. Conclusions/Significance: Detection of proCOL11A1 through immunostaining with this newly-developed antibody allows for a highly accurate distinction between PDAC and CP. Unlike other available antibodies commonly used to detect CAFs, anti-proCOL11A1 is negative in stromal cells of the normal pancreas and almost absent in benign inflammation. These results strongly suggest that proCOL11A1 is a specific marker for CAFs, and thus, anti-proCOL11A1 is a powerful new tool for cancer research and clinical diagnostics.
Siderurgical Aggregate Cement-Treated Bases and Concrete Using Foundry Sand
2021
Applied Sciences
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Cement-treated bases are soils, gravels or manufactured aggregates mixed with certain quantities of cement and water in order to improve the characteristics of a base or sub-base layer. Due to the exploitation of natural aggregates, it is a matter of importance to avoid shortage of natural resources, which is why the use of recycled aggregates is a practical solution. In this paper we studied the feasibility of the use of untreated electric arc furnace slags and foundry sand in the development
doi:10.3390/app11010435
fatcat:6fd6adrnmfan7cyqxqcq63lwky
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... f cement-treated bases and slag aggregate concrete with a lower quantity of cement. We analyzed the physical, mechanical and durability characteristics of the aggregates, followed by the design of mixes to fabricate test specimens. With cement-treated bases, results showed an optimal moisture content of 5% and a dry density of 2.47 g/cm3. Cement-treated bases made with untreated slag aggregate, foundry sand and 4% of cement content showed an unconfined compression strength at seven days of 3.73 MPa. For siderurgical aggregate concrete mixes, compressive strength, modulus of elasticity and flexural strength tests were made. The results showed that the mixes had good mechanical properties but durability properties could be an issue.
Incidence of eating disorders in Navarra (Spain)
2005
European psychiatry
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Purpose. -To estimate the overall annual incidence and age group distribution of eating disorders in a representative sample of adolescent female residents of Navarra, Spain. Methods. -We studied a representative sample of 2734 adolescent Navarran females between 13 and 22 years of age who were free of any eating disorder at the start of our study. Eighteen months into the study, we visited the established centers and the eating attitudes test (EAT-40) and eating disorder inventory (EDI)
doi:10.1016/j.eurpsy.2004.07.008
pmid:15797704
fatcat:pg4hmkuxivgxzlyhfcsfdkldre
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... nnaires were administered to the entire study population. We obtained a final response of 92%. All adolescents whose EAT score was over 21 points and a randomized sample of those who scored 21 or below, were interviewed. Any person meeting the DSM-IV diagnostic criteria for Anorexia Nervosa (AN), Bulimia Nervosa (BN) or eating disorder not otherwise specified (EDNOS) was considered a case. Results. -We detected 90 new cases of eating disorders. Taking into consideration the randomly selected group whose EAT score was 21 points or below, we estimated the overall weighted incidence of eating disorders to be 4.8% (95% CI: 2.8-6.8), after 18 months of observation, in which EDNOS predominated with an incidence of 4.2% (95% CI: 2.0-6.3). The incidence of AN was 0.3% (95% CI: 0.2-0.5), while that of BN was also found to be 0.3% (95% CI: 0.2-0.5). The highest incidence was observed in the group of adolescents between 15 and 16 years of age. Conclusions. -The overall incidence of ED in a cohort of 2509 adolescents after 18 months of follow-up was 4.8% (95% CI: 2.8-6.8), with EDNOS outweighing the other diagnoses. The majority of new cases of eating disorders were diagnosed between ages 15 and 16.
On Lightweight Metamodel Extension to Support Modeling Tools Agility
[chapter]
2015
Lecture Notes in Computer Science
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Modeling in real industrial projects implies dealing with different models, metamodels and supporting tools. They continuously have to be adapted to changing requirements, involving (often costly) problems in terms of traceability, coherence or interoperability. To this intent, solutions ensuring a better adaptability and flexibility of modeling tools are needed. As metamodels are cornerstones in such tools, metamodel extension capabilities are fundamental. However, current modeling frameworks
doi:10.1007/978-3-319-21151-0_5
fatcat:ktdt2jtajfcr5ouei36dazjb7q
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... re not flexible or dynamic enough. Thus, following the ongoing OMG MOF Extension Facility (MEF) RFP, this paper proposes a generic lightweight metamodel extension mechanism developed as part of the MoNoGe collaborative project. A base list of metamodel extension operators as well as a DSL for easily using them are introduced. Two different implementations of this extension mechanism (including a model-level support when (un)applying metamodel extensions) are also described, respectively based on Eclipse/EMF and the Modelio modeling environment.
