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Hybrid magnonics has recently attracted intensive attentions as a promising platform for coherent information processing. In spite of its rapid development, on-demand control over the interaction of magnons with other information carriers, in particular microwave photons in electromagnonic systems, has been long missing, significantly limiting the broad applications of hybrid magnonics. Here, we show that by introducing Floquet engineering into cavity electromagnonics, coherent control on thearXiv:2010.14727v1 fatcat:iffrk3gumfh23idtc4hlpkge54
more »... gnon-microwave photon coupling can be realized. Leveraging the periodic temporal modulation from a Floquet drive, our first-of-its-kind Floquet cavity electromagnonic system can manipulate the interaction between hybridized cavity electromagnonic modes on demand. Moreover, we demonstrate a new coupling regime in such systems: the Floquet ultrastrong coupling, where the Floquet splitting is comparable with or even larger than the level spacing of the two interacting modes, resulting in the breakdown of the rotating wave approximation. Our findings open up new directions for magnon-based coherent signal processing.
Protein translational machinery is an important component of the proteostasis network that maintains cellular proteostasis and regulates aging and other cellular processes. Ample evidence indicates that inhibition of translation initiation factor activities enhances stress resistance in model organisms. Eukaryotic translation initiation factor 5B (eIF5B) acts by joining the pre-40S subunit with the 60S ribosomal unit to form an 80S-like complex during protein translational initiation. Reduceddoi:10.1371/journal.pone.0168387 pmid:27959964 pmcid:PMC5154608 fatcat:zsdxircbrraybfisaptheozj4q
more »... F5B expression may disrupt proteostasis and trigger cellular processes associated with stress responses. In this study, the physiological effects of altered eIF5B expression were examined in 293T and HepG2 cells. Cells with eIF5B-knockdown (eIF5B-KN) grew more slowly than control cells, and had a lower level of intracellular reactive oxygen species (ROS), increased resistance to oxidative stress and enhanced autophagy. Proteomic analysis showed that eIF5B knockdown resulted in upregulation of 88 proteins and downregulation of 130 proteins compared with control cells. The differentially expressed proteins were associated with diverse cellular processes including amino acid metabolism, RNA processing and protein metabolism, and DNA synthesis. Autonomous downregulation of the mitogen-activated protein kinase (MAPK) signaling pathway was identified as confirmed by western blotting and qPCR. We proposed that deactivation of MAPK pathway modulated proteostasis and induced prolonged S-phase of the cell-cycle, contributing to the slow growth of eIF5B-KN cells. eIF5B silencing also inactivated the mTOR pathway, downregulated glutamine transporters, enhanced autophagy, and decreased 28S rRNA and 5.8S rRNA expression levels which were reversed by restoration of eIF5B expression. Taken together, these results suggest that eIF5B silencing provides a negative feedback to deactivate MAPK signaling, leading to reduced cell growth. These findings provide a useful resource to further biological exploration of the functions of protein synthesis in regulation of proteostasis and stress responses.
Authors' Contributions Hui Xu and Feng-yuan Lyu contributed equally to this work. Figure 1 : 1 The etiopathogenesis of OSMF caused by chewing areca nut. ...doi:10.1155/2021/6631856 pmid:33791368 pmcid:PMC7997751 fatcat:qwy6vyfxrrfvfkyabyutcxd25y
There are no two identical leaves in the world, so how to find effective markers or features to distinguish them is an important issue. Function transformation, such as f(x,y) and f(x,y,z), can transform two, three, or multiple input/observation variables (in biology, it generally refers to the observed/measured value of biomarkers, biological characteristics, or other indicators) into a new output variable (new characteristics or indicators). This provided us a chance to re-cognize objectivearXiv:1808.05766v1 fatcat:cn4lxa5idjg2xgk5ayiaq6hk6u
more »... ings or relationships beyond the original measurements. For example, Body Mass Index, which transform weight and high into a new indicator BMI=x/y^2 (where x is weight and y is high), is commonly used in to gauge obesity. Here, we proposed a new system, Funomics (Function Transformation Omics), for understanding the world in a different perspective. Funome can be understood as a set of math functions consist of basic elementary functions (such as power functions and exponential functions) and basic mathematical operations (such as addition, subtraction). By scanning the whole Funome, researchers can identify some special functions (called handsome functions) which can generate the novel important output variable (characteristics or indicators). We also start "the Funome project" to develop novel methods, function library and analysis software for Funome studies. The Funome project will accelerate the discovery of new useful indicators or characteristics, will improve the utilization efficiency of directly measured data, and will enhance our ability to understand the world. The analysis tools and data resources about the Funome project can be found gradually at http://www.funome.com.
