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Lung image segmentation plays an important role in computer-aid pulmonary diseases diagnosis and treatment. This paper proposed a lung image segmentation method by generative adversarial networks. We employed a variety of generative adversarial networks and use its capability of image translation to perform image segmentation. The generative adversarial networks was employed to translate the original lung image to the segmented image. The generative adversarial networks based segmentationarXiv:1907.13033v1 fatcat:cb5el2ws3ra2pci6y2dv6urwgm
more »... was test on real lung image data set. Experimental results shows that the proposed method is effective and outperform state-of-the art method.
Stroke is a worldwide public health problem that has caused a substantial economic burden to families and society. Despite recent major advances, there is still a need for more timely, effective diagnosis and treatment methods for acute ischemic stroke. Non-coding RNAs (ncRNAs), which widely exist in the human body, do not encode proteins. Instead, these mediate various cellular processes as functional regulatory molecules from the RNA level. Each ncRNA node in organisms is not isolated butdoi:10.3389/fneur.2022.820858 pmid:35309579 pmcid:PMC8927803 doaj:fda4e65f2c134c87a55227566052396d fatcat:4bccycc63renppxuj6m3acluhu
more »... titutes a complex regulatory network, regulating multiple molecular targets and triggering specific physiological or pathological reactions, leading to different outcomes. Abundant studies have proclaimed the impact of ncRNAs in ischemic stroke, which may enlighten new inspirations for diagnosing and treating ischemic stroke. This paper outlines the current understanding of the ncRNA regulatory network and reviews the recent evidence for the contribution of ncRNAs in the experimental ischemic stroke model.
Diazo compounds are the most commonly used carbene precursors. They can be dediazonized to obtain highly reactive free carbene intermediates or metal cabenoid under transition metal catalysts. Then varieties of chemical transformations can be proceeded, such as X-H (X=C, N, O, S, Si, etc.) insertions, 1,2-hydrogen migration reactions and cyclopropanations. Varieties of pharmaceuticals, natural products and other bioactive moleculars could be synthesized through these methods. As one of the mostdoi:10.6023/cjoc201511021 fatcat:txb6mmeth5h5vitwrrwuoc3cca
more »... important diazo compounds α-diazophosphonates could also proceed various chemical transformations and be used to synthesize varieties of organic functional phosphorous compounds. Because organic phosphorous compounds exhibit extensive bioactivities and pharmaceutic activities, the research of α-diazophosphonates has attracted lots of attentions of scientists. The recent development of the reactions of α-diazophosphonates catalyzed by various kinds of catalysts is summarized.
The ballbot is a dynamically stable mobile robot designed to balance on a single ball, whose dynamic stability enables improved navigability in narrow, crowded, and dynamic environments. Through its single contact point with the ground, ballbot is omnidirectional and exceptionally agile, maneuverable, and organic in motion compared to other ground vehicles. For dealing with the challenging and imperative issues about ballbot, such as balancing, yaw, position control algorithms as well as thedoi:10.1109/access.2019.2902219 fatcat:dfjl7zkdzvgurpz2rhhojiv5py
more »... hematical kinematic model, a novel model employing the Lagrange Equation is derived and control algorithm based on the similar principle as the second-order inverted pendulum is proposed, which is used for tackling the balancing, yaw, and position control. A cascade fuzzy proportional derivative (PD) controller and another controller with proportional integral (PI) control and PD feedback are designed for position and speed, respectively. Yaw control is presented, including head-hold mode and head-free mode. Some experiments are carried out to validate the effectiveness of the mathematical model and control algorithm. INDEX TERMS Ballbot, Lagrange equation, cascade fuzzy control. 38314 2169-3536
PPP (Public-Private Partnership) project performance management refers to the project management activities such as performance targets and indicators management, performance monitoring, performance evaluation and result application in the whole life cycle of PPP project. At present, under the background that most PPP projects have started, constructed and operated one after another, strengthening the performance management of PPP projects has become the focus of attention of all parties. Thisdoi:10.22158/rem.v6n1p96 fatcat:hiimkqx7lbaa5lcck6uj56offm
more »... aper sorts out the general situation of PPP project performance evaluation management based on questionnaires and expert interviews, discusses and analyzes the key points of PPP project overall performance, success factors, problems in project implementation, clearing out of library, application of performance evaluation results, and future development trend, and puts forward opinions and suggestions to guide all parties to standardize the implementation of PPP projects in the next step.
