Filters








22,431 Hits in 4.5 sec

Acceptance and Appropriation of "The Lake Isle of Innisfree" by Literary Figures of Colonized Joseon: Kim Eok, Kim Yeongrang, Han Hukgu, and Jeong Inseop
식민지 조선 문인들의 "The Lake Isle of Innisfree" 수용과 전유—김억, 김영랑, 한흑구, 정인섭을 중심으로

Sejeong Han
2018 The Yeats Journal of Korea  
doi:10.14354/yjk.2018.57.321 fatcat:gqc2v7rs3zarnh465c7x7xaidu

Novel Polymorphisms and Genetic Characteristics of the Prion Protein Gene in Pheasants

Kyung Han Kim, Kyung Han Kim, Yong-Chan Kim, Yong-Chan Kim, Byung-Hoon Jeong, Byung-Hoon Jeong
2022 Frontiers in Veterinary Science  
Transmissible spongiform encephalopathies (TSEs) also known as prion diseases, are fatal neurodegenerative diseases. Prion diseases are caused by abnormal prion protein (PrPSc) derived from normal prion protein (PrPC), which is encoded by the prion protein gene (PRNP). Prion diseases have been reported in several mammals. Notably, chickens, one species of bird, have not been reported to develop prion diseases and showed resistance to bovine spongiform encephalopathy (BSE) infection. However,
more » ... etic polymorphisms of the PRNP gene and protein structure of the prion protein (PrP) related to vulnerability to prion diseases have not been investigated in pheasants, another species of bird. We performed amplicon sequencing of the pheasant PRNP gene to identify genetic polymorphisms in 148 pheasants. We analyzed the genotype, allele and haplotype frequencies of the pheasant PRNP polymorphisms. In addition, we evaluated the effect of genetic polymorphisms of the pheasant PRNP gene on pheasant PrP by the AMYCO, PROVEAN, PolyPhen-2 and PANTHER softwares. Furthermore, we compared the amino acid sequences of tandem repeat domains and secondary and tertiary structures of prion proteins (PrPs) among several animals. Finally, we investigated the impact of non-synonymous single nucleotide polymorphisms (SNPs) on hydrogen bonds and tertiary structures of pheasant PrP by Swiss PDB viewer software. We identified 34 novel genetic polymorphisms of the pheasant PRNP gene including 8 non-synonymous SNPs and 6 insertion/deletion polymorphisms. Among the non-synonymous SNPs, the L23F, G33C and R177Q SNPs showed that they could have a deleterious effect on pheasant PrP. In addition, the R177Q SNP was predicted to show an increase in amyloid propensity and a reduction in hydrogen bonds of pheasant PrP. Among the insertion/deletion polymorphisms, c.163_180delAACCCGGGGTATCCCCAC showed that it could have a detrimental effect on pheasant PrP. Furthermore, secondary and tertiary structures of pheasant PrP were predicted to have structures simil [...]
doi:10.3389/fvets.2022.935476 pmid:35903139 pmcid:PMC9322948 doaj:37d979f9c0ad433dbec8856b931ee15f fatcat:rtvamwidfbdzbo4u723glg7v2i

Influence of Vasoactive Substances on the Regulation of Cardiac ATP-Sensitive Potassium Channel Activity

