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High cumulative doxorubicin dose for advanced soft tissue sarcoma

Zhichao Tian, Yang Yang, Yonghao Yang, Fan Zhang, Po Li, Jiaqiang Wang, Jinpo Yang, Peng Zhang, Weitao Yao, Xin Wang
2020 BMC Cancer  
Background The recommended cumulative doxorubicin dose in soft tissue sarcoma (STS) treatment was based on cardiotoxicity data from retrospective studies of breast cancer patients. However, the treatment and prognosis of STS and breast cancer are quite different, and reference to breast cancer data alone may not reflect the efficacy of doxorubicin treatment in STS. This study, thus, aimed to review and analyze clinical data of STS patients treated with a high cumulative doxorubicin dose, to
more » ... ide a reference for treatment selection and clinical trial design. Methods We retrospectively collected and analyzed clinical data of patients with advanced STS who received doxorubicin-based chemotherapy from January 2016 to January 2020. The patients were divided into a standard-dose group (who received ≤6 cycles of doxorubicin after the initial diagnosis) and an over-dose group (who were re-administered doxorubicin [doxorubicin-rechallenge] after receiving 6 cycles of doxorubicin therapy discontinuously). Patient characteristics, cumulative doxorubicin dose, objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), cardiotoxicity incidence, and treatment effectiveness were evaluated in both groups. Results A total of 170 patients with advanced STS were recruited (146 in the standard-dose group and 24 in the over-dose group). The average cumulative doxorubicin dose was 364.04 ± 63.81 mg/m2 in the standard-dose group and 714.38 ± 210.09 mg/m2 in the over-dose group. The ORR, DCR, and median PFS were 15.07, 58.9%, and 6 (95% confidence interval [CI]: 5.8–6.5) months in the standard-dose group and 16.67, 66.67%, and 4 (95%CI: 2.0–5.8) months in the over-dose group, respectively. Symptomatic heart failure occurred in five patients (3.42%) of the standard-dose group and in one patient (4.17%) of the over-dose group. In these patients with cardiotoxicity, doxorubicin was discontinued, and all of them died of uncontrolled tumor growth. No drug-related deaths occurred. Conclusions The continuation of or rechallenge with doxorubicin beyond the recommended cumulative dose could be a promising therapeutic option in the treatment of chemotherapy-sensitive advanced sarcomas. Further evaluation is necessary in prospective trials.
doi:10.1186/s12885-020-07663-x pmid:33228579 fatcat:7357wl2qpvg7lgdgnpjgxylqmq

Magnetic imaging of antiferromagnetic domain walls [article]

Paul M. Sass, Wenbo Ge, Jiaqiang Yan, D. Obeysekera, J.J Yang, and Weida Wu
2019 arXiv   pre-print
The control of domain walls or spin textures is crucial for spintronic applications of antiferromagnets. Despite many efforts, it has been challenging to directly visualize antiferromagnetic domains or domain walls with nanoscale resolution, especially in magnetic field. Here, we report magnetic imaging of domain walls in several uniaxial antiferromagnets, the topological insulator MnBi_2Te_4 family and the Dirac semimetal EuMnBi_2, using cryogenic magnetic force microscopy (MFM). Our MFM
more » ... s reveal higher magnetic susceptibility or net moments inside the domain walls than in domains. Domain walls in these antiferromagnets form randomly with strong thermal and magnetic field dependences. The direct visualization of domain walls and domain structure in magnetic field will not only facilitate the exploration of intrinsic phenomena in topological antiferromagnets, but also open a new path toward control and manipulation of domain walls or spin textures in functional antiferromagnets.
arXiv:1910.06488v1 fatcat:plq4xbaefneb3fmqpjyid2thlm

Robust Control of Winding-Based DC-Bus Capacitor Discharge for PMSM Drives in Electric Vehicles

Xiaojun Zhang, Jiaqiang Yang, Haolin Yang
2021 IEEE Access  
doi:10.1109/access.2021.3110050 fatcat:l6wzzrbljjgghpyhqbag3wfuu4

Evolution of quantum correlation undergoing decoherence using the information entropy inequality

