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A 68-year-old woman presented with yellowish discharge oozing from a fistula opening in the upper epigastric area that had persisted for one month prior to her visit. The patient had undergone a left lateral segmentectomy of the liver ten years prior for treatment of intrahepatic duct (IHD) stones. An abdominal computed tomography (CT) scan showed focal stricture and proximal dilatation of remnant IHD and a 1 cm-sized rim-enhancing lesion located under the surgical bed of the abdominal walldoi:10.2169/internalmedicine.50.4431 pmid:21372455 fatcat:odvtn5kqxncezep2gy5p6iiem4
more »... ounding the dilated remnant IHD. Despite conservative management including nasobiliary drainage, no further improvement was anticipated. Partial hepatectomy and fistulectomy were performed for pathologic diagnosis and treatment of the enhancing lesion. Histopathology revealed adenocarcinoma. In this case, cholangiocarcinoma might have arisen in association with IHD stones and then developed a choledocho-cutaneous fistula as a clinical manifestation.
Hyo Jeong Kim and Jong Soo Kim were partly supported by the BK21 program of the Korea Research Foundation. ... Recently, iridoviral epizootics have occurred frequently among cultured fish in Korea (Jung and Oh, 2000; Kim et al., 2002) and, especially, iridoviral disease has caused severe damage to rock bream ...doi:10.1016/j.virol.2004.05.008 pmid:15246274 fatcat:pcg4ycnjbnhwpprzkosgm2bgne
In this study, the infestation rate was not significantly high when compared to those of previous reports (Kim et al., 1984; Lee et al., 1984; Pai and Huh, 1987; Pai et al., 1989; Huh et al., 1993) . ...doi:10.3347/kjp.2000.38.1.41 pmid:10743359 pmcid:PMC2721107 fatcat:lyijdyu2unhypbjrqufjyh7h5q
Despite the observed higher affinity to the YY1 protein (Fig. 3) , these motifs are not common to all the known genes controlled by YY1, but are found in Peg3 and Xist (14; Kang & Kim, unpublished). ...doi:10.1016/j.ygeno.2008.09.013 pmid:18950698 pmcid:PMC2668202 fatcat:dd5mawwvrbhgrl3sads7gget4m
Korea is one of the fastest aging country in the world. As the old population increases, incidence of stroke would rapidly increase. We estimated future of the neurologist supply in Korea, and assessed whether the present neurologist supply is appropriate to cope with future increase of stroke. We reviewed the resource database of neurologists affiliated to Korean Neurological Association. Age, sex, location of workplace, and work positions were identified. The stroke incidence was calculateddoi:10.17340/jkna.2018.3.4 fatcat:dobbcbfnozctlhprsklgihmyry
more »... om age group specific incidence data and projected age group number. Age group specific incidence data was adapted from the 2006 report of the Construction of National Surveillance System for Cardiovascular and Cerebrovascular Disease. Total 1,828 neurologists in practice were identified. Six hundred and fifty-five (30%) worked in training hospitals. 457 (21%) in other general hospitals, 305 (14%) in private clinics, and 148 (7%) worked in nursing hospitals. Assuming that the neurologists are trained 82 people per year as in the present, 2,073 neurologists would be present in 2020, 2,659 in 2030. However, stroke incidence would show more rapid increment, and is expected about 170,000 per year in 2020 and 300,000 per year in 2030. Therefore, there will be a shortage of neurologists needed for stroke care in the future. Because of rapid increase in the elderly population, current supply of neurologists may not meet the expected need for stroke care. Therefore, national health system needs more neurologists to cope with that situation. J Korean Neurol Assoc 36 (3) :  2018
Thus, further increments of the length of the thymidine base sequence in the template do not lead to concomitant increments of the uridine length in the crRNA. ...doi:10.1038/s41467-018-06129-w pmid:30194297 pmcid:PMC6128929 fatcat:5gd4omdbifa6bbhwcx4soiigk4
monovalent Pd ions and coordinated oxygens for the good in-plane conductivity, based on the photon energy dependent photoemission study which indicates that Pd 4d mainly contributes to the density of states (DOS ...doi:10.1103/physrevlett.102.256404 pmid:19659104 fatcat:vyx7owfy6fhplmen4w4pvazthu
The primary neurotransmitter utilized by the RHT is glutamate (Kim & Dudek, 1991; Colwell & Menaker, 1992; Ebling, 1996) . ... In addition, we present results supporting the notion that the differential contribution of T-type VGCC to the phase delays and advances may have something to do with a nocturnal modulation of T-type Ca ...doi:10.1111/j.1460-9568.2005.03950.x pmid:15813931 fatcat:krlaz2fl7re37i7l6fvuuejcf4
Phytochromes are dimeric pigment proteins with reversible photochromism between red and far-red light-absorbing forms. They are photoreceptors that regulate various aspects of plant growth and development and have been used for biotechnological applications to improve agricultural performance of crops.Miscanthusspecies have been suggested as one of the most promising energy crops. In this paper,Arabidopsisphytochrome B(PHYB)gene was introduced intoMiscanthus sinensisusingAgrobacterium-mediateddoi:10.1155/2014/501016 fatcat:ypufrptepfeybbfenaorwzdqgq
more »... ransformation method that we developed recently, with the herbicide resistance gene(BAR)as a selection marker. After putative transgenic plants were selected using the herbicide resistance assay, genomic integration of the transgene was confirmed by genomic PCR and Southern blot analysis, and transgene expression was validated by Northern blot analysis. Compared to nontransformed control plants, transgenic plants overexpressingPHYBshowed phenotypes with increased phytochrome B function, which includes increased chlorophyll content, decreased plant height, and delayed flowering. Therefore, these results suggest thatArabidopsisphytochrome B is functional inM. sinensisand provide a method to developMiscanthusvarieties with enhanced agricultural performance using phytochromes.
