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An inverse model feedforward compensator is established based on the modified Bouc–Wen model. ... A particle swarm optimization method (PSO) is employed to identify these parameters of the Bouc–Wen hysteresis model. ... on the Bouc-Wen model. ...doi:10.3390/mi10120861 pmid:31817860 pmcid:PMC6953070 fatcat:cqgk2vsshvdpjco4hhq6cshmsi
Substation maintenance work of the specific operational procedures, maintenance operators 20 | WANG Ji-wen, et. al. ... divided into regular and occasional inspection, can be combined with substation power equipment, the specific circumstances, a reasonable match to ensure the safe operation of substations. 22 | WANG Ji-wen ...doi:10.18686/esta.v4i1.34 fatcat:t5hkpskmv5cmza2uc2eqnhupxi
IFIP Advances in Information and Communication Technology
diagnosis knowledge conceptualization, the description of diagnosis problems, diagnosis knowledge representation, the construction and solution of diagnosis, the development of diagnosis system and so on (Wen ...doi:10.1007/978-1-4419-0211-5_26 fatcat:zaetcnzac5ct5dqydum4ou2tta
The performance of a convolutional neural network (CNN) based face recognition model largely relies on the richness of labelled training data. Collecting a training set with large variations of a face identity under different poses and illumination changes, however, is very expensive, making the diversity of within-class face images a critical issue in practice. In this paper, we propose a 3D model-assisted domain-transferred face augmentation network (DotFAN) that can generate a series ofarXiv:2002.09859v1 fatcat:3w5pfhbxhfgbvllox2eycbgz64
more »... nts of an input face based on the knowledge distilled from existing rich face datasets collected from other domains. DotFAN is structurally a conditional CycleGAN but has two additional subnetworks, namely face expert network (FEM) and face shape regressor (FSR), for latent code control. While FSR aims to extract face attributes, FEM is designed to capture a face identity. With their aid, DotFAN can learn a disentangled face representation and effectively generate face images of various facial attributes while preserving the identity of augmented faces. Experiments show that DotFAN is beneficial for augmenting small face datasets to improve their within-class diversity so that a better face recognition model can be learned from the augmented dataset.
Background Wilms tumor is a highly heritable malignancy. Aberrant METTL14, a critical component of N6-methyladenosine (m6A) methyltransferase, is involved in carcinogenesis. The association between genetic variants in the METTL14 gene and Wilms tumor susceptibility remains to be fully elucidated. We aimed to assess whether variants within this gene are implicated in Wilms tumor susceptibility. Methods A total of 403 patients and 1198 controls were analyzed. METTL14 genotypes were assessed bydoi:10.1186/s12885-021-09019-5 pmid:34863142 pmcid:PMC8643011 fatcat:ouit2a77cbfuheh7l2kxohv5wm
more »... Man genotyping assay. Result Among the five SNPs analyzed, rs1064034 T > A and rs298982 G > A exhibited a significant association with decreased susceptibility to Wilms tumor. Moreover, the joint analysis revealed that the combination of five protective genotypes exerted significantly more protective effects against Wilms tumor than 0–4 protective genotypes with an OR of 0.69. The stratified analysis further identified the protective effect of rs1064034 T > A, rs298982 G > A, and combined five protective genotypes in specific subgroups. The above significant associations were further validated by haplotype analysis and false-positive report probability analysis. Preliminary mechanism exploration indicated that rs1064034 T > A and rs298982 G > A are correlated with the expression and splicing event of their surrounding genes. Conclusions Collectively, our results suggest that METTL14 gene SNPs may be genetic modifiers for the development of Wilms tumor.
A facile one-step Cu(i)-catalyzed "click" reaction, between a dansyl-azide and a propargyl-substituted rhodamine B hydrazide, is employed to fabricate a novel FRET ratiometric "off-on" fluorescent probe. The sensitive emission of the donor, a dansyl group, overlaps perfectly with the absorption of the acceptor, xanthene in the open-ring rhodamine. The proposed probe shows high selectivity towards Cu2+. The ratio of emission intensities at 568 and 540 nm (I568/I540) exhibits a drastic 28-folddoi:10.1039/c4tb00441h pmid:32261548 fatcat:oiwpuqbmezbpferafikiiv264i
more »... ancement upon addition of Cu2+. The probe shows an excellent linear relationship between emission ratios and the concentrations of Cu2+ from 10 to 50 μM, with a detection limit (S/N = 3) of 0.12 μM. The preliminary cellular studies demonstrated that the probe is cell membrane permeable and could be applied for ratiometric fluorescence imaging of intracellular Cu2+ with almost no cytotoxicity. The ingenuity of the probe design is to construct a FRET donor-acceptor interconnector and a selective receptor simultaneously by "click" reaction. The strategy was verified to have great potential for developing novel FRET probes for Cu2+.
