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The Yeats Journal of Korea
식민지 조선 문인들의 "The Lake Isle of Innisfree" 수용과 전유—김억, 김영랑, 한흑구, 정인섭을 중심으로
식민지 조선 문인들의 "The Lake Isle of Innisfree" 수용과 전유—김억, 김영랑, 한흑구, 정인섭을 중심으로
Transmissible spongiform encephalopathies (TSEs) also known as prion diseases, are fatal neurodegenerative diseases. Prion diseases are caused by abnormal prion protein (PrPSc) derived from normal prion protein (PrPC), which is encoded by the prion protein gene (PRNP). Prion diseases have been reported in several mammals. Notably, chickens, one species of bird, have not been reported to develop prion diseases and showed resistance to bovine spongiform encephalopathy (BSE) infection. However,doi:10.3389/fvets.2022.935476 pmid:35903139 pmcid:PMC9322948 doaj:37d979f9c0ad433dbec8856b931ee15f fatcat:rtvamwidfbdzbo4u723glg7v2i
more »... etic polymorphisms of the PRNP gene and protein structure of the prion protein (PrP) related to vulnerability to prion diseases have not been investigated in pheasants, another species of bird. We performed amplicon sequencing of the pheasant PRNP gene to identify genetic polymorphisms in 148 pheasants. We analyzed the genotype, allele and haplotype frequencies of the pheasant PRNP polymorphisms. In addition, we evaluated the effect of genetic polymorphisms of the pheasant PRNP gene on pheasant PrP by the AMYCO, PROVEAN, PolyPhen-2 and PANTHER softwares. Furthermore, we compared the amino acid sequences of tandem repeat domains and secondary and tertiary structures of prion proteins (PrPs) among several animals. Finally, we investigated the impact of non-synonymous single nucleotide polymorphisms (SNPs) on hydrogen bonds and tertiary structures of pheasant PrP by Swiss PDB viewer software. We identified 34 novel genetic polymorphisms of the pheasant PRNP gene including 8 non-synonymous SNPs and 6 insertion/deletion polymorphisms. Among the non-synonymous SNPs, the L23F, G33C and R177Q SNPs showed that they could have a deleterious effect on pheasant PrP. In addition, the R177Q SNP was predicted to show an increase in amyloid propensity and a reduction in hydrogen bonds of pheasant PrP. Among the insertion/deletion polymorphisms, c.163_180delAACCCGGGGTATCCCCAC showed that it could have a detrimental effect on pheasant PrP. Furthermore, secondary and tertiary structures of pheasant PrP were predicted to have structures simil [...]
and Objectives:It has been known that various vasoactive agents are involved in the regulation of cardiac function through the modification of the K + channel activities, including the ATP-sensitive K + channel (K ATP ). We examined the effects of several vasoactive agents on the cardiac K ATP currents in isolated cardiac myocytes. Materials and Methods:Ventricular myocytes were isolated from the hearts of ICR mice by enzymatic digestion. The channel currents were recorded by the exciseddoi:10.4070/kcj.2006.36.7.516 fatcat:lope7wpivnhf5agsyg6yomj5tu
more »... out and cell-attached patch clamp configurations. Results:In the excised inside-out patches, bradykinin (BRK; 1-10 μM) and prostaglandin I 2 (PGI; 10-50 μM) did not affect the channel activities, whereas the vasodilators increased the attenuated channel activities in the presence of 100 μM ATP. BRK and PGI in parallel shifted the dose-response curves of ATP (1-1,000 μM), and this inhibited the K ATP currents to the right. Endothelin (ET-1; 0.1-1 nM) and leukotriene D 4 (LTD; 3-10 μM) decreased the channel activities immediately after making the inside-out patches. However, the vasoconstrictors did not affect the attenuated channel activities by ATP. In the cell-attached patches, both BRK and PGI increased the channel activities and these effects were markedly attenuated by glibenclamide (50 μM). ET-1 and LTD did not affect the baseline channel activities in the cell-attached patches, but they markedly attenuated the dinitrophenol-induced activities. Conclusion:It was inferred that certain vasoactive substances are involved in the regulation of cardiac K ATP channel activities, and that bradykinin and PGI 2 enhance the channel activities, and ET-1 and LTD4 inhibit the channel activities. (Korean Circulation J 2006;36:516-525) KEY WORDS:ATP;Potassium channels;Vasoconstrictors;Vasodilators. 논문접수일:2006년 2월 6일 수정논문접수일:2006년 5월 30일 심사완료일:2006년 6월 7일 교신저자:조정관, 501-757 광주광역시 동구 학동 8번지 전남대학교 의과대학 순환기내과학교실 전화:(062) 220-6242·전송:(062) 228-7174·E-mail:email@example.com