In this paper, we firstly character the structures of symmetries J such that a projection P is J-contractive. Then the minimal and maximal elements of the symmetries J with P^∗JP≤ J(or JP≥0) are given. Moreover, some formulas between P_(2I-P-P^∗)^+ (P_(2I-P-P^∗)^-) and P_(P+P^∗)^- (P_(P+P^∗)^+) are established.arXiv:1810.05381v2 fatcat:v3klllcrzbaovizi233opdttzm
In order to reduce the total cost of empty container repositioning, a multi-period empty container repositioning optimization model of the China Railway Express was established by using distributed robust chance-constrained programming based on partial information such as mean and variance of demand. This established model considered sea-land intermodal transportation, uncertain empty container demand and foldable containers. To simplify the model, the distributed robust chance constraints weredoi:10.3390/sym12050706 fatcat:6cieriddqzdrnbrtycohn4yte4
more »... transformed into equivalent ones that could be easily solved, and the empty container demands were determined. Numerical experiments were carried out to analyze the influence of different parameters on the total cost. The results showed that the total cost could be greatly reduced by sea-land intermodal transportation. Using foldable containers could reduce the total cost of empty container repositioning. With the improvement of service level, the numbers of empty container repositioning increased owing to the distributional robust chance constraints. When standard and foldable containers were used simultaneously, the total cost could be greatly reduced by appropriately using foldable containers under three different supply–demand relationships of containers. The optimization results may provide a greatly feasible reference for the decision makers of the China Railway Express.
γ-Glutamylcysteine synthetase (GCS) is the rate-limiting enzyme in the biosynthesis of glutathione and is composed of a heavy and a light subunit. Although the heavy subunit is enzymically active alone, the light subunit plays an important regulatory role by making the holoenzyme function more efficiently. In the current study we examined whether conditions which are known to influence gene expression of the heavy subunit also influence that of the light subunit, and the mechanisms involved.doi:10.1042/bj3260167 pmid:9337864 pmcid:PMC1218650 fatcat:k7rblihkwnbq3cg7jvhyjjoqwi
more »... atment of cultured rat hepatocytes with hormones such as insulin and hydrocortisone, or plating hepatocytes under low cell density increased the steady-state mRNA level of the heavy subunit only. Treatment with diethyl maleate (DEM), buthionine sulphoximine (BSO) and t-butylhydroquinone (TBH) increased the steady state mRNA level and gene transcription rates of both subunits.
Urine has evolved as a promising body fluids in clinical proteomics because it can be easily and noninvasively obtained and can reflect physiological and pathological status of the human body. Many efforts have been made to characterize more urinary proteins in recent years, but few have focused on the analysis throughput and detection reproducibility. Increasing the urine proteomic profiling throughput and reproducibility is urgently needed for discovering potential biomarker in large cohorts.doi:10.1186/s12014-018-9220-2 pmid:30607141 pmcid:PMC6303996 fatcat:4sgvpbopdrairfww2ribassbxi
more »... In this study, we developed a fast and robust workflow for streamlined urinary proteome analysis. The workflow integrate highly efficient sample preparation technique and urinary specific data-independent acquisition (DIA) approach. The performance of the workflow was systematically evaluated and the workflow was subsequently applied in a proof-of-concept urine proteome study of 21 kidney cancer (KC) patients and 22 healthy controls. With this workflow, the entire sample preparation process takes less than 3 h and allows multiplexing on standard centrifuges. Without pre-fractionation, our newly developed DIA method allows quantitative analysis of ~ 1000 proteins within 80 min of MS time (~ 15 samples/day). The quantitation accuracy of the whole workflow was excellent with median CV of 9.1%. The preliminary study on KC identified 125 significantly changed proteins. The result suggested the feasibility of applying the high throughput workflow in extensive urinary proteome profiling and clinical relevant biomarker discovery.
