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FAD: A Chinese Dataset for Fake Audio Detection
[article]
2022
arXiv
pre-print
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Fake audio detection is a growing concern and some relevant datasets have been designed for research. But there is no standard public Chinese dataset under additive noise conditions. In this paper, we aim to fill in the gap and design a Chinese fake audio detection dataset (FAD) for studying more generalized detection methods. Twelve mainstream speech generation techniques are used to generate fake audios. To simulate the real-life scenarios, three noise datasets are selected for noisy adding
arXiv:2207.12308v1
fatcat:erob7zf4yndvxpfjhsdc2vvhhm
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... five different signal noise ratios. FAD dataset can be used not only for fake audio detection, but also for detecting the algorithms of fake utterances for audio forensics. Baseline results are presented with analysis. The results that show fake audio detection methods with generalization remain challenging. The FAD dataset is publicly available.
Half-Truth: A Partially Fake Audio Detection Dataset
[article]
2021
arXiv
pre-print
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Wang et al. [8] have built a English and Mandarin fake dataset with an open-sourced voice conversion and speech synthesis tool. ...
arXiv:2104.03617v1
fatcat:bqcfeohulza4bnjup2y4czxhju
Continual Learning for Fake Audio Detection
[article]
2021
arXiv
pre-print
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Wang et al. [12] proposed a dual-adversarial domain adaptation framework to solve out-of-domain dataset problem. However, these methods require both original and new data. ...
arXiv:2104.07286v1
fatcat:3og3ewfs3zebzidapgnwdk3hie
Synthesis and Characterization of Water-Soluble Polythiophene Derivatives for Cell Imaging
2015
Scientific Reports
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Two-dimensional carbon leading to new photoconversion processes
2014
Chemical Society Reviews
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Rev., 2014, 00, 1À19 | 17
Jiangyan Wang Jiangyan Wang received her BE
from the School of Chemical and
Environmental Engineering in
2010 at the China University of
Mining and Technology, Beijing. ...
Dan Wang
Dan Wang received his BS and
MS at Jilin University (1994 and
1997) and PhD at Yamanashi
University (2001). ...
doi:10.1039/c3cs60437c
pmid:24654006
fatcat:gwp4x3ykpzhbpaexohnjpgvv7y
Multi-shelled LiMn2O4 hollow microspheres as superior cathode materials for lithium-ion batteries
2016
Inorganic Chemistry Frontiers
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Multi-shelled LiMn2O4 hollow microspheres are prepared with high uniformity, exhibiting impressive cycling stability as cathode materials for lithium-ion batteries.
doi:10.1039/c5qi00213c
fatcat:4ozd2xnvtvh2xjrupbtxdgstou
Determination of Polar Cap Boundary for the Substorm Event of 8 March 2008
2018
Frontiers in Physics
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Taking advantage of the simulation data used previously by Wang et al. ...
The PCB locations are directly determined from the simulation data used previously by Wang et al. [19] . ...
Copyright © 2018 Wang, Wang, Lopez, Li, Zhang and Tang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). ...
doi:10.3389/fphy.2018.00050
fatcat:pqd6k4olmzewpgrfxv5stlppvq
Dynamic Soft Real-Time Scheduling with Preemption Threshold for Streaming Media
2019
International Journal of Digital Multimedia Broadcasting
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Over the last decades, the advancements in networking technology and new multimedia devices have motivated the research on efficient video streaming mechanisms under wireless. We consider combing soft real-time video streaming scheduling with threshold to minimize the ineffective preemption. Based on the value density and urgency of soft real-time task, the dynamic scheduling with preemption threshold strategy (DSPT) is proposed in the paper. By analyzing the response time and preemption
doi:10.1155/2019/5284968
fatcat:qcr3er43frbbhirficecoatkty
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... nship of tasks, the preemption thresholds are assigned. Simulation results show that the DSPT strategy achieves improvements about success rate, delay time, and benefit of the system.
