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Respiratory Rhythm Generation In Vivo

Diethelm W. Richter, Jeffrey C. Smith
2014 Physiology  
Richter was supported by DFG grants and the DFG Research Center for Molecular Physiology of the Brain (CMPB). J. C.  ...  inhibitory synaptic volleys in pre-I/I, early-I, aug-I, and aug-E/E2 neurons and, therefore, exerts an effective control of rhythm generation by activity and voltage resetting, as originally described by Richter  ... 
doi:10.1152/physiol.00035.2013 pmid:24382872 pmcid:PMC3929116 fatcat:cpwx7odbkfh4hbipfzlp2vztlq

TerraService.NET: An Introduction to Web Services [article]

Tom Barclay, Jim Gray, Eric Strand, Steve Ekblad, Jeffrey Richter
2002 arXiv   pre-print
This article explores the design and construction of a geo-spatial Internet web service application from the host web site perspective and from the perspective of an application using the web service. The TerraService.NET web service was added to the popular TerraServer database and web site with no major structural changes to the database. The article discusses web service design, implementation, and deployment concepts and design guidelines. Web services enable applications that aggregate and
more » ... interact with information and resources from Internet-scale distributed servers. The article presents the design of two USDA applications that interoperate with database and web service resources in Fort Collins Colorado and the TerraService web service located in Tukwila Washington.
arXiv:cs/0208010v1 fatcat:fl3pe4girfhsnkkqquoije4rga

Lobbying and Taxes

Brian Kelleher Richter, Krislert Samphantharak, Jeffrey F. Timmons
2009 American Journal of Political Science  
Lobbying dominates corporate political spending, but comprehensive studies of the benefits accrued are scarce. Using a dataset of all U.S. firms with publicly available financial statements, we delve into the tax benefits obtained from lobbying. Firms that spend more on lobbying in a given year pay lower effective tax rates in the next year. Increasing registered lobbying expenditures by 1% appears to lower effective tax rates by somewhere in the range of 0.5 to 1.6 percentage points for the
more » ... rage firm that lobbies. While individual firms amass considerable benefits, the costs of lobbying-induced tax breaks appear modest for the government.
doi:10.1111/j.1540-5907.2009.00407.x fatcat:gj3etpzotjb63ehufsxtkhmcru

How much water does a river need?

1997 Freshwater Biology  
This streamflow record is then characterized using thirty-two different hydrological parameters, using methods defined in Richter et al. (1996).  ...  Trim- Richter & Powell, 1996) .  ...  The potential for Schneider & Latka, 1994; Allan, 1995; Richter et al., 1996) .  ... 
doi:10.1046/j.1365-2427.1997.00153.x fatcat:wyfpujjwjfc3xmd2vcp7ud7alm

Substrate-mediated hyperbolic phonon polaritons in MoO3

Jeffrey J. Schwartz, Son T. Le, Sergiy Krylyuk, Curt A. Richter, Albert V. Davydov, Andrea Centrone
2021 Nanophotonics  
Hyperbolic phonon polaritons (HPhPs) are hybrid excitations of light and coherent lattice vibrations that exist in strongly optically anisotropic media, including two-dimensional materials (e.g., MoO3). These polaritons propagate through the material's volume with long lifetimes, enabling novel mid-infrared nanophotonic applications by compressing light to sub-diffractional dimensions. Here, the dispersion relations and HPhP lifetimes (up to ≈12 ps) in single-crystalline α-MoO3 are determined
more » ... Fourier analysis of real-space, nanoscale-resolution polariton images obtained with the photothermal induced resonance (PTIR) technique. Measurements of MoO3 crystals deposited on periodic gratings show longer HPhPs propagation lengths and lifetimes (≈2×), and lower optical compressions, in suspended regions compared with regions in direct contact with the substrate. Additionally, PTIR data reveal MoO3 subsurface defects, which have a negligible effect on HPhP propagation, as well as polymeric contaminants localized under parts of the MoO3 crystals, which are derived from sample preparation. This work highlights the ability to engineer substrate-defined nanophotonic structures from layered anisotropic materials.
doi:10.1515/nanoph-2020-0640 fatcat:vginc423hzbddiripwhl3wxaiq

A Method for Assessing Hydrologic Alteration within Ecosystems

Brian D. Richter, Jeffrey V. Baumgartner, Jennifer Powell, David P. Braun
1996 Conservation Biology  
Altered flood patterns may lead to significant alterations in the composition and structure of the Roanoke's bottomland hardwood forest by changing the magnitude and duration of floods (Lea 1991; Richter  ... 
doi:10.1046/j.1523-1739.1996.10041163.x fatcat:bd74aqlb3vau3ilnpof6fermw4

