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Ethyl 5-(4-aminophenyl)isoxazole-3-carboxylate

Jun-Tao Zhao, Jing-Jing Qi, You-Jun Zhou, Jia-Guo Lv, Ju Zhu
2012 Acta Crystallographica Section E  
The asymmetric unit of the title compound, C12H12N2O3, contains two molecules in which the benzene and isoxazole rings are almost coplanar, the dihedral angles between their mean planes being 1.76 (9) and 5.85 (8)°. The two molecules interact with each otherviaN—H...N and N—H...O hydrogen bonds, which link the molecules into layers parallel to theacplane. The layers stack in a parallel mode with an interlayer distance of 3.36 (7) Å.
doi:10.1107/s1600536812010653 pmid:22589968 pmcid:PMC3344059 fatcat:2nowwhqopvcbdeqle76z6vtewu

Testing symmetry based on empirical likelihood

Jun Zhang, Jing Zhang, Xuehu Zhu, Tao Lu
2018 Figshare  
In this paper, we propose a general kth correlation coefficient between the density function and distribution function of a continuous variable as a measure of symmetry and asymmetry. We first propose a root-n moment-based estimator of the kth correlation coefficient and present its asymptotic results. Next, we consider statistical inference of the kth correlation coefficient by using the empirical likelihood (EL) method. The EL statistic is shown to be asymptotically a standard chi-squared
more » ... ribution. Last, we propose a residual-based estimator of the kth correlation coefficient for a parametric regression model to test whether the density function of the true model error is symmetric or not. We present the asymptotic results of the residual-based kth correlation coefficient estimator and also construct its EL-based confidence intervals. Simulation studies are conducted to examine the performance of the proposed estimators, and we also use our proposed estimators to analyze the air quality dataset.
doi:10.6084/m9.figshare.5772933 fatcat:3yyv22l6tbgnnntkg2wk2d4vxa


Kui Cheng, Hai-Liang Zhu, Jing-Jing Liu, Meng Gao, Jun-He Zeng
2006 Acta Crystallographica Section E  
E62, o1932-o1933 [] 2-(1-Naphthyliminomethyl)phenol Kui Cheng, Hai-Liang Zhu, Jing-Jing Liu, Meng Gao and Jun-Bruker SMART CCD area-detector diffractometer Radiation  ...  Comment Recently, we have reported a few Schiff base compounds and complexes Zhu et al., 2005; You et al., 2004) .  ... 
doi:10.1107/s1600536806013341 fatcat:ymwifxfdcnaczmitls73rxzzkm

Bremsstrahlung spectra produced by 10-25 keV electron impact on thick W, Au targets

Tan Wen-Jing, An Zhu, Zhu Jing-Jun, Zhao Jian-Ling, Liu Man-Tian
2016 Wuli xuebao  
doi:10.7498/aps.65.113401 fatcat:oh3knrz6grdu3oyh5bqn7wyqxq

Organ failure associated with severe acute pancreatitis

Ai-Jun Zhu, Jing-Sen Shi, Xue-Jun Sun
2003 World Journal of Gastroenterology  
Zhu AJ, Shi JS, Sun XJ. Organ failure associated with severe acute pancreatitis.  ... 
doi:10.3748/wjg.v9.i11.2570 pmid:14606099 pmcid:PMC4656543 fatcat:alxmjqhfvjbstd4jq5upqvqd64

Ultrasensitive self-powered cytosensor

Pan-Pan Gai, Yu-Sheng Ji, Wen-Jing Wang, Rong-Bin Song, Cheng Zhu, Yun Chen, Jian-Rong Zhang, Jun-Jie Zhu
2016 Nano Energy  
We developed an ultrasensitive self-powered cytosensor based on biofuel cells (BFC) for the detection of acute leukemia CCRF-CEM cells. The core component of the BFC cytosensor was composed of an aptamer (Sgc8c)-functionalized cathode and a nitrogen-doped graphene/gold nanoparticles/glucose oxidase (NG/AuNPs/GOD) anode, which generated a maximum power output density (P max ) of 115 μW cm À 2 . Once the negatively charged CCRF-CEM cells were captured by the cathode via aptamer recognition, their
more » ... dramatic steric hindrance and electrostatic repulsion to the redox probe [Fe(CN) 6 ] 3 À efficiently blocked the electron transfer between the probe and the cathode surface, and thereby caused a remarkable decrease in power output of the BFC, which could be used to sensitively detect the cells. Notably, the power output density of the BFC cytosensor could be restored when the captured CCRF-CEM cells were released from the aptamer-functionalized cathode by raising the temperature of the cathode to alter the specific conformation of the aptamer. Then the re-activated cathode could capture CCRF-CEM cells once again achieving the regeneration of the BFC cytosensor. This selfpowered BFC cytosensor showed a linear relationship between the P max and the logarithm of the cell numbers over a range of 5-50,000 cells (r =0.9979) with a detection limit of 4 cells (S/ N =3), which is expected to have potential application as a powerful point-of-care tool for the early detection of circulating tumor cells.
doi:10.1016/j.nanoen.2015.03.035 fatcat:t2vrelhudjdrldoqcwnt3u4vvu

