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Jerzy Adamski, maszynopis ze zbiorów własnych. Molier, Don Jun albo Kamienna uczta, przeł. ... Jerzy Radziwiłowicz, maszynopis ze zbiorów własnych. przedmiotowa: Adamski, J., 1985, Teatr z bliska, Ludowa Spółdzielnia Wydawnicza, Warszawa. ... Jerzy Adamski and his unknown translation of molière's Dom juan Summary Jerzy Adamski -an outstanding literary critic and educator, the author of numerous articles and essays, was also a translator of ...doi:10.12775/rp.2017.017 fatcat:kilcyazn3vh2hmf45gvmplpkyu
Wspomnienie pośmiertne Profesor zw. dr hab. med. Jerzy Bowszyc
Wspomnienie pośmiertne Profesor zw. dr hab. med. Jerzy Bowszyc
Adamski, Janusz Prokop). ... Jerzy Bowszyc, wybitny naukowiec, lekarz, nauczyciel akademicki, wychowawca wielu pokoleń lekarzy. ...doi:10.5114/dr.2014.43872 fatcat:fvl5ud24ovd75f6a2apavflm2a
Notes on the biology and ecology of Labidostomma (Acari Prostigmata Labidostommidae) in Poland. The current article is a brief summary of results obtained from long-term observations (for over 67 years) of Labidostommatidae mites in Poland. The study is based on 21,470 samples collected in different environments and different locations, and each of them had a different protection status. The analysis focuses on the frequency of occurrence and habitat preferences of Labidostomma luteum Kramer,doi:10.19263/redia-101.18.21 fatcat:qp4y3hi3bvbbhi6b45wwbix66e
more »... 79, Labidostomma denticulatum (Schrank, 1776) and Labidostomma cornutum (G. Canestrini & Fanzago, 1878) in Poland. The results of the analysis show that L. luteum was the most frequent species found in the analyzed material, whereas specimens of L. cornutum were very rare. Moreover, the long-term research conducted in Poland since 1950 has allowed to analyze changes in the average abundance of the examined species in this area. The results of the analysis has revealed a decrease in the abundance of L. luteum, which is evident especially after 1990. Finally, the comparison of the abundance of Labidostomma in legally protected areas and those without any legal protection shows that the mites definitely prefer areas with a low anthropogenic pressure.
Adamski Genome Medicine 2012, 4:34 http://genomemedicine.com/content/4/4/34 Page 4 of 7 ...doi:10.1186/gm333 pmid:22546499 pmcid:PMC3446262 fatcat:oqnuq6i55nayzfy6k4ftbemmre
Cyberprzestępczość jest zjawiskiem relatywnie nowym, nic więc dziwnego, że pozostaje poza głównym nurtem zainteresowań badawczych kryminologii (Adamski 1999, s. 214) . ...doi:10.7420/ak2005-2006g doaj:b7d7fec09ddc4a04b213ad2280e90712 fatcat:cya6xtsc35gevhtyxbiu4akwxy
Metabolomics is instrumental in the analysis of disease mechanisms and biomarkers of disease. The human metabolome is influenced by genetics and environmental interactions and reveals characteristic signatures of disease. Population studies with metabolomics require special study designs and care needs to be taken with pre-analytics. Gas chromatography coupled to mass spectrometry, liquid chromatography coupled to mass spectrometry or NMR are popular techniques used for metabolomic analyses indoi:10.1007/s00125-016-4044-y pmid:27714446 fatcat:engihy5onzfqfkjb5bbcvx62i4
more »... uman cohorts. Metabolomics has been successfully used in the biomarker search for disease prediction and progression, for analyses of drug action and for the development of companion diagnostics. Several metabolites or metabolite classes identified by metabolomics have gained much attention in the field of diabetes research in the search for early disease detection, differentiation of progressor types and compliance with medication. This review summarises
A large part of metabolomics research relies on experiments involving mouse models, which are usually 6 to 20 weeks of age. However, in this age range mice undergo dramatic developmental changes. Even small age differences may lead to different metabolomes, which in turn could increase inter-sample variability and impair the reproducibility and comparability of metabolomics results. In order to learn more about the variability of the murine plasma metabolome, we analyzed male and femaledoi:10.3390/metabo10110472 pmid:33228074 fatcat:fjnl3kah25arroh257meqqhtfq
more »... , C57BL/6NTac, 129S1/SvImJ, and C3HeB/FeJ mice at 6, 10, 14, and 20 weeks of age, using targeted metabolomics (BIOCRATES AbsoluteIDQ™ p150 Kit). Our analysis revealed high variability of the murine plasma metabolome during adolescence and early adulthood. A general age range with minimal variability, and thus a stable metabolome, could not be identified. Age-related metabolomic changes as well as the metabolite profiles at specific ages differed markedly between mouse strains. This observation illustrates the fact that the developmental timing in mice is strain specific. We therefore stress the importance of deliberate strain choice, as well as consistency and precise documentation of animal age, in metabolomics studies.