Cooling microwave resonators to near the quantum ground state, crucial for their operation in the quantum regime, is typically achieved by direct device refrigeration to a few tens of millikelvin. However, in quantum experiments that require high operation power such as microwave-to-optics quantum transduction, it is desirable to operate at higher temperatures with non-negligible environmental thermal excitations, where larger cooling power is available. In this Letter, we present a radiativearXiv:1910.01203v1 fatcat:7o4iw7j6mfagxke7o2jpacykte
more »... oling protocol to prepare a superconducting microwave mode near its quantum ground state in spite of warm environment temperatures for the resonator. In this proof-of-concept experiment, the mode occupancy of a 10-GHz superconducting resonator thermally anchored at 1.02 K is reduced to 0.44±0.05 by radiatively coupling to a 70-mK cold load. This radiative cooling scheme allows high-operation-power microwave experiments to work in the quantum regime, and opens possibilities for routing microwave quantum states to elevated temperatures.
Atrial fibrillation (AF) is the most common form of sustained cardiac arrhythmia in humans and is responsible for substantial morbidity and mortality worldwide. Emerging evidence indicates that abnormal cardiovascular development is involved in the pathogenesis of AF. In this study, the coding exons and splice sites of the NKX2-5 gene, which encodes a homeodomain-containing transcription factor essential for cardiovascular genesis, were sequenced in 146 unrelated patients with lone AF as welldoi:10.7150/ijms.8407 pmid:24782644 pmcid:PMC4003540 fatcat:pght5ecc45f7rkocdfwjvfbmri
more »... the available relatives of the mutation carriers. A total of 700 unrelated ethnically matched healthy individuals used as controls were genotyped. The disease-causing potential of the identified NKX2-5 variations was predicted by MutationTaster and PolyPhen-2. The functional characteristics of the mutant NKX2-5 proteins were analyzed using a dual-luciferase reporter assay system. As a result, two heterozygous NKX2-5 mutations, including a previously reported p.E21Q and a novel p.T180A mutation, were identified in two families with AF transmitted in an autosomal dominant pattern. The mutations co-segregated with AF in the families with complete penetrance. The detected substitutions, which altered the amino acids highly conserved evolutionarily across species, were absent in 700 control individuals and were both predicted to be causative. Functional analyses demonstrated that the NKX2-5 mutants were associated with significantly decreased transcriptional activity compared with their wild-type counterpart. The findings expand the spectrum of NKX2-5 mutations linked to AF and provide additional evidence that dysfunctional NKX2-5 may confer vulnerability to AF, suggesting the potential benefit for the early prophylaxis and personalized treatment of AF.
Littoral wetlands are globally important for sustainable development; however, they have recently been identified as critical hotspots of nitrous oxide (N2O) emissions. N2O flux from subtropical littoral wetlands remains unclear, especially under the current global warming environment. In the littoral zone of Lake Poyang, a simulated warming experiment was conducted to investigate N2O flux. Open-top chambers were used to raise temperature, and the static chamber-gas chromatograph method wasdoi:10.3390/su12145674 fatcat:ech3icr5pvdwpeuc2ifk7kucd4
more »... to measure N2O flux. Results showed that the littoral zone of Lake Poyang was an N2O source, with an average flux rate of 8.9 μg N2O m−2 h−1. Warming significantly increased N2O emission (13.8 μg N2O m−2 h−1 under warming treatment) by 54% compared to the control treatment. N2O flux in the spring growing season was also significantly higher than that of the autumn growing season. In addition, temperature was not significantly related to N2O flux, while soil moisture only explained about 7% of N2O variation. These results imply that N2O emission experiences positive feedback effect on the ongoing warming of the climate, and abiotic factors (e.g., soil temperature and soil moisture) were not main controls on N2O variation in this littoral wetland.
We propose a secure computation solution for blockchain networks. The correctness of computation is verifiable even under malicious majority condition using information-theoretic Message Authentication Code (MAC), and the privacy is preserved using Secret-Sharing. With state-of-the-art multiparty computation protocol and a layer2 solution, our privacy-preserving computation guarantees data security on blockchain, cryptographically, while reducing the heavy-lifting computation job to a fewarXiv:1812.05820v1 fatcat:wpu3uxpo6vcftomeeeufovd3ai
more »... This breakthrough has several implications on the future of decentralized networks. First, secure computation can be used to support Private Smart Contracts, where consensus is reached without exposing the information in the public contract. Second, it enables data to be shared and used in trustless network, without disclosing the raw data during data-at-use, where data ownership and data usage is safely separated. Last but not least, computation and verification processes are separated, which can be perceived as computational sharding, this effectively makes the transaction processing speed linear to the number of participating nodes. Our objective is to deploy our secure computation network as an layer2 solution to any blockchain system. Smart Contractssmartcontract will be used as bridge to link the blockchain and computation networks. Additionally, they will be used as verifier to ensure that outsourced computation is completed correctly. In order to achieve this, we first develop a general MPC network with advanced features, such as: 1) Secure Computation, 2) Off-chain Computation, 3) Verifiable Computation, and 4)Support dApps' needs like privacy-preserving data exchange.