et al. 2007; Alves et al. 2009; Li and Qu 2011; Kim et al. 2013) . ... Then, the egfp gene and nos gene terminator was subcloned from pCSVMV-eGFP-N-999 (Kim et al. 2008 ) into downstream of the ubiquitin promoter using BamHI and SmaI. ...doi:10.1007/s11240-013-0419-7 fatcat:4up4mxs4pbdebaogpvy2fy6nae
Contact: Sungha Kim, email@example.com http://dx. ... Contact : Min-Kyeoung Kim, firstname.lastname@example.org http://dx.doi.org/10.1016/j.imr.2015.04.273 ... The 21 sites in the Gyeongsang-do region (Gyeongsangnam-do, Gyeonsangbuk-do) 58 villages 346 people in the towns with traditional medicinal knowledge holders to secured a total 2,758 folk remedies. ...doi:10.1016/j.imr.2015.04.273 fatcat:dxri7lxddjfjtb7l36ex5yao2u
In order to elucidate the role of the system L-type amino acid transporters (LATs) in the wound healing process of aged and young subjects, we investigated the expression of LAT1, LAT2 and their subunit 4F2hc in the skin healing process after artificial wounds of dorsal skin in the young and old rats. Methods: The 1 cm fullthickness incisional wounds were made through the skin and panniculus carnosus muscle. The wounds were harvested at days 1, 3, 5 and 7 post-wounding, the experimentaldoi:10.1248/bpb.31.395 pmid:18310899 fatcat:mya66tqpwfaw7onxcvf3j4mqgy
more »... were harvested the skin of rat without wounds and the various analyses were performed. Results: In young rats, gradually and noticeable wound healing was detected, however, in old rats, wound healing was found to be greatly delayed. In young rats, the expression of LAT1 was increased rapidly on the day 1 after wound induction, on the other hand, in old rats, the expression of LAT1 after wound induction was not different from the control group. In young rats, the expression of LAT2 after the induction of wound was not different from the control group, however in old rats, the expression of LAT2 on the day 1 of wound induction was rapidly elevated. Conclusion: These results suggest that the LAT1 and LAT2 increase in the wound healing process after cell injury in young and old rats, respectively.
doi:10.5021/ad.2013.25.2.255 pmid:23717027 pmcid:PMC3662929 fatcat:vdqgu3u4azg5hes3rxp2426s2i
and Objectives: Irregular RR intervals in atrial fibrillation (AF) results in beat to beat changes in hemodynamical parameters. Early diastolic mitral annulus velocity (E') is one of the parameters that represent diastolic function of the left ventricle (LV). In this study, we have investigated the effects of continuous changes of systolic functions in AF on the diastolic functions of the LV. Subjects and Methods: E' (35-40 beats) was recorded in 31 AF patients that did not have significantdoi:10.4070/kcj.2008.38.10.551 fatcat:xpwq6ewphvfsvlvfefpqfwvrde
more »... ular heart diseases. The relationships between preceding RR intervals (RR-1) or pre-preceding RR intervals (RR-2) and E's were obtained using a logarithmic function. Results: Slopes between RR-1 and E' varied from -1.62 to 1.04 in total coordinates. In the logistic regression analysis patients with negative slopes were found to have a larger left atrial size than patients with positive slopes (5.5±0.67 cm vs. 4.9±0.56 cm, p=0.02). Slopes were negatively related with mean RR intervals in the Pearson correlation analysis (r=-0.40, p=0.028). Slopes between RR-2 and E' were also variable and were not associated with other parameters. Conclusion: Beat to beat changes in systolic functions derived from irregular RR intervals in AF had variable effects on diastolic functions among patients. The relationship between RR-1 and E' was associated with LA sizes and mean RR intervals. (Korean Circ J 2008;38:551-556)
Vitamin D is known to elicit a vasoprotective effect, while vitamin D deficiency is a risk factor for endothelial dysfunction (ED). ED is characterized by reduced bioavailability of a potent endothelium-dependent vasodilator, nitric oxide (NO), and is an early event in the development of atherosclerosis. In endothelial cells, vitamin D regulates NO synthesis by mediating the activity of the endothelial NO synthase (eNOS). Under pathogenic conditions, the oxidative stress caused by excessivedoi:10.3390/nu12020575 pmid:32098418 pmcid:PMC7071424 fatcat:tvmnfyr4kffl7pdzh3ogsze72a
more »... uction of reactive oxygen species (ROS) facilitates NO degradation and suppresses NO synthesis, consequently reducing NO bioavailability. Vitamin D, however, counteracts the activity of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase which produces ROS, and improves antioxidant capacity by enhancing the activity of antioxidative enzymes such as superoxide dismutase. In addition to ROS, proinflammatory mediators such as TNF-α and IL-6 are risk factors for ED, restraining NO and eNOS bioactivity and upregulating the expression of various atherosclerotic factors through the NF-κB pathway. These proinflammatory activities are inhibited by vitamin D by suppressing NF-κB signaling and production of proinflammatory cytokines. In this review, we discuss the diverse activities of vitamin D in regulating NO bioavailability and endothelial function.
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