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Chronology Protection Implementation in Analogue Gravity [article]

Carlos Barceló, Jokin Eguia Sánchez, Gerardo García-Moreno, Gil Jannes
2022 arXiv   pre-print
Analogue gravity systems offer many insights into gravitational phenomena, both at the classical and at the semiclassical level. The existence of an underlying Minkowskian structure (or Galilean in the non-relativistic limit) in the laboratory has been argued to directly forbid the simulation of geometries with Closed Timelike Curves (CTCs) within analogue systems. We will show that this is not strictly the case. In principle, it is possible to simulate spacetimes with CTCs whenever this does
more » ... t entail the presence of a chronological horizon separating regions with CTCs from regions that do not have CTCs. We find an Analogue-gravity Chronology protection mechanism very similar in spirit to Hawking's Chronology Protection hypothesis. We identify the universal behaviour of analogue systems near the formation of such horizons and discuss the further implications that this analysis has from an emergent gravity perspective. Furthermore, we build explicit geometries containing CTCs, for instance spacetimes constructed from two warp-drive configurations, that might be useful for future analysis, both from a theoretical and an experimental point of view.
arXiv:2201.11072v1 fatcat:uklartu7izd5hc3bdkgovfjxxa


Alexander Bergmayr, Hugo Bruneliere, Jordi Cabot, Jokin García, Tanja Mayerhofer, Manuel Wimmer
2016 Proceedings of the 8th International Workshop on Modeling in Software Engineering - MiSE '16  
Reverse engineering is still a challenging process, notably because of the growing number, heterogeneity, complexity, and size of software applications. While the analysis of their structural elements has been intensively investigated, there is much less work covering the reverse engineering of their behavioral aspects. To further stimulate research on this topic, we propose fREX as an open framework for reverse engineering of executable behaviors from existing software code bases. fREX
more » ... y provides model discovery support for behavior embedded in Java code, employs the OMG's fUML standard language as executable pivot format for dynamic analysis, and uses model transformations to bridge Java and fUML. Thus, fREX also aims at contributing to explore the relationship between programming languages (e.g., Java) and executable modeling languages (e.g., fUML). In this paper, we describe the proposed fREX framework and its current reverse engineering support covering some core Java features. In addition we discuss how the framework can be used for performing different kinds of dynamic analysis on existing software, as well as how it could be extended in the future.
doi:10.1145/2896982.2896984 dblp:conf/icse/BergmayrBCGMW16 fatcat:vsyjkwdd7rezbd56dh5x3mfsce

EMF Views: A View Mechanism for Integrating Heterogeneous Models [chapter]

Hugo Bruneliere, Jokin Garcia Perez, Manuel Wimmer, Jordi Cabot
2015 Lecture Notes in Computer Science  
Modeling complex systems involves dealing with several heterogeneous and interrelated models defined using a variety of languages (UML, ER, BPMN, DSLs, etc.). These models must be frequently combined in different cross-domain perspectives to provide stakeholders the view of the system they need to best perform their tasks. Several model composition approaches have already been proposed addressing this problem. Nevertheless, they present some important limitations concerning efficiency,
more » ... ability and synchronization between the base models and the composed ones. As an alternative we introduce EMF Views, an approach coming with a dedicated language and tooling for defining views on potentially heterogeneous models. Similarly to views in databases, model views are not materialized but instead redirect all model access and manipulation requests to the base models from which they are obtained. This is realized in a transparent way for both the modeler and the other modeling tools using the concerned (meta)models.
doi:10.1007/978-3-319-25264-3_23 fatcat:qihuuqnacjedhmfg3qsmzdtali

Overexpression of COL11A1 by Cancer-Associated Fibroblasts: Clinical Relevance of a Stromal Marker in Pancreatic Cancer

