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Optimized Electrostatic Linear Ion Trap for Charge Detection Mass Spectrometry

Joanna A. Hogan, Martin F. Jarrold
2018 Journal of the American Society for Mass Spectrometry  
The new ELIT design uses a duty cycle of 50%. We show that a 50% duty cycle produces the lowest uncertainty in the charge determination.  ...  In charge detection mass spectrometry (CDMS), ions are passed through a detection tube and the m/z ratio and charge are determined for each ion.  ...  A signal frequency of 10 kHz was employed with a signal amplitude equivalent to a charge of 220 e. One thousand 100 ms signal files were collected and analyzed at each duty cycle.  ... 
doi:10.1007/s13361-018-2007-x pmid:29987663 fatcat:l26aip2zcrgb5gwzr4fghlcosq

Metalloproteinase Expression in PMA-stimulated THP-1 Cells

Joanna R. Worley, Mark D. Baugh, David A. Hughes, Dylan R. Edwards, Aileen Hogan, Mike J. Sampson, Jelena Gavrilovic
2003 Journal of Biological Chemistry  
This study aims to identify other metalloproteinase genes of the ADAM (A Disintegin And Metalloproteinase) and ADAMTS families that are regulated by PPAR␥ or RXR agonists, which are potentially important  ...  therapeutic strategies. . 1 The abbreviations used are: PPAR, peroxisome proliferator-activated receptor; PMA, phorbol 12-myristate 13-acetate; TZD, thiazolidinedione; MMP, matrix metalloproteinase; ADAM, a  ...  The endogenous agonist of RXR is 9-cis-retinoic acid, a natural derivative of vitamin A, which is also able to activate the RAR.  ... 
doi:10.1074/jbc.m310865200 pmid:14534304 fatcat:myggc4nclbcopl62l5gc6qsgwm

Intraspecies Signaling between Common Variants of Pseudomonas aeruginosa Increases Production of Quorum-Sensing-Controlled Virulence Factors

Dallas L. Mould, Nico J. Botelho, Deborah A. Hogan, Joanna B. Goldberg
2020 mBio  
Citrate, a metabolite often secreted in low iron environments, stimulated RhlR signaling and RhlI levels in LasR−but not in LasR+ strains.  ...  The lasR gene, which encodes a central QS regulator, is frequently mutated in clinical isolates from chronic infections, and loss of LasR function (LasR−) generally impairs the activity of downstream QS  ...  Colonies were grown in a 12-well plate with a 2-ml total volume and imaged after 24 h.  ... 
doi:10.1128/mbio.01865-20 pmid:32843558 fatcat:2tysvyqsnnez3jtzrjbdpf2ece

Charge detection mass spectrometry of bacteriophage P22 procapsid distributions above 20 MDa

David Z. Keifer, Elizabeth E. Pierson, Joanna A. Hogan, Gregory J. Bedwell, Peter E. Prevelige, Martin F. Jarrold
2014 Rapid Communications in Mass Spectrometry  
In addition, a peak at 19.84 MDa with a relative abundance of~15% is attributed to empty capsids.  ...  METHODS: P22 procapsids containing a native cargo of scaffolding protein were assembled in E. coli and purified via differential centrifugation.  ...  A QTOF mass spectrometer, equipped with a collision cell to improve desolvation, was used.  ... 
doi:10.1002/rcm.6809 pmid:24497286 fatcat:ii35i34rt5hqrkl3wfrtigy6hq

Pseudomonas aeruginosa Alginate Overproduction Promotes Coexistence with Staphylococcus aureus in a Model of Cystic Fibrosis Respiratory Infection

Dominique H. Limoli, Gregory B. Whitfield, Tomoe Kitao, Melissa L. Ivey, Michael R. Davis, Nora Grahl, Deborah A. Hogan, Laurence G. Rahme, P. Lynne Howell, George A. O'Toole, Joanna B. Goldberg, Caroline S. Harwood
2017 mBio  
We also observed that the least competitive P. aeruginosa isolates possessed a mucoid phenotype.  ...  Finally, the approach used here can serve as a platform to investigate the interactions among other CF pathogens.  ...  Twenty microliters of each dilution was spotted onto the underside of the lid of a petri plate and tilted at a 90°angle.  ... 
doi:10.1128/mbio.00186-17 pmid:28325763 pmcid:PMC5362032 fatcat:z5pczb3eyzhr7j6e7dmp4324nq

Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma

Joanna Poźniak, Jérémie Nsengimana, Jonathan P. Laye, Sally J. O'Shea, Joey Mark S. Diaz, Alastair P. Droop, Anastasia Filia, Mark Harland, John R. Davies, Tracey Mell, Juliette A. Randerson-Moor, Sathya Muralidhar (+6 others)
2019 Cancer Research  
Furthermore, we showed that cigarette smoking, a globally detrimental environmental factor, modulates immunity, reducing the survival primarily in patients with a strong immune response.  ...  Here, we report genetic and environmental predictors of the immune response in a large primary cutaneous melanoma cohort.  ...  , a vitamin D level from a blood sample at diagnosis and a deprivation index measured by the Townsend score [24] ).  ... 
doi:10.1158/0008-5472.can-18-2864 pmid:30773503 pmcid:PMC6544535 fatcat:m5gjquisgfhl5apwkv5ycmxtdq

Extracting social determinants of health from electronic health records using natural language processing: a systematic review

Braja G Patra, Mohit M Sharma, Veer Vekaria, Prakash Adekkanattu, Olga V Patterson, Benjamin Glicksberg, Lauren A Lepow, Euijung Ryu, Joanna M Biernacka, Al'ona Furmanchuk, Thomas J George, William Hogan (+10 others)
2021 JAMIA Journal of the American Medical Informatics Association  
A total of 6402 publications were initially identified, and after applying the study inclusion criteria, 82 publications were selected for the final review.  ...  This article presents a systematic review of the state-of-the-art NLP approaches and tools that focus on identifying and extracting SDoH data from unstructured clinical text in EHRs.  ...  The authors manually reviewed the initial labeled data from a rule-based system and developed a supervised ML system using embeddings to identify unseen notes containing smoking status.  ... 
doi:10.1093/jamia/ocab170 pmid:34613399 pmcid:PMC8633615 fatcat:qvxulgar5bcuhov2xtakcor6le

Integrative structure and functional anatomy of a nuclear pore complex

Seung Joong Kim, Javier Fernandez-Martinez, Ilona Nudelman, Yi Shi, Wenzhu Zhang, Barak Raveh, Thurston Herricks, Brian D. Slaughter, Joanna A. Hogan, Paula Upla, Ilan E. Chemmama, Riccardo Pellarin (+20 others)
2018 Nature  
Eight spokes assemble into even larger modules: coaxial outer and inner rings form a symmetric core scaffold, which is connected to a membrane ring, a nuclear basket and cytoplasmic RNA export complexes  ...  However, their large size and dynamic nature have impeded a full structural and functional elucidation.  ...  Å.  ... 
doi:10.1038/nature26003 pmid:29539637 fatcat:y5o267xpkfhk3e4fagdjuycjzm

Fetal Cardiac Intervention for Pulmonary Atresia with Intact Ventricular Septum: International Fetal Cardiac Intervention Registry

Whitnee J. Hogan, Sofia Grinenco, Aimee Armstrong, Roland Devlieger, Joanna Dangel, Queralt Ferrer, Michele Frommelt, Alberto Galindo, Helena Gardiner, Sarah Gelehrter, Ulrike Herberg, Lisa Howley (+13 others)
2020 Fetal Diagnosis and Therapy  
Among 60 liveborn with known outcome, there was a higher percentage having a biventricular circulation following successful FCI (87 vs. 43%).  ...  Of the 84 maternal/fetal dyads in the registry, 58 underwent pulmonary valvuloplasty at a median gestational age of 26.1 (21.9-31.0) weeks.  ...  Participating IFCIR member sites obtained local Institutional Review Board and ethics board approval or a waiver, governed by applicable local standards.  ... 
doi:10.1159/000508045 pmid:32634804 fatcat:a4uxtmymyfb6nl5zqzbhatk7qy

