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(Photograph by Susy Ziegler, November 2013). ... (Graph by John Hudson). FIG. 4 - 4 Fishing cycles in Lake Michigan, 1936-2007. Source: Baldwin and others 2009. (Graph by John Hudson). ...doi:10.1111/j.1931-0846.2014.12041.x fatcat:mjku6yf2lrabpflyd5c5buyitq
A, cells were labeled with [ 35 S]Met/Cys for 30 min, then chased for 0 -4 h. ... C1R transfectants were pulsed for 5 min with [ 35 S]Met/Cys and chased for up to 2 h. ...doi:10.1074/jbc.m110336200 pmid:11978783 fatcat:ldy3pjavkbgl3d7chdoi2mjfde
The population is not synchronized with respect to cell division, but the YRO gates when a cell can enter S phase. ... PRXs in the yeast S. cerevisiae have the nine amino acid sequence recognized by the PRX-SO 2/3 antisera when over-oxidized. ...doi:10.1016/j.cub.2015.02.035 pmid:25866393 pmcid:PMC4406945 fatcat:c5sxazqg35gfzoajboontyw5hi
In these cells, NM23-H1's DNase I activity is limited by its inhibitor, TAF-Iβ. However, a different scenario ensues when cytotoxic T lymphocytes detect a virally infected or tumor cell. ... Table 2 : 2 ERα-associated protein interactions Protein Interacting Protein Reference(s) APE1 ERα Curtis and Nardulli, Submitted FEN1  HMG-2 [61,69] NM23-H1  PCNA [68,70] pp32 [ ...doi:10.1186/1471-2199-9-97 pmid:18973695 pmcid:PMC2585101 fatcat:xulvgfolhzdspjvwp64axkbjnq
Consistent with an oligodendroglial identity, these cells were immunostained for glutamine S-transferase (GST)-π and possessed long, thin processes that ran parallel to and adjacent to subcortical axons ... (F): NSPs were cultured for 6 DIV in 4.4 nM insulin and then transferred Ziegler et al. Page 17 Stem Cells. Author manuscript; available in PMC 2017 September 02. ...doi:10.1002/stem.1095 pmid:22593020 pmcid:PMC5581406 fatcat:jtrg4kgambemppww4d4phpbjoy
Introduction and Aims: For women who carry BRCA mutations, risk-reducing surgeries are an option to decrease breast and ovarian cancer risk. This study aims to determine the uptake, time course, and predictors of riskreducing mastectomy (RRM) and risk-reducing salpingo-oophorectomy (RRSO) in BRCA carriers. Results: In 272 female carriers, followed for a median of 3.7 years, 23% of those eligible chose RRM, and 51% percent chose RRSO. Among BRCA carriers who chose these procedures, median timedoi:10.1089/gtmb.2008.0067 pmid:19309274 pmcid:PMC2981359 fatcat:7twln2wlv5ayhg2b6c42jcat5e
more »... both RRM and RRSO was approximately 4 months after learning of BRCA-positive results. Predictors of RRM were as follows: age below 60 years (hazard ratio 1.8, p ¼ 0.04), prior breast cancer (hazard ratio 2.4, p ¼ 0.0004), and RRSO (hazard ratio 7.2, p < 0.0001). Predictors of RRSO were as follows: age below 60 years (hazard ratio 3.6, p ¼ 0.006), prior breast cancer (hazard ratio 1.8, p ¼ 0.002), and RRM (hazard ratio 5.4, p < 0.0001). Conclusions: Many women who undergo BRCA testing use these results to make clinical decisions; those who choose risk-reducing surgeries typically do so within months of receiving BRCA-positive results. Predictors of risk-reducing surgery uptake include the following: age below 60 years, prior breast cancer, and utilization of another risk-reducing surgery. Future research directions include examining other preventive and screening options in BRCA carriers as well as studying motivations for choosing or declining risk-reducing surgeries.
