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This work deals with the treatment planning optimization for intravascular brachytherapy (IVB) in peripheral arteries. The objective is both to quantitatively study the validity of different hypotheses required for a reliable application of the treatment with current techniques, and to contribute to the definition and the specification of a new optimized procedure taking into account the actual patient's vessel geometry. The detection of vascular luminal surface was performed by an imagedoi:10.1016/j.compmedimag.2007.03.001 pmid:17574815 fatcat:whashw57y5getovl6ybygtot5u
more »... s process, i.e. virtual active navigation, applied to standard CT data. Dose distribution was calculated according to the formalism proposed and recommended by the AAPM in TG43 and TG60. A method combining simulated annealing and BFGS algorithms was applied to optimize the parameters associated with the dwell points such as their number, positions, and dwell times. Dose-surface histogram (DSH) was used to evaluate the dose distribution results. Four levels of accuracy in target surface description were tested. The application of this optimization method to four different CT data sets including patient data, phantom and animal models showed that the treatment plan can be improved when the actual vessel geometry has been taken into account.
Lecture Notes in Computer Science
This work involves the conception of the experimental dosimetric testing setup of an image based procedure for intravascular brachytherapy by 192 Ir seed in peripheral arteries. After making sure of the suitability of the basis dosimetry data used for dose calculation, the treatment sequence as a whole has been tested in a customized tissue-equivalent phantom. The method is based on the use of CT preoperative images and 2D intra-operative radiographs. Experimental dosimetric results agree withdoi:10.1007/978-3-540-30136-3_156 fatcat:mcsvensoo5hafdcnr3zmlrftfu
more »... he planning and demonstrate the feasibility of the procedure.
Bulletin archéologique des Écoles françaises à l'étranger
pcrtmkRNd3ikl4, https:// ark.frantiq.fr/ark:/26678/pcrtbfqVEeganP, https://ark.frantiq.fr/ark:/26678/pcrtNBrnOdttU9 UMR 5608 « Travaux et Recherches Archéologiques sur les Cultures, les Espaces et les Sociétés » JEAN-DENIS ... Robitaille, L'enregistrement et l'analyse des objets de parure en pierre et en coquille fossile par S. ...doi:10.4000/baefe.1695 fatcat:dlxclnxrrramtd4wwsxgd2rjri
Many genome-wide association studies have been performed on progression towards the acquired immune deficiency syndrome (AIDS) and they mainly identified associations within the HLA loci. In this study, we demonstrate that the integration of biological information, namely gene expression data, can enhance the sensitivity of genetic studies to unravel new genetic associations relevant to AIDS. Methods We collated the biological information compiled from three databases of expression quantitativedoi:10.1371/journal.pone.0136989 pmid:26367535 pmcid:PMC4569262 fatcat:bruavnicizajjj4o65ty4dgeqa
more »... trait loci (eQTLs) involved in cells of the immune system. We derived a list of single nucleotide polymorphisms (SNPs) that are functional in that they correlate with differential expression of genes in at least two of the databases. We tested the association of those SNPs with AIDS progression in two cohorts, GRIV and ACS. Tests on permuted phenotypes of the GRIV and ACS cohorts or on randomised sets of equivalent SNPs allowed us to assess the statistical robustness of this method and to estimate the true positive rate. Results Eight genes were identified with high confidence (p = 0.001, rate of true positives 75%). Some of those genes had previously been linked with HIV infection. Notably, ENTPD4 belongs to the same family as CD39, whose expression has already been associated with AIDS progression; while DNAJB12 is part of the HSP90 pathway, which is involved in the control of HIV latency. Our study also drew our attention to lesser-known functions such as PLOS ONE |
Prevalence and prognosis impact of early repolarisation pattern in a general population Anne Rollin [Orateur] (1), Jean-Bernard Ruidavets (2) Background: Early repolarisation pattern (ERP) is characterized ...doi:10.1016/s1878-6480(12)70636-5 fatcat:2uvj5ynrtnf5perbphkedn7yhu
Even, et al.. Comparison between two treatment planning systems for volumetric modulated arc therapy optimization for prostate cancer.: VMAT with Monaco versus Pinnacle. Physica Medica, Elsevier, 2012, 30 (1), pp.2-9. . HAL Id: inserm-00750958 2 ABSTRACT Purpose: To investigate the performances of two commercial treatment planning systems (TPS) for Volumetric Modulated Arc Therapy (VMAT) optimization regarding prostate cancer. The TPS were compared in terms of dose distributions, treatmentdoi:10.1016/j.ejmp.2012.10.003 pmid:23116552 fatcat:yrj42zonvfdmtiuwueyjpj7f4a
more »... ery parameters and quality control results. Materials and Methods: For ten patients, two VMAT plans were generated: one with Monaco TPS (Elekta) and one with Pinnacle TPS (Philips Medical Systems). The total prescribed dose was 78 Gy delivered in one 360° arc with a Synergy ® linear accelerator equipped with a MLCi2 ® . Results: VMAT with Monaco provided better homogeneity and conformity indexes but lower mean dose to PTVs than Pinnacle. For the bladder wall (p=0.019), the femoral heads (p=0.017), and healthy tissues (p=0.005), significantly lower mean doses were found using Monaco. For the rectal wall, VMAT with Pinnacle provided a significantly (p=0.047) lower mean dose, and lower dose into 50% of the volume (p=0.047) compared to Monaco. Despite a greater number of monitor units (factor 1.5) for Monaco TPS, the total treatment time was equivalent to that of Pinnacle. The treatment delivery parameter analysis showed larger mean MLC area for Pinnacle and lower mean dose rate compared to Monaco. The quality control results gave a high passing rate (> 97.4%) for the gamma index for both TPS but Monaco provided slightly better results. Conclusion: For prostate cancer patients, VMAT treatment plans obtained with Monaco and Pinnacle offered clinically acceptable dose distributions. Further investigations are in progress to confirm the performances of the two TPS for irradiating more complex volumes.