An Adapter-Based Approach to Co-evolve Generated SQL in Model-to-Text Transformations
[chapter]
2014
Lecture Notes in Computer Science
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Jokin enjoyed a pre-doctoral grant from the Basque Government under the "Researchers Training Program". ...
doi:10.1007/978-3-319-07881-6_35
fatcat:ejtex2kgqbhp5hmj2yr3cgfhke
Genetic Contribution of Endometriosis to the Risk of Developing Hormone-Related Cancers
2021
International Journal of Molecular Sciences
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Endometriosis is a common gynecological disorder that has been associated with endometrial, breast and epithelial ovarian cancers in epidemiological studies. Since complex diseases are a result of multiple environmental and genetic factors, we hypothesized that the biological mechanism underlying their comorbidity might be explained, at least in part, by shared genetics. To assess their potential genetic relationship, we performed a two-sample mendelian randomization (2SMR) analysis on results
doi:10.3390/ijms22116083
fatcat:7wor3prohrhkdk52efhp73ekbe
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... rom public genome-wide association studies (GWAS). This analysis confirmed previously reported genetic pleiotropy between endometriosis and endometrial cancer. We present robust evidence supporting a causal genetic association between endometriosis and ovarian cancer, particularly with the clear cell and endometrioid subtypes. Our study also identified genetic variants that could explain those associations, opening the door to further functional experiments. Overall, this work demonstrates the value of genomic analyses to support epidemiological data, and to identify targets of relevance in multiple disorders.
Runtime support for rule-based access-control evaluation through model-transformation
2016
Proceedings of the 2016 ACM SIGPLAN International Conference on Software Language Engineering - SLE 2016
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A Systematic Two-Sample Mendelian Randomization Analysis Identifies Shared Genetic Origin of Endometriosis and Associated Phenotypes
2021
Life
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Endometriosis, one of the most common gynecological disorders, is a complex disease characterized by the growth of endometrial-like tissue in extra-uterine locations and is a cause of pelvic pain and infertility. Evidence from observational studies indicate that endometriosis usually appears together with several other phenotypes. These include a list of autoimmune diseases, most of them more prevalent in women, anthropometric traits associated with leanness in the adulthood, as well as female
doi:10.3390/life11010024
pmid:33401535
fatcat:zq67hhshkfemjp67aklxwtttka
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... eproductive traits, including altered hormone levels and those associated with a prolonged exposure to menstruation. However, the biological mechanisms underlying their co-morbidity remains unknown. To explore whether those phenotypes and endometriosis share a common genetic origin, we performed a systematic Two-Sample Mendelian Randomization (2SMR) analysis using public GWAS data. Our results suggest potential common genetic roots between endometriosis and female anthropometric and reproductive traits. Particularly, our data suggests that reduced weight and BMI might be mediating the genetic susceptibility to suffer endometriosis. Furthermore, data on female reproductive traits strongly suggest that genetic variants that predispose to a more frequent exposure to menstruation, through earlier age at menarche and shorter menstrual cycles, might also increase the risk to suffer from endometriosis.
Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma
2004
Biochimica et Biophysica Acta - Molecular Basis of Disease
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Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine and adenine salvage pathways. In mammals, the liver plays a central role in methionine metabolism, and this essential function is lost in the progression from liver cirrhosis to hepatocarcinoma. Deficient MTAP gene expression has been recognized in many transformed cell lines and tissues. In the present work, we have studied the expression of MTAP in human and experimental liver cirrhosis and hepatocarcinoma. We observe
doi:10.1016/j.bbadis.2004.08.002
pmid:15511635
fatcat:ngg3xgkjuzfndkuebm3xbhe654
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... hat MTAP gene expression is significantly reduced in human hepatocarcinoma tissues and cell lines. Interestingly, MTAP gene expression was also impaired in the liver of CCl 4cirrhotic rats and cirrhotic patients. We provide evidence indicating that epigenetic mechanisms, involving DNA methylation and histone deacetylation, may play a role in the silencing of MTAP gene expression in hepatocarcinoma. Given the recently proposed tumor suppressor activity of MTAP, our observations can be relevant to the elucidation of the molecular mechanisms of multistep hepatocarcinogenesis. D
SECOND WEEK METHYL-PREDNISOLONE PULSES IMPROVE PROGNOSIS IN PATIENTS WITH SEVERE CORONAVIRUS DISEASE 2019 PNEUMONIA: AN OBSERVATIONAL COMPARATIVE STUDY USING ROUTINE CARE DATA
[article]
2020
medRxiv
pre-print
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OBJECTIVE: To analyze the effects of a short course of methyl-prednisolone pulses (MP) during the second week of disease (week-2) on the clinical course of patients with severe coronavirus disease 2019 (COVID-19) pneumonia. DESIGN: Comparative observational study using data collected from routine care. SETTING: Hospital Universitario Cruces, a tertiary level University hospital at Barakaldo, Bizkaia, Spain. PARTICIPANTS: All patients with COVID-19 pneumonia admitted between 1st March and 30th
doi:10.1101/2020.07.16.20152868
fatcat:w3sedta4lrfzfare3wwtf7jtca
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... ril 2020 to the services of Infectious Diseases and Internal Medicine. INTERVENTIONS: Treatment with week-2-MP (125-250 mg/d for 3 consecutive days with no subsequent tapering) vs. standard of care. MAIN OUTCOMES MEASURES: Time to death and time to death or endotracheal intubation. RESULTS: Two hundred and forty-two patients with confirmed COVID-19 pneumonia and elevated inflammatory markers at admission were included in the study. Sixty-one patients (25%) received week-2-MP. Twenty-two patients (9%) died during the study period. Thirty-one patients (12.8%) suffered death or intubation. The adjusted HR for death was 0.35 (95%CI 0.11 to 1.06, p= 0.064) for patients in the week-2-MP group. The adjusted HR for death or intubation week-2-MP was 0.33 (95%CI 0.13 to 0.84, p=0.020) for patients in the week-2-MP group. These differences were seen in the subcohort of patients with a SaO2/FiO2 at day 7 lower than the median of the whole population: HR 0.31, 95% CI 0.08 to 1.12, p=0.073 and HR 0.34, 95%CI 0.12 to 0.94, p=0.038, respectively, but not in patients with higher SaO2/FiO2. Other predictors of the final outcomes were arterial hypertension, SaO2/FiO2, high-risk CURB65 scores and the use of non-pulse glucocorticoids. Non-pulse glucocorticoids were a predictor of infections (OR 4.72, 95%CI 1.90 to 11.80, p<0.001), while week-2-MP were not (OR 1.04, 95%CI 0.40 to 2.70, p=0.938). CONCLUSIONS: Week-2-MP are effective in improving the prognosis of patients with COVID-19 pneumonia with features of inflammatory activity and respiratory deterioration entering the second week of disease. The recognition of this high-risk population should prompt early use of MP at this point. REGISTRATION: This study has been registered in the EU PAS Register with the number EUPAS36287.
Second week methyl-prednisolone pulses improve prognosis in patients with severe coronavirus disease 2019 pneumonia: An observational comparative study using routine care data
2020
PLoS ONE
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Writing -review & editing: Guillermo Ruiz-Irastorza, Jose-Ignacio Pijoan, Elena Bereciartua, Susanna Dunder, Jokin Dominguez, Paula Garcia-Escudero, Alejandro Rodrigo, Carlota Gomez-Carballo, Jimena Varona ...
doi:10.1371/journal.pone.0239401
pmid:32960899
pmcid:PMC7508405
fatcat:fws7r4tvnrgr3medpsyulsbxnu
La arquitectura Administrativa de la Cultura en Italia
2020
Revista AC
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Recensión de Luis Miguel García Lozano: La Arquitectura Administrativa de la Cultura en Italia. Análisis del diseño organizativo de la Administración para la tutela de los bienes culturales. ...
Jokin Babaze Aizpurua Funcionario interino del Gobierno Vasco rencia de otros países, no existe reparto constitucional de las competencias en materia cultural, con lo que se consolida en manos de la ...
Conclusión A lo largo de esta obra, el profesor García Lozano ofrece una visión global del diseño institucional de la gobernanza cultural de Italia, país en el que es sabido que la materia supone un interés ...
doi:10.36402/ac.v14i2.110
fatcat:uch6v4ww6bd4xbknghejpunn5i
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