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Darier Disease with Psoriasis

Seok-Young Kang, So-Yeon Lee, Jin-Seo Park, Jin-Cheol Kim, Bo-Young Chung, Chun-Wook Park, Hye-One Kim
2022 Medicina  
Darier disease is an autosomal dominant disorder with dark crusty patches and is classified as hereditary acantholytic dermatosis. Keratotic papules and crust are often present on the scalp, forehead, chest, back, upper arms, elbows, groin, and behind the ears, predominantly in seborrheic areas. A 48-year-old male patient presented skin lesions with pruritus on the trunk and both upper and lower extremities. He first noticed the lesion 15 years before. On physical examination, there were
more » ... e erythematous papules with crust on the trunk and red-brown colored keratotic plaque on both extremities. The suspected histopathological diagnosis was psoriasis vulgaris. The patient's skin lesions and pruritus were significantly improved after the psoriasis treatment. While continuing psoriasis treatment, the patient showed sudden worsening of the skin lesions on the scalp, abdomen, and fingernails (V-shaped nicks) with pruritus. Punch biopsy was performed on the abdominal lesion again and the final diagnosis was Darier disease. The patient was then treated using alitretinoin while maintaining the use of guselkumab for psoriasis. There are only a few cases that we found in which patients with Darier disease also had psoriasis. We report this rare case of Darier disease with psoriasis and propose that an additional biopsy might be necessary for accurate diagnosis and proper treatment.
doi:10.3390/medicina58070902 pmid:35888621 pmcid:PMC9319658 fatcat:rm5yua74ore2bdczht4h67yzue

Moisturizer in Patients with Inflammatory Skin Diseases

Seok-Young Kang, Ji-Young Um, Bo-Young Chung, So-Yeon Lee, Jin-Seo Park, Jin-Cheol Kim, Chun-Wook Park, Hye-One Kim
2022 Medicina  
As interest in skin increases, the cosmetic market is also growing. It is difficult to choose between the numerous types of basic cosmetics on the market. This article aims to provide advice and guidance on which products to recommend according to a patient's skin condition. Appropriate application of a moisturizer attempts not only to improve the dryness, but also improve the skin's natural barrier function to protect the skin from internal and external irritants to keep the skin healthy.
more » ... urizers consist of various ingredients, including occlusive agents, emollients, humectants, lipid mixture, emulsifiers, and preservatives. Pathophysiology of dry skin is also discussed to provide readers with the background they need to choose the right moisturizer for themselves. As moisturizers play an important role as adjuvant in the treatment of common skin diseases, such as atopic dermatitis, contact dermatitis, psoriasis, acne and rosacea, which type of moisturizer is appropriate for each disease was also dealt with. Basic cosmetics, especially moisturizers, should be recommended in consideration of the ingredients, effectiveness and safety of each product, and the skin condition of each patient.
doi:10.3390/medicina58070888 pmid:35888607 pmcid:PMC9315586 fatcat:tupa4dw2pzebnifgwpzg35iv24

Fabrication of polytetrafluoroethylene nanofibrous membranes for guided bone regeneration

Jin-Young Park, Jung-Hee Lee, Chun-Ho Kim, Young-Jin Kim
2018 RSC Advances  
In this study, PTFE nanofibrous membranes were fabricated by sintering the previously electrospun polytetrafluoroethylene (PTFE)/poly(ethylene oxide) (PEO) nanofibrous membranes.
doi:10.1039/c8ra05637d pmid:35548619 pmcid:PMC9086911 fatcat:7uik3vqy3ndaba2x6zv4xvmnc4

A Generalized Fading Model with Multiple Specular Components [article]

Young Jin Chun
2018 arXiv   pre-print
The wireless channel of 5G communications will have unique characteristics that can not be fully apprehended by the traditional fading models. For instance, the wireless channel may often be dominated by a finite number of specular components, the conventional Gaussian assumption may not be applied to the diffuse scattered waves and the point scatterers may be inhomogeneously distributed. These physical attributes were incorporated into the state-of-the-art fading models, such as the kappa-mu
more » ... adowed fading model, the generalized two-ray fading model, and the fluctuating two ray fading model. Unfortunately, much of the existing published work commonly imposed arbitrary assumptions on the channel parameters to achieve theoretical tractability, thereby limiting their application to represent a diverse range of propagation environments. This motivates us to find a more general fading model that incorporates multiple specular components with clusterized diffuse scattered waves, but achieves analytical tractability at the same time. To this end, we introduced the Multiple-Waves with Generalized Diffuse Scatter (MWGD) and Fluctuating Multiple-Ray (FMR) model that allow an arbitrary number of specular components and assume generalized diffuse scattered model. We derive the distribution functions of the signal envelop in closed form and calculate second order statistics of the proposed fading model. Furthermore, we evaluate the performance metrics of wireless communications systems, such as the capacity, outage probability, and average bit error rate. Through numerical simulations, we obtain important new insights into the link performance of the 5G communications while considering a diverse range of fading conditions and channel characteristics.
arXiv:1810.05258v1 fatcat:dgltikugzncp3oubi6u6jq3oiu