Efficacy of Foliar Insecticides on Eggs ofNezara viridula(Hemiptera: Pentatomidae)

Sebe A. Brown, Jeffrey A. Davis, Arthur R. Richter
2012 Florida Entomologist  
stink bugs (Hemiptera: pentatomidae) are important insect pests of crops. stink bug feeding reduces yields, lowers crop quality, induces delayed maturity, and wounds tissues allowing for pathogen entry. Historically, effective adult and nymph control of stink bugs has been with insecticides. However, little insecticide efficacy against stink bug eggs is known. the objective of this study was to determine how foliar insecticides currently recommend for southern green stink bug, Nezara viridula
more » ... .), control in soybean impact pre-emergence nymphal mortality using an egg dip bioassay. Eight formulate insecticides were tested. Differences in nymphal stink bug pre-emergence mortality were recorded. the lowest instances of stink bug emergence (and highest mortality) were observed in egg masses treated with bifenthrin (78.7%) followed by beta-cyfluthrin + acephate (42.5%) and acephate (40.9%). the highest emergence (and lowest mortality) occurred in egg masses treated with spinosad (10.4%). results indicate that insecticides used to control stink bug nymphs and adults can impact nymphal pre-emergence mortality and control southern green stink bugs before emergence.
doi:10.1653/024.095.0449 fatcat:mbbuntlrv5h3np5hilvp7yjza4

Mapping Long Non-Coding RNA Structures with Fragmentation and Next-Generation Sequencing

Jeffrey Vieregg, William Richter, Alex Ruthenburg
2015 Biophysical Journal  
130-Plat Mapping Long Non-Coding RNA Structures with Fragmentation and Next-Generation Sequencing Jeffrey Vieregg 1 , William Richter 2 , Alex Ruthenburg 2 . 1 Institute for Molecular Engineering, University  ... 
doi:10.1016/j.bpj.2014.11.172 fatcat:mu5gk4yp4rhdleq5da3ci2bile

Infectious Diseases of the Upper Respiratory Tract: Implications for Toxicology Studies

Jeffrey I. Everitt, Conrad B. Richter
1990 Environmental Health Perspectives  
EVERI1T AND RICHTER Microscopic lesions in experimental SDAV infection begin in the nasal respiratory epithelium approximately 48 hr postinfection.  ... 
doi:10.2307/3430687 pmid:2200664 pmcid:PMC1568352 fatcat:wxz2ldl2fze53jpaq6q43ldoue

Communist social structure and post-communist elections: Voting for reunification in East Germany

Jeffrey Kopstein, Karl-Otto Richter
1992 Studies in Comparative Communism  
doi:10.1016/0039-3592(92)90011-8 fatcat:t3fhua6wwbclddbcow7esujv2m

Comparative Analysis of Vertebrate Diurnal/Circadian Transcriptomes

Greg Boyle, Kerstin Richter, Henry D. Priest, David Traver, Todd C. Mockler, Jeffrey T. Chang, Steve A. Kay, Ghislain Breton, Nicolas Cermakian
2017 PLoS ONE  
From photosynthetic bacteria to mammals, the circadian clock evolved to track diurnal rhythms and enable organisms to anticipate daily recurring changes such as temperature and light. It orchestrates a broad spectrum of physiology such as the sleep/wake and eating/fasting cycles. While we have made tremendous advances in our understanding of the molecular details of the circadian clock mechanism and how it is synchronized with the environment, we still have rudimentary knowledge regarding its
more » ... nnection to help regulate diurnal physiology. One potential reason is the sheer size of the output network. Diurnal/circadian transcriptomic studies are reporting that around 10% of the expressed genome is rhythmically controlled. Zebrafish is an important model system for the study of the core circadian mechanism in vertebrate. As Zebrafish share more than 70% of its genes with human, it could also be an additional model in addition to rodent for exploring the diurnal/circadian output with potential for translational relevance. Here we performed comparative diurnal/circadian transcriptome analysis with established mouse liver and other tissue datasets. First, by combining liver tissue sampling in a 48h time series, transcription profiling using oligonucleotide arrays and bioinformatics analysis, we profiled rhythmic transcripts and identified 2609 rhythmic genes. The comparative analysis revealed interesting features of the output network regarding number of rhythmic genes, proportion of tissue specific genes and the extent of transcription factor family expression. Undoubtedly, the Zebrafish model system will help identify new vertebrate outputs and their regulators and provides leads for further characterization of the diurnal cis-regulatory network. The 12-plex arrays were custom-designed by NimbleGen (OID 22743). The 60-mer probes were designed in June 2009 based on transcript sequences annotations from Danio rerio version Zv8. Four probes were designed for 27,082 out of the 28,717 annotated transcripts in Zv8.
doi:10.1371/journal.pone.0169923 pmid:28076377 pmcid:PMC5226840 fatcat:g3qnoqwwxjcf5ks2nqbs2bpv6y