Carmen García-Pravia, José A. Galván, Natalia Gutiérrez-Corral, Lorena Solar-García, Eva García-Pérez, Marcos García-Ocaña, Jokin Del Amo-Iribarren, Primitiva Menéndez-Rodríguez, Juan García-García, Juan R. de los Toyos, Laureano Simón-Buela, Luis Barneo (+1 others)
2013 PLoS ONE  
The collagen11A1 (COL11A1) gene is overexpressed in pancreatic cancer. The expression of COL11A1 protein could be involved in desmoplastic events in pancreatic cancer, but an antibody that specifically stains the COL11A1 protein is not currently available. Methods and findings: A total of 54 pancreatic ductal adenocarcinomas (PDAC), 23 chronic pancreatitis (CP) samples, and cultured peritumoral stromal cells of PDAC (passages 3-6) were studied. Normal human pancreas tissue samples were obtained
more » ... through a cadaveric organ donation program. 1) Validation of COL11A1 gene overexpression by q-RT-PCR. Findings: the expression of COL11A1 gene is significantly increased in PDAC samples vs. normal and CP samples. 2) Analysis of COL11A1 by immunohistochemistry using highly specific anti-proCOL11A1 antibodies. Findings: anti-proCOL11A1 stains stromal cells/cancer-associated fibroblasts (CAFs) of PDAC but it does not stain chronic benign condition (chronic pancreatitis) stromal cells, epithelial cells, or normal fibroblasts. 3) Evaluation of the discrimination ability of the antibody. Findings: anti-proCOL11A1 immunostaining accurately discriminates between PDAC and CP (AUC 0.936, 95% CI 0.851, 0.981). 4) Phenotypic characterization of proCOL11A1+ stromal cells co-staining with mesenchymal, epithelial and stellate cell markers on pancreatic tissue samples and cultured peritumoral pancreatic cancer stromal cells. Findings: ProCOL11A1+ cells present co-staining with mesenchymal, stellate and epithelial markers (EMT phenotype) in different proportions. Conclusions/Significance: Detection of proCOL11A1 through immunostaining with this newly-developed antibody allows for a highly accurate distinction between PDAC and CP. Unlike other available antibodies commonly used to detect CAFs, anti-proCOL11A1 is negative in stromal cells of the normal pancreas and almost absent in benign inflammation. These results strongly suggest that proCOL11A1 is a specific marker for CAFs, and thus, anti-proCOL11A1 is a powerful new tool for cancer research and clinical diagnostics.
doi:10.1371/journal.pone.0078327 pmid:24194920 pmcid:PMC3808536 fatcat:v6wvhfgijrghpirdr2ieyhstui

Siderurgical Aggregate Cement-Treated Bases and Concrete Using Foundry Sand

Gilberto Garcia Del Angel, Ali Aghajanian, Pablo Tamayo, Jokin Rico, Carlos Thomas
2021 Applied Sciences  
Cement-treated bases are soils, gravels or manufactured aggregates mixed with certain quantities of cement and water in order to improve the characteristics of a base or sub-base layer. Due to the exploitation of natural aggregates, it is a matter of importance to avoid shortage of natural resources, which is why the use of recycled aggregates is a practical solution. In this paper we studied the feasibility of the use of untreated electric arc furnace slags and foundry sand in the development
more » ... f cement-treated bases and slag aggregate concrete with a lower quantity of cement. We analyzed the physical, mechanical and durability characteristics of the aggregates, followed by the design of mixes to fabricate test specimens. With cement-treated bases, results showed an optimal moisture content of 5% and a dry density of 2.47 g/cm3. Cement-treated bases made with untreated slag aggregate, foundry sand and 4% of cement content showed an unconfined compression strength at seven days of 3.73 MPa. For siderurgical aggregate concrete mixes, compressive strength, modulus of elasticity and flexural strength tests were made. The results showed that the mixes had good mechanical properties but durability properties could be an issue.
doi:10.3390/app11010435 fatcat:6fd6adrnmfan7cyqxqcq63lwky

Incidence of eating disorders in Navarra (Spain)