Neutrino Oscillations in Dark Matter

Ki-Young Choi, Eung Jin Chun, Jongkuk Kim
2020 Zenodo  
We study neutrino oscillations in a medium of dark matter which generalizes the standard matter effect. A general formula is derived to describe the effect of various mediums and their mediators to neutrinos. Neutrinos and anti-neutrinos receive opposite contributions from asymmetric distribution of (dark) matter and anti-matter, and thus it could appear in precision measurements of neutrino or anti-neutrino oscillations. Furthermore, it leads to an amusing possibility that neutrino
more » ... can occur from the dark-matter-induced flavorful potential even for massless neutrinos.
doi:10.5281/zenodo.4124136 fatcat:pvgqgjq7encnll5wj6pj2dta2u

Stem Cell Dynamics in an Experimental Model of Stroke

Min-Cheol Lee, Chun-Yan Jin, Hyung-Seok Kim, Jae-Hyu Kim, Myeong-Kyu Kim, Hyoung-Ihl Kim, Young-Jin Lee, Young-Jun Son, Young-Ok Kim, Young-Jong Woo
2011 Chonnam medical journal  
Lee MC and Jin CY were equally contributed to the study.  ... 
doi:10.4068/cmj.2011.47.2.90 pmid:22111067 pmcid:PMC3214868 fatcat:v5xsr5oup5hyfd6rdfcpykdsva

Post-carotid stenting reperfusion injury with blood-brain barrier disruption on gadolinium-enhanced FLAIR MRI

