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We investigate a new metric, the normalized point source sensitivity (PSSN), for characterizing the seeing-limited performance of large telescopes. As the PSSN metric is directly related to the photometric error of background limited observations, it represents the efficiency loss in telescope observing time. The PSSN metric properly accounts for the optical consequences of wave front spatial frequency distributions due to different error sources, which differentiates from traditional metricsdoi:10.1364/ao.48.005997 pmid:19881667 fatcat:p3jz6kpouraqhbioyq7iurgfli
more »... ch as the 80% encircled energy diameter and the central intensity ratio. We analytically show that multiplication of individual PSSN values due to individual errors is a good approximation for the total PSSN when various errors are considered simultaneously. We also numerically confirm this feature for Zernike aberrations as well as for the numerous error sources considered in the error budget of the Thirty Meter Telescope (TMT) using a ray optics simulator. Additionally, we discuss other pertinent features of the PSSN, including its relations to Zernike aberration, RMS wave front error, and central intensity ratio.
Drainage systems are integral parts of agricultural landscapes and have the ability to intercept nutrient loading from runoff to surface water. This study investigated nutrient removal efficiency within replicated experimental agricultural drainage ditches during a simulated summer runoff event. Study objectives were to examine the influence of routine mowing of vegetated ditches on nutrient mitigation and to assess spatial transformation of nutrients along ditch length. Both mowed and unmoweddoi:10.1007/s00128-016-1783-x pmid:27022936 fatcat:xp2baiunnjhqdahamzesn2ibzq
more »... itch treatments decreased NO 3 --N by 79 % and 94 % and PO 4 3by 95 % and 98 %, respectively, with no significant difference in reduction capacities between the two treatments. This suggests occasional ditch mowing as a management practice would not undermine nutrient mitigation capacity of vegetated drainage ditches. Agriculture is a contributing source of surface water pollution by way of erosion and chemical runoff (US EPA 2012). As a result, increased emphasis has been placed on developing and implementing new, innovative best management practices (BMPs) to reduce surface water contamination from edge-of-field runoff containing nutrients, pesticides, bacteria and sediments (Cooper et al. 2004) .
Objectives: We aimed to identify the functional abnormality of sinusitis-affected mucosa by observing the responsiveness of the mucosa to purinergic stimulation after the onset of sinusitis and during the recovery period. We also aimed to identify possible beneficial effects of purinergic agonists on sinusitis. Methods: A rabbit sinusitis model was developed by blocking maxillary ostia. Sinus mucosae were harvested immediately and 1 and 4 weeks after reopening the ostia. We measured chloridedoi:10.1097/mlg.0b013e31806911cc pmid:17632427 fatcat:nsgxk5sh6bf2nj4cv44lpe4z4e
more »... retion and ciliary beat frequencies responding to purinergic stimulation. Results: The increases of ciliary beat frequency by adenosine triphosphate (100 mol/L) were 3.2% Ϯ 8.5%, 7.9% Ϯ 2.3%, and 12.2% Ϯ 1.9% immediately after establishment of sinusitis and 1 week and 4 weeks after reopening of ostia, respectively. Chloride secretion stimulated by adenosine triphosphate also showed gradual increase during the recovery period. Grossly, the mucosae appeared to have normalized in 80% (4 of 5) after 4 weeks; however, functional and microscopic improvements were still incomplete. Conclusions: Mucosal functions, assessed by increase of ciliary activity and ion secretion by purinergic stimulation, and microscopic findings showed gradual but incomplete recovery after 4 weeks of recovery, in contrast to the gross normalization. Purinergic agonists may have beneficial effects on sinusitis by stimulating decreased ciliary motility and chloride secretion in sinusitis.
The demands for computing resource allocation, user management, and various contents management are increasing with the proliferation of cloud computing. A cloud service system has to provide the system services that are combined or shared based on the web environment, unlike a single application in the past. It has also evolved to appropriately allocate and combine service resources according to the needs and needs of various users to provide a user-dependent web environment. There is andoi:10.13189/ujeee.2019.060301 fatcat:xk2wsq4egzbhpftsjxiyyozkfu
more »... sing need for software convergence services in the form of software. In response to these needs, a variety of customized services are provided to a user who promises an optional service environment. Those services can be used in combination according to a user's purpose and needs, instead of providing an environment in which a user purchases and uses software locally. In particular, because cloud computing provides the process that a user gain accessing authority to the system which has been granted a service access right for a certain period of time, and including a process of expire the corresponding right is completed, a various authority access control method is designed. In this paper, we define the roles of users who access cloud computing service, and manage user rights according to each role, provide and expire appropriate service resources according to user's privilege and session information. Moreover we analyzed the procedures for constructing an algorithm for service ripple effects according to the procedure of granting service resources to each user and accessing web services and constructing a new role.
