7,156 Hits in 3.2 sec

Propagation of shockwave in nanocrystalline copper: Molecular dynamics simulation

Chen Kai-Guo, Zhu Wen-Jun, Ma Wen, Deng Xiao-Liang, He Hong-Liang, Jing Fu-Qian
2010 Wuli xuebao  
doi:10.7498/aps.59.1225 fatcat:tyfban35c5hx5hmyd5pc4l4nc4

Angiotensin-converting enzyme 2 overexpression protects against doxorubicin-induced cardiomyopathy by multiple mechanisms in rats

Hui Ma, Jing Kong, Yu-Lin Wang, Jun-Long Li, Nai-Hao Hei, Xin-Ran Cao, Jing-Jing Yang, Wen-Jiang Yan, Wen-Jing Liang, Hong-Yan Dai, Bo Dong
2017 OncoTarget  
Angiotensin-converting enzyme 2 (ACE2) is considered a potential therapeutic target of the renin-angiotensin system (RAS) for the treatment of cardiovascular diseases. We aimed to explore the effects of ACE2 overexpression on doxorubicininduced cardiomyopathy in rats. Rats were randomly divided into treatment and control groups. The rats of treatment group were injected intraperitoneally with 6 doses of doxorubicin (2.5 mg/kg) within a period of two weeks. Two weeks after the initial injection
more » ... f doxorubicin, these rats were randomly divided into Mock, Ad-EGFP, Ad-ACE2, and Cilazapril groups. The rats of Ad-EGFP and Ad-ACE2 groups received intramyocardial injection of Ad-EGFP and Ad-ACE2, respectively. The rats of Cilazapril group received cilazapril (10 mg/kg/day) via intragastric intubation. Apoptosis, inflammation, oxidative stress, cardiac function, the extent of myocardial fibrosis, and levels of ACE2, ACE, angiotensin II (AngII), and angiotensin (1-7) were evaluated. Four weeks after ACE2 gene transfer, the Ad-ACE2 group showed not only reduced apoptosis, inflammatory response, oxidative stress, left ventricular (LV) volume, extent of myocardial fibrosis and mortality of rats, but also increased LV ejection fraction and ACE2 expression level compared with the Mock and Ad-EGFP groups. ACE2 overexpression was superior to cilazapril in improving doxorubicin-induced cardiomyopathy. The putative mechanisms may involve activation of the AMPK and PI3K-AKT pathways, inhibition of the ERK pathway, decrease of TGF-β1 expression, and interactions of shifting RAS components, such as decreased myocardium AngII levels, increased myocardium Ang (1-7) levels, and reduced ACE expression. Thus, ACE2 may be a novel therapeutic approach to prevent and treat doxorubicin-induced cardiomyopathy.
doi:10.18632/oncotarget.15595 pmid:28445944 pmcid:PMC5421869 fatcat:cd7clwdtqvfazbr4at77tipn7i

Interferon alpha antagonizes the anti-hepatoma activity of the oncolytic virus M1 by stimulating anti-viral immunity

Liu Ying, Hu Cheng, Xu Wen Xiong, Lin Yuan, Zhang Hai Peng, Zhong Wen Wen, Liang Jian Ka, Xiao Xiao, Cai Jing, Tan Ya Qian, Gao Zhi Liang, Yan Guang Mei (+2 others)
2017 OncoTarget  
Alpha virus M1 is an oncolytic virus that targets zinc-finger antiviral protein (ZAP)-defective cancer cells, and may be useful for treatment of hepatocellular carcinoma (HCC). Most of HCC patients have hepatitis and need long-term antiviral medication. Thus, it is necessary to clarify whether anti-virus medicines influence oncolytic effect of M1. We examined the effect of drugs used to treat hepatitis B/C on M1-mediated oncolysis in vitro and in vivo. Interferon (IFN)-α induces expression of
more » ... tiviral IFN-stimulated genes (ISGs) in HCC cells with moderate sensitivity to M1 virus. This leads to reduced replication of M1, and blocking of M1-mediated apoptosis. The antagonistic effect of IFN-α is positively related with the expressive level of ISGs. We also examined a population of 147 HCC patients. A total of 107 patients (73%) had low ZAP expression in liver tissues relative to adjacent tissues. Among these 107 patients, 77% were positive for hepatitis B and 2% were positive for hepatitis C. A combination of M1 virus and IFN should be avoided in those patients with HBV or HCV infection, of who ZAP expression is low but ISGs expression is moderate. In conclusion, this study provides a basis for anti-viral regimens for HCC patients with hepatitis B or C who are given oncolytic virus M1.
doi:10.18632/oncotarget.15788 pmid:28445966 pmcid:PMC5421880 fatcat:l4mjd7ydu5bk7kgipfprkdqof4