Wilms tumour is a renal malignancy that commonly occurs in children. LIN28A gene overexpression has been reported to be involved in various human malignancies, while its roles in Wilms tumour risk are still under investigation. Here, we genotyped four LIN28A polymorphisms in 355 Wilms tumour patients and 1070 healthy controls from four hospitals in China. The genotyped single nucleotide polymorphisms (SNPs) include the following: rs3811464 G>A, rs3811463 T>C, rs34787247 G>A and rs11247957 G>A.doi:10.1111/jcmm.14561 pmid:31338973 pmcid:PMC6787499 fatcat:lenrywagvvhtlcdlksac3zwb3u
more »... verall, we found that rs3811463 T>C and rs34787247 G>A were associated with increased risk of Wilms tumour. Combination analysis of risk genotypes showed that, compared to non-carriers, subjects with 1 risk genotype and 1-3 risk genotypes were more likely to develop Wilms tumour, with an adjusted odds ratio (OR) of 1.58 and 1.56, respectively. Stratified analysis further demonstrated that the risk effect remained prominent in some subgroups. We also found that presence of 1-3 risk genotypes was associated with Wilms tumour risk in subgroups > 18 months of age, females, males and those with clinical stage I + II diseases. Furthermore, expression quantitative trait locus (eQTL) analysis indicated that rs3811463 C allele was significantly associated with increased transcripts of LIN28A gene. These findings suggest that LIN28A gene polymorphisms may be associated with increased predisposition to Wilms tumour.
Wilms tumor (WT) is a common embryonal malignancy in the kidney, ranking fourth in childhood cancer worldwide. MYC, a critical proto-oncogene, plays an important role in tumorigenesis. Single nucleotide polymorphisms in the MYC gene may lead to the deregulation of MYC proto-oncogene protein and thereby promote the initiation and development of tumors. Here, we assessed the association between MYC gene associated polymorphisms and WT susceptibility by performing a case-control study with 355doi:10.21037/atm.2019.08.31 pmid:31700911 pmcid:PMC6803173 fatcat:c25lmrbwmrhcfbaolwb75jyj24
more »... s and 1070 controls. Two MYC gene associated polymorphisms (rs4645943 C > T, rs2070583 A > G) were genotyped by TaqMan technique. Odds ratios (ORs) and 95% confidence intervals (CIs) were used for evaluating the association between these two polymorphisms and WT susceptibility. No significant association was detected between the selected polymorphisms and WT risk in the overall analysis as well as stratification analysis. These results indicate that neither of two selected MYC gene associated polymorphisms might affect WT susceptibility in the Chinese population. Large well-designed studies with diverse ethnicities are warranted to verify these results.
Wilms tumor is a frequently diagnosed renal cancer among children with unclear genetic causes. N6-methyladenosine (m6 A) modification genes play critical roles in tumorigenesis. However, whether genetic variations of m6 A modification genes predispose to Wilms tumor remain unclear. ALKBH5 (AlkB homolog 5), a crucial member of m6 A modification genes, encodes a demethylase that functions to reverse m6 A RNA methylation. Herein, we evaluated the association of single nucleotide polymorphismsdoi:10.1002/jcla.23251 pmid:32091154 fatcat:afzxlan7m5dqbdv4p4cd4tnflm
more »... ) in the m6 A modification gene ALKBH5 and Wilms tumor susceptibility in a large multi-center case-control study. A total of 414 Wilms tumor cases and 1199 healthy controls were genotyped for ALKBH5 rs1378602 and rs8400 polymorphisms by TaqMan. No significant association was detected between these two polymorphisms and Wilms tumor risk. Moreover, 1, 2, and 1-2 protective genotypes (rs1378602 AG/AA or rs8400 GG) did not significantly reduce Wilms tumor risk, compared with risk genotypes only. Stratification analysis revealed a significant relationship between rs1378602 AG/AA genotypes and decreased Wilms tumor risk in children in clinical stage I diseases [adjusted odds ratio (OR) = 0.56, 95% confidence interval (CI) = 0.32-0.98, P = .042]. The presence of 1-2 protective genotypes was correlated with decreased Wilms tumor risk in subgroups of age > 18 months, when compared to the absence of protective genotypes (adjusted OR = 0.74, 95% CI = 0.56-0.98, P = .035). Collectively, our results demonstrate that ALKBH5 SNPs may exert a weak influence on susceptibility to Wilms tumor. This finding increases the understanding of the role of the m6 A gene in tumorigenesis of Wilms tumor.