Hyun-Ji Cho, Young Jin Kim, Joon Hwa Lee, Jin Woo Choi, Won-Jin Moon, Hong Gee Roh, Young Il Chun, Hahn Young Kim
2014 BMC Neurology  
Following carotid revascularization, an abrupt increase in cerebral blood flow may disrupt the blood-brain barrier, resulting in reperfusion injury. This damage to the blood-brain barrier may be reflected by subarachnoid enhancement on FLAIR MRI after gadolinium injection. Case presentation: The authors present two cases of post-carotid stenting reperfusion injury that showed hyperintensity in the subarachnoid spaces on FLAIR MRI after gadolinium injection. Conclusion: These MRI findings may
more » ... resent a marker for reperfusion injury after carotid revascularization. Background The mechanism of hyperperfusion syndrome (HPS) occurring after carotid endarterectomy or carotid artery stenting (CAS) may involve disruption of the blood-brain barrier (BBB) induced by abrupt increases in cerebral blood flow [1] . Patients with HPS present a variety of clinical manifestations, including headache, visual disturbance, confusion and other hemispheric symptoms [1, 2]. Recently, extravasation and stagnation of intravenous gadolinium (Gd) in the subarachnoid space has been suggested to be an imaging marker for early BBB disruption in ischemic stroke. This has been denominated as a "hyperintense acute reperfusion marker (HARM)" [3]. Herein, two patients with post-carotid stenting HPS and HARM are presented. Case presentation Serial T2 FLAIR MRI protocol To detect Gd extravasation and stagnation in the subarachnoid space, serial fluid-attenuated inversionrecovery (FLAIR) MRIs were performed using a protocol similar to that reported previously [4, 5]. FLAIR MRIs were performed thrice. First, pre-stenting FLAIR MRI was performed before CAS. Gd was then injected 6-8 hours after CAS to perform perfusion-weighted MRI (PWI). In patient 1, an additional FLAIR MRI was performed immediately after Gd injection. Second, post-stenting FLAIR MRI was performed 24-30 hours after CAS (i.e. 18-24 hours after Gd injection). Third, FLAIR MRIs were performed 4-5 days after CAS. Patient 1 A 67-year-old man with hypertension and diabetes mellitus was admitted for transient aphasia. Diffusion-weighted MRI (DWI) performed 5 hours after the onset of symptoms did not reveal the presence of acute infarction in the left hemisphere. MR angiography and conventional cerebral angiography revealed > 70% stenosis of the left proximal internal carotid artery (ICA) ( Figure 1A ). CAS of the left proximal ICA was successfully performed with a distal protection device at 7 days after the onset of symptoms ( Figure 1B ). Three hours later, he was disoriented, agitated, and experienced sensory aphasia and drift of his right arm. Systolic blood pressure was maintained between 129 and 163 mmHg, and diastolic blood pressure was maintained between 90 and 107 mmHg, values that were slightly higher than the pre-stenting blood pressure. DWI performed 6 hours post-stenting showed several small subcortical infarctions in the frontal subcortex, probably Reperfusion injury after CAS 4 associated with the stenting procedure ( Figure 2B ). PWI performed 6 hours post-stenting showed mildly increased perfusion on the time-to-peak map in the left hemisphere ( Figure 2C ). Immediate FLAIR MRI after Gd injection showed diffuse leptomeningeal enhancement along the cerebral cortex in the hemisphere with hyperperfusion ( Figure 3A ) that was accompanied by signal changes on DWI ( Figure 3B ). Follow-up FLAIR MRI performed 18 hours after Gd injection showed subarachnoid hyperintensities in the left cerebral hemisphere ( Figure 2D ). The patient recovered in 5 days and experienced only mild dysarthria. Subarachnoid hyperintensities were completely resolved on follow-up FLAIR MRI ( Figure 2E ). Increased perfusion in the left hemisphere was nearly normalized on the follow-up PWI, which was performed 24 hours after stenting. Patient 2 A 66-year-old man with hypertension and diabetes mellitus was admitted for left proximal internal carotid arterial stenosis. He had presented 1 week earlier with mild dysarthria that had completely resolved. DWI showed several small acute lesions in the left hemispheric borderzone; therefore, the carotid stenosis was symptomatic. MR angiography and conventional cerebral angiography revealed 70% stenosis at the bifurcation of the left ICA ( Figure 1C) . CAS of the left proximal ICA was successfully performed with a distal protection device ( Figure 1D ). Blood pressure was strictly controlled during and after the procedure. Five hours later, he was disoriented and agitated with aphasia. DWI performed 8 hours after stenting showed several small cortical infarctions in the left frontal subcortex ( Figure 2G ). PWI performed 8 hours after stenting showed no perfusion abnormalities ( Figure 2H ). One day later, his aphasia worsened. Follow-up FLAIR MRI performed 24 hours after Gd injection showed subarachnoid hyperintensities in the left cerebral hemisphere ( Figure 2I ). No new lesions were revealed on follow-up DWI. The patient completely recovered in 4 days. Subarachnoid hyperintensities appeared to be completely resolved on follow-up FLAIR MRI ( Figure 2J ). Discussion An abrupt increase in cerebral blood flow following revascularization has been identified as the direct physiological cause of HPS [1]. Impaired autoregulation of cerebral blood flow and subsequent disruption of the BBB are possible conditions associated with HPS [1, 2]. Leptomeningeal enhancement on Gd-enhanced FLAIR MRI has been observed in patients with meningitis, subarachnoid hemorrhage (SAH), leptomeningeal carcinomatosis or renal dysfunction [6, 7]. First, the patients described herein did not show any clinical symptoms of SAH or meningitis such as severe headache or neck stiffness, and had no evidence of intracranial Reperfusion injury after CAS 5 aneurysms or infection. Sulcal FLAIR hyperintensities, which were not observed in either patient before stenting (Figure 2A and 2F) , appeared after Gd injection and rapidly disappeared in 4-5 days ( Figure 2E and 2J ). In cases of SAH or meningitis, sulcal FLAIR hyperintensities may be present before stenting and remain for longer periods of time. Hyperintensities on FLAIR MRI after Gd enhancement have been suggested to be a marker of reperfusion injury after thrombolysis [3, 8, 9]. Serial pre-and post-stenting Gd-enhanced FLAIR MRI studies in patients with CAS have revealed leptomeningeal enhancement after stenting [10, 11]. Wilkinson et al. reported asymptomatic leptomeningeal enhancements that were the consequence of hemodynamic changes after CAS [11]. Because that study only involved patients with symptomatic carotid stenosis, the underlying disruption of the BBB by previous ischemic injury may have resulted in leakage of the Gd injected. The authors recommended further studies using DWI to clarify these findings [11]. The patients described herein showed clinical symptoms of HPS. Post-stenting DWI showed only a few small ischemic lesions that were probably associated with the stenting procedure; however, these limited lesions do not fully explain the extent of the patients' hemispheric symptoms. Post-stenting cerebral blood flow measurements by PWI showed mild hyperperfusion on the time-to-peak map in patient 1. The FLAIR MRI performed immediately after Gd injection showed leptomeningeal enhancements along the cerebral cortex; this "on the spot" image may reflect Gd extravasation through the disrupted BBB during the hyperperfusion state ( Figure 3A) . Interestingly, DWI also showed acute high-signal intensities along the cerebral cortex ( Figure 3B ). Focal disruption of the BBB in patients with acute ischemic stroke may be the cause of HARM as seen by FLAIR MRI. However, HARM in patients with HPS may be due to transient reversible diffuse hemispheric disruption of the BBB. Although the possibility for multiple microembolic infarctions was present, cortical neuronal injury associated with hyperperfusion is a possible explanation for the lesions observed on DWI. However, considering that pre-stenting stenoses in both patients were less than 80% (74.8% in patient 1 and 70.2% in patient 2), alternative explanations, such as no-reflow or luxury perfusion phenomena, should be considered [12, 13]. Extravasated Gd appeared on the follow-up MRI as hyperintensities in the subarachnoid space. After 4-5 days, Gd washout was complete, and the clinical symptoms rapidly improved. In the presence of concomitant acute infarcted lesions in which the BBB is already disrupted, the clinical significance of poststenting HARM may be quite limited; it could be a simple consequence of Gd leakage through the disrupted BBB in the normal perfusion state, but not in the hyperperfusion state. Recently, similar case and research Reperfusion injury after CAS 6 reports have been published suggesting that reperfusion syndrome may be associated with transient neurological deficits after carotid revascularization without classical HPS [4, 5]. Several factors including advanced age, underlying leukoaraiosis, and postprocedural high blood pressure have been associated with symptomatic HARM [4]. Similar to the patients in a previous case series study [5], the patients herein also showed reversible neurological deterioration and limited abnormalities on PWI. Findings on PWI in our patients (mild asymmetry on the time-to-peak map in patient 1 and no asymmetry in patient 2) seemed to be very similar to those in that report (symmetric in 2 patients and mild asymmetry on the mean-transit-time map in one patient) [5]. HARM may be associated with a mild form of reperfusion injury instead of full-blown HPS. Therefore, further studies considering the multiple factors that are potentially related to post-stenting HARM, such as acute or chronic infarction, white matter hyperintensities, microbleeds, and clinical symptoms of HPS, may be needed.
doi:10.1186/s12883-014-0178-z pmid:25204402 pmcid:PMC4174251 fatcat:qetfo3p24jhihdgy7rzytobgiy