Other studies have shown that FOXM1-deficient cells exhibit delayed S-phase entry, reflecting the importance of FOXM1 at the G1/S transition  . ... and G2/M transitions and S-phase functions such as DNA replication and DNA damage repair, as well as the progression of mitosis. ...doi:10.3390/cancers13246282 pmid:34944900 pmcid:PMC8699539 fatcat:u3kjg6qnurckbfqp3ykuil4svq
Physics Letters B
(l)ln m l m Z − h C s (h)ln M X M h + δ s (1.b) 1 α X = 1 4 3 5α e + 12 5α 3 + 1 20π l C a (l)ln m l m Z − h C a (h)ln M X M h + δ a (1.c) where the sums over the light m l > ∼ m Z , and heavy M h < ∼ ... = −5 12 b y + 5 4 b 2 − 5 6 b 3 (5.a) δ d = − 3π α e δ s + δ m (5.b) and we have used the experimental value of sin 2 θ with explicit top mass dependence  . ...doi:10.1016/0370-2693(94)01331-6 fatcat:w7t6wvissrc4xig7mivj5bdn24
Peterson, BJ, Fitzgerald, JS, Dietz, CC, Ziegler, KS, Ingraham, SJ, Baker, SE, and Snyder, EM. Aerobic capacity is associated with improved repeated shift performance in hockey. ... INTRODUCTION S port-specific training has been shown to improve performance in repeated sprint sport athletes (i.e., soccer, football, rugby, basketball, and ice hockey). ... Variable (s) Mean 6 SD Fastest course time 23.02 6 0.61 Slowest course time 26.47 6 1.53 Average course time 25.05 6 1.02 Average first gate time 9.90 6 0.86 Average second gate time 15.30 ...doi:10.1519/jsc.0000000000000786 pmid:25756322 fatcat:7qrehmwfgbdtxi3qyrlwvgf2hu
Vaginal microbicides potentially empower women to protect themselves from HIV and other sexually transmitted infections (STIs), especially when culture, religion, or social status may prevent them from negotiating condom use. The open literature contains minimal information on factors that drive user acceptability of women's health products or vaginal drug delivery systems. By understanding what women find to be most important with regard to sensory properties and product functionality,doi:10.1371/journal.pone.0150896 pmid:26999009 pmcid:PMC4801188 fatcat:jcazsjlgbzalleizjcf3jm4oy4
more »... rs can iteratively formulate a more desirable product. Conjoint analysis is a technique widely used in market research to determine what combination of elements influence a consumer's willingness to try or use a product. We applied conjoint analysis here to better understand what sexually-active woman want in a microbicide, toward our goal of formulating a product that is highly acceptable to women. Both sensory and non-sensory attributes were tested, including shape, color, wait time, partner awareness, messiness/leakage, duration of protection, and functionality. Heterosexually active women between 18 and 35 years of age in the United States (n = 302) completed an anonymous online conjoint survey using IdeaMap software. Attributes (product elements) were systematically presented in various combinations; women rated these combinations of a 9-point willingness-to-try scale. By coupling systematic combinations and regression modeling, we can estimate the unique appeal of each element. In this population, a multifunctional product (i.e., broad spectrum STI protection, coupled with conception) is far more desirable than a microbicide targeted solely for HIV protection; we also found partner awareness and leakage are potentially strong barriers to use.
In recent years, there has been an emphasis on personalizing breast cancer treatment in order to avoid the debilitating side effects caused by broad-spectrum chemotherapeutic drug treatment. Development of personalized medicine requires the identification of proteins that are expressed by individual tumors. Herein, we reveal the identity of plasma membrane proteins that are overexpressed in estrogen receptor α-positive, HER2-positive, and triple negative breast cancer cells. The proteins wedoi:10.1186/s12014-018-9206-0 pmid:30250408 pmcid:PMC6145347 fatcat:wtu6vkwdrzexpkw4rxxnv7jvpm
more »... tified are involved in maintaining protein structure, intracellular homeostasis, and cellular architecture; enhancing cell proliferation and invasion; and influencing cell migration. These proteins may be useful for breast cancer detection and/or treatment.
