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Alcohol and gene interactions

John B. Whitfield
2005 Clinical Chemistry and Laboratory Medicine  
: Alcohol and gene interactions Article in press -uncorrected proof Whitfield: Alcohol and gene interactions  ...  alcohol 1, 2, 9, 21 (21) P3 evoked potential 4, 5 (22) Platelet MAO 2, 9, 12 (19) Factor score from data on alcohol 1, 15 (23) use and alcohol-related symptoms Alcoholism/smoking 2 Whitfield  ... 
doi:10.1515/cclm.2005.086 pmid:15899669 fatcat:ybw6z2mp3bd3vgp2jocikcyzfe

Genetic insights into cardiometabolic risk factors

John B Whitfield
2014 Clinical biochemist reviews  
HOMA-IR measures insulin resistance and HOMA-B measures islet beta-cell function. Filled cells indicate p < 10 -3 for the most significant SNP for that locus and phenotype.  ...  showed a mix of effects on beta-cell function and insulin resistance, with more of the former. 70, 71 igure 2 summarises the overlap of loci for Type 2 diabetes, glucose, beta-cell function (HOMA-B)  ... 
pmid:24659834 pmcid:PMC3961996 fatcat:gb7tfh4p4jhhrfkrwnejbpr7oa

Traditional markers of excessive alcohol use

Katherine M. Conigrave, Peter Davies, Paul Haber, John B. Whitfield
2003 Addiction  
Macrocytosis can occur in liver disease of other causes, in bleeding, vitamin (B 12 or folate) deficiencies and in a variety of haematological conditions, and in association with several common medications  ...  including hepatic congestion) hypertriglyceridaemia diabetes pancreatitis Obesity Liver and biliary conditions Muscle diseases Extreme exertion Obesity Liver and biliary conditions Folate or B  ... 
doi:10.1046/j.1359-6357.2003.00581.x pmid:14984240 fatcat:se5uctb555e37gbx5onvo7b5ii

Birthweights in Same-sex and Opposite-sex Twin Pregnancies

Susan A. Treloar, John B. Whitfield
2002 Twin research  
., 2000; Whitfield et al., 2001) .  ... 
doi:10.1375/twin.5.4.310 fatcat:e6xxr3v4tjbybhpxbdxr3hk32i

Genetics and molecular biology in laboratory medicine, 1963–2013

John B. Whitfield
2013 Clinical Chemistry and Laboratory Medicine  
Unauthenticated Download Date | 7/27/18 7:27 PM Unauthenticated Download Date | 7/27/18 7:27 PM Whitfield: Genetics and molecular biology in laboratory medicine, 1963-2013 Whitfield: Genetics  ... 
doi:10.1515/cclm-2012-0478 pmid:23095204 fatcat:2mvlyc6ghrdczgny5sawo4s5m4

Longitudinal Genetic Analysis of Plasma Lipids

Rita P. Middelberg, Nicholas G. Martin, John B. Whitfield
2006 Twin Research and Human Genetics  
AC1 SB1 SY1 ACR1 VC1 E2 A2 E1 A1 E3 A3 E8 E7 E6 E5 E4 b b b a c c a a a a Early A2 A1 A3 E2 E1 b c a a Late Figure 1a Path diagram of hypothesized model showing the genetic (A1−A3) and environmental  ...  In addition, the intraclass correlation for within-subject repeatability at repeat visits (S b 2 /(S b 2 + S w 2 )) was obtained using a conventional analysis of variance.  ... 
doi:10.1375/183242706778024946 pmid:16899162 fatcat:2i5256b4svaxxeu3rbw2z3z6za

Longitudinal Genetic Analysis of Plasma Lipids

Rita P. Middelberg, Nicholas G. Martin, John B. Whitfield
2006 Twin Research and Human Genetics  
AC1 SB1 SY1 ACR1 VC1 E2 A2 E1 A1 E3 A3 E8 E7 E6 E5 E4 b b b a c c a a a a Early A2 A1 A3 E2 E1 b c a a Late Figure 1a Path diagram of hypothesized model showing the genetic (A1−A3) and environmental  ...  In addition, the intraclass correlation for within-subject repeatability at repeat visits (S b 2 /(S b 2 + S w 2 )) was obtained using a conventional analysis of variance.  ... 
doi:10.1375/twin.9.4.550 pmid:16899162 fatcat:guspsxsqhnhwbpa4gndignez24