S. pombe. Previous work has suggested that Fun30 is a nucleosome remodeler. The experiments presented in this manuscript address the role of Fun30 in controlling the level of RNA polymerase II and histone H3, as well as the relationship between Fun30 and FACT. From their analyses, the authors conclude that Fun30 help to overcome nucleosomal barriers during transcription elongation. There are some interesting results in this paper, but the density of both the writing and the data make the noveldoi:10.1038/ncomms14527 pmid:28218250 pmcid:PMC5321744 fatcat:cblum3ltg5fgfgrxfr4ppuepru
more »... esults less apparent than they should be. The writing needs some editing to make it more concise and clear, and to shape the story in a way that will make it more accessible to readers. There are also other issues to address, listed below. Comments are below, generally presented as they arose during the reading of the manuscript. 1. A lot of the conclusions in this work rest on the evaluation of correlation coefficients. In some cases, it seems that the authors are making a strong conclusion based on r values that may not merit it -the most striking example of this is in Fig. 4b . Compare Fig. 4b (r=0.41) and Supp. Fig. 4a (r=0.25) . The first is discussed as meaningful and the second as not meaningful. Also in many cases, we are asked to evaluate the r values for comparisons between chip-seq of different proteins when we haven't been given the r values for the replicate experiments. We need those values as well. A clearer discussion of what the authors consider to be meaningful r values, as well as more information about duplicates should be provided throughout the manuscript. 2. line 39 -Why cite these references for a statement about epigenetic regulation? 3. lines 42-44 -This statement should be referenced.
Journal of Internet Computing and services
EDISON 플랫폼의 통합 파일관리 서비스 구현 및 적용
EDISON 플랫폼의 통합 파일관리 서비스 구현 및 적용
As computer technology continues to evolve, the Computational Sciences utilized in Physics, Chemistry, Materials Science, and Life Sciences have been attracting more attention. In Korea, to compensate for the drawbacks in Computational Science, students and researchers have been using the EDISON platform. The EDISON platform provides a web portal service for education and research and an environment for addressing complex issues involving five fields, e.g., Computational Fluid Dynamics (CFD),doi:10.7472/jksii.2016.17.6.71 fatcat:n25hi2cssnazndfetdpizmblmu
more »... nophysics, Computational Chemistry, Structural Dynamics, and Computational Design. As the platform and user scale increase beyond service provision, the need for efficient operation of its currently running data management system is on the rise. In this study, we resolve the data synchronization issues between the existing EDISON platform and web portal. As the EDISON platform is integrated with the web portal, a file management service is implemented to integrate the management of user data and files, which ultimately improves the overall efficiency of file management.
Modeling, Systems Engineering, and Project Management for Astronomy III
We investigate a new metric, Normalized Point Source Sensitivity (PSSN), for characterizing the seeing limited performance of the Thirty Meter Telescope. As the PSSN metric is directly related to the photometric error of background limited observations, it truly represents the efficiency loss in telescope observing time. The PSSN metric properly accounts for the optical consequences of wavefront spatial frequency distributions due to different error sources, which makes it superior todoi:10.1117/12.790453 fatcat:3jsakvpbnvghzcfhc57eissde4
more »... l metrics such as the 80% encircled energy diameter. We analytically show that multiplication of individual PSSN values due to individual errors is a good approximation for the total PSSN when various errors are considered simultaneously. We also numerically confirm this feature for Zernike aberrations, as well as for the numerous error sources considered in the TMT error budget using a ray optics simulator, Modeling and Analysis for Controlled Optical Systems. We also discuss other pertinent features of the PSSN including its relations to Zernike aberration and RMS wavefront error.
Transforming growth factor beta (TGFβ) is transiently increased in the mammary gland during involution and by radiation. While TGFβ normally has a tumour suppressor role, prolonged exposure to TGFβ can induce an oncogenic epithelial to mesenchymal transition (EMT) program in permissive cells and initiate the generation of cancer stem cells. Our objective is to mimic the transient exposure to TGFβ during involution to determine the persistent effects on premalignant mammary epithelium. Method:doi:10.1186/1475-2867-13-74 pmid:23883065 pmcid:PMC3733955 fatcat:dd54x4cperfulffzre7clkgxhi
more »... βGeo cells, a transplantable mouse mammary epithelial cell line, were treated in vitro for 14 days with TGFβ (5 ng/ml). The cells were passaged for an additional 14 days in media without TGFβ and then assessed for markers of EMT and transformation. Results: The 14-day exposure to TGFβ induced EMT and transdifferentiation in vitro that persists after withdrawal of TGFβ. TGFβ-treated cells are highly tumorigenic in vivo, producing invasive solid de-differentiated tumours (100%; latency 6.7 weeks) compared to control (43%; latency 32.7 weeks). Although the TGFβ-treated cells have initiated a persistent EMT program, the stem cell population was unchanged relative to the controls. The gene expression profiles of TGFβ-treated cells demonstrate de-differentiation with decreases in the expression of genes that define luminal, basal and stem cells. Additionally, the gene expression profiles demonstrate increases in markers of EMT, growth factor signalling, TGFβ2 and changes in extra cellular matrix. Conclusion: This model demonstrates full oncogenic EMT without an increase in stem cells, serving to separate EMT markers from stem cell markers.