Francisca Lahortiga-Ramos, Jokin De Irala-Estévez, Adrián Cano-Prous, Pilar Gual-García, Miguel Ángel Martínez-González, Salvador Cervera-Enguix
2005 European psychiatry  
Purpose. -To estimate the overall annual incidence and age group distribution of eating disorders in a representative sample of adolescent female residents of Navarra, Spain. Methods. -We studied a representative sample of 2734 adolescent Navarran females between 13 and 22 years of age who were free of any eating disorder at the start of our study. Eighteen months into the study, we visited the established centers and the eating attitudes test (EAT-40) and eating disorder inventory (EDI)
more » ... nnaires were administered to the entire study population. We obtained a final response of 92%. All adolescents whose EAT score was over 21 points and a randomized sample of those who scored 21 or below, were interviewed. Any person meeting the DSM-IV diagnostic criteria for Anorexia Nervosa (AN), Bulimia Nervosa (BN) or eating disorder not otherwise specified (EDNOS) was considered a case. Results. -We detected 90 new cases of eating disorders. Taking into consideration the randomly selected group whose EAT score was 21 points or below, we estimated the overall weighted incidence of eating disorders to be 4.8% (95% CI: 2.8-6.8), after 18 months of observation, in which EDNOS predominated with an incidence of 4.2% (95% CI: 2.0-6.3). The incidence of AN was 0.3% (95% CI: 0.2-0.5), while that of BN was also found to be 0.3% (95% CI: 0.2-0.5). The highest incidence was observed in the group of adolescents between 15 and 16 years of age. Conclusions. -The overall incidence of ED in a cohort of 2509 adolescents after 18 months of follow-up was 4.8% (95% CI: 2.8-6.8), with EDNOS outweighing the other diagnoses. The majority of new cases of eating disorders were diagnosed between ages 15 and 16.
doi:10.1016/j.eurpsy.2004.07.008 pmid:15797704 fatcat:pg4hmkuxivgxzlyhfcsfdkldre

On Lightweight Metamodel Extension to Support Modeling Tools Agility [chapter]

Hugo Bruneliere, Jokin Garcia, Philippe Desfray, Djamel Eddine Khelladi, Regina Hebig, Reda Bendraou, Jordi Cabot
2015 Lecture Notes in Computer Science  
Modeling in real industrial projects implies dealing with different models, metamodels and supporting tools. They continuously have to be adapted to changing requirements, involving (often costly) problems in terms of traceability, coherence or interoperability. To this intent, solutions ensuring a better adaptability and flexibility of modeling tools are needed. As metamodels are cornerstones in such tools, metamodel extension capabilities are fundamental. However, current modeling frameworks
more » ... re not flexible or dynamic enough. Thus, following the ongoing OMG MOF Extension Facility (MEF) RFP, this paper proposes a generic lightweight metamodel extension mechanism developed as part of the MoNoGe collaborative project. A base list of metamodel extension operators as well as a DSL for easily using them are introduced. Two different implementations of this extension mechanism (including a model-level support when (un)applying metamodel extensions) are also described, respectively based on Eclipse/EMF and the Modelio modeling environment.
doi:10.1007/978-3-319-21151-0_5 fatcat:ktdt2jtajfcr5ouei36dazjb7q

An Adapter-Based Approach to Co-evolve Generated SQL in Model-to-Text Transformations [chapter]

Jokin García, Oscar Dìaz, Jordi Cabot
2014 Lecture Notes in Computer Science  
Jokin enjoyed a pre-doctoral grant from the Basque Government under the "Researchers Training Program".  ... 
doi:10.1007/978-3-319-07881-6_35 fatcat:ejtex2kgqbhp5hmj2yr3cgfhke

Genetic Contribution of Endometriosis to the Risk of Developing Hormone-Related Cancers

Aintzane Rueda-Martínez, Aiara Garitazelaia, Ariadna Cilleros-Portet, Sergi Marí, Rebeca Arauzo, Jokin de Miguel, Bárbara P. González-García, Nora Fernandez-Jimenez, Jose Ramon Bilbao, Iraia García-Santisteban
2021 International Journal of Molecular Sciences  
Endometriosis is a common gynecological disorder that has been associated with endometrial, breast and epithelial ovarian cancers in epidemiological studies. Since complex diseases are a result of multiple environmental and genetic factors, we hypothesized that the biological mechanism underlying their comorbidity might be explained, at least in part, by shared genetics. To assess their potential genetic relationship, we performed a two-sample mendelian randomization (2SMR) analysis on results
more » ... rom public genome-wide association studies (GWAS). This analysis confirmed previously reported genetic pleiotropy between endometriosis and endometrial cancer. We present robust evidence supporting a causal genetic association between endometriosis and ovarian cancer, particularly with the clear cell and endometrioid subtypes. Our study also identified genetic variants that could explain those associations, opening the door to further functional experiments. Overall, this work demonstrates the value of genomic analyses to support epidemiological data, and to identify targets of relevance in multiple disorders.
doi:10.3390/ijms22116083 fatcat:7wor3prohrhkdk52efhp73ekbe