Chronically Infused Intrathecal Morphine in Dogs

Tony L. Yaksh, Kjersti A. Horais, Nicolle A. Tozier, Jeffrey W. Allen, Michael Rathbun, Steven S. Rossi, Claudia Sommer, Carol Meschter, Philip J. Richter, Keith R. Hildebrand
2003 Anesthesiology  
Despite the extensive use of intrathecal morphine infusion for pain, no systematic safety studies exist on its effects in high concentrations. The authors assessed the effects of morphine and clonidine given 28 days intrathecally in dogs. Methods: Beagles with lumbar intrathecal catheters received solutions delivered by a vest-mounted infusion pump. Six groups (n ‫؍‬ 3 each) received infusions (40 l/h) of saline or 1.5, 3, 6, 9, or 12 mg/day of morphine for 28 days. Additional groups received
more » ... rphine at 40 l/h (1.5 mg/day) plus clonidine (0.25-1.0 mg/day) or clonidine alone at 100 g/h (4.8 mg/day). Results: In animals receiving 9 or 12 mg/day morphine, allodynia was observed shortly after initiation of infusion. A concentration-dependent increase in hind limb dysfunction evolved over the infusion interval. Necropsy revealed minimal reactions in saline animals. At the higher morphine concentrations (all dogs receiving 12 mg/day), there was a local inflammatory mass at the catheter tip that produced significant local tissue compression. All animals with motor dysfunction displayed masses, although all animals with masses did not show motor dysfunction. The mass, arising from the dura-arachnoid layer, consisted of multifocal accumulations of neutrophils, monocytes, macrophages, and plasma cells. Inflammatory cells and endothelial cells displayed significant IL1␤, TNF␣, iNOS, and eNOS immunoreactivity. No evidence of bacterial or fungal involvement was detected. There were no other changes in spinal morphologic characteristics. In four other groups of dogs, clonidine alone had no effect and in combination with morphine reduced the morphine reaction. Conclusions: The authors found that high intrathecal morphine concentrations lead to aseptic intrathecal inflammatory masses. The lack of effect of clonidine and the possible suppressive effects of clonidine on the local reaction suggest the utility of such coadministration. * Daily doses delivered at 0.96 ml/day (40 l/hour) except clonidine (2 mg/ml), which was delivered at 2.4 ml/day (100 l/h). Clon ϭ clonidine; Mor ϭ morphine.
doi:10.1097/00000542-200307000-00028 pmid:12826864 fatcat:eljxf7n3v5gafgmaditmnzuh7a

A Three-Level Framework for Assessing and Implementing Environmental Flows

Jeffrey J. Opperman, Eloise Kendy, Rebecca E. Tharme, Andrew T. Warner, Eugenio Barrios, Brian D. Richter
2018 Frontiers in Environmental Science  
Army Corps of Engineers following the "Savannah Process" (Postel and Richter, 2003; Richter et al., 2006) . The Corps is the largest dam owner and TABLE 2 | Steps in a level 2 process.  ...  Here we describe a three-level framework for developing and implementing environmental flows in the pursuit of ecologically sustainable water management (sensu Richter et al., 2003) .  ... 
doi:10.3389/fenvs.2018.00076 fatcat:sh5k6ob6erh6tizw3h6gg2etdm

As instituições e a implementação do controle do tabaco no Brasil

Raphael Lencucha, Jeffrey Drope, Stella Aguinaga Bialous, Ana Paula Richter, Vera Luiza da Costa e Silva
2017 Cadernos de Saúde Pública  
Resumo: Esta pesquisa examina as características institucionais da Comissão Nacional para a Implementação da Convenção-Quadro sobre Controle do Tabaco (CONICQ) e como essas características institucionais facilitaram e impediram sua capacidade de promover o controle intersetorial do tabagismo. Os autores avaliam particularmente as características da CONICQ enquanto um dos principais fatores de mudanças e melhorias nas primeiras políticas de controle do tabaco, e que ajudaram a transformar o
more » ... l em líder mundial nessa área. O artigo também analisa como a Comissão evoluiu junto com a melhora do controle do tabaco, além de discutir alguns dos maiores desafios para reunir diversos setores do governo na elaboração de políticas de saúde pública.
doi:10.1590/0102-311x00168315 pmid:29069213 fatcat:tk4m4lcbijhrhnj4xi5ggk7zvm
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