Zeszyty Naukowe Uniwersytetu Szczecińskiego Acta Politica
IV Kongres Ruchów Miejskich – retrospekcja
IV Kongres Ruchów Miejskich – retrospekcja
Tkacz Rafał Grupiński Jerzy Wierchowicz Justyna Drath Piotr Bauć Robert Anacki C C A A C C B H. ... Ciekawe było także to, że w większości podczas debaty zgadzali się ze sobą Rafał Grupiński (PO) i Jerzy Wierchowicz (.Nowoczesna) 17 . ...doi:10.18276/ap.2015.33-08 fatcat:yllgxbbeive4xe3uwbgdh2byse
Aldo-keto reductases (AKRs) are enzymes involved in the metabolism of carbonyl substrates. Results: Two alternatively spliced protein isoforms encoded by the human AKR gene AKR1B15 were identified. The AKR1B15.1 isoform catalyzes reduction of steroids and 3-keto-acyl-CoA conjugates and localizes to mitochondria. Conclusion: AKR1B15.1 is a mitochondrial carbonyl reductase. Significance: AKR1B15.1 is a new enzyme with unique localization and catalytic features. Aldo-keto reductases (AKRs)doi:10.1074/jbc.m114.610121 pmid:25577493 pmcid:PMC4358287 fatcat:o7zfyew7tvganpr4fohfs4j5ea
more »... a superfamily of proteins involved in the reduction and oxidation of biogenic and xenobiotic carbonyls. In humans, at least 15 AKR superfamily members have been identified so far. One of these is a newly identified gene locus, AKR1B15, which clusters on chromosome 7 with the other human AKR1B subfamily members (i.e. AKR1B1 and AKR1B10). We show that alternative splicing of the AKR1B15 gene transcript gives rise to two protein isoforms with different N termini: AKR1B15.1 is a 316-amino acid protein with 91% amino acid identity to AKR1B10; AKR1B15.2 has a prolonged N terminus and consists of 344 amino acid residues. The two gene products differ in their expression level, subcellular localization, and activity. In contrast with other AKR enzymes, which are mostly cytosolic, AKR1B15.1 co-localizes with the mitochondria. Kinetic studies show that AKR1B15.1 is predominantly a reductive enzyme that catalyzes the reduction of androgens and estrogens with high positional selectivity (17␤-hydroxysteroid dehydrogenase activity) as well as 3-ketoacyl-CoA conjugates and exhibits strong cofactor selectivity toward NADP(H). In accordance with its substrate spectrum, the enzyme is expressed at the highest levels in steroid-sensitive tissues, namely placenta, testis, and adipose tissue. Placental and adipose expression could be reproduced in the BeWo and SGBS cell lines, respectively. In contrast, AKR1B15.2 localizes to the cytosol and displays no enzymatic activity with the substrates tested. Collectively, these results demonstrate the exis-tence of a novel catalytically active AKR, which is associated with mitochondria and expressed mainly in steroid-sensitive tissues.
Moreover, pesticides may lower animal fecundity (AdAmski & Ziemnicki 2004 , AdAmski et al. 2009 ), which was not checked in this work. ... Since pesticides are not 100% specific, they cause lethal and sublethal effects within non-target species (AdAmski & Ziemnicki 2004 , AdAmski et al. 2007 ) and their lethality may show stage-dependence ...doi:10.2478/v10120-009-0008-y fatcat:w3v5bcnqqfhrjd6ablo6fjo7eu
This systematic review analyses the contribution of metabolomics to the identification of diagnostic and prognostic biomarkers for uterine diseases. These diseases are diagnosed invasively, which entails delayed treatment and a worse clinical outcome. New options for diagnosis and prognosis are needed. PubMed, OVID, and Scopus were searched for research papers on metabolomics in physiological fluids and tissues from patients with uterine diseases. The search identified 484 records. Based ondoi:10.3390/jpm10040294 pmid:33371433 pmcid:PMC7767462 fatcat:ctjo6bxonncyfpeyse3y2t7zca
more »... usion and exclusion criteria, 44 studies were included into the review. Relevant data were extracted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) checklist and quality was assessed using the QUADOMICS tool. The selected metabolomics studies analysed plasma, serum, urine, peritoneal, endometrial, and cervico-vaginal fluid, ectopic/eutopic endometrium, and cervical tissue. In endometriosis, diagnostic models discriminated patients from healthy and infertile controls. In cervical cancer, diagnostic algorithms discriminated patients from controls, patients with good/bad prognosis, and with/without response to chemotherapy. In endometrial cancer, several models stratified patients from controls and recurrent from non-recurrent patients. Metabolomics is valuable for constructing diagnostic models. However, the majority of studies were in the discovery phase and require additional research to select reliable biomarkers for validation and translation into clinical practice. This review identifies bottlenecks that currently prevent the translation of these findings into clinical practice.
