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Central Artery Stiffness in Hypertension and Aging
2016
Circulation Research
Preserved Fulltext
A nonlinear rotation-free shell formulation with prestressing for vascular biomechanics
2020
Scientific Reports
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ijkl = 4 ∂ 2 ψ el ∂C ij ∂C kl − 4 ∂ 2 ψ el ∂C 33 ∂C ij C 33 + ∂ψ el ∂C 33 δ i3 δ j3 Č kl − 4Č ij ∂ 2 ψ el ∂C 33 ∂C kl C 33 + ∂ψ el ∂C 33 δ k3 δ l3 − 2 ∂ψ el ∂C 33 C 33 Č ijČkl −Č ikČjl −Č ilČjk . (41) ...
ψ el (C). (32) S ij = 2 ∂ψ ∂C ij = 2 ∂ψ el ∂C ij − 2 ∂p ∂C ij (J − 1) − 2p ∂J ∂C ij . (33) C ijkl = 4 ∂ 2 ψ ∂C ij ∂C kl = 4 ∂ 2 ψ el ∂C ij ∂C kl − 4 ∂ 2 p ∂C ij ∂C kl (J − 1) − 4 ∂p ∂C ij ∂J ∂C kl − 4 ...
doi:10.1038/s41598-020-74277-5
pmid:33067508
fatcat:tox2a3g4lba35onkammmhff2cm
What do cells regulate in soft tissues on short time scales?
[article]
2021
arXiv
pre-print
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This yields F t = F 1 = F 2 + F c . (2) We now assume the system to be in a homeostatic state (Fig. 5 A) , in which the initially stress-free regions 1 and 2 were deformed by tensile cell forces F c > ...
With 0 = ∆F 1 = ∆F 2 + ∆F c , one obtains ∆F c = −∆F 2 = −k 2 ∆L t . (8) From this equation we see a possible reason why cells apparently do not restore the strain and thereby not exactly the tension in ...
arXiv:2104.05580v1
fatcat:2uhefcv42jhutizf5qrnvktxqi
Pressure Wave Propagation in Full-body Arterial Models: A Gateway to Exploring Aging and Hypertension
2014
Procedia IUTAM
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d 1 1 0 , d exp / d d d , t M p a R t t R C t a t a v n w w n v n v n (3) out out out f f f m p d d 0 ( 0 ) d e x p / d, H a a p R tR C a n v n w wn (4) out out out f f c f c , d d , d =0. ...
Face name
ID
R p / 10 3
C/ 10 6
R d / 10 4
Face name
ID
R p / 10 4
C/ 10 7
R d / 10 5
Ext. Carotid L
80
3.23
6.84
5.44
Post. Tibial L
2
1.05
12.4
1.76
Ext. ...
doi:10.1016/j.piutam.2014.01.033
fatcat:vfcvsbe6ifabzgl3utisbnqriq
A computational framework for modeling cell-matrix interactions in soft biological tissues
[article]
2021
arXiv
pre-print
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., 2011; Humphrey et al., 2014; Ross et al., 2013; Cox and Erler, 2011; Bonnans et al., 2014) . ...
associated cumulative distribution function C c (β) = 1 + 3 k=1 − b k 2k (1 − β) 2k−1 . ...
arXiv:2103.13110v1
fatcat:ab3jh7b3jjcetieisaqkuzk3ky
Mechanical homeostasis in tissue equivalents: a review
2021
Biomechanics and Modeling in Mechanobiology
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(a) (b) (c) (d) Fig. 2 Free-floating (a), uniaxially constrained (b), and biaxially constrained (c) fibroblast-seeded collagen gels (i.e., tissue equivalents) are observed to contract substantially over ...
of mechanics in governing biological form and function has been known since the time of Galileo Galilei (1564-1641) and Giovanni Borelli (1608-1667), that is, for at least four centuries (Cyron and Humphrey ...
doi:10.1007/s10237-021-01433-9
pmid:33683513
pmcid:PMC8154823
fatcat:6wkq5jq7sfbjrbxr3sdcl6wsjm
Myh11R247C/R247C mutations increase thoracic aorta vulnerability to intramural damage despite a general biomechanical adaptivity
2015
Journal of Biomechanics
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C vvvv and C zzzz are values of linearized stiffness in circumferential and axial direction, respectively. ...
Humphrey (2002) ), preliminary experiments revealed that overnight storage does not affect the passive mechanical properties. ...
doi:10.1016/j.jbiomech.2014.10.031
pmid:25433566
pmcid:PMC4283495
fatcat:i4n6od3hujeprjzngg7jhkeeji
Knock-out of matrix metalloproteinase-12 exacerbates compromised mechanical homeostasis in arterial aging
2018
Artery Research
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At first sight, MMP12-/-aging resembles WT aging: increased wall thickness (figure, panel A) leading to decreased circumferential stress (B) and decreased stored strain energy (C) [3] [4] [5] . ...