Kinosternon subrubrum (Bonnaterre 1789) – Eastern Mud Turtle [chapter]

Walter E. Meshaka, Jr., J. Whitfield Gibbons, Daniel F. Hughes, Michael W. Klemens, John B. Iverson
2017 Chelonian Research Monographs  
The Eastern Mud Turtle, Kinosternon subrubrum (Family Kinosternidae), is a small (carapace length 85 to 120 mm) polytypic species of the eastern and central United States. All three historically recognized subspecies (K. s. subrubrum, K. s. steindachneri, and K. s. hippocrepis) are semi-aquatic turtles that inhabit much of the U.S. Atlantic and Gulf Coastal Plains. The Florida taxon (K. s. steindachneri) appears to represent a distinct species, but we continue to treat it as a subspecies for
more » ... purposes of this account. Nesting seasons are shorter and clutch sizes (range: 1-8, modal: 2-3 eggs) larger in northern populations of the species, with up to four clutches annually in the South. Populations vary greatly in size and may comprise only a small segment or major portion of an aquatic turtle assemblage. Population declines are well documented in the Northeast and Midwest (K. s. subrubrum). Major threats to this species come from the disruption or destruction of freshwater and surrounding terrestrial habitats as well as road mortality, but it is not considered globally threatened at this time. distribution. -USA. Distributed in the eastern coastal plain from New York in the northeast throughout the Gulf Coast Plain to Texas in the southwest, north in the Mississippi Valley to Illinois and Indiana, and south through peninsular Florida.
doi:10.3854/crm.5.101.subrubrum.v1.2017 fatcat:fdapkuvyy5fmvfuvlv4owjtqxm

Platelet Adenylyl Cyclase Activity as a Trait Marker of Alcohol Dependence

John A. Menninger, Anna E. Bar??n, Katherine M. Conigrave, John B. Whitfield, John B. Saunders, Anders Helander, C. J. Peter Eriksson, Bridget Grant, Paula L. Hoffman, Boris Tabakoff
2000 Alcoholism: Clinical and Experimental Research  
Tests of significance: a p Ͻ 0.05 and b p Ͻ 0.005 compared with recent drinkers (independent t tests for equality of means assuming unequal variances).  ...  Analytical conditions were as follows: column 60/80 Carbopack B/5% Carbowax (20 m, 6 ft ϫ 2 mm inner diameter; Supelco, Bellefonte, PA); oven temperature 75°C; detector temperature 140°C; carrier gas (  ... 
doi:10.1097/00000374-200006000-00010 pmid:10888069 fatcat:um35osg3njgnlebdmeymzbnjlu

Platelet Adenylyl Cyclase Activity as a Trait Marker of Alcohol Dependence

John A. Menninger, Anna E. Baron, Katherine M. Conigrave, John B. Whitfield, John B. Saunders, Anders Helander, C. J. Peter Eriksson, Bridget Grant, Paula L. Hoffman, Boris Tabakoff
2000 Alcoholism: Clinical and Experimental Research  
Tests of significance: a p Ͻ 0.05 and b p Ͻ 0.005 compared with recent drinkers (independent t tests for equality of means assuming unequal variances).  ...  Tests of significance: a p Ͻ 0.05 and b p Ͻ 0.005 compared with subjects without lifetime alcohol dependence (independent t tests for equality of means assuming unequal variances).  ... 
doi:10.1111/j.1530-0277.2000.tb02060.x pmid:10888069 fatcat:lyy4ajrcebdhjpsyz2rrwi4rr4