Background/Aims: Coronary vasospasms are one of the important causes of sudden cardiac death (SCD). Provocation of coronary vasospasms can be useful, though some results may lead to false positives, with patients potentially experiencing recurrent SCD despite appropriate medical treatments. We hypothesized that it is not coronary vasospasms but inherited primary arrhythmia syndromes (IPAS) that underlie the development of SCD. Methods: We analyzed 74 consecutive patients (3.8%) who surviveddoi:10.3904/kjim.2015.283 pmid:28797161 pmcid:PMC5583445 fatcat:e7nmppsokjemvlryoenrfcqkny
more »... of-hospital cardiac arrest among 1,986 patients who had angiographically proven coronary vasospasms. Electrical abnormalities were evaluated in serial follow-up electrocardiograms (ECGs) during and after the index event for a 3.9 years median follow-up. Major clinical events were defined as the composite of death and recurrent SCD events. Results: Forty five patients (60.8%) displayed electrocardiographic abnormalities suggesting IPAS: Brugada type patterns in six (8.2%), arrhythmogenic right ventricular dysplasia patterns in three (4.1%), long QT syndrome pattern in one (2.2%), and early repolarization in 38 (51.4%). Patients having major clinical events showed more frequent Brugada type patterns, early repolarization, and more diffuse multivessel coronary vasospasms. Brugada type pattern ECGs (adjusted hazard ratio [HR], 4.22; 95% confidence interval [CI], 1.16 to 15.99; p = 0.034), and early repolarization (HR, 2.97; 95% CI, 1.09 to 8.10; p = 0.034) were ultimately associated with an increased risk of mortality. Conclusions: Even though a number of aborted SCD survivors have coronary vasospasms, some also have IPAS, which has the potential to cause SCD. Therefore, meticulous evaluations and follow-ups for IPAS are required in those patients.
The antioxidant effects of Panax ginseng have been reported in several articles; however, little is known about the antimelanogenesis effect, skin-protective effect, and cellular mechanism of Panax ginseng, especially of P. ginseng calyx. To understand how an ethanol extract of P. ginseng berry calyx (Pg-C-EE) exerts skin-protective effects, we studied its activities in activated melanocytes and reactive oxygen species (ROS)-induced keratinocytes. To confirm the antimelanogenesis effect ofdoi:10.1016/j.jgr.2018.02.007 pmid:29983620 pmcid:PMC6026384 fatcat:luv44as4cvb3riewu43jcj2dfe
more »... EE, we analyzed melanin synthesis and secretion and messenger RNA and protein expression levels of related genes. Ultraviolet B (UVB) and hydrogen peroxide (H2O2) were used to induce cell damage by ROS generation. To examine whether this damage is inhibited by Pg-C-EE, we performed cell viability assays and gene expression and transcriptional activation analyses. Pg-C-EE inhibited melanin synthesis and secretion by blocking activator protein 1 regulatory enzymes such as p38, extracellular signal-regulated kinases (ERKs), and cyclic adenosine monophosphate response element-binding protein. Pg-C-EE also suppressed ROS generation induced by H2O2 and UVB. Treatment with Pg-C-EE decreased the expression of matrix metalloproteinases, mitogen-activated protein kinases, and hyaluronidases and increased the cell survival rate. These results suggest that Pg-C-EE may have antimelanogenesis properties and skin-protective properties through regulation of activator protein 1 and cyclic adenosine monophosphate response element-binding protein signaling. Pg-C-EE may be used as a skin-improving agent, with moisture retention and whitening effects.