This dosimetric study investigated the impact of multileaf collimators (MLC) leaf width in volumetric-modulated arc therapy (VMAT) for head and neck cancers (HNC), either with a "standard" simultaneously integrated boost technique (S-SIB) or with a "dose painting" SIB technique (DP-SIB). HNC patients were planned either with an S-SIB comprising three dose levels, from 56 to 70 Gy (16 patients), or with a DP-SIB comprising five dose levels, from 56 to 84 Gy (8 patients), in 35 fractions. Twodoi:10.1120/jacmp.v14i6.4074 pmid:24257269 pmcid:PMC5714620 fatcat:mu3smjviljhsfpnjbfsfoipehe
more »... plans were calculated for each SIB technique using two Elekta MLCs: MLCi2 with 10 mm leaf width and Beam Modulator (BM) with 4 mm leaf width. Dose distributions were evaluated by comparing doses on PTVs, main OARs, and healthy tissue, and by comparing conformation indexes. Treatment efficiencies were evaluated by comparing the number of monitor units and the number of needed arcs. Comparisons of the two MLCs depending on the two SIB techniques showed: i) Regarding PTVs: Dmean and D2% on lower doses PTV decreased respectively by 0.5 Gy (p = 0.01) and 0.9 Gy (p = 0.01) with BM than with MLCi2 for S-SIB; no significant difference was found for DP-SIB; ii) Regarding OARs: for spinal cord and brainstem, D2% decreased respectively by 1.2 Gy (p = 0.03) and 4.2 Gy (p = 0.04) with BM than with MLCi2 for S-SIB; for controlateral parotid, D50% decreased by 1.5 Gy (p = 0.01) with BM than with MLCi2 for S-SIB; iii) Regarding treatment efficiency: the number of monitor units was 44% (p = 0.00) and 51% (p = 0.01) higher with BM for S-SIB and DP-SIB, respectively. Two arcs were more frequently needed with BM to reach an acceptable dose distribution. This study demonstrated that Beam Modulator (4 mm leaf width) and MLCi2 (10 mm leaf width) MLCs from Elekta provided satisfactory dose distributions for treatment delivery with VMAT technique for complex HNC cases with standard and dose painting prescriptions. OAR sparing was better with BM, mainly for brainstem and spinal cord. However, delivery efficiency of VMAT plans was better with MLCi2.
Danièle Williaume, et al.. Salivary gland-sparing other than parotid-sparing in definitive head-and-neck intensity-modulated radiotherapy does not seem to jeopardize local control. Abstract Background: The objective was to analyze locoregional (LR) failure patterns in patients with head-and-neck cancer (HNC) treated using intensity-modulated radiotherapy (IMRT) with whole salivary gland-sparing: parotid (PG), submandibular (SMG), and accessory salivary glands represented by the oral cavitydoi:10.1186/1748-717x-8-132 pmid:23721062 pmcid:PMC3680304 fatcat:zjjokfeb4rgmrdx7hezp7e7lly
more »... Methods: Seventy consecutive patients with Stage I-II (23%) or III/IV (77%) HNC treated by definitive IMRT were included. For all LR failure patients, the FDG-PET and CT scans documenting recurrence were rigidly registered to the initial treatment planning CT. Failure volumes (Vf) were delineated based on clinical, radiological, and histological data. The percentage of Vf covered by 95% of the prescription isodose (Vf-V95) was analyzed. Failures were classified as "in-field" if Vf-V95 ≥ 95%, "marginal" if 20% < Vf-V95 < 95%, and "out-of-field" if Vf-V95 ≤20%. Correlation between Vf-V95 and mean doses (Dmean) in the PG, SMG, and OC was assessed using Spearman's rank-order correlation test. The salivary gland dose impact on the LR recurrence risk was assessed by Cox analysis. Results: The median follow-up was 20 months (6-35). Contralateral and ipsilateral PGs were spared in 98% and 54% of patients, respectively, and contralateral and ipsilateral SMG in 26% and 7%, respectively. The OC was spared to a dose ≤40 Gy in 26 patients (37%). The 2-year LR control rate was 76.5%. One recurrence was "marginal", and 12 were "in-field". No recurrence was observed in vicinity of spared structures. Vf-V95 was not significantly correlated with Dmean in PG, SMG, and OC. The LR recurrence risk was not increased by lower Dmean in the salivary glands, but by T (p = 0.04) and N stages (p = 0.03). Conclusion: Over 92% of LR failures occurred "in-field" within the high dose region when using IMRT with a whole salivary gland-sparing strategy. Sparing SMG and OC in addition to PG thus appears a safe strategy.