BMC Systems Biology
With the advent of high-throughput targeted metabolic profiling techniques, the question of how to interpret and analyze the resulting vast amount of data becomes more and more important. In this work we address the reconstruction of metabolic reactions from cross-sectional metabolomics data, that is without the requirement for time-resolved measurements or specific system perturbations. Previous studies in this area mainly focused on Pearson correlation coefficients, which however aredoi:10.1186/1752-0509-5-21 pmid:21281499 pmcid:PMC3224437 fatcat:miqrtrmeinesfjevlr6mbps5we
more »... incapable of distinguishing between direct and indirect metabolic interactions. Results: In our new approach we propose the application of a Gaussian graphical model (GGM), an undirected probabilistic graphical model estimating the conditional dependence between variables. GGMs are based on partial correlation coefficients, that is pairwise Pearson correlation coefficients conditioned against the correlation with all other metabolites. We first demonstrate the general validity of the method and its advantages over regular correlation networks with computer-simulated reaction systems. Then we estimate a GGM on data from a large human population cohort, covering 1020 fasting blood serum samples with 151 quantified metabolites. The GGM is much sparser than the correlation network, shows a modular structure with respect to metabolite classes, and is stable to the choice of samples in the data set. On the example of human fatty acid metabolism, we demonstrate for the first time that high partial correlation coefficients generally correspond to known metabolic reactions. This feature is evaluated both manually by investigating specific pairs of high-scoring metabolites, and then systematically on a literature-curated model of fatty acid synthesis and degradation. Our method detects many known reactions along with possibly novel pathway interactions, representing candidates for further experimental examination. Conclusions: In summary, we demonstrate strong signatures of intracellular pathways in blood serum data, and provide a valuable tool for the unbiased reconstruction of metabolic reactions from large-scale metabolomics data sets.
REVIEWER Reviewer #1: The manuscript entitled "Endocrinology and metabolomics: genetic impact and functional phenotyping" by Tokarz J, Haid M, Cecil A, Prhn C, Artati A, Möller G, Adamski J. is a very ...doi:10.1016/j.tem.2017.07.001 pmid:28780001 fatcat:rl76cmevprc3xoosewejp6cswa
AbstractResults of research on the chaetotaxy and morphology of setae in Nenteria pandioni (Acari: Uropodina) from Poland are presented. Certain idiosomal setae were found to be variable in structure. This variability may result from differences within the gene pool and/or from intra-specific variation associated with the process of aging. A full range of setal morphology was observed — from simple and needle-like setae to those with many notches and branches. Variability was observed onlydoi:10.2478/s11756-008-0032-0 fatcat:cj4cosxi6naxzco67qxfylngoi
more »... adult mites (both sexes), not in juvenile stages. Marginal, ventral and adanal setae were most variable. Incomplete or superficial examination of setal morphology, without considering setal variability, may cause mistakes in taxonomic research and may also limit the value of this feature as diagnostic character in acarology. Therefore, variability of setae should be carefully accounted for during description of new species, because some setae are not stable in their shapes, whereas others have fixed shape. Finally, hypotheses to explain the observed pattern in setal variability in mites are proposed.
Differentiation of preadipocytes into mature adipocytes is a highly complex cellular process. At lipidome level, the adipogenesis remains poorly characterized. To investigate the lipidomic changes during human adipogenesis, we used the LipidyzerTM assay, which quantified 743 lipid species from 11 classes. The undifferentiated human SGBS cell strain showed a heterogeneous lipid class composition with the most abundant classes, phosphatidylethanolamines (PE), phosphatidylcholines (PC), anddoi:10.3390/metabo10060217 pmid:32466532 fatcat:d4dkddeyonbmrbhmtmhgof4rdy
more »... myelins (SM). The differentiation process was accompanied by increased ceramide concentrations. After completion of differentiation around day 4, massive lipid remodeling occurred during maturation, characterized by substantial synthesis of diacylglycerols (DAG), lysophosphatidylethanolamines (LPE), PC, PE, SM, and triacylglycerols (TAG). Lipid species composition became more homogeneous during differentiation to highly concentrated saturated and monounsaturated long-chain fatty acids (LCFA), with the four most abundant being C16:0, C16:1, C18:0, and C18:1. Simultaneously, the amount of polyunsaturated and very long-chain fatty acids (VLCFA) markedly decreased. High negative correlation coefficients between PE and PC species containing VLCFA and TAG species as well as between ceramides and SM imply that PE, PC, and ceramides might have served as additional sources for TAG and SM synthesis, respectively. These results highlight the enormous remodeling at the lipid level over several lipid classes during adipogenesis.
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