Rabies virus (RABV) matrix protein (M) plays crucial roles in viral transcription, replication, assembly, and budding; however, its function during the early stage of virus replication remains unknown. Here, we mapped the protein interactome between RABV M and human host factors using a proteomic approach, finding a link to the V-type proton ATPase (V-ATPase) catalytic subunit A (ATP6V1A) which is located in the endosomes where RABV first enters. By downregulating or upregulating ATP6V1Adoi:10.1074/jbc.ra120.014190 pmid:33460948 pmcid:PMC7949080 fatcat:cualexvxazcb7ohz5h5mprj45u
more »... ion in HEK293T cells, we found that ATP6V1A facilitated RABV replication. We further found that ATP6V1A was involved in the dissociation of incoming viral M proteins during viral uncoating. Co-immunoprecipitation demonstrated that M interacted with the full length or middle domain of ATP6V1A, which was dependent on the lysine residue at position 256 and the glutamic acid residue at position 279. RABV growth and uncoating in ATP6V1A-depleted cells was restored by trans-complementation with the full length or interaction domain of ATP6V1A. Moreover, stably overexpressed ATP6V1A enhanced RABV growth in Vero cells which are used for the production of rabies vaccine. Our findings identify a new partner for RABV M proteins and establish a new role of ATP6V1A by promoting virion uncoating during RABV replication.
Cyclodextrin metal-organic framework (CD-MOF) as a highly porous supramolecular carrier could be one of the solutions to the insolubility of isosteviol (STV). The solubility of STV was lower than 20.00 ng/mL at pH 1.0 and pH 4.5, whilst its solubility increased to 20,074.30 ng/mL at pH 6.8 and 129.58 ng/mL in water with a significant pH-dependence. The in vitro release profiles of STV from STV@CD-MOF (0.5:1) were pH-independent in distinct pH media and closed to be thoroughly released but nodoi:10.1016/j.apsb.2021.04.018 pmid:34589404 pmcid:PMC8463510 fatcat:vrgr6wnxqrc4npk6theubf2jxy
more »... h release profiles were observed for STV@CD-MOF (1:1) owing to nanoclusters formation. The bioavailability of STV@CD-MOF (1:1) in rats was 8.67-fold higher than that of STV, and was 1.32- and 1.27-fold higher than that of STV@CD and STV@CD-MOF (0.5:1). Our results indicated that the inclusion mechanism played a primary role when STV in CD-MOF was at a low loading ratio, while the increasement in bioavailability at a high loading ratio, which was attributed to the nanocluster mechanism. This was confirmed by molecular simulation. In conclusion, CD-MOF is a promising system for STV loading, overcoming the insolubility and to improve the bioavailability of this natural compound.
In the present study, we selected the first ASFV isolated in China, Pig/ Heilongjiang/2018 (HLJ/18) Wen et al., 2019) , as a backbone to develop a live attenuated vaccine. ... ., 2014) ; in 2018, the virus was transmitted to pigs in China and 10 other Asian countries (Wen et al., 2019; Ge et al., 2018; Le et al., 2019; Kim et al., 2020) (http://www.oie.int/). ...doi:10.1007/s11427-020-1657-9 pmid:32124180 fatcat:uonlwmgt5nesxmsqmzwzt3jsii
Wan, Wen 2014. 13 Zheng, and Yu-Shen Liu. ... Liang Pan1 Tong Wu2 Zhongang Cai1,3,4 Ziwei Liu1 Xumin Yu5 Yongming Rao5 Jiwen ...arXiv:2112.12053v1 fatcat:dhbtm45zfbbchbzwv7rck3qnxm
As with other members of this family, TRPV4 has been shown to be localized both to the plasma membrane and endomembrane systems, including the endoplasmic reticulum (ER) (Wen et al., 2017) . ...doi:10.1016/j.cmet.2019.05.018 pmid:31204282 pmcid:PMC6720459 fatcat:l32cf2g4mvf2tf3ue56wp2zxki
2021 IEEE 23rd International Workshop on Multimedia Signal Processing (MMSP)
Patrick Le Callet • Roberto Caldelli • Sanghoon Lee • Shrikanth (Shri) Narayanan • Wanqing Li • Weiyao Lin • Wen-Huang Cheng • Yonggang Wen • Yuming Fang ... Valenzise • Guo-Jun Qi • Hairong Qi • Igor Curcio • Ivan Bajic • Jiwen Lu • Joao Ascenso • Laura Toni • Luca Magri • Marc Antonini • Marco Carli • Marta Mrak • Nikolaos Boulgouris • Nikolaos Thomos • ...doi:10.1109/mmsp53017.2021.9733544 fatcat:vpocz2tkabhwjlpnltwjbwyo2e
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