Nkx2-1: a novel tumor biomarker of lung cancer

Li Yang, Min Lin, Wen-jing Ruan, Liang-liang Dong, En-guo Chen, Xiao-hong Wu, Ke-jing Ying
2012 Journal of Zhejiang University SCIENCE B  
Nkx2-1 (Nkx homeobox-1 gene), also known as TTF-1 (thyroid transcription factor-1), is a tissue-specific transcription factor of the thyroid, lung, and ventral forebrain. While it has been shown to play a critical role in lung development and lung cancer differentiation and morphogenesis, molecular mechanisms mediating Nkx2-1 cell- and tissue-specific expression in normal and cancerous lungs have yet to be fully elucidated. The recent identification of prognostic biomarkers in lung cancer,
more » ... cularly in lung adenocarcinoma (ADC), and the different reactivity of patients to chemotherapeutic drugs have opened new avenues for evaluating patient survival and the development of novel effective therapeutic strategies. The function of Nkx2-1 as a proto-oncogene was recently characterized and the gene is implicated as a contributory factor in lung cancer development. In this review, we summarize the role of this transcription factor in the development, diagnosis, and prognosis of lung cancer in the hope of providing insights into the utility of Nkx2-1 as a novel biomarker of lung cancer.
doi:10.1631/jzus.b1100382 pmid:23125078 pmcid:PMC3494024 fatcat:bau7ijt4ufdpla7clykwh4piju

In situ constructed zeolite membranes on rough supports with the assistance of reticulated hydrotalcite interlayer

Wen-Yan Pan, Liang-Liang Peng, Wen-Jing Wang, Yuan-Yuan Li, Xue-Ling Wei
2021 RSC Advances  
Reticulated hydrotalcite interlayer controls infiltration of active ingredients into the support, improving the quality and stability of the zeolite membrane.
doi:10.1039/d1ra05132f pmid:35496391 pmcid:PMC9043786 fatcat:6igu3vb6ozfujgqdq3xqoplpde

Focusing on Mouth Movement to Improve Genuine Smile Recognition

Qian-Nan Ruan, Jing Liang, Jin-Yu Hong, Wen-Jing Yan
2020 Frontiers in Psychology  
Copyright © 2020 Ruan, Liang, Hong and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).  ... 
doi:10.3389/fpsyg.2020.01126 pmid:32848960 pmcid:PMC7399707 fatcat:bvlbc2u3kzgxvmy3fxecr2j3bi

2′-(1H-Indol-3-ylmethylene)isonicotinohydrazide ethanol solvate

Zuo-Liang Jing, Wen-Wen Cheng, Xin Chen, Yu Ming
2006 Acta Crystallographica Section E  
E62, o1360-o1361 [] 2′-(1H-Indol-3-ylmethylene)isonicotinohydrazide ethanol solvate Zuo-Liang Jing, Wen-Wen Cheng, Xin Chen and Yu Ming 2′-(1H-Indol-3-ylmethylene  ...  ., 2005; Jing et al., 2005; Guo et al., 2006) , we report the synthesis and structure of the title compound, (I).  ... 
doi:10.1107/s1600536806008361 fatcat:iiyhpra2kzhrrpxb55bh3w5bg4

Surgical Outcomes and Prognostic Factors of T4 Gastric Cancer Patients without Distant Metastasis