Xia Liu, Huaixin Lu, JiaQiang Zhao, Yang Yang, Yingde Li, LianZhen Cao
2018 Laser Physics Letters  
Using the information-theoretic inequality proposed by Braunstein and Caves, we study the evolution of quantum correlation in the presence of different noisy channels. First, we experimentally prepare the high-fidelity two-bit entangled state and simulated the bit-flip and phase-shift noise using an all-optical experimental setup. Then, we study the quantum correlation evolution of a two-bit entangled system using the information difference of entropy under different noisy channels and noisy
more » ... ironments. It is found that the quantum correlation degradation depends on the type of noise and noisy channels. Our work provides a new essential tool for quantum information processing and measurement, and offers new insight into the evolution of quantum correlation in open systems.
doi:10.1088/1612-202x/aaea6f fatcat:2n3rlxy45zfqhgy4ovvmncpuge

Experimentally Demonstrate the Spin-1 Information Entropic Inequality Based on Simulated Photonic Qutrit States

Lianzhen Cao, Xia Liu, Yang Yang, Qinwei Zhang, Jiaqiang Zhao, Huaixin Lu
2020 Entropy  
Quantum correlations of higher-dimensional systems are an important content of quantum information theory and quantum information application. The quantification of quantum correlation of high-dimensional quantum systems is crucial, but difficult. In this paper, using the second-order nonlinear optical effect and multiphoton interference enhancement effect, we experimentally implement the photonic qutrit states and demonstrate the spin-1 information entropic inequality for the first time to
more » ... titative quantum correlation. Our work shows that information entropy is an important way to quantify quantum correlation and quantum information processing.
doi:10.3390/e22020219 pmid:33285993 fatcat:jdqfo4ixgfeofh5536ncbjurgm

Polymorphism of duck MHC class molecules

Lin Zhang, Dongmei Lin, Sen Yu, Junping Bai, Wanchun Jiang, Wenzheng Su, Yanyan Huang, Shaohua Yang, Jiaqiang Wu
2018 Immunogenetics  
. * Lin Zhang lzhang3406@163.com * Jiaqiang Wu 443794629@qq.com region of duck (Anpl-MHC I), only UAA, which is adjacent to the polymorphic TAP2 gene, is highly expressed (Mesa et al. 2004 ; Moon et  ... 
doi:10.1007/s00251-018-1076-0 pmid:30187087 fatcat:btislij3jva6zehiu4gasvlmge

Photocatalytic reduction of Cr(VI) within mesoporous TiO 2 templated and confined with chlorophyll

Haiyan Yang, Yepeng Yang, Liang Jiang, Yuanfeng Wang, Yongjuan Chen, Jiao He, Wei Wang, Jiaqiang Wang
2021 Nano Select  
Biomimetic light-harvesting architecture has been proposed as an alternative for existing solar conversion systems. Chlorophyll-sensitized TiO 2 have been identified as promising catalyst for photocatalytic reduction system, but it is largely limited to complicated process for purification of chlorophyll and adding extra hole scavenger in system. In sharp contrast to conventional photosensitization methods in which the organic dyes were often adsorbed after photosensitization, herein mesoporous
more » ... TiO 2 incorporated with chlorophyll extract was synthesized in situ (TiO 2 /Chl). Interestingly, TiO 2 incorporated with chlorophyll exhibited two distinct absorption bands around 407 and 668 nm which are closed to the characteristic absorption peak of chlorophyll. TiO 2 incorporated with chlorophyll kept at 185 • C for 1.5 hours (TiO 2 /Chl-185) achieved a high photoreduction rate of 86.1% for the photocatalytic reduction of Cr(VI), which was approximately 29 and 20 times higher than that of TiO 2 and TiO 2 adsorbing chlorophyll (TiO 2 /ads Chl), respectively. The significant enhancement was due to the confinement of chlorophyll. This demonstrates that mesoporous TiO 2 templated and confined with chlorophyll could offer a new approach for synergistic photoreduction of Cr(VI).
doi:10.1002/nano.202100070 fatcat:xwkq7yq4brg5jdx2usss6jrkzm

A Fast Response Robust Deadbeat Predictive Current Control for Permanent Magnet Synchronous Motor