2019 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)
Stéphane Acounis, Nicolas Beaupère, Jean-Luc Beney, Stéphane Bouvier, Clotilde Canot, Jean-Pierre Cussonneau, Sara Diglio, Patrick Le Ray, Frédéric Lefèvre, Julien Masbou, Eric Morteau, Jean-Sébastien ... . , Mounir Abaline, Stéphane Acounis, Nicolas Beaupère, Jean-Luc Beney, Julien Bert, Stéphane Bouvier, Clotilde Canot, Thomas Carlier, Hervé Chanal, Michel Cherel, Jean-Pierre Cussonneau, Sara Diglio, ...doi:10.1109/nss/mic42101.2019.9059808 fatcat:cpjk26jsljerhnydptf2qcrram
The European Commission asked EFSA for a scientific evaluation on the risks to human health related to the presence of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in food. Regarding PFOS and PFOA occurrence, the final data set available for dietary exposure assessment contained a total of 20,019 analytical results (PFOS n = 10,191 and PFOA n = 9,828). There were large differences between upper and lower bound exposure due to analytical methods with insufficientdoi:10.2903/j.efsa.2018.5194 pmid:32625773 pmcid:PMC7009575 fatcat:l4apxljmjrfnjmbe4tlya4dxye
more »... vity. The CONTAM Panel considered the lower bound estimates to be closer to true exposure levels. Important contributors to the lower bound mean chronic exposure were 'Fish and other seafood', 'Meat and meat products' and 'Eggs and egg products', for PFOS, and 'Milk and dairy products', 'Drinking water' and 'Fish and other seafood' for PFOA. PFOS and PFOA are readily absorbed in the gastrointestinal tract, excreted in urine and faeces, and do not undergo metabolism. Estimated human half-lives for PFOS and PFOA are about 5 years and 2-4 years, respectively. The derivation of a health-based guidance value was based on human epidemiological studies. For PFOS, the increase in serum total cholesterol in adults, and the decrease in antibody response at vaccination in children were identified as the critical effects. For PFOA, the increase in serum total cholesterol was the critical effect. Also reduced birth weight (for both compounds) and increased prevalence of high serum levels of the liver enzyme alanine aminotransferase (ALT) (for PFOA) were considered. After benchmark modelling of serum levels of PFOS and PFOA, and estimating the corresponding daily intakes, the CONTAM Panel established a tolerable weekly intake (TWI) of 13 ng/kg body weight (bw) per week for PFOS and 6 ng/kg bw per week for PFOA. For both compounds, exposure of a considerable proportion of the population exceeds the proposed TWIs.
National Union Catalog
Texte de Jean Alazard. Lausanne, J. ... Paroles francaises par Pierre Laclau. Neuausg. Fir, Gesang und Klavier. ...
Multiple genome-wide association studies (doi:10.1371/journal.ppat.1003515 pmid:23935489 pmcid:PMC3723635 fatcat:wmmgfinflfcadpgjm3wpxylym4
Bulletin de la Sabix
) 1815-1858 1834 LYASSE (Léon) 1864-1914 1883 MANEN (Eugène-Hyppolyte-Léopold) 1829-1897 1849 MARESTIER (Jean-Baptiste) 1781-1832 1799 MILLE (Georges) 1905-1943 1827 PAGE (Théogène-François ... ) 1784-1852 1800 LAUBEUF (Maxime) 1864-1939 1883 Soixante grands marins polytechniciens Bulletin de la Sabix, 35 | 2009 LE BRETHON de CALIGNY (Albert-Edouard) 1833-1863 1853 LIEUSSOU (Jean-Pierre-Hyppolyte-Aristide ...doi:10.4000/sabix.442 fatcat:6qjqtxxktrdbnhf25qsz2zqc7e
National Union Catalog
(Series) PQ1993.L22L5 1946 48-24488° ag Pierre Ambroise Frangeis Chederles de, 1741-1808. Les liaisons di du texte, introd. et notes par Jean Mistler. ... Title. 1951 (Series) 51-28022 ace ommer, Abort, 1076- Laclau, Pierre, ¢r. see Manén, Juan, 1883- Selections, iLieder, op. A4. Fiinf Lieder. Five songs. Cinq chansons. ...
Vár út 1, 3300 Eger, Hungary. 23 Dipartimento Civiltà e Forme del Sapere, Università di Pisa, Via Galvani 1, 56126 Pisa, Italy. 24 CNRS -UMR 5608 -TRACES, Maison de la recherche, Université Toulouse Jean ...doi:10.1038/nature15757 pmid:26560301 fatcat:le3dkbzhrjgedibf73rhieml24
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