Mutation and loss of function in p53 are common features among human breast cancers. Here we use BALB/c-Trp53 ؉/؊ mice as a model to examine the sequence of events leading to mammary tumors. Mammary gland proliferation rates were similar in both BALB/c-Trp53 ؉/؊ mice and wild-type controls. In addition , sporadic mammary hyperplasias were rare in BALB/c-Trp53 ؉/؊ mice and not detectably different from those of wild-type controls. Among the 28 mammary tumors collected from BALB/c-Trp53 ؉/؊ micedoi:10.2353/ajpath.2010.090438 pmid:20110418 pmcid:PMC2832161 fatcat:ymp3aldsjbff5nd65zvxcqtu5u
more »... loss of heterozygosity for Trp53 was detected in more than 90% of invasive mammary tumors. Transplantation of Trp53 ؉/؊ ductal hyperplasias also indicated an association between loss of the wild-type allele of Trp53 and progression to invasive carcinomas. Therefore , loss of p53 function seems to be a rate-limiting step in progression. Moreover , expression of biomarkers such as estrogen receptor ␣, progesterone receptor , Her2/Neu , and activated Notch1 varied among mammary tumors , suggesting that multiple oncogenic lesions collaborate with loss of p53 function. Expression of biomarkers was retained when tumor fragments were transplanted to syngeneic hosts. Tumors expressing solely luminal or basal keratins were also observed (27 and 11%, respectively), but the largest class of tumors expressed both luminal and basal keratins (62%). Overall, this panel of transplantable tumors provides a resource for detailed evaluation of the cell lineages undergoing transformation and preclinical testing of therapeutic agents targeting a variety of oncogenic pathways including cancer stem cells. Compromised function of the p53 tumor suppressor pathway remains among the most common alterations found in cancers. 1,2 Although disruption of p53 function predisposes to a broad spectrum of malignancies, the breast epithelium seems exquisitely sensitive to proper p53 function. Polymorphisms in MDM2, CHK2, and ATM alter the stability and activity of p53 and have been linked to breast cancer risk in women. The activity of p53 has also been shown to be responsive to hormones in rodent models. 3-5 Exogenous estrogen and progesterone are sufficient to render the mammary epithelium resistant to carcinogen-induced tumors, mimicking the protective effect afforded by a full-term pregnancy, 6 and the p53 pathway participates in the hormone-induced protection. 7,8 Furthermore, breast cancer is the most prevalent tumor among women with Li-Fraumeni syndrome, which is most commonly associated with heterozygous mutations in TP53. 9 -11 Reduced dosage of the p53 gene has been associated with haploinsufficiency with respect to levels of p53 protein and activity, cell cycle arrest, apoptosis, and homology-directed DNA re-
Carcinogenesis in Tp53 null tissue is similar to human breast cancer in that tumors exhibit genomic instability, differential expression of estrogen receptor (ER) a, and heterogeneous histology (Jerry ... Irradiation Breast cancer in women is a heterogeneous disease in terms of histology, marker expression, and prognosis (Parise et al., 2009) , as are breast tumors that develop in Trp53 knockout mice (Jerry ...doi:10.1016/j.ccr.2011.03.011 pmid:21575864 pmcid:PMC3110779 fatcat:g2a2t5exezh57pworj7mobbe74
Southern Folklore Quarterly
Seo C. Birge, Westport, Connecticut (New York, c. 1926), giv for dia ... “Why,” said Jerry, “TJ was shingling a shed that morning, and I shingled right over = =. ° that fog before I knew it.” (The Berkshire Hills, -Oct. 1, 1901. ...
Por the Microsgoe “TOM AND JERRY. ‘8 Ihave observed, that there area vast quantity of th above named high—no--Sugar Loaf hats, common called Tom and Jerry go—I have it from un saving _ ble authority, that ... wild, for the pre therday my attention was at- sent tone of the public fiddle—we | insert it 2 oF man, along the street, at acorer, he broke forth i inthe follow. . dag 8 eat consideration, as alae.‘ Gn Seo ...
National Union Catalog
Tuffy Bean’s puppy days, by Leo Edwards —_ seo illustrated by Bert Salg. New York, Grosset & Dunlap 1931, W'eil (ly 210 p. front, tllus, 194 cm. (de Tuffy Bean neries) 1. Title. ... PZTLS12Jew 34-2425 rev (Hts Jerry Todd series) 38-23775 rev Lee, Edward Edson, 1884-1944. Jerry Todd, caveman, by Leo Edwards ,pseud., ..._ Ilus- trated by Bert Salg. ...
Mirror of the Stage; Or, New Dramatic Censor
That excresence—‘ Tom and Jerry’—that filthy drug at which * the g rises’, has been again brought forward. ... who pollutes ‘civilized . inter- course, and rational conversa- tion, with terms so gross and unmeaning,, become, in some way subject toits infliction 1--We.are no: Methodists; but: we anerfre- i I i | SEO ...
Shieber, Stuart M. see Hobbs, Jerry R. Shieber, Stuart M.; van Noord, Gertjan; Pereira, Fernando C. ... Seo, Jungyun and Simmons, Robert FE. 15(1): 19-32 Syntactic Graphs: A Representation for the Union of All Ambiguous Parse Trees. ...
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