Haowei Nie, Jiaqiang Yang, Rongfeng Deng
2021 Energies  
Deadbeat predictive current control (DBPCC) has the characteristic of fast current response, but it is sensitive to motor parameters. Observer-based DBPCC can eliminate the steady state current tracking error when parameter mismatch exists. However, the actual current will deviate from the reference current during transient state in the case of inductance mismatch. In this paper, a fast response robust deadbeat predictive current control (FRRDBPCC) method is proposed for surface mounted
more » ... t magnet synchronous motor (SPMSM). Firstly, the current tracking error caused by inductance mismatch during transient state is analyzed in detail. Then, an extended state observer (ESO) is proposed to estimate the lumped disturbance caused by parameter mismatch. Based on discrete time ESO, the predicted currents are used to replace the sampled currents to compensate for one-step delay caused by calculation and sampling. Furthermore, an online inductance identification algorithm and a modified prediction model are proposed. The dq-axis currents can be completely decoupled by updating the inductance in the modified prediction model online, ensuring that the current can track the reference value in two control periods. The proposed method improves robustness against parameter mismatch and guarantees dynamic response performance simultaneously. The experimental results verify the effectiveness of the proposed method.
doi:10.3390/en14227563 fatcat:u3vkohsvjnbxtl55m6tjvta7oi

MOFzyme: Enzyme Mimics of Fe/Fe-MIL-101

Lingli Li, Daomei Chen, Bin Li, Dongqi Yang, Jingchen Zhao, Danhua Ma, Liang Jiang, Yepeng Yang, Yizhou Li, Jiaqiang Wang
2019 Journal of Biosciences and Medicines  
In this work, metal-organic frameworks (MOFs) Fe-MIL-101 was synthesized by hydrothermal method, and Fe/Fe-MIL-101 with different loadings was prepared. The crystal structure of the Fe/Fe-MIL-101 sample was characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and specific surface area measurement (BET). Fe/Fe-MIL-101 was found to posses an intrinsic enzyme mimicking activity similar to that found in natural horseradish peroxidase (HRP). The Michaelis constant (K m ) of
more » ... Fe/Fe-MIL-101 with ABTS as the substrate is about 10-fold smaller than Fe-MIL-101 and about 3-fold smaller than HRP, and about 108 times less than that of CuO NPs (K m = 10.28 mM), indicating a much higher affinity for ABTS than HRP and most of the peroxidase mimetics.
doi:10.4236/jbm.2019.75023 fatcat:mpwb2iqsn5caxmcyys5mpkwb6u

Novel ultra-sensitive, wide-frequency domain flexible bionic vibration sensor

LianHui LI, Yang GU, JiaQiang XU, Ting ZHANG
2017 Scientia Sinica Technologica  
(a) 带通滤波 振动传感器(sensor)信号和原音乐文件(original sound wave) 对比图; (b) 图(a)中随机选取的片段(8.2~9.2 s)放大对比图 ultra-sensitive, wide-frequency domain flexible bionic vibration sensor LI LianHui 1,2 , GU Yang 2 , XU JiaQiang  ... 
doi:10.1360/n092016-00444 fatcat:mrez7z35jnfh7csfc7lvyolsii

Ionic Liquid-Microwave-Based Extraction of Biflavonoids from Selaginella sinensis

Dan Li, Chengxin Sun, Jiaqiang Yang, Xiankui Ma, Yongmei Jiang, Shaoliang Qiu, Gang Wang
2019 Molecules  
Yang and others [10] proved HIN could inhibit cell proliferation of human melanoma A375 and CHL-1 cells in a dose-and time-dependent manner.  ... 
doi:10.3390/molecules24132507 fatcat:cz4t7kx2uraqncfcwopgyswof4

Microwave-Assisted Synthesis and Antitumor Activity of Salicyl Acyloxy Phosphonate Derivatives

Jiaqiang Yang, Jun Ma, Wanli Che, Minggang Li, Gang Li, Baoan Song
2014 Youji huaxue  
a 遵义医学院药学院 遵义 563003) ( b 贵州大学精细化工研究中心 贵阳 550025) 摘要 微波辅助下, 采用水杨酸与 α-羟基膦酸酯在 DCC/DMAP 催化下酯化, 合成了 12 个结构新颖的水杨酰氧基膦酸 酯衍生物, 其结构经 IR, 1 H NMR, 13 C NMR 及元素分析确认. 优化得最适微波合成条件: 以 15 mL CH 2 Cl 2 为溶剂, 辐射 功率 800 W, 室温反应 3.5 h, 有最好产率, 该方法具有反应时间较短、产率较高等优点. 四甲基偶氮唑蓝(MTT)法测试 了目标化合物的抗肿瘤活性, 结果表明: 目标化合物对所测试的四种肿瘤细胞均有增殖抑制作用. 其中化合物 2f 对 HEp-2 的抑制活性 [IC 50 =(13.9±0.6) μmol/L]略低于对照药[IC 50 =(9.3±1.1) μmol/L], 化合物 2k 对 EC-109 的抑制活性 [IC 50 =(8.5±0.9) μmol/L]接近对照药[IC 50 =(5.9±1.0) μmol/L]. Abstract Twelve new salicyl
more » ... xy phosphonate derivatives were synthesized via microwave-assisted reactions of salicylic acid with α-hydroxyphosphonate in DCC/DMAP. The structures of the products were confirmed by elemental analysis, IR, 1 H NMR and 13 C NMR data. The suitable synthetic conditions were as follows: in 15 mL of CH 2 Cl 2 with power 800 W at room temperature for 3.5 h. The cytotoxic activities of all compounds on A-549, SGC-7901, HEp-2 and EC-109 in vitro were evaluated by using an 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method, and some of them showed good antitumor activity. Among the active compounds, espectively, compound 2f had better inhibition effect on HEp-2 cells growth [IC 50 =(13.9±0.6) μmol/L], the IC 50 values of compound 2k was (8.5±0.9) μmol/L against EC-109 cells, similar to cisplatin [IC 50 =(5.9±1.0) μmol/L].
doi:10.6023/cjoc201406026 fatcat:oyu5vd7pvzfctj3vcovcbx7qeu