Korean Circulation Journal
The stent graft can be used for the treatment of coronary artery aneurysms, perforations, dissection and arteriovenous fistula. A 54-year-old man presented with progressively worsening chest pain for several months. A diagnostic coronary angiogram revealed critical stenosis with a huge aneurysmal sac (6.0×8.2 mm in size) in the proximal right coronary artery. We implanted two membrane covered stent grafts (3.0×16 mm, JoStent GraftMaster ® , JoMed, Germany) without complication. No visibledoi:10.4070/kcj.2004.34.5.507 fatcat:yxb76ptzfrdfjfwrok5ole5s34
more »... ry aneurysm or residual stenosis was demonstrated after stent grafting. A two-month follow-up coronary angiogram showed patent stent grafted right coronary artery. (Korean Circulation J 2004;34 (5):507-511) KEY WORDS:Stents;Graft;Coronary aneurysm;Angina.
doi:10.3201/eid2201.151055 pmid:26691200 pmcid:PMC4696701 fatcat:c5wgbo5o4vbgfhvh52ihp4f25q
Rationale: Nephropathy with concurrent invasive thymoma is a type of paraneoplastic syndrome. Patient concerns and Diagnoses: We report a 32-year-old female with nephrotic syndrome that was first diagnosed along with invasive thymoma and treated by means of cisplatin-based chemotherapy for the thymoma. The patient initially presented with dyspnea and generalized edema. Chest radiography and computed tomography scans revealed right pleural effusion and a mass in the right middle lung field,doi:10.1097/md.0000000000005408 pmid:28072685 pmcid:PMC5228645 fatcat:jpbmdpdrrnaothfzq6kxorikh4
more »... were confirmed by a percutaneous lung biopsy as metastatic invasive thymoma. Severe hypoalbuminemia, heavy proteinuria, hyponatremia, and hypercholesterolemia were features of the nephrotic syndrome. A kidney needle biopsy suggested focal segmental glomerulosclerosis. Interventions and Outcomes: All of the symptoms of nephrotic syndrome were resolved simultaneously during the first 2 cycles of chemotherapy. The patient was on regular follow-up with no specific treatment for nephrotic syndrome and underwent successful resection of the left pleura and anterior thymoma. The patient has shown no evidence of recurrence for 2 years. Lessons: We conclude that chemotherapy for invasive thymoma is an effective treatment for nephrotic syndrome accompanying the thymoma. Abbreviations: ADOC = adriamycin cisplatin vincristine and cyclophosphamide, C3 = complement 3, CT = computed tomography, Ig = immunoglobulin, Na = sodium.
Hyo Jeong Kim and Jong Soo Kim were partly supported by the BK21 program of the Korea Research Foundation. ... Recently, iridoviral epizootics have occurred frequently among cultured fish in Korea (Jung and Oh, 2000; Kim et al., 2002) and, especially, iridoviral disease has caused severe damage to rock bream ...doi:10.1016/j.virol.2004.05.008 pmid:15246274 fatcat:pcg4ycnjbnhwpprzkosgm2bgne
Also, grape seed extracts, another powerful antioxidant, was demonstrated to stimulate the crosslinking of collagen produced in the fibroblasts (Han et al., 2003) . ... There are various medications available to assist in the skin wound healing and from the ancient times, various natural substances have been widely used for wound healing (Kim et al., 2011) . ...doi:10.9729/am.2013.43.4.133 fatcat:pj6re4entrfgxbsqukcgery2dq
doi:10.4161/psb.5.7.11898 pmid:20495342 pmcid:PMC3014540 fatcat:k4fbj6ek2bf3lj34jxomsqrhpi
In an effort to discover novel scaffolds of non-nucleotide-derived Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitors to stimulate the Stimulator of Interferon Genes (STING) pathway, we designed and synthesised pyrrolopyrimidine and pyrrolopyridine derivatives and performed structure-activity relationship (SAR) study. We found 18p possessed high potency (IC50 = 25.0 nM) against ENPP1, and activated STING pathway in a concentration dependent manner. Also, in response to STINGdoi:10.6084/m9.figshare.21023913.v1 fatcat:onpzsstzvbdchp3xbkavm4fcmy
more »... athway activation, cytokines such as IFN-β and IP-10 were induced by 18p in a concentration dependent manner. Finally, we discovered that 18p causes inhibition of tumour growth in 4T1 syngeneic mouse model. This study provides new insight into the designing of novel ENPP1 inhibitors and warrants further development of small molecule immune modulators for cancer immunotherapy.