Ming-zhe Li, Liang Deng, Jing-jing Wang, Long-bin Xiao, Wen-hui Wu, Shi-bin Yang, Wen-feng Li, Domenico Coppola
2014 PLoS ONE  
Objective: To evaluate surgical outcomes and prognostic factors for T4 gastric cancer treated with curative resection. Methods: Between January 1994 and December 2008, 94 patients diagnosed with histological T4 gastric carcinoma and treated with curative resection were recruited. Patient characteristics, surgical complications, survival, and prognostic factors were analyzed. Results: Postoperative morbidity and mortality were 18.1% and 2.1%, respectively. Multivariate analysis indicated lymph
more » ... de metastasis (hazard ratio, 2.496; 95% confidence interval, 1.218-5.115; p = 0.012) was independent prognostic factor. Conclusions: For patients with T4 gastric cancer, lymph node metastasis was associated with poorer survival. Neoadjuvant chemotherapy or aggressive adjuvant chemotherapy after radical resection was strongly recommended for these patients.
doi:10.1371/journal.pone.0107061 pmid:25211331 pmcid:PMC4161379 fatcat:slkadxavf5bkposb5kyvtwstl4

Epigenetic Switch Driven by DNA Inversions Dictates Phase Variation in Streptococcus pneumoniae

Jing Li, Jing-Wen Li, Zhixing Feng, Juanjuan Wang, Haoran An, Yanni Liu, Yang Wang, Kailing Wang, Xuegong Zhang, Zhun Miao, Wenbo Liang, Robert Sebra (+4 others)
2016 PLoS Pathogens  
DNA methylation is an important epigenetic mechanism for phenotypic diversification in all forms of life. We previously described remarkable cell-to-cell heterogeneity in epigenetic pattern within a clonal population of Streptococcus pneumoniae, a leading human pathogen. We here report that the epigenetic diversity is caused by extensive DNA inversions among hsdS A, hsdS B, and hsdS C , three methyltransferase hsdS genes in the Spn556II type-I restriction modification (R-M) locus. Because hsdS
more » ... encodes the sequence recognition subunit of this type-I R-M DNA methyltransferase, these site-specific recombinations generate pneumococcal cells with variable HsdS A alleles and thereby diverse genome methylation patterns. Most importantly, the DNA methylation pattern specified by the HsdS A1 allele leads to the formation of opaque colonies, whereas the pneumococci lacking HsdS A1 produce transparent colonies. Furthermore, this HsdS A1 -dependent phase variation requires intact DNA methylase activity encoded by hsdM in the Spn556II (renamed colony opacity determinant or cod) locus. Thus, the DNA inversion-driven ON/OFF switch of the hsdS A1 allele in the cod locus and resulting epigenetic switch dictate the phase variation between the opaque and transparent phenotypes. Phase variation has been well documented for its importance in pneumococcal carriage and invasive infection, but its molecular basis remains unclear. Our work has discovered a novel epigenetic cause for this significant pathobiology phenomenon in S. pneumoniae. Lastly, our findings broadly represents a significant advancement in our understanding of bacterial R-M systems and their potential in shaping epigenetic and phenotypic diversity of the prokaryotic organisms because similar site-specific recombination systems widely exist in many archaeal and bacterial species. PLOS Pathogens | DNA methylation is a well-known epigenetic mechanism for phenotypic diversification in all forms of life. This study reports our discovery that the Spn556II type-I RM locus in human pathogen Streptococcus pneumoniae undergoes extensive DNA inversions among three homologous DNA methyltransferase genes. These site-specific recombinations generate subpopulations of progeny cells with dramatic epigenetic and phenotypic differences. This is exemplified by the striking differences in colony morphology among the pneumococcal variants that carried different allelic variants of the methyltransferase genes. Phase variation has been well documented for its importance in pneumococcal pathogenesis, but it is currently unknown how this phenotypic switch occurs at the molecular level. This work has thus discovered an epigenetic cause for pneumococcal phase variation. Our findings have a broad implication on the epigenetic and phenotypic diversification in prokaryotic organisms because similar DNA rearrangement systems also exist in many archaeal and bacterial species. Epigenetic Cause of Pneumococcal Phase Variation PLOS Pathogens | Results DNA rearrangements occur in the Spn556II locus Our recent study identified three DNA motifs specifically methylated by three R-M systems (two type-I: Spn556II and Spn556III; a type-II: Spn556I) in the multi-drug resistant type 19F strain ST556 of S. pneumoniae (Fig 1A) [35]. We observed remarkable heterogeneity in Epigenetic Cause of Pneumococcal Phase Variation PLOS Pathogens | 7 / 36 Fig 4. The pneumococcal genomic DNA motifs methylated by the hsdS A allelic variants. The DNA methylation sequences in the genomes of strain ST556 (WT) or its derivatives (A1-A9) each possessing one of the 9 hsdS A alleles were detected by SMRT sequencing. The methylation motifs recognized by Spn556I and Spn556III were also detected in all of the strains but are not shown here for the sake of space; methylated m6A bases are indicated with red characters. R = A or G, Y = T or C.
doi:10.1371/journal.ppat.1005762 pmid:27427949 pmcid:PMC4948785 fatcat:r3zwtbunnrffri66um5qtaysby