Robust Control of Unstable Non-linear Quantum Systems [article]

Jing-Jun Zhu, Xi Chen, Hans-Rudolf Jauslin, Stéphane Guérin
2020 arXiv   pre-print
Adiabatic passage is a standard tool for achieving robust transfer in quantum systems. We show that, in the context of driven nonlinear Hamiltonian systems, adiabatic passage becomes highly non-robust when the target is unstable. We show this result for a generic (1:2) resonance, for which the complete transfer corresponds to a hyperbolic fixed point in the classical phase space featuring an adiabatic connectivity strongly sensitive to small perturbations of the model. By inverse engineering,
more » ... devise high-fidelity and robust partially non-adiabatic trajectories. They localize at the approach of the target near the stable manifold of the separatrix, which drives the dynamics towards the target in a robust way. These results can be applicable to atom-molecule Bose-Einstein condensate conversion and to nonlinear optics.
arXiv:2005.12321v1 fatcat:srs7exiuprextkdt3gwuvb7dai

Label-free amperometric immunobiosensor based on a gold colloid and Prussian blue nanocomposite film modified carbon ionic liquid electrode

Ke-Jing Huang, De-Jun Niu, Jun-Yong Sun, Xiao-Li Zhu, Jun-Jie Zhu
2010 Analytical and Bioanalytical Chemistry  
A novel experimental methodology based on a Prussian blue (PB) and gold nanoparticles (AuNPs) modified carbon ionic liquid electrode (CILE) was developed for use in a label-free amperometric immunosensor for the sensitive detection of human immunoglobulin G (HIgG) as a model protein. The CILE was fabricated by using the ionic liquid 1-octyl-3-methylimidazolium hexafluorophosphate as binder. Controllable electrodeposition of PB on the surface of the CILE and coating with 3-aminopropyl
more » ... silane (APS) formed a film with high electronic catalytic activity and large surface area for the assembly of AuNPs and further immobilization of HIgG antibody. The electrochemistry of the formed nanocomposite biofilm was investigated by electrochemical techniques including cyclic voltammetry, differential pulse voltammetry, and electrochemical impedance spectroscopy. The HIgG concentration was measured through the decrease of amperometric responses in the corresponding specific binding of antigen and antibody. The decreased differential pulse voltammetric values were proportional to the HIgG concentration in two ranges, 0.05-1.25 ng mL −1 and 1.25-40 ng mL −1 , with a detection limit of 0.001 ng mL −1 (S/N=3). This electro-chemical immunoassay combined the specificity of the immunological reaction with the sensitivity of the AuNPs, ionic liquid, and PB amplified electrochemical detection and would therefore be valuable for clinical immunoassays.
doi:10.1007/s00216-010-3868-4 pmid:20577722 fatcat:sx3tx7isljfankybw5dfpg7x4a

Analyzing the Noise Robustness of Deep Neural Networks [article]

Kelei Cao, Mengchen Liu, Hang Su, Jing Wu, Jun Zhu, Shixia Liu
2020 arXiv   pre-print
Zhu are with Dept. of Comp. Sci. & Tech., Institute for AI, THBI Lab, Tsinghua University. • M. Liu is with Microsoft; J. Wu is with Cardiff University.  ...  Jun Zhu received his BS and PhD degrees from the Department of Computer Science and Technology in Tsinghua University, where he is currently a professor.  ...  Jing Wu is a lecturer in computer science and informatics at Cardiff University, UK.  ... 
arXiv:2001.09395v1 fatcat:zomxsvebq5ambllj4qakvodxdm

Investigations of magneto-elastic coupling in a multiferroic ferrite by in-situ precession diffraction