At first sight, MMP12-/-aging resembles WT aging: increased wall thickness (figure, panel A) leading to decreased circumferential stress (B) and decreased stored strain energy (C) [3] [4] [5] . ...
doi:10.1016/j.artres.2018.10.024
fatcat:ctohoa74qzadhc4yblnpdeylem
Hemodynamic Alterations Associated with Coronary and Cerebral Arterial Remodeling Following a Surgically-Induced Aortic Coarctation
[chapter]
2013
Computer Models in Biomechanics
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Two parameters, C a−total and C im−total , were defined as the sum of all coronary arterial (C a ) and intramyocardial (C im ) compliances. ...
Windkessel Parameters Coronary Parameters Outlet R p R d C Outlet R a R a−micro R v C a C im
Acute Cardiac Compensation Following Coarctation When first introducing the coarctation, parameters for the ...
doi:10.1007/978-94-007-5464-5_15
fatcat:ceutnqkqcnc33ht7vxkgxnbzva
Multi-scale computational model of three-dimensional hemodynamics within a deformable full-body arterial network
2013
Journal of Computational Physics
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In this case, LðP Ks Þ ¼K þP, with 0:5kð1 À mÞ 0 B B B B B B @ 1 C C C C C C A ð7Þ ¼ @u 1 =@x 1 @u 2 =@x 2 @u 1 =@x 2 þ @u 2 =@x 1 @u 3 =@x 1 @u 3 =@x 2 0 B B B B B B @ 1 C C C C C C A ;P ¼ P 11 P 22 ...
P 12 P 31 P 32 0 B B B B B B @ 1 C C C C C C A ð8Þ where m represents the Poisson's ratio, k is a transverse shear factor, u is the displacement vector, andP is a pre-stress tensor. ...
doi:10.1016/j.jcp.2012.09.016
pmid:23729840
pmcid:PMC3667207
fatcat:fsjxrnm76zcwpapktku3neukz4
Design and Use of a Novel Bioreactor for Regeneration of Biaxially Stretched Tissue-Engineered Vessels
2015
Tissue Engineering. Part C, Methods
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Desmosine assay Tissue samples with wet weight of at least 3 mg were first hydrolyzed in 6 N HCl at 110°C for 24 h. ...
In comparison with static conditioning, both uniaxial and biaxial loading resulted in robust smoothelin expression in SMCs ( Fig. 9A-C) . ...
doi:10.1089/ten.tec.2014.0287
pmid:25669988
pmcid:PMC4523101
fatcat:l3iu4gkb5rd5hnu364qsalfcji
An Experimental–Computational Study of Catheter Induced Alterations in Pulse Wave Velocity in Anesthetized Mice
2015
Annals of Biomedical Engineering
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θθ (MPa)
0.98
0.72
0.88
0.75
0.57
C
ZZ (MPa)
1.16
2.29
1.80
2.32
1.23
h (µm)
40.69 42.93 36.07 33.61 27.98
ATA Cath
C
θθ (MPa)
1.05
0.76
0.90
0.73
0.60
C
ZZ ...
C θθ and C ZZ refer respectively to the circumferential and axial component of the 5×5 stiffness matrix; h is the vessel wall thickness. Ann Biomed Eng. ...
doi:10.1007/s10439-015-1272-0
pmid:25698526
pmcid:PMC4497847
fatcat:ufdarp6e5rbfdhpunhpe5ummxi
Roles of mTOR in thoracic aortopathy understood by complex intracellular signaling interactions
2021
PLoS Computational Biology
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For example, let the activation of species C (y C ) depend on the combined activation of species A (y A ) and E (y E ), namely dy C dt ¼ 1 t C AND y A ; y E ð Þy C;max À y C À � with, AND ¼ W AEC f act ...
While there is no bifurcation for PDK1, the other three species in the network (AKT, mTOR, and mTORC2) exhibit a limit point bifurcation (LP), indicated by a star, detected at a level of PI3K = 0.27083. c) ...
doi:10.1371/journal.pcbi.1009683
pmid:34898595
pmcid:PMC8700007
fatcat:kp7lrmk2cjhxzctbu7xdkji5gi
A computational framework for fluid–solid-growth modeling in cardiovascular simulations
2009
Computer Methods in Applied Mechanics and Engineering
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@X f ¼ C in [ C t [ C out ; C in \ C t \ C out ¼ ;; ð37Þ where C in represents the boundary where a velocity field v ¼ v in is prescribed; this usually corresponds to the inflow face of the model. ...
; ð20Þ where C e n½11 and C e n½22 are diagonal components of C e n . ...
doi:10.1016/j.cma.2008.09.013
pmid:20160923
pmcid:PMC2770883
fatcat:sjce55dcajbxzl3g73ajyv7iy4
Biaxial Stretch Improves Elastic Fiber Maturation, Collagen Arrangement, and Mechanical Properties in Engineered Arteries
2016
Tissue Engineering. Part C, Methods
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S2A-C) . ...
(A, D) Static vessels; (B, E) uniaxial vessels; (C, F) biaxial vessels. (A-C) Immunofluroscence staining of elastin. Elastin, b-actin, and DAPI are in red, green, and blue, respectively. ...
doi:10.1089/ten.tec.2015.0309
pmid:27108525
pmcid:PMC4921901
fatcat:hkvkifk3dzd6zj6rlcpns5cjxm
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