PD-L1 is upregulated by EBV-driven LMP1 through NF-κB pathway and correlates with poor prognosis in natural killer/T-cell lymphoma

Xi-wen Bi, Hua Wang, Wen-wen Zhang, Jing-hua Wang, Wen-jian Liu, Zhong-jun Xia, Hui-qiang Huang, Wen-qi Jiang, Yu-jing Zhang, Liang Wang
2016 Journal of Hematology & Oncology  
Natural killer/T-cell lymphoma (NKTCL) is an Epstein-Barr virus (EBV)-associated, highly aggressive lymphoma. Treatment outcome remains sub-optimal, especially for advanced-stage or relapsed diseases. Programmed cell death receptor 1 (PD-1) and PD ligand 1 (PD-L1) have become promising therapeutic targets for various malignancies, but their role in the pathogenesis and their interactions with EBV in NKTCL remains to be investigated. Methods: Expression of PD-L1 was measured in NK-92
more » ... e) and SNK-6 (EBV-positive) cells by western blot, quantitative real-time PCR and enzyme-linked immunosorbent assay, and flow cytometry, respectively. Latent membrane protein 1 (LMP1)-harboring lentiviral vectors were transfected into NK-92 cells to examine the correlation between LMP1 and PD-L1 expression. Proteins in the downstream pathways of LMP1 signaling were measured in NK-92 cells transfected with LMP1-harboring or negative control vectors as well as in SNK-6 cells. PD-L1 expression on tumor specimens and serum concentration of soluble PD-L1 were collected in a retrospective cohort of patients with Ann Arbor stage I~II NKTCL, and their prognostic significance were analyzed. Results: Expression of PD-L1 was significantly higher in SNK-6 cells than in NK-92 cells, at both protein and mRNA levels. Expression of PD-L1 was remarkably upregulated in NK-92 cells transfected with LMP1-harboring lentiviral vectors compared with those transfected with negative control vectors. Proteins in the MAPK/NF-κB pathway were upregulated in LMP1-expressing NK-92 cells compared with the negative control. Selective inhibitors of those proteins induced significant downregulation of PD-L1 expression in LMP1-expressing NK-92 cells as well as in SNK-6 cells. Patients with a high concentration of serum soluble PD-L1 (≥3.4 ng/ml) or with a high percentage of PD-L1 expression in tumor specimens (≥38 %) exhibited significantly lower response rate to treatment and remarkably worse survival, compared with their counterparts. A high concentration of serum soluble PD-L1 and a high percentage of PD-L1 expression in tumor specimens were independent adverse prognostic factors among patients with stage I~II NKTCL.
doi:10.1186/s13045-016-0341-7 pmid:27737703 pmcid:PMC5064887 fatcat:ouic6ixp2rgrdmjvfx66mkpghq

Is TOL 1326-379 a Prototype of gamma-ray Emitting FR0 Radio Galaxy? [article]