Efficient sequential harvesting of solar light by heterogeneous hollow shells with hierarchical pores
2020
National Science Review
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In nature, sequential harvesting of light widely exists in the old life entity, i.e., cyanobacteria, to maximize the light absorption and enhance the photosynthesis efficiency. Inspired by nature, we propose a brand-new concept of temporally-spatially sequential harvesting of light in one single particle, which has purpose-designed heterogeneous hollow multi-shelled structures (HoMSs) with porous shells composed of nanoparticle subunits. Structurally, HoMSs consist of different band-gap
doi:10.1093/nsr/nwaa059
pmid:34691499
pmcid:PMC8290956
fatcat:bjha2mmgzzfw3h3snadtgfskzm
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... s outside-in, thus realizing the efficient harvesting of light with different wavelengths. Moreover, introducing oxygen vacancies into each nanoparticle subunit can also enhance the light absorption. With the benefit of sequential harvesting of light in HoMSs, the quantum efficiency at wavelength of 400 nm is enhanced by 6 times compared with the corresponding nanoparticles. Impressively, using these aforementioned materials as photocatalysts, highly efficient photocatalytic water splitting is realized, which cannot be achieved by using the nanoparticle counterparts. This new concept of temporally-spatially sequential harvesting of solar light paves the way to solving the ever-growing energy demand.
Combating the SARS-CoV-2 Omicron variant with non-Omicron neutralizing antibodies
[article]
2022
bioRxiv
pre-print
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The highly mutated and transmissible Omicron variant has provoked serious concerns over its decreased sensitivity to the current coronavirus disease 2019 (COVID-19) vaccines and evasion from most anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) neutralizing antibodies (NAbs). In this study, we explored the possibility of combatting the Omicron variant by constructing bispecific antibodies based on non-Omicron NAbs. We engineered ten IgG-like bispecific antibodies with
doi:10.1101/2022.01.30.478305
fatcat:6scxxmhkfzb5lcekiwqpqbuxva
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... n NAbs named GW01, 16L9, 4L12, and REGN10987 by fusing the single-chain variable fragments (scFvs) of two antibodies through a linker and then connecting them to the Fc region of IgG1. Surprisingly, eight out of ten bispecific antibodies showed high binding affinity to the Omicron receptor-binding domain (RBD) and exhibited extreme breadth and potency against pseudotyped SARS-CoV-2 variants of concern (VOCs) including Omicron, as well as authentic Omicron(+R346K) variants. Six bispecific antibodies containing the cross-NAb GW01 neutralized Omicron variant and retained their abilities to neutralize other sarbecoviruses. Bispecific antibodies inhibited Omicron infection by binding to the ACE2 binding site. A cryo-electron microscopy (cryo-EM) structure study of the representative bispecific antibody FD01 in complex with the Omicron spike (S) revealed 5 distinct trimers and one unique bi-trimer conformation. The structure and mapping analyses of 34 Omicron S variant single mutants elucidated that two scFvs of the bispecific antibody synergistically induced the RBD-down conformation into 3-RBD-up conformation, enlarged the interface area, accommodated the S371L mutation, improved the affinity between a single IgG and the Omicron RBD, and hindered ACE2 binding by forming bi-trimer conformation. Our study offers an important foundation for anti-Omicron NAb design. Engineering bispecific antibodies based on non-Omicron NAbs may provide an efficient solution to combat the Omicron variant.
Smooth simultaneous confidence bands for cumulative distribution functions
2013
Journal of nonparametric statistics (Print)
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Other related works on smooth estimation of cdf include Cheng and Peng (2002) and Xue and Wang (2010) . ...
Simultaneous confidence bands are powerful tools for global inference of complex functions, see, for instance, the confidence band for pdf in Bickel and Rosenblatt (1973) and for regression function in Wang ...