Shiqing Deng, Shengdong Sun, Ping Miao, Jun Li, Chengchao Xu, Wenbin Wang, Yimei Zhu, Jun Chen, Jing Zhu
2021 Microscopy and Microanalysis  
Imitate couplings among charge, lattice, and spin degrees of freedom are widely considered to breed rich emergent physical properties, like multiferroics and colossal magnetoresistance [1, 2] . Deciphering the intertwined interplay among these degrees of freedom is one of the major themes at the core of condensed matter physics. Such an interplay is generally complex and can be further complicated especially at phase transitions, where delicate changes in different kinds of energy can induce
more » ... minent changes in different degrees of freedom and introduce emergent physical properties. A typical example is multiferroics, where atomic displacements at phase transitions can interact with charge and spin degrees of freedom and bridge the ferroelectric moment and the (anti)ferromagnetic moment, therefore bringing in the desired magneto-electric coupling [3] . Hence quantitatively determining how atoms move as a function of temperature and unraveling how they respond to the ferroelectric or (anti)ferromagnetic transition in multiferroics, as well as their influences on the electronic structure, can be of great importance to the community, allowing the in-depth understanding and fine control of the multiferroic properties. In this study, we report a strong magneto-elastic coupling in a typical multiferroic ferrite, h-Lu 1-x Sc x FeO 3 (x ~ 0.5), deciphering how lattice and spin interact and couple with each other at the atomic level. In-situ cooling precession electron diffraction results show the lowering of the in-plane symmetry right at the magnetic transition, manifested by the generation of a constellation of satellite reflections ( Fig. 1(a) ). Quantitative analysis of these satellite reflections reveals that their temperature-dependent intensities vary synchronously with the magnetic susceptibility, suggesting a close coupling between the lattice and spin. Furthermore, combining with the refinement of the in-situ neutron diffraction and synchrotron X-ray diffraction results, we quantitatively determine the temperature-dependent lattice parameters ( Fig. 1(d) ) and more importantly all the atomic positions and displacements of atoms in the unit cell ( Fig. 1(e) ), where Lu/Sc and O atoms show distinct anomalies at the magnetic transition. Especially for the in-plane oxygens (O3 and O4), they show the most dramatic z-axial displacement, which is as large as around ~ 0.1 Å (Fig. 2(e) and 2(f)). Such a displacement magnitude is almost comparable to the atomic displacement at Curie temperature in classic ferroelectrics, like BaTiO 3 (0.05-0.4 Å) [4] . While, interestingly, the Fe atoms remain at the high-symmetry position over the whole temperature range (Fig. 2(g) ), which is in contrast to the behaviors of multiferroic hexagonal manganites [3] . This suggests that the magnetic-elastic coupling observed in the hexagonal ferrite is mainly governed by the atomic displacement of the oxygen rather than the transition metal. These movements of oxygens induce https://doi.
doi:10.1017/s1431927621007807 fatcat:gkyv7lrdfjgjtdvg5kgyjtk7im

Synthesis and Antitumor Activity of Amino Acid Ester Derivatives Containing 5-Fluorouracil

Jing Xiong, Hai-Feng Zhu, Ya-Juan Zhao, Yun-Jun Lan, Ji-Wang Jiang, Jing-Jing Yang, Shu-Feng Zhang
2009 Molecules  
A series of amino acid ester derivatives containing 5-fluorouracil were synthesized using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC·HCl) and N-hydroxybenzotriazole (HOBt) as a coupling agent. The structures of the products were assigned by NMR, MS, IR etc. The in vitro antitumor activity tests against leukaemia HL-60 and liver cancer BEL-7402 indicated that (R)-ethyl 2-(2-(5-fluoro-2,4dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)-3-(4-hydroxyphenyl) propanoate showed more inhibitory effect against BEL-7402 than 5-FU.
doi:10.3390/molecules14093142 pmid:19783913 pmcid:PMC6254981 fatcat:zxqyd5z64vc6nfxdafnqvzpdxa