Analytical method of New POPs in environmental samples
환경 중 신규 POPs 분석방법 고찰

Sun-Kyoung Shin, Jin-Soo Park, Young-Yeul Kang, Su-Young Lee, Jin-Won Chun, Dong-Hoon Kim, Jin-Mo Yeon
2010 Analytical Science and Technology  
doi:10.5806/ast.2010.23.2.128 fatcat:vtvlo2gzfjchnj4cejbgbs5b54

Long-term outcome of vertebral artery origin stenosis in patients with acute ischemic stroke

Young Jin Kim, Joon Hwa Lee, Jin Woo Choi, Hong Gee Roh, Young Il Chun, Ji-Sung Lee, Hahn Young Kim
2013 BMC Neurology  
JW Choi, HG Roh, and YI Chun participated in patient enrollment. JS Lee helped to perform the statistical analyses. All authors read and approved the final manuscript.  ... 
doi:10.1186/1471-2377-13-171 pmid:24215371 pmcid:PMC3833629 fatcat:meyjpy232rgfbkmoppg73w6u5y

Experience of Y-Configured Stents for Small Basilar Tip Aneurysms

Chun-Sung Cho, Young-Joon Kim, Jin Kyung Kim, Young Jin Kim, Sang Koo Lee, Maeng Ki Cho
2007 Interventional Neuroradiology  
doi:10.1177/159101990701300105 pmid:20566128 pmcid:PMC3329165 fatcat:peqidtgcyjcu3de5txtyaoduxe

Neutrino Oscillations in Dark Matter [article]