doi:10.1080/10485252.2012.759219
fatcat:fe2vr4fr7ngyhgmc3lmejsqgae
Clinical significance of high expression of stanniocalcin-2 in hepatocellular carcinoma
2019
Bioscience Reports
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To investigate the significance of stanniocalcin-2 (STC2) expression in hepatocellular carcinoma (HCC) tissues and adjacent tissues. Levels of STC2 in HCC tissue were detected in 200 HCC patients tissues and adjacent tissues as controls by immunohistochemistry technique (IHC) and reverse transcriptase-PCR (RT-PCR). Single factor analysis was used to study the relationship between expression of STC2 mRNA and protein and clinicopathological features of HCC. Multifactor Cox survival analysis was
doi:10.1042/bsr20182057
pmid:30962272
pmcid:PMC6487261
fatcat:of3ftdbllrb6lfselmarjcoemu
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... ed to relationship between the expression of STC2 and overall survival of postoperative patients with HCC. IHC staining showed that the expression of STC2 protein rate was 81.00% (163/200). And the positive rate of adjacent tissues was 29.00% (58/200). Western blot showed that the expression of STC2 protein in HCC was significantly higher than that in the adjacent tissues (P<0.05). RT-PCR showed that the positive rates of STC2 mRNA expression in HCC were 75.50% (151/200), which was significantly higher than that in adjacent tissues 14.50% (29/200) (P<0.05). Both STC2 mRNA and protein expression are related to tumor diameter, stage, tumor metastasis, carcinoma emboli in the portal vein and the degree of tumor differentiation in HCC. The HCC patients with higher expression of STC2 had shorter median survival time. STC2 expression, tumor diameter, carcinoma emboli in the portal vein, tumor differentiation degree, and tumor stage were independent factors affecting the overall survival of postoperative patients. The high expression of STC2 mRNA and protein expression in HCC may be associated with the occurrence, development, and prognosis of HCC. STC2 may also be possible to help developing new therapeutic strategies for HCC.
Prognostic Value of Overexpressed p16INK4a in Vulvar Cancer: A Meta-Analysis
2016
PLoS ONE
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Data extraction Three investigators (Hanyu Cao, Si Wang, and Zhenyu Zhang) extracted independently all articles complying with the aforementioned inclusion criteria. ...
doi:10.1371/journal.pone.0152459
pmid:27031618
pmcid:PMC4816296
fatcat:4u6rxw4dljgkzasdbsxwibztay
IL-6 is involved in malignancy and doxorubicin sensitivity of renal carcinoma cells
2017
Cell Adhesion & Migration
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Various survival factors such as the pleiotropic cytokine interleukin-6 (IL-6), a major mediator of inflammation and activator of signal transducer and activator of transcription 3 (STAT3), serve to block apoptosis in cancer cells. Our present study revealed that the expression of IL-6, while not other IL-2, IL-4, IL-8, or IL-10, was significantly elevated in resistance of renal carcinoma cells (RCC) when compared with human renal proximal tubule epithelial cell line HK-2. The inhibition of
doi:10.1080/19336918.2017.1307482
pmid:28328292
pmcid:PMC5810756
fatcat:olqpxkhbgbavvadhs3xne7tz4a
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... by siRNA can suppress the proliferation, migration and invasion of RCC cells and increase the doxorubicin (Dox) sensitivity. While recombination IL-6 can attenuate the inhibition effects of Dox on proliferation of RCC cells. Further studies indicated that inhibition of IL-6 by siRNA can decrease the phosphorylation of STAT3 in RCC cells. Over expression of STAT3 increased the proliferation, migration and invasion of RCC cells and reversed si-IL-6 induced increase of Dox sensitivity of ACHN and A498 cells. In addition, IL-6 treatment can activate ERK1/2 via increasing its phosphorylation. PD98059, the ERK1/2 inhibitor, attenuated IL-6 induced proliferation and synergistically increased the Dox sensitivity of si-IL-6 transfected ACHN cells. Collectively, our data suggested that IL-6 plays an important role in malignancy and Dox sensitivity of RCC. The targeted inhibition of IL-6 signals might be a promising therapeutic strategy for the treatment of renal cancer.
Guanidinium-pendant oligofluorene for rapid and specific identification of antibiotics with membrane-disrupting ability
2015
Chemical Communications
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A new method based on fluorescence resonance energy transfer was developed for specifically screening membrane-disrupting antibiotics.
doi:10.1039/c4cc09729g
pmid:25664361
fatcat:bqld6wb7vrhjvke3tjriig7okm
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