Korean Circulation Journal
The stent graft has recently been used for the treatment of coronary artery aneurysms, perforations, dissection and arteriovenous fistula. An 81-year-old male presented with chest pain of 2-day duration. A 12lead electrocardiogram showed atrial fibrillation and ST-T changes over the precordial leads. A diagnostic left coronary angiogram (CAG) revealed critical stenosis in the proximal left anterior descending coronary artery (LAD) and prestenotic dilatation with large coronary arteriovenousdoi:10.4070/kcj.2004.34.6.610 fatcat:nrqmuyu7j5edrmyipigxpxt7lu
more »... ula draining into the main pulmonary artery. After predilation, a polytetrafluoroethylene (PTFE) covered stent graft (3.0×16 mm JoStent Graft Master ® , JoMed, Germany) for fistula and an additional conventional stent for just below the graft stented site of proximal LAD stenosis were implanted successfully. After stenting, no visible large fistula or remaining stenosis was demonstrated on CAG. The stent graft was deployed with a high success rate. The restenosis rate was not higher than expected for bare stents. However, as subacute occlusion may occur more frequently, long-term ticlopidine or clopidogrel treatment should be required. (Korean Circulation J 2004;34(6):610-614) KEY WORDS:Stents;Grafts;Coronary disease;Fistula;Myocardial infarction.
Neoadjuvant endocrine therapy with an aromatase inhibitor has shown efficacy comparable to that of neoadjuvant chemotherapy in patients with postmenopausal breast cancer. Preclinical and clinical studies have shown that the antidiabetic drug metformin has anti-tumor activity. This prospective, multicenter, phase II randomized, placebo controlled trial was designed to evaluate the direct anti-tumor effect of metformin in non-diabetic postmenopausal women with estrogen-receptor (ER) positivedoi:10.1186/1471-2407-14-170 pmid:24612502 pmcid:PMC3984742 fatcat:ohpwyhidyfedphxeo5xl2qmnhe
more »... t cancer. Methods/Design: Patients meeting the inclusion criteria and providing written informed consent will be randomized to 24 weeks of neoadjuvant treatment with letrozole (2.5 mg/day) and either metformin (2000 mg/day) or placebo. Target accrual number is 104 patients per arm. The primary endpoint will be clinical response rate, as measured by calipers. Secondary endpoints include pathologic complete response rate, breast conserving rate, change in Ki67 expression, breast density change, and toxicity profile. Molecular assays will be performed using samples obtained before treatment, at week 4, and postoperatively. Discussion: This study will provide direct evidence of the anti-tumor effect of metformin in non-diabetic, postmenopausal patients with ER-positive breast cancer. Trial registration: ClinicalTrials.gov Identifier NCT01589367
Citation: Kim H-J, Kim HJ, Jeong J-E, Baek JY, Jeong J, et al. (2014) N-Terminal Truncated UCH-L1 Prevents Parkinson's Disease Associated Damage. PLOS ONE 9(6): e99654. ...doi:10.1371/journal.pone.0099654 pmid:24959670 pmcid:PMC4069018 fatcat:sgeuym3syjhvhl5ecaym6viuwi
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