Ki-Young Choi, Eung Jin Chun, Jongkuk Kim
2019 arXiv   pre-print
We study neutrino oscillations in a medium of dark matter which generalizes the standard matter effect. A general formula is derived to describe the effect of various mediums and their mediators to neutrinos. Neutrinos and anti-neutrinos receive opposite contributions from asymmetric distribution of (dark) matter and anti-matter, and thus it could appear in precision measurement of neutrino or anti-neutrino oscillations. Furthermore, the standard neutrino oscillation can occur from the symmetric dark matter effect even for massless neutrinos.
arXiv:1909.10478v2 fatcat:dgxtfni42nbftfqnzvvdwid4ua

Oral Alitretinoin for Patients with Refractory Prurigo

Bo Young Chung, Ji Young Um, Seok Young Kang, Min Je Jung, Jin Cheol Kim, In-Suk Kwak, Chun Wook Park, Hye One Kim
2020 Medicina  
prurigo is a chronic skin disorder associated with a history of chronic pruritus. The pathogenesis of prurigo is largely unknown and the treatment of prurigo is unsatisfactory and challenging. Conventional systemic treatments may be beneficial; however, their possible side effects and possible transient efficacy is still a problem. We aimed to present the clinical course and effect of treatment with alitretinoin on patients with prurigo nodularis initially treated with conventional treatments
more » ... ke oral antihistamine, cyclosporine, and phototherapy. Methods: all the patients had prurigo nodularis refractory to conventional treatment. Their medical records included demographic features, past medical history, duration of disease, and treatment modalities; and the clinical courses of the patients were reviewed for this retrospective study. We evaluated patient pruritus and skin lesions for the duration. Results: we present reports involving 10 patients with refractory prurigo. All the patients in our cases were treated with oral alitretinoin after previous treatments and reported the improvement of skin lesions and pruritus within 2 weeks to 3 months. Conclusions: we suggest that oral alitretinoin may be an effective and well tolerated treatment option for patients with intractable prurigo. Further clinical studies are warranted to confirm the long-lasting efficacy and safety of alitretinoin for treating patients with prurigo.
doi:10.3390/medicina56110599 pmid:33182351 fatcat:v5my4c7tbjfple3gk6ygl3daoy

Epiphyseal Hemangioma of the Humeral Head: Imaging Findings and Literature Review

Woo Jin Yang, Wook Jin, Young Soo Chun, Gou Young Kim, So Young Park, Ji Seon Park, Kyung Nam Ryu
2015 Journal of the Korean Society of Radiology  
Magnetic Epiphyseal Hemangioma of the Humeral Head: Imaging Findings and Literature Review 상완골두에 발생한 골단 혈관종: 영상 소견 및 선행 문헌 검토 Woo Jin Yang, MD 1 , Wook Jin, MD 1 * , Young Soo Chun, MD 2 , Gou Young Kim  ...  , MD 3 , So Young Park, MD 1 , Ji Seon Park, MD 4 , Kyung Nam Ryu, MD 4 Departments of 1 Radiology, 2 Orthopaedic Surgery, 3 Pathology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung  ... 
doi:10.3348/jksr.2015.73.6.403 fatcat:aye2a5ha6jfhhf3mrtwmb6zgii

Differential Diagnosis and Treatment of Itching in Children and Adolescents

Seok-Young Kang, Ji-Young Um, Bo-Young Chung, Jin-Cheol Kim, Chun-Wook Park, Hye-One Kim
2021 Biomedicines  
In addition, young infants typically develop pustules in the plantar area.  ...  Sites of predilection for atopic dermatitis include the face, trunk, and extremities in young children.  ... 
doi:10.3390/biomedicines9080919 fatcat:ow3boqfr7vd2tce5yndpm6oswy

Altered core networks of brain connectivity and personality traits in internet gaming disorder

Ji-Won Chun, Chang-Hyun Park, Jin-Young Kim, Jihye Choi, Hyun Cho, Dong Jin Jung, Kook-Jin Ahn, Jung-Seok Choi, Dai-Jin Kim, In Young Choi
2020 Journal of Behavioral Addictions  
Recently, the BAS has been linked not only to Internet addiction (Dong, Hu, & Lin, 2013) , but also to excessive smartphone use (Chun et al., 2017) .  ... 
doi:10.1556/2006.2020.00014 pmid:32592635 pmcid:PMC8939405 fatcat:xiz43e3stjaexjhyc6uzybyame
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