Page 725 of Acta Apostolicae Sedis Vol. 3, Issue 18 [page]

1911 Acta Apostolicae Sedis  
Joanna (B.) de Arc, 316. Joanna (Ven.) Delanoue, 406. Joanna (Ven.) Guillen, 406. Joannes (S.) Apostolus, 59. Joannes (Ven.) Bosco, 410. Joannes Maria Robertus (Ven.) De la Mennais, 155, 165.  ...  Hogan Guilelmus, 255. Hogan Ioseph Ioannes, Episc. Kansa- nopolitan., 597. Homaide, 500. Hoog Otho I. S., 583. Hospital Iuventius, Episc. tit. Caunen., 524, 602. Hourcastagné Raymundus, 632.  ... 

ACKNOWLEDGMENTS [chapter]

2020 Other Englands  
More than a decade ago, Crystal Bartolovich first planted the seeds of my interest in utopian literature and thought, in a memorably rigorous seminar at Syracuse University.  ...  In countless dérives around the side streets of Winston-Salem, Joanna Ruocco has proven to be the best interlocutor for exploring and imagining other worlds.  ...  x ACKNOWLEDGMENTS Emily-Jane Cohen, who was willing to gamble on a first book, and also to Faith Wilson Stein and Elspeth MacHattie.  ... 
doi:10.1515/9781503606135-001 fatcat:47ug4ilbxrechfxp3saybcrezu

Page 399 of American Spirit Vol. 15, Issue 3 [page]

1899 American Spirit  
Casey, Joanna B., .........++: \ug. Boston, Mass. 26 ©) Xa 23, 18, ; DAR EC. E. Oliver, Mrs. Eliza Newcomb Alexan- der. s DASH Bic. R.C.M.T.N. D.,A. R. H. C. R.C.M.L.N. Mrs. Chas H. Halcomb. D. A. R.  ...  Hogan, Elizabeth, ......... Oct. Albany, N. Y. Houser, Elizabeth S., ...... Oct. St. Louis, Mo. King, Ella Blanche, ........ Oct. Philadelphia, Pa. Konkle, Lena Luda, ........ Oct.  ... 

Page 353 of American Spirit Vol. 70, Issue 4 [page]

1936 American Spirit  
(a) HocaN.—Wanted given name & parentage of — Hogan whose wife was Re- becca. Rebecca Hogan died in Hempstead Co., Arkansas, Jan. 2, 1830. (b) Moss.  ...  David Perkins married Ist Joanna — who was born 10 Oct. 1769 & died 3 March 1833. Their children were Mary, Bradbury, Abigail, Harriet, Abigail, Han- nah & David.  ... 

Page 828 of The National and English Review Vol. 109, Issue 658 [page]

1937 The National and English Review  
By A. C. Pigou, M.A. (Macmillan, 4s. 6d.) THE GOVERNMENT OF GREAT BRITAIN AND THE DOMINIONS AND COLONIES. By A. E. Hogan, LL.D., and I. G. Powell. (University Tutorial Press, 5s.) THE FALSE STATE.  ...  By Joanna Field. (Chatto and Windus, 7s. 6d.) SILVER TONGUES. A Collection of Famous Speeches from Burke to Baldwin. Edited by John Hayward. (Joseph, 8s. 6d.) MEMORY LOOKS FORWARD. An Autobiography.  ... 

Note from the editor

Joanna O'Riordan
2020 Administration  
The second group of papers look at specific aspects of the reform agenda requiring further energy -William Roche & Joanna O'Riordan look at people issues, Mary Murphy & John Hogan focus on policy analysis  ...  Our realisation that December 2020 marked a decade since the troika bailout provided a useful reference point for reflections.  ... 
doi:10.2478/admin-2020-0019 fatcat:n3p5agb4tbaopaibvjbvkpllku
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