Runtime support for rule-based access-control evaluation through model-transformation

Salvador Martínez, Jokin García, Jordi Cabot
2016 Proceedings of the 2016 ACM SIGPLAN International Conference on Software Language Engineering - SLE 2016  
doi:10.1145/2997364.2997375 fatcat:pkvbgt3r6zfs3hz4jwvryy3xci

A Systematic Two-Sample Mendelian Randomization Analysis Identifies Shared Genetic Origin of Endometriosis and Associated Phenotypes

Aiara Garitazelaia, Aintzane Rueda-Martínez, Rebeca Arauzo, Jokin de Miguel, Ariadna Cilleros-Portet, Sergi Marí, Jose Ramon Bilbao, Nora Fernandez-Jimenez, Iraia García-Santisteban
2021 Life  
Endometriosis, one of the most common gynecological disorders, is a complex disease characterized by the growth of endometrial-like tissue in extra-uterine locations and is a cause of pelvic pain and infertility. Evidence from observational studies indicate that endometriosis usually appears together with several other phenotypes. These include a list of autoimmune diseases, most of them more prevalent in women, anthropometric traits associated with leanness in the adulthood, as well as female
more » ... eproductive traits, including altered hormone levels and those associated with a prolonged exposure to menstruation. However, the biological mechanisms underlying their co-morbidity remains unknown. To explore whether those phenotypes and endometriosis share a common genetic origin, we performed a systematic Two-Sample Mendelian Randomization (2SMR) analysis using public GWAS data. Our results suggest potential common genetic roots between endometriosis and female anthropometric and reproductive traits. Particularly, our data suggests that reduced weight and BMI might be mediating the genetic susceptibility to suffer endometriosis. Furthermore, data on female reproductive traits strongly suggest that genetic variants that predispose to a more frequent exposure to menstruation, through earlier age at menarche and shorter menstrual cycles, might also increase the risk to suffer from endometriosis.
doi:10.3390/life11010024 pmid:33401535 fatcat:zq67hhshkfemjp67aklxwtttka

Methylthioadenosine phosphorylase gene expression is impaired in human liver cirrhosis and hepatocarcinoma

Carmen Berasain, Henar Hevia, Jokin Fernández-Irigoyen, Esther Larrea, Juan Caballería, José M. Mato, Jesús Prieto, Fernando J. Corrales, Elena R. García-Trevijano, Matías A. Avila
2004 Biochimica et Biophysica Acta - Molecular Basis of Disease  
Methylthioadenosine phosphorylase (MTAP) is a key enzyme in the methionine and adenine salvage pathways. In mammals, the liver plays a central role in methionine metabolism, and this essential function is lost in the progression from liver cirrhosis to hepatocarcinoma. Deficient MTAP gene expression has been recognized in many transformed cell lines and tissues. In the present work, we have studied the expression of MTAP in human and experimental liver cirrhosis and hepatocarcinoma. We observe
more » ... hat MTAP gene expression is significantly reduced in human hepatocarcinoma tissues and cell lines. Interestingly, MTAP gene expression was also impaired in the liver of CCl 4cirrhotic rats and cirrhotic patients. We provide evidence indicating that epigenetic mechanisms, involving DNA methylation and histone deacetylation, may play a role in the silencing of MTAP gene expression in hepatocarcinoma. Given the recently proposed tumor suppressor activity of MTAP, our observations can be relevant to the elucidation of the molecular mechanisms of multistep hepatocarcinogenesis. D
doi:10.1016/j.bbadis.2004.08.002 pmid:15511635 fatcat:ngg3xgkjuzfndkuebm3xbhe654