Disease-Associated Plasmacytoid Dendritic Cells

Shuang Li, Jing Wu, Shan Zhu, Yong-Jun Liu, Jingtao Chen
2017 Frontiers in Immunology  
Plasmacytoid dendritic cells (pDCs), also called natural interferon (IFN)-producing cells, represent a specialized cell type within the innate immune system. pDCs are specialized in sensing viral RNA and DNA by toll-like receptor-7 and -9 and have the ability to rapidly produce massive amounts of type 1 IFNs upon viral encounter. After producing type 1 IFNs, pDCs differentiate into professional antigen-presenting cells, which are capable of stimulating T cells of the adaptive immune system.
more » ... nic activation of human pDCs by self-DNA or mitochondrial DNA contributes to the pathogenesis of systemic lupus erythematosis and IFN-related autoimmune diseases. Under steady-state conditions, pDCs play an important role in immune tolerance. In many types of human cancers, recruitment of pDCs to the tumor microenvironment contributes to the induction of immune tolerance. Here, we provide a systemic review of recent progress in studies on the role of pDCs in human diseases, including cancers and autoimmune/inflammatory diseases.
doi:10.3389/fimmu.2017.01268 pmid:29085361 pmcid:PMC5649186 fatcat:bmqa34pwkbaypgncsd2462gnom

One-way Acoustic Beam Splitter

Yifan Tang, Yifan Zhu, Bin Liang, Jing Yang, Jun Yang, Jianchun Cheng
2018 Scientific Reports  
As a key component of various acoustic systems, acoustic beam splitter (BS) finds important application in many scenarios, yet are conventionally based on the assumption that the acoustic waves propagate as easily when incident from either input or output side. It would therefore be intriguing, from the viewpoints of both science and technology, to break through this limit by realizing acoustic BSs supporting asymmetric transmission. Here we propose the concept of one-way acoustic BS capable of
more » ... splitting acoustic beam incident from the input port into multiple beams while effectively reducing the backward transmission from any of the output ports. Furthermore, our design enables flexibly adjusting the number and angle of output beams by blocking the unused line defects. The numerical results verify the theoretical predictions and demonstrate the phenomenon of one-way acoustic BS at the predesigned frequency. Our design with functionality and flexibility bridges the gap between acoustic diodes and BSs and may enable novel multi-functional devices with great application prospects in diverse fields such as acoustic integrated circuits and acoustic communication.
doi:10.1038/s41598-018-29579-0 pmid:30206365 pmcid:PMC6134148 fatcat:pb7xqxfm3zguzmocvypv2e37xe

Unoccupied electronic states inCaB6studied by density functional theory and EELS measurements

Shang-Peng Gao, Jun Jiang, Minghe Cao, Jing Zhu, Jun Yuan
2004 Physical Review B  
The electronic structure of CaB 6 has recently attracted great interest because of the discovery that this compound is unexpectedly ferromagnetic and exhibits a surprisingly large thermoelectric effect. We have concentrated on studying the unoccupied electronic states by investigating the boron 1s core-level spectroscopy. Comparison of our data from electron energy-loss spectroscopy with that from x-ray absorption spectroscopy using the total electron yield mode reveals evidence for sample
more » ... ogeneity. The ab initio band structural method has been successfully applied to simulate the overall features found in the boron 1s absorption spectrum. Correlation with the results of a ground state energy-band calculation allows the interpretation of the spectral features in terms of the density of states of the unoccupied conduction band, in particular the identification of a feature associated with hybridization of Ca d orbitals with B p orbitals. This interpretation is confirmed by comparison with similar calculations for related boride systems. However, simulation spectral data cannot be reconciled with high-resolution experimental data at the absorption threshold. The possibility of either the failure of the theoretical method employed to account for many-body effects and/or the need for improved experimental measurements is discussed.
doi:10.1103/physrevb.69.214419 fatcat:6clxanvlrvcrfm7kjxo4y4qume

Systematic cancer-testis gene expression analysis identified CDCA5 as a potential therapeutic target in esophageal squamous cell carcinoma

Jing Xu, Chengxiang Zhu, Yue Yu, Weibing Wu, Jing Cao, Zhihua Li, Juncheng Dai, Cheng Wang, Yu Tang, Quan Zhu, Jun Wang, Wei Wen (+15 others)
2019 EBioMedicine  
Zhu, J. Wang, W. Wen and L. Xue performed the functional assays; F. Zhen, J. Liu, C. Huang, F. Zhao, Y. Zhou and Z. He were involved in material and technical support; X. Pan, H. Wei, Y. Zhu, Y.  ...  Zhu, Y. Yu and W. Wu participated in data analysis and drafting of the manuscript; J. Cao, Z. Li, J. Dai and C. Wang contributed to the analysis and the making of tables and figures; Y. Tang, Q.  ... 
doi:10.1016/j.ebiom.2019.07.030 pmid:31324603 pmcid:PMC6710982 fatcat:y6g6zulxqfakrigyjjgeyeagqy
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