Pancreatic cancer (PC) is an aggressive and fatal disease with high incidences of metastasis and recurrence. However, there are no effective treatment options for the majority of PC patients, especially for those with locally advanced tumors and metastatic diseases. Therefore, it is urgently needed to develop safe and effective anti-PC therapeutic agents. We have recently identified a novel marine-derived natural product terphenyllin with potent anti-PC activity. The present study was designeddoi:10.3389/fphar.2020.00457 pmid:32322210 pmcid:PMC7157903 fatcat:hshleb5bdndt5mjq2j3chsxlme
more »... o investigate the efficacy and mechanisms of action of terphenyllin in several human PC cell lines and an orthotopic PC mouse model. The results showed that terphenyllin significantly inhibited the viability of all PC cell lines with minimal effects on a normal human pancreatic cell line (HPNE). We next demonstrated the effects of terphenyllin on colony formation, apoptosis, migration, and invasion in both Panc1 and HPAC cell lines in a concentration-dependent manner. Terphenyllin also suppressed the tumor growth and metastasis in the Panc1 orthotopic mouse model. We further showed the profound effects of terphenyllin on the expression of apoptosis-associated proteins, including Bax, Bad, Puma, BimL, Bcl-2, phos-Bcl-2 (Ser70), Bcl-xL, caspase 7, and PARP, which contributed to its anti-PC activity. In summary, terphenyllin suppressed the PC cell growth and metastasis in vitro and in vivo and may be developed as an anti-PC therapeutic agent in the future.
., 2013; Jiang et al., 2019; Moon et al., 2019; Petroni et al., 2020) . ... Xu et al. (2018a) have shown that Rab5a expression level is positively associated with drug resistance in gastric cancer cells. ...doi:10.3389/fcell.2020.621428 pmid:33344463 pmcid:PMC7744622 fatcat:ompgalzpxrdsdjnrwqujcseq3i
Jiang et al., Does removal of implants for ankle fractures improve clinical outcomes?, Asian Journal of Surgery, https://doi.org/10.1016/j.asjsur.2021.03.038 ...doi:10.1016/j.asjsur.2021.03.038 pmid:33888371 fatcat:vlnm45wdorgfrkyob3vbtbcggm
Xu et al. ...doi:10.1155/2014/321081 fatcat:dicy23mhwvbkza2a6apibvmxju
Hard and soft attention To visualize where and what an image caption generation model should focus on, Xu et al. ...arXiv:2111.07624v1 fatcat:2nreclzam5eqhmwolot5fkhvyu
Periodontal disease is one of the most common chronic infectious diseases. It has been reported that periodontal disease is associated with various adverse pregnancy outcomes including preterm birth, low birth weight, and gestational diabetes mellitus. Given the fact that the treatment for periodontal disease during pregnancy was ineffective in improving pregnancy outcomes by most of studies, the pre-conception period has been put forward as a more optimal time. However, very few studies havedoi:10.1186/s12978-016-0256-3 pmid:27903295 pmcid:PMC5131524 fatcat:yssoauqzyzb2bna63wgzaxod7m
more »... ported the prevalence of periodontal disease among pre-conception women. This study aimed to examine the prevalence and risk factors of periodontal disease among Chinese pre-conception women. Methods: A survey was conducted among pre-conception women at the Maternal and Child Health Hospital, Changzhou, China between January 2012 and December 2014. A total of 987 pre-conception women were recruited for a full-mouth dental examination after providing informed consent. A dental examination was carried out by probing six sites per tooth using a manual UNC-15 probe and a recording form. Results: The overall rate of periodontal disease among participants was 73.9% (729/987) (95% confidence interval (CI): 71.0-76.6%). Among women with periodontal disease, 48.0% of cases were mild, 50.9% were moderate and 1. 1% were severe. Self-reported bleeding during tooth brushing was the only significant predictive factor for overall periodontal disease (adjusted odds ratio (aOR): 3.71, 95% CI: 2.24, 6.15, P < 0.001) and moderate/severe periodontal disease (aOR: 5.17, 95% CI: 3.05, 8.79, P < 0.001). Conclusion: A high prevalence of periodontal disease was found in pre-conception Chinese women. Women who have bleeding during tooth brushing could be at increased risk of periodontal disease, and might require further oral health care.
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