Experimental quantum data locking

Yang Liu, Zhu Cao, Cheng Wu, Daiji Fukuda, Lixing You, Jiaqiang Zhong, Takayuki Numata, Sijing Chen, Weijun Zhang, Sheng-Cai Shi, Chao-Yang Lu, Zhen Wang (+4 others)
2016 Physical Review A  
Classical correlation can be locked via quantum means--quantum data locking. With a short secret key, one can lock an exponentially large amount of information, in order to make it inaccessible to unauthorized users without the key. Quantum data locking presents a resource-efficient alternative to one-time pad encryption which requires a key no shorter than the message. We report experimental demonstrations of quantum data locking scheme originally proposed by DiVincenzo et al. [Phys. Rev.
more » ... 92, 067902 (2004)] and a loss-tolerant scheme developed by Fawzi, Hayde, and Sen [J. ACM. 60, 44 (2013)]. We observe that the unlocked amount of information is larger than the key size in both experiments, exhibiting strong violation of the incremental proportionality property of classical information theory. As an application example, we show the successful transmission of a photo over a lossy channel with quantum data (un)locking and error correction.
doi:10.1103/physreva.94.020301 fatcat:6cn2arv2ozeizdz6nvpshyu2m4

An Accurate Discrete Current Controller for High-Speed PMSMs/Gs in Flywheel Applications

Xiang Zhang, Yunlong Chen, Yves Mollet, Jiaqiang Yang, Johan Gyselinck
2020 Energies  
High-speed Permanent-Magnet Synchronous Motors/Generators (PMSMs/Gs) in a Flywheel Energy Storage System (FESS) are faced with high cross-coupling voltages and low switching-to-fundamental frequency ratios. High cross-coupling voltages between d-q axis current loops lead to transient current errors, which is more serious at lower switching-to-fundamental-frequency ratios. If the delays are not properly considered during the current controller design in a digital control system, the low
more » ... -to-fundamental-frequency ratios may result in oscillatory or unstable responses. In this study, an accurate discrete current controller for high-speed PMSMs/Gs is proposed based on an accurate discrete model that takes the phase and magnitude errors generated during the sampling period into consideration, and an Extended State Observer (ESO) is applied to estimate and compensate the back EMF error. The cross-coupling problem is well settled, and the current loop dynamic at lower switching-to-fundamental frequency ratios is improved. Finally, the proposed discrete controller is validated on a 12,000 rpm PMSM/G prototype.
doi:10.3390/en13061458 fatcat:3znkcvh24fcyvneclfxtqapmre

Association between DAPK1 Promoter Methylation and Cervical Cancer: A Meta-Analysis

Jiaqiang Xiong, Ya Li, Kecheng Huang, Meixia Lu, Hao Shi, Lanfang Ma, Aiyue Luo, Shuhong Yang, Zhiyong Lu, Jinjin Zhang, Lilan Yang, Shixuan Wang (+1 others)
2014 PLoS ONE  
After the omission of the heterogeneous study (Yang et al., 2010) , the pooled OR changed dramatically compared to when other studies were removed.  ...  Subgroup meta-analysis of the association between DAPK1 promoter methylation and cervical cancer omitting one heterogeneous study (Yang et al.) .  ... 
doi:10.1371/journal.pone.0107272 pmid:25268905 pmcid:PMC4182030 fatcat:vsgd4df3erdqzlw2fjqyuley4q
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