Jae-Ha Kim, Jeong-Min Ju, Ling-Hua Piao, Yun-Yee Kim, Han-Seong Jeong, Hyung-Wook Park, Dae-Ho Jeong, Sang-Rok Lee, Nam-Sik Yoon, Kye-Hun Kim, Young-Joon Hong, Ju-Han Kim (+6 others)
2006 Korean Circulation Journal  
and Objectives:It has been known that various vasoactive agents are involved in the regulation of cardiac function through the modification of the K + channel activities, including the ATP-sensitive K + channel (K ATP ). We examined the effects of several vasoactive agents on the cardiac K ATP currents in isolated cardiac myocytes. Materials and Methods:Ventricular myocytes were isolated from the hearts of ICR mice by enzymatic digestion. The channel currents were recorded by the excised
more » ... out and cell-attached patch clamp configurations. Results:In the excised inside-out patches, bradykinin (BRK; 1-10 μM) and prostaglandin I 2 (PGI; 10-50 μM) did not affect the channel activities, whereas the vasodilators increased the attenuated channel activities in the presence of 100 μM ATP. BRK and PGI in parallel shifted the dose-response curves of ATP (1-1,000 μM), and this inhibited the K ATP currents to the right. Endothelin (ET-1; 0.1-1 nM) and leukotriene D 4 (LTD; 3-10 μM) decreased the channel activities immediately after making the inside-out patches. However, the vasoconstrictors did not affect the attenuated channel activities by ATP. In the cell-attached patches, both BRK and PGI increased the channel activities and these effects were markedly attenuated by glibenclamide (50 μM). ET-1 and LTD did not affect the baseline channel activities in the cell-attached patches, but they markedly attenuated the dinitrophenol-induced activities. Conclusion:It was inferred that certain vasoactive substances are involved in the regulation of cardiac K ATP channel activities, and that bradykinin and PGI 2 enhance the channel activities, and ET-1 and LTD4 inhibit the channel activities. (Korean Circulation J 2006;36:516-525) KEY WORDS:ATP;Potassium channels;Vasoconstrictors;Vasodilators. 논문접수일:2006년 2월 6일 수정논문접수일:2006년 5월 30일 심사완료일:2006년 6월 7일 교신저자:조정관, 501-757 광주광역시 동구 학동 8번지 전남대학교 의과대학 순환기내과학교실 전화:(062) 220-6242·전송:(062) 228-7174·E-mail:chojg@unitel.co.kr
doi:10.4070/kcj.2006.36.7.516 fatcat:lope7wpivnhf5agsyg6yomj5tu

Masked inherited primary arrhythmia syndromes in sudden cardiac death patients accompanied by coronary vasospasm

Ki Hong Lee, Hyung Wook Park, Jeong Nam Eun, Jeong Gwan Cho, Nam Sik Yoon, Mi Ran Kim, Yo Han Ku, Hyukjin Park, Seung Hun Lee, Jeong Han Kim, Min Chul Kim, Woo Jin Kim (+11 others)
2017 The Korean Journal of Internal Medicine  
Background/Aims: Coronary vasospasms are one of the important causes of sudden cardiac death (SCD). Provocation of coronary vasospasms can be useful, though some results may lead to false positives, with patients potentially experiencing recurrent SCD despite appropriate medical treatments. We hypothesized that it is not coronary vasospasms but inherited primary arrhythmia syndromes (IPAS) that underlie the development of SCD. Methods: We analyzed 74 consecutive patients (3.8%) who survived
more » ... of-hospital cardiac arrest among 1,986 patients who had angiographically proven coronary vasospasms. Electrical abnormalities were evaluated in serial follow-up electrocardiograms (ECGs) during and after the index event for a 3.9 years median follow-up. Major clinical events were defined as the composite of death and recurrent SCD events. Results: Forty five patients (60.8%) displayed electrocardiographic abnormalities suggesting IPAS: Brugada type patterns in six (8.2%), arrhythmogenic right ventricular dysplasia patterns in three (4.1%), long QT syndrome pattern in one (2.2%), and early repolarization in 38 (51.4%). Patients having major clinical events showed more frequent Brugada type patterns, early repolarization, and more diffuse multivessel coronary vasospasms. Brugada type pattern ECGs (adjusted hazard ratio [HR], 4.22; 95% confidence interval [CI], 1.16 to 15.99; p = 0.034), and early repolarization (HR, 2.97; 95% CI, 1.09 to 8.10; p = 0.034) were ultimately associated with an increased risk of mortality. Conclusions: Even though a number of aborted SCD survivors have coronary vasospasms, some also have IPAS, which has the potential to cause SCD. Therefore, meticulous evaluations and follow-ups for IPAS are required in those patients.
doi:10.3904/kjim.2015.283 pmid:28797161 pmcid:PMC5583445 fatcat:e7nmppsokjemvlryoenrfcqkny

Antimelanogenesis and skin-protective activities of Panax ginseng calyx ethanol extract