Guillermo Ruiz-Irastorza, Jose-Ignacio Pijoan, Elena Bereciartua, Susanna Dunder, Jokin Dominguez, Paula Garcia-Escudero, Alejandro Rodrigo, Carlota Gomez-Carballo, Jimena Varona, Laura Guio, Marta Ibarrola, Amaia Ugarte (+1 others)
2020 medRxiv   pre-print
OBJECTIVE: To analyze the effects of a short course of methyl-prednisolone pulses (MP) during the second week of disease (week-2) on the clinical course of patients with severe coronavirus disease 2019 (COVID-19) pneumonia. DESIGN: Comparative observational study using data collected from routine care. SETTING: Hospital Universitario Cruces, a tertiary level University hospital at Barakaldo, Bizkaia, Spain. PARTICIPANTS: All patients with COVID-19 pneumonia admitted between 1st March and 30th
more » ... ril 2020 to the services of Infectious Diseases and Internal Medicine. INTERVENTIONS: Treatment with week-2-MP (125-250 mg/d for 3 consecutive days with no subsequent tapering) vs. standard of care. MAIN OUTCOMES MEASURES: Time to death and time to death or endotracheal intubation. RESULTS: Two hundred and forty-two patients with confirmed COVID-19 pneumonia and elevated inflammatory markers at admission were included in the study. Sixty-one patients (25%) received week-2-MP. Twenty-two patients (9%) died during the study period. Thirty-one patients (12.8%) suffered death or intubation. The adjusted HR for death was 0.35 (95%CI 0.11 to 1.06, p= 0.064) for patients in the week-2-MP group. The adjusted HR for death or intubation week-2-MP was 0.33 (95%CI 0.13 to 0.84, p=0.020) for patients in the week-2-MP group. These differences were seen in the subcohort of patients with a SaO2/FiO2 at day 7 lower than the median of the whole population: HR 0.31, 95% CI 0.08 to 1.12, p=0.073 and HR 0.34, 95%CI 0.12 to 0.94, p=0.038, respectively, but not in patients with higher SaO2/FiO2. Other predictors of the final outcomes were arterial hypertension, SaO2/FiO2, high-risk CURB65 scores and the use of non-pulse glucocorticoids. Non-pulse glucocorticoids were a predictor of infections (OR 4.72, 95%CI 1.90 to 11.80, p<0.001), while week-2-MP were not (OR 1.04, 95%CI 0.40 to 2.70, p=0.938). CONCLUSIONS: Week-2-MP are effective in improving the prognosis of patients with COVID-19 pneumonia with features of inflammatory activity and respiratory deterioration entering the second week of disease. The recognition of this high-risk population should prompt early use of MP at this point. REGISTRATION: This study has been registered in the EU PAS Register with the number EUPAS36287.
doi:10.1101/2020.07.16.20152868 fatcat:w3sedta4lrfzfare3wwtf7jtca

Second week methyl-prednisolone pulses improve prognosis in patients with severe coronavirus disease 2019 pneumonia: An observational comparative study using routine care data

Guillermo Ruiz-Irastorza, Jose-Ignacio Pijoan, Elena Bereciartua, Susanna Dunder, Jokin Dominguez, Paula Garcia-Escudero, Alejandro Rodrigo, Carlota Gomez-Carballo, Jimena Varona, Laura Guio, Marta Ibarrola, Amaia Ugarte (+2 others)
2020 PLoS ONE  
Writing -review & editing: Guillermo Ruiz-Irastorza, Jose-Ignacio Pijoan, Elena Bereciartua, Susanna Dunder, Jokin Dominguez, Paula Garcia-Escudero, Alejandro Rodrigo, Carlota Gomez-Carballo, Jimena Varona  ... 
doi:10.1371/journal.pone.0239401 pmid:32960899 pmcid:PMC7508405 fatcat:fws7r4tvnrgr3medpsyulsbxnu

La arquitectura Administrativa de la Cultura en Italia

Jokin Babaze Aizpurua
2020 Revista AC  
Recensión de Luis Miguel García Lozano: La Arquitectura Administrativa de la Cultura en Italia. Análisis del diseño organizativo de la Administración para la tutela de los bienes culturales.  ...  Jokin Babaze Aizpurua Funcionario interino del Gobierno Vasco rencia de otros países, no existe reparto constitucional de las competencias en materia cultural, con lo que se consolida en manos de la  ...  Conclusión A lo largo de esta obra, el profesor García Lozano ofrece una visión global del diseño institucional de la gobernanza cultural de Italia, país en el que es sabido que la materia supone un interés  ... 
doi:10.36402/ac.v14i2.110 fatcat:uch6v4ww6bd4xbknghejpunn5i
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