Metastasis-related complications account for the overwhelming majority of breast cancer mortalities. Triple negative breast cancer (TNBC), the most aggressive breast cancer subtype, has a high propensity to metastasize to distant organs, leading to poor patient survival. The forkhead transcription factor, FOXM1, is especially upregulated and overexpressed in TNBC and is known to regulate multiple signaling pathways that control many key cancer properties, including proliferation, invasiveness,doi:10.3390/cancers12092677 pmid:32961773 pmcid:PMC7565743 fatcat:env22wcbfjbjjdk4hxels6u4v4
more »... tem cell renewal, and therapy resistance, making FOXM1 a critical therapeutic target for TNBC. In this study, we test the effectiveness of a novel class of 1,1-diarylethylene FOXM1 inhibitory compounds in suppressing TNBC cell migration, invasion, and metastasis using in vitro cell culture and in vivo tumor models. We show that these compounds inhibit the motility and invasiveness of TNBC MDA-MB-231 and DT28 cells, along with reducing the expression of important epithelial to mesenchymal transition (EMT) associated genes. Further, orthotopic tumor studies in NOD-SCID-gamma (NSG) mice demonstrate that these compounds reduce FOXM1 expression and suppress TNBC tumor growth as well as distant metastasis. Gene expression and protein analyses confirm the decreased levels of EMT factors and FOXM1-regulated target genes in tumors and metastatic lesions in the inhibitor-treated animals. The findings suggest that these FOXM1 suppressive compounds may have therapeutic potential in treating triple negative breast cancer, with the aim of reducing tumor progression and metastatic outgrowth.
■ ASSOCIATED CONTENT * S Supporting Information Complete experimental procedures, characterization data, additional discussion of catalyst optimization and substrate scope, and crystallographic information ...doi:10.1021/ja508523g pmid:25213353 pmcid:PMC4235369 fatcat:7yzpfp6i7ze6xfjz47thjb23ru
The increasing demand for rotator cuff (RC) repair patients to return to work as soon as they are physically able has led to exploration of when this is feasible. Current guidelines from our orthopedic surgery clinic recommend a return to work at 9 weeks postoperation. To more fully define capacity to return to work, the current study was conducted using a unique series of quantitative tools. To date, no study has combined 3-dimensional (3D) motion analysis with electromyography (EMG)doi:10.1016/j.pmrj.2016.08.031 pmid:27639653 fatcat:tyw2q3f2rjcmrarntlutgnstv4
more »... during activities of daily living (ADLs), including desk tasks, and commonly prescribed rehabilitation exercise. Objective: To apply a quantitative, validated upper extremity model to assess the kinematics and muscle activity of the shoulder following repair of the supraspinatus RC tendon compared to that in healthy shoulders. Design: A prospective, cross-sectional comparison study. Setting: All participants were evaluated during a single session at the Medical College of Wisconsin Department of Orthopaedic Surgery's Motion Analysis Laboratory. Participants: Ten participants who were 9-12 weeks post-operative repair of a supraspinatus RC tendon tear and 10 participants with healthy shoulders (HS) were evaluated. Methods: All participants were evaluated with 3D motion analysis using a validated upper extremity model and synchronized EMG. Data from the 2 groups were compared using multivariate Hotelling T 2 tests with post hoc analyses based on Welch t-tests. Main Outcome Measurements: Participants' thoracic and thoracohumeral joint kinematics, temporal-spatial parameters, and RC muscle activity were measured by applying a quantitative upper extremity model during 10 activities of daily living and 3 rehabilitation exercises. These included tasks of hair combing, drinking, writing, computer mouse use, typing, calling, reaching to back pocket, pushing a door open, pulling a door closed, external rotation, internal rotation, and rowing. Results: There were significant differences of the thoracohumeral joint motion in only a few of the tested tasks: comb maximal flexion angle (P = .004), pull door internal/external rotation range of motion (P = .020), reach abduction/adduction range of motion (P = .001), reach flexion/extension range of motion (P = .001), reach extension minimal angle (P = .025), active external rotation maximal angle (P = .012), and active external rotation minimal angle (P = .004). The thorax showed significantly different kinematics of maximal flexion angle during the call (P = .011), mouse (P = .007), and drink tasks (P = .005) between the 2 groups. The EMG data analysis showed significantly increased subscapularis activity in the RC repair group during active external rotation. Conclusions: Although limited abduction was expected due to repair of the supraspinatus tendon, only a single ADL (reaching to back pocket) had a significantly reduced abduction range of motion. Thoracic motion was shown to be used as a compensatory strategy during seated ADLs. Less flexion of the thorax may create passive shoulder flexion at the thoracohumeral joint in efforts to avoid active flexion. The RC repair group participants were able to accomplish the ADLs within the same time frame and through thoracohumeral joint kinematics similar to those in the healthy shoulder group participants. In summary, this study presents a quantification of the effects of RC repair and rehabilitation on the ability to perform ADLs. It may also point to a need for increased rehabilitation focus on either regaining external rotation strength or range of motion following RC repair to enhance recovery and return to the workforce.
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