We have shown previously that plating primary cultures of rat hepatocytes under low density, which stimulates hepatocytes to shift from the G 0 to the G 1 phase of the cell cycle, resulted in increased levels of glutathione (GSH) and cysteine, and increased activity of ␥-glutamylcysteine synthetase (GCS), the rate-limiting enzyme in GSH synthesis (Lu et al., Am. J. Physiol. 1992;263:C1181-C1189). In the current work we examined changes in GSH homeostasis after two-thirds partial hepatectomydoi:10.1002/hep.510270123 pmid:9425930 fatcat:a2lvamoj25f3jppt34erqnpc5y
more »... . Male Sprague-Dawley rats underwent two-thirds PH or sham operation. GSH, oxidized glutathione (GSSG), cysteine, GSH efflux, DNA synthesis, changes in GCS subunit messenger RNA (mRNA), and protein levels were measured 12 and 24 hours after PH. Both liver GSH and cysteine levels were doubled at 12 hours and remained elevated at 24 hours after PH. GSSG levels also increased, but the ratio of GSH to GSSG levels remained unchanged. The increase in GSH and cysteine levels preceded the increase in DNA synthesis. Sinusoidal GSH efflux was unchanged after two-thirds PH, but biliary GSH efflux decreased. However, total GSH efflux was minimally altered after two-thirds PH. The increase in GSH can be largely accounted for by the increase in both cysteine availability and the activity of GCS. The steadystate mRNA and protein levels of the GCS heavy subunit were increased at 12 hours after PH. The mRNA level of the GCS light subunit was unchanged. In summary, early in the course of liver regeneration the steady-state hepatic GSH levels double because of an increase in the biosynthesis of GSH. (HEPATOLOGY 1998;27:147-153.) Glutathione (GSH) is a tripeptide, ␥-glutamylcysteinylglycine, that is essential for the survival of all aerobic cells. GSH
Visual information extraction (VIE) has attracted considerable attention recently owing to its various advanced applications such as document understanding, automatic marking and intelligent education. Most existing works decoupled this problem into several independent sub-tasks of text spotting (text detection and recognition) and information extraction, which completely ignored the high correlation among them during optimization. In this paper, we propose a robust visual informationarXiv:2102.06732v1 fatcat:sdda3rbjrfey3bajxvw7klkovi
more »... system (VIES) towards real-world scenarios, which is a unified end-to-end trainable framework for simultaneous text detection, recognition and information extraction by taking a single document image as input and outputting the structured information. Specifically, the information extraction branch collects abundant visual and semantic representations from text spotting for multimodal feature fusion and conversely, provides higher-level semantic clues to contribute to the optimization of text spotting. Moreover, regarding the shortage of public benchmarks, we construct a fully-annotated dataset called EPHOIE (https://github.com/HCIILAB/EPHOIE), which is the first Chinese benchmark for both text spotting and visual information extraction. EPHOIE consists of 1,494 images of examination paper head with complex layouts and background, including a total of 15,771 Chinese handwritten or printed text instances. Compared with the state-of-the-art methods, our VIES shows significant superior performance on the EPHOIE dataset and achieves a 9.01% F-score gain on the widely used SROIE dataset under the end-to-end scenario.
542 Shanghai Municipality (No. 13JC1401704) (N.S.). 543 Author contributions: Conceptualization, Qian R and Lu C; Methodology, Lu C, 544 Xu L, Li X, Sun N, Yan Z; Investigation, Xu L, Cheng Q, Hua B, Cai ...doi:10.1101/365452 fatcat:b3thzzgilreqdfuzsgklgoxee4
The integrated allocation and scheduling of handling resources are crucial problems in the railway container terminal (RCT). We investigate the integrated optimization problem for handling resources of the crane area, dual-gantry crane (GC), and internal trucks (ITs). A creative handling scheme is proposed to reduce the long-distance, full-loaded movement of GCs by making use of the advantages of ITs. Based on this scheme, we propose a flexible crossing crane area to balance the workload ofdoi:10.3390/su13031190 fatcat:wxc3v3cbifdolnwfmsqw2cn7ly
more »... -GC. Decomposing the integrated problem into four sub-problems, a multi-objective mixed-integer programming model (MIP) is developed. By analyzing the characteristic of the integrated problem, a three-layer hybrid heuristic algorithm (TLHHA) incorporating heuristic rule (HR), elite co-evolution genetic algorithm (ECEGA), greedy rule (GR), and simulated annealing (SA) is designed for solving the problem. Numerical experiments were conducted to verify the effectiveness of the proposed model and algorithm. The results show that the proposed algorithm has excellent searching ability, and the simultaneous optimization scheme could ensure the requirements for efficiency, effectiveness, and energy-saving, as well as the balance rate of dual-GC.
Motivation is the impetus for patients to seek orthodontic treatment, affecting adherence, treatment outcomes, and satisfaction. The aim of this study was to assess the motivation of adult female patients seeking orthodontic treatment, and classify the patients according to their motivations. Methods: This study used Q-methodology as the main tool. Q-samples were collected and categorized (35 items). Forty-two adult female patients were interviewed before treatment as the P-sample, and theirdoi:10.2147/ppa.s78691 pmid:25709410 pmcid:PMC4332290 fatcat:ru2djrmpana2bnz3ufnhhzupvm
more »... ponses were categorized into the Q-methodology grid. Participants were asked to rank-order a set of 35 statements (Q-sample) from "agree most" to "disagree most" (Q-sorting). The finished Q-grids were analyzed using PQ method 2.35. Results: Four main factors were identified based on how adult female patients ranked statements: factor 1, patients who focus on their self-perception of their appearance; factor 2, patients who are concerned about the esthetics and function of their teeth; factor 3, patients who are easily influenced by others; factor 4, patients who want to improve their confidence and avoid negative thoughts caused by their teeth. The remaining patients who had other views did not match any of the above four groups. Conclusion: The motivations of adult female patients seeking orthodontic treatment are complex. This study found that most adult female patients fell into one of four typical factor groups. Our findings may improve the adherence of adult female patients by developing a more ideal treatment program.
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