Fu Wen-Jing, Zhang Hai-Ming, Zhang Jin, Liang Yun-Feng, Yao Su, Liang En-Wei
2021 arXiv   pre-print
With the possible spacial association to the Fermi/LAT source 3FGL J1330.0-3818, TOL 1326-379 may be the first one that is identified as a gamma-ray emitting Fanaroff-Riley type 0 radio galaxy (FR0 RG). We analyze the ~12 yr Fermi/LAT observation data of this gamma-ray source and examine its association to TOL 1326-379. We show that the gamma-ray source (named as J1331.0-3818) is tentatively detected with a TS value of 28.7, 3FGL J1330.0-3818 is out of the 95% containment of J1331.0-3818, and
more » ... eir positions are spatially separated ~0.2 degr. 4FGL J1331.3-3818 falls into the 68% containment of J1331.0-3818, suggesting that our result agrees with that reported in the Fourth Fermi LAT Source Catalog. TOL 1326-379 is out of the 95% containment of J1331.0-3818, and their positions are spatially separated ~0.4 degr, indicating that the association between J1331.0-3818 and TOL 1326-379 is quite ambiguous. However, we do not find other possible potential radio or X-ray counterpart within the circle centered at J1331.0-3818 with a radius of 0.4 degr. The spectral energy distribution (SED) of TOL 1326-379 shows a bimodal feature as seen in the gamma-ray emitting RGs. We fit the SED with the one-zone leptonic model and find that the average energy spectrum of J1331.0-3818 agrees with the model prediction. Assuming that J1331.0-3818 is an unidentified gamma-ray source, we derive the upper-limit of the gamma-ray flux for TOL 1326-379. It is not tight enough to exclude this possibility with the SED modeling. Based on these results, we cautiously argue that the gamma-ray source J1331.0-3818 is associated with TOL 1326-379 and its jet radiation physic is similar to those gamma-ray emitting RGs.
arXiv:2112.07958v1 fatcat:rhujxeexabd23pzk4supj45qty

Light Opens a New Window for N-Heterocyclic Carbene Catalysis

Jing Liu, Xiao-Ning Xing, Jin-Hai Huang, Liang-Qiu Lu, Wen-Jing Xiao
2020 Chemical Science  
Heterocyclic carbenes (NHCs) are a class of important and efficient Lewis basic catalysts for the umpolung of various polarized unsaturated compounds usually including aldehydes, imines, acyl chlorides and activated esters....
doi:10.1039/d0sc03595e pmid:34094315 pmcid:PMC8162372 fatcat:qg774qjnrnghle2vrjdegqcp2a

Unique 3D CoII/ZnII-coordination polymers with (3,4,5)-connected self-penetrating topology: Syntheses, topological structures, luminescent and magnetic properties

Wen-Wen Dong, Dong-Sheng Li, Jun Zhao, Ya-Ping Duan, Liang Bai, Jing-Jing Yang
2012 RSC Advances  
doi:10.1039/c2ra21474a fatcat:d5cpyuzjrbazldpxmir7k6mt2a

Manipulating Hubbard-type Coulomb blockade effect of metallic wires embedded in an insulator [article]

Xing Yang, Huimin Wang, Jing-Jing Xian, Sheng Meng, Naoto Nagaosa, Wen-Hao Zhang, Hai-Wen Liu, Zi-Heng Ling, Kai Fan, Zhi-Mo Zhang, Le Qin, Zhi-Hao Zhang (+2 others)
2021 arXiv   pre-print
Correlated states emerge in low-dimensional systems owing to enhanced Coulomb interactions. Elucidating these states requires atomic scale characterization and delicate control capabilities. In this study, spectroscopic imaging-scanning tunneling microscopy was employed to investigate the correlated states residing in the one-dimensional electrons of the monolayer and bilayer MoSe2 mirror twin boundary (MTB). The Coulomb energies, determined by the wire length, drive the MTB into two types of
more » ... ound states with distinct respective out-of-phase and in-phase charge orders. The two ground states can be reversibly converted through a metastable zero-energy state with in situ voltage pulses, which tunes the electron filling of the MTB via a polaronic process, as substantiated by first-principles calculations. Our modified Hubbard model reveals the ground states as correlated insulators from an on-site U-originated Coulomb interaction, dubbed Hubbard-type Coulomb blockade effect. Our work sets a foundation for understanding correlated physics in complex systems and for tailoring quantum states for nano-electronics applications.
arXiv:2104.08577v1 fatcat:ydvqxjobuzfolbfboqal56nkny

Construction of metallic nanocrystalline samples by molecular dynamics simulation

Ma Wen, Zhu Wen-Jun, Zhang Ya-Lin, Chen Kai-Guo, Deng Xiao-Liang, Jing Fu-Qian
2010 Wuli xuebao  
t¿dO/m! /#c M K > ? [7 ;?VK M < # D'" Å ÐÏ
doi:10.7498/aps.59.4781 fatcat:lifcebld5rbzply5q6nd3k6g2y
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