Jeong-Oog Lee, Eunji Kim, Ji Hye Kim, Yo Han Hong, Han Gyung Kim, Deok Jeong, Juewon Kim, Su Hwan Kim, Chanwoong Park, Dae Bang Seo, Young-Jin Son, Sang Yun Han (+1 others)
2018 Journal of Ginseng Research  
The antioxidant effects of Panax ginseng have been reported in several articles; however, little is known about the antimelanogenesis effect, skin-protective effect, and cellular mechanism of Panax ginseng, especially of P. ginseng calyx. To understand how an ethanol extract of P. ginseng berry calyx (Pg-C-EE) exerts skin-protective effects, we studied its activities in activated melanocytes and reactive oxygen species (ROS)-induced keratinocytes. To confirm the antimelanogenesis effect of
more » ... EE, we analyzed melanin synthesis and secretion and messenger RNA and protein expression levels of related genes. Ultraviolet B (UVB) and hydrogen peroxide (H2O2) were used to induce cell damage by ROS generation. To examine whether this damage is inhibited by Pg-C-EE, we performed cell viability assays and gene expression and transcriptional activation analyses. Pg-C-EE inhibited melanin synthesis and secretion by blocking activator protein 1 regulatory enzymes such as p38, extracellular signal-regulated kinases (ERKs), and cyclic adenosine monophosphate response element-binding protein. Pg-C-EE also suppressed ROS generation induced by H2O2 and UVB. Treatment with Pg-C-EE decreased the expression of matrix metalloproteinases, mitogen-activated protein kinases, and hyaluronidases and increased the cell survival rate. These results suggest that Pg-C-EE may have antimelanogenesis properties and skin-protective properties through regulation of activator protein 1 and cyclic adenosine monophosphate response element-binding protein signaling. Pg-C-EE may be used as a skin-improving agent, with moisture retention and whitening effects.
doi:10.1016/j.jgr.2018.02.007 pmid:29983620 pmcid:PMC6026384 fatcat:luv44as4cvb3riewu43jcj2dfe

Successful Stent Grafting for a Coronary Aneurysm

Han Gyun Kim, Myung Ho Jeong, Wan Kim, Jong Cheol Park, Jeong Soo Lee, Young Joon Hong, Hyung Wook Park, Ji Hyun Lim, Ok Young Park, Ju Han Kim, Weon Kim, Young Keun Ahn (+3 others)
2004 Korean Circulation Journal  
The stent graft can be used for the treatment of coronary artery aneurysms, perforations, dissection and arteriovenous fistula. A 54-year-old man presented with progressively worsening chest pain for several months. A diagnostic coronary angiogram revealed critical stenosis with a huge aneurysmal sac (6.0×8.2 mm in size) in the proximal right coronary artery. We implanted two membrane covered stent grafts (3.0×16 mm, JoStent GraftMaster ® , JoMed, Germany) without complication. No visible
more » ... ry aneurysm or residual stenosis was demonstrated after stent grafting. A two-month follow-up coronary angiogram showed patent stent grafted right coronary artery. (Korean Circulation J 2004;34 (5):507-511) KEY WORDS:Stents;Graft;Coronary aneurysm;Angina.
doi:10.4070/kcj.2004.34.5.507 fatcat:yxb76ptzfrdfjfwrok5ole5s34

Variations in Spike Glycoprotein Gene of MERS-CoV, South Korea, 2015

Dae-Won Kim, You-Jin Kim, Sung Han Park, Mi-Ran Yun, Jeong-Sun Yang, Hae Ji Kang, Young Woo Han, Han Saem Lee, Heui Man Kim, Hak Kim, A-Reum Kim, Deok Rim Heo (+8 others)
2016 Emerging Infectious Diseases  
doi:10.3201/eid2201.151055 pmid:26691200 pmcid:PMC4696701 fatcat:c5wgbo5o4vbgfhvh52ihp4f25q

Nephrotic syndrome associated with metastatic thymoma treated with chemotherapy

Shin Hye Yoo, Hyean-Ji Kim, Jeong-Han Kim, Gyeong-Won Lee, Jeong Hee Lee, Se Hyun Kim, Ji-Won Kim, Jin Won Kim, Jeong-Ok Lee, Yu Jung Kim, Keun-Wook Lee, Jee Hyun Kim (+2 others)
2017 Medicine  
Rationale: Nephropathy with concurrent invasive thymoma is a type of paraneoplastic syndrome. Patient concerns and Diagnoses: We report a 32-year-old female with nephrotic syndrome that was first diagnosed along with invasive thymoma and treated by means of cisplatin-based chemotherapy for the thymoma. The patient initially presented with dyspnea and generalized edema. Chest radiography and computed tomography scans revealed right pleural effusion and a mass in the right middle lung field,
more » ... were confirmed by a percutaneous lung biopsy as metastatic invasive thymoma. Severe hypoalbuminemia, heavy proteinuria, hyponatremia, and hypercholesterolemia were features of the nephrotic syndrome. A kidney needle biopsy suggested focal segmental glomerulosclerosis. Interventions and Outcomes: All of the symptoms of nephrotic syndrome were resolved simultaneously during the first 2 cycles of chemotherapy. The patient was on regular follow-up with no specific treatment for nephrotic syndrome and underwent successful resection of the left pleura and anterior thymoma. The patient has shown no evidence of recurrence for 2 years. Lessons: We conclude that chemotherapy for invasive thymoma is an effective treatment for nephrotic syndrome accompanying the thymoma. Abbreviations: ADOC = adriamycin cisplatin vincristine and cyclophosphamide, C3 = complement 3, CT = computed tomography, Ig = immunoglobulin, Na = sodium.
doi:10.1097/md.0000000000005408 pmid:28072685 pmcid:PMC5228645 fatcat:jpbmdpdrrnaothfzq6kxorikh4