CDT, GGT, and AST As Markers of Alcohol Use: The WHO/ISBRA Collaborative Project

Katherine M. Conigrave, Louisa J. Degenhardt, John B. Whitfield, John B. Saunders, Anders Helander, Boris Tabakoff
2002 Alcoholism: Clinical and Experimental Research  
Significant Predictors of CDT, GGT, and AST Levels From Multiple Regression Analyses CDT GGT AST ␤ B (95% CI) ␤ B (95% CI) ␤ B (95% CI) Sex 1 0.14*** 0.15 (0.09-0.21) Ϫ0.17*** Ϫ0.34 (Ϫ0.44  ...  This confirms the effect of obesity in lowering CDT levels that has been previously reported in a sample of Australian twins (Whitfield et al., 1998 ).  ... 
doi:10.1111/j.1530-0277.2002.tb02542.x pmid:11923585 fatcat:hau2cu7n4reh7dcb7hmc7jmide

Higher genetic risk for schizophrenia is associated with living in urban and populated areas [article]

Lucia Colodro-Conde, Baptiste Couvy-Duchesne, John B. Whitfield, Fabian Streit, Scott Gordon, Marcella Rietschel, John McGrath, Sarah E. Medland, Nicholas G. Martin
2017 bioRxiv   pre-print
The model is as follows 51 : Population density = μ + bCovariates +b 1 Age + (a + b a Age)A + (c + b c Age)C + (e + b e Age)E With b and b 1 the fixed effects parameters of age and other covariates effects  ...  on population density mean; a, c, e, b a, b c, and b e the parameters of the random effects.  ... 
doi:10.1101/179432 fatcat:cwwurr6xqnczrbbl2vrypw7vja

Genome-wide linkage scan for loci influencing plasma triglycerides

Rita P. Middelberg, Nicholas G. Martin, Grant W. Montgomery, John B. Whitfield
2006 Clinica Chimica Acta  
Plasma triglyceride concentration is known to be a significant risk factor for cardiovascular disease (CVD). Previous studies have found that the level of triglycerides is strongly influenced by genetic factors. Methods: To identify quantitative trait loci influencing triglycerides, we conducted a genome-wide linkage scan on data from 485 Australian adult dizygotic twin pairs. Prior to linkage analysis, triglyceride values were adjusted for the effects of covariates including age, sex, time
more » ... e last meal, time of blood collection (CT) and time to plasma separation. Results: The heritability estimate for ln(triglyceride) adjusted for all above fixed effects was 0.49. The highest multipoint LOD score observed was 2.94 (genome-wide p = 0.049) on chromosome 7 (at 65 cM). This 7p region contains several candidate genes. Two other regions with suggestive multipoint LOD scores were also identified on chromosome 4 (LOD score = 2.26 at 62 cM) and chromosome X (LOD score = 2.01 at 81 cM). Conclusions: The linkage peaks found represent newly identified regions for more detailed study, in particular the significant linkage observed on chromosome 7p13.
doi:10.1016/j.cca.2006.05.033 pmid:16828726 fatcat:7zqokkjmjbhbhlldefhjl3vgiy

A systematic pipeline for classifying bacterial operons reveals the evolutionary landscape of biofilm machineries [article]

Cedoljub Bundalovic-Torma, Gregory B Whitfield, Lindsey S Marmont, P. Lynne Howell, John Parkinson
2019 bioRxiv   pre-print
to PelD (Whitfield et al submitted). 617 618Together this work demonstrates a novel integrative approach combining phylogenomics and genomic-619 context approaches to systematically explore the adaptive  ...  Xu D, Zhang W, Zhang B, Liao C, Shao Y. Characterization of a biofilm-forming Shigella 820 flexneri phenotype due to deficiency in Hep biosynthesis.  ... 
doi:10.1101/769745 fatcat:avkqx5zke5ddnan2wnoqam3oju

Alcohol Dehydrogenase and Alcohol Dependence: Variation in Genotype-Associated Risk between Populations

John B. Whitfield
2002 American Journal of Human Genetics  
JOHN B.  ...  John B.  ... 
doi:10.1086/344287 pmid:12452180 pmcid:PMC385114 fatcat:spqpr4c665ekhmwxgk2w3rrei4
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