Complete genomic DNA sequence of rock bream iridovirus

Jeong Wan Do, Chang Hoon Moon, Hyo Jeong Kim, Myoung Seok Ko, Sung Bum Kim, Ji Hee Son, Jong Soo Kim, Eun Jeong An, Min Kyoung Kim, Seung Koo Lee, Myung Shin Han, Seung Ju Cha (+5 others)
2004 Virology  
Hyo Jeong Kim and Jong Soo Kim were partly supported by the BK21 program of the Korea Research Foundation.  ...  Recently, iridoviral epizootics have occurred frequently among cultured fish in Korea (Jung and Oh, 2000; Kim et al., 2002) and, especially, iridoviral disease has caused severe damage to rock bream  ... 
doi:10.1016/j.virol.2004.05.008 pmid:15246274 fatcat:pcg4ycnjbnhwpprzkosgm2bgne

Effect of Pycnogenol on Skin Wound Healing

Moon-Jin Jeong, Soon-Jeong Jeong, Soo-Han Lee, Young-Soo Kim, Baik-Dong Choi, Seung-Hyun Kim, Ara Go, Se Eun Kim, Seong-Soo Kang, Chang-Jong Moon, Jong-Choon Kim, Sung-Ho Kim (+1 others)
2013 Applied Microscopy  
Also, grape seed extracts, another powerful antioxidant, was demonstrated to stimulate the crosslinking of collagen produced in the fibroblasts (Han et al., 2003) .  ...  There are various medications available to assist in the skin wound healing and from the ancient times, various natural substances have been widely used for wound healing (Kim et al., 2011) .  ... 
doi:10.9729/am.2013.43.4.133 fatcat:pj6re4entrfgxbsqukcgery2dq

Autophosphorylation desensitizes phytochrome signal transduction

Yun-Jeong Han, Hwan-Sik Kim, Pill-Soon Song, Jeong-Il Kim
2010 Plant Signalling & Behavior  
doi:10.4161/psb.5.7.11898 pmid:20495342 pmcid:PMC3014540 fatcat:k4fbj6ek2bf3lj34jxomsqrhpi

Identification of novel pyrrolopyrimidine and pyrrolopyridine derivatives as potent ENPP1 inhibitors

Hee Jin Jeong, Hye Lim Lee, Sung Joon Kim, Jeong Hyun Jeong, Su Hyun Ji, Han Byeol Kim, Miso Kang, Hwan Won Chung, Chan Sun Park, Hyunah Choo, Hyo Jae Yoon, Nam-Jung Kim (+3 others)
2022 figshare.com  
In an effort to discover novel scaffolds of non-nucleotide-derived Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitors to stimulate the Stimulator of Interferon Genes (STING) pathway, we designed and synthesised pyrrolopyrimidine and pyrrolopyridine derivatives and performed structure-activity relationship (SAR) study. We found 18p possessed high potency (IC50 = 25.0 nM) against ENPP1, and activated STING pathway in a concentration dependent manner. Also, in response to STING
more » ... athway activation, cytokines such as IFN-β and IP-10 were induced by 18p in a concentration dependent manner. Finally, we discovered that 18p causes inhibition of tumour growth in 4T1 syngeneic mouse model. This study provides new insight into the designing of novel ENPP1 inhibitors and warrants further development of small molecule immune modulators for cancer immunotherapy.
doi:10.6084/m9.figshare.21023913.v1 fatcat:onpzsstzvbdchp3xbkavm4fcmy

Stent Graft for a Coronary Arteriovenous Fistula in Acute Myocardial Infarction

Han Gyun Kim, Myung Ho Jeong, Wan Kim, Jong Cheol Park, Jeong Soo Lee, Young Joon Hong, Hyung Wook Park, Ji Hyun Lim, Ok Young Park, Ju Han Kim, Weon Kim, Young Keun Ahn (+3 others)
2004 Korean Circulation Journal  
The stent graft has recently been used for the treatment of coronary artery aneurysms, perforations, dissection and arteriovenous fistula. An 81-year-old male presented with chest pain of 2-day duration. A 12lead electrocardiogram showed atrial fibrillation and ST-T changes over the precordial leads. A diagnostic left coronary angiogram (CAG) revealed critical stenosis in the proximal left anterior descending coronary artery (LAD) and prestenotic dilatation with large coronary arteriovenous
more » ... ula draining into the main pulmonary artery. After predilation, a polytetrafluoroethylene (PTFE) covered stent graft (3.0×16 mm JoStent Graft Master ® , JoMed, Germany) for fistula and an additional conventional stent for just below the graft stented site of proximal LAD stenosis were implanted successfully. After stenting, no visible large fistula or remaining stenosis was demonstrated on CAG. The stent graft was deployed with a high success rate. The restenosis rate was not higher than expected for bare stents. However, as subacute occlusion may occur more frequently, long-term ticlopidine or clopidogrel treatment should be required. (Korean Circulation J 2004;34(6):610-614) KEY WORDS:Stents;Grafts;Coronary disease;Fistula;Myocardial infarction.
doi:10.4070/kcj.2004.34.6.610 fatcat:nrqmuyu7j5edrmyipigxpxt7lu

Phase II randomized trial of neoadjuvant metformin plus letrozole versus placebo plus letrozole for estrogen receptor positive postmenopausal breast cancer (METEOR)

Jisun Kim, Woosung Lim, Eun-Kyu Kim, Min-Kyoon Kim, Nam-Sun Paik, Sang-Seol Jeong, Jung-han Yoon, Chan Heun Park, Sei Hyun Ahn, Lee Su Kim, Sehwan Han, Seok Jin Nam (+18 others)
2014 BMC Cancer  
Neoadjuvant endocrine therapy with an aromatase inhibitor has shown efficacy comparable to that of neoadjuvant chemotherapy in patients with postmenopausal breast cancer. Preclinical and clinical studies have shown that the antidiabetic drug metformin has anti-tumor activity. This prospective, multicenter, phase II randomized, placebo controlled trial was designed to evaluate the direct anti-tumor effect of metformin in non-diabetic postmenopausal women with estrogen-receptor (ER) positive
more » ... t cancer. Methods/Design: Patients meeting the inclusion criteria and providing written informed consent will be randomized to 24 weeks of neoadjuvant treatment with letrozole (2.5 mg/day) and either metformin (2000 mg/day) or placebo. Target accrual number is 104 patients per arm. The primary endpoint will be clinical response rate, as measured by calipers. Secondary endpoints include pathologic complete response rate, breast conserving rate, change in Ki67 expression, breast density change, and toxicity profile. Molecular assays will be performed using samples obtained before treatment, at week 4, and postoperatively. Discussion: This study will provide direct evidence of the anti-tumor effect of metformin in non-diabetic, postmenopausal patients with ER-positive breast cancer. Trial registration: ClinicalTrials.gov Identifier NCT01589367
doi:10.1186/1471-2407-14-170 pmid:24612502 pmcid:PMC3984742 fatcat:ohpwyhidyfedphxeo5xl2qmnhe

N-Terminal Truncated UCH-L1 Prevents Parkinson's Disease Associated Damage

Hee-Jung Kim, Hyun Jung Kim, Jae-Eun Jeong, Jeong Yeob Baek, Jaeho Jeong, Sun Kim, Young-Mee Kim, Youhwa Kim, Jin Han Nam, Sue Hee Huh, Jawon Seo, Byung Kwan Jin (+2 others)
2014 PLoS ONE  
Citation: Kim H-J, Kim HJ, Jeong J-E, Baek JY, Jeong J, et al. (2014) N-Terminal Truncated UCH-L1 Prevents Parkinson's Disease Associated Damage. PLOS ONE 9(6): e99654.  ... 
doi:10.1371/journal.pone.0099654 pmid:24959670 pmcid:PMC4069018 fatcat:sgeuym3syjhvhl5ecaym6viuwi
« Previous Showing results 1 — 15 out of 22,431 results