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Cell death and tissue remodeling in planarian regeneration

Jason Pellettieri, Patrick Fitzgerald, Shigeki Watanabe, Joel Mancuso, Douglas R. Green, Alejandro Sánchez Alvarado
<span title="">2010</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2ojtrdr5enbotexnfakgsvrhai" style="color: black;">Developmental Biology</a> </i> &nbsp;
Many long-lived organisms, including humans, can regenerate some adult tissues lost to physical injury or disease. Much of the previous research on mechanisms of regeneration has focused on adult stem cells, which give rise to new tissue necessary for the replacement of missing body parts. Here we report that apoptosis of differentiated cells complements stem cell division during regeneration in the planarian Schmidtea mediterranea. Specifically, we developed a whole-mount TUNEL assay that
more &raquo; ... ed us to document two dramatic increases in the rate of apoptosis following amputation-an initial localized response near the wound site and a subsequent systemic response that varies in magnitude depending on the type of fragment examined. The latter cell death response can be induced in uninjured organs, occurs in the absence of planarian stem cells, and can also be triggered by prolonged starvation. Taken together, our results implicate apoptosis in the restoration of proper anatomical scale and proportion through remodeling of existing tissues. We also report results from initial mechanistic studies of apoptosis in planarians, which revealed that a S. mediterranea homolog of the antiapoptotic gene BCL2 is required for cell survival in adult animals. We propose that apoptosis is a central mechanism working in concert with stem cell division to restore anatomical form and function during metazoan regeneration.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.ydbio.2009.09.015">doi:10.1016/j.ydbio.2009.09.015</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19766622">pmid:19766622</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2835816/">pmcid:PMC2835816</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/arnwuudrqndkfct2asult56d6a">fatcat:arnwuudrqndkfct2asult56d6a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171003155305/http://publisher-connector.core.ac.uk/resourcesync/data/elsevier/pdf/ce7/aHR0cDovL2FwaS5lbHNldmllci5jb20vY29udGVudC9hcnRpY2xlL3BpaS9zMDAxMjE2MDYwOTAxMTkzMg%3D%3D.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/50/bb/50bbf157b1e46ad2a8590cf875de46e9174543fa.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.ydbio.2009.09.015"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835816" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

A generic framework for privacy preserving deep learning [article]

Theo Ryffel, Andrew Trask, Morten Dahl, Bobby Wagner, Jason Mancuso, Daniel Rueckert, Jonathan Passerat-Palmbach
<span title="2018-11-13">2018</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
We detail a new framework for privacy preserving deep learning and discuss its assets. The framework puts a premium on ownership and secure processing of data and introduces a valuable representation based on chains of commands and tensors. This abstraction allows one to implement complex privacy preserving constructs such as Federated Learning, Secure Multiparty Computation, and Differential Privacy while still exposing a familiar deep learning API to the end-user. We report early results on
more &raquo; ... e Boston Housing and Pima Indian Diabetes datasets. While the privacy features apart from Differential Privacy do not impact the prediction accuracy, the current implementation of the framework introduces a significant overhead in performance, which will be addressed at a later stage of the development. We believe this work is an important milestone introducing the first reliable, general framework for privacy preserving deep learning.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1811.04017v2">arXiv:1811.04017v2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/74y4wgsqqnaflf6bxgjtxdr3vq">fatcat:74y4wgsqqnaflf6bxgjtxdr3vq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191026013551/https://arxiv.org/pdf/1811.04017v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/bd/86/bd865eb307049aaa901dfca19c9abe56b4e39ead.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1811.04017v2" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Private Machine Learning in TensorFlow using Secure Computation [article]

Morten Dahl, Jason Mancuso, Yann Dupis, Ben Decoste, Morgan Giraud, Ian Livingstone, Justin Patriquin, Gavin Uhma
<span title="2018-10-23">2018</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
We present a framework for experimenting with secure multi-party computation directly in TensorFlow. By doing so we benefit from several properties valuable to both researchers and practitioners, including tight integration with ordinary machine learning processes, existing optimizations for distributed computation in TensorFlow, high-level abstractions for expressing complex algorithms and protocols, and an expanded set of familiar tooling. We give an open source implementation of a
more &raquo; ... e-art protocol and report on concrete benchmarks using typical models from private machine learning.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1810.08130v2">arXiv:1810.08130v2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/i46i3lsvvvarhgcqfzumoudj3y">fatcat:i46i3lsvvvarhgcqfzumoudj3y</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200922010921/https://arxiv.org/pdf/1810.08130v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/2f/73/2f73a63d7dc3659afa59d8f58d63128cbca9c319.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1810.08130v2" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

GimpGirl grows up: Women with disabilities rethinking, redefining, and reclaiming community

Jennifer Cole, Jason Nolan, Yukari Seko, Katherine Mancuso, Alejandra Ospina
<span title="2011-04-27">2011</span> <i title="SAGE Publications"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/jsbr3gyvknexziljx6ajpw2e5i" style="color: black;">New Media &amp; Society</a> </i> &nbsp;
Formulation of this article took place solely online with members in different parts of the world, and incorporated recent scholarly contributions from the group (Cole, 2009; Cole and Mancuso, 2009; Mancuso  ...  (Staff members Jennifer Cole, Katherine Mancuso and Krishanna Spencer specifically requested use of their real names, as a statement of pride in their work for GGC.)  ...  Katherine Mancuso is an academic specializing in digital media, online education, community building, and digital accessibility. She attends Georgia Tech's master's program in digital media.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1177/1461444811398032">doi:10.1177/1461444811398032</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/d3oyhjwdhbga3ewkge3fl2slya">fatcat:d3oyhjwdhbga3ewkge3fl2slya</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200321065154/http://edgelab.ryerson.ca/files/2011/05/1461444811398032.full_.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/0c/15/0c154dbf0657687c45c96f739baeefe24d58c9fe.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1177/1461444811398032"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> sagepub.com </button> </a>

Privacy-preserving collaborative machine learning on genomic data using TensorFlow [article]

Cheng Hong, Zhicong Huang, Wen-jie Lu, Hunter Qu, Li Ma, Morten Dahl, Jason Mancuso
<span title="2020-02-29">2020</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Machine learning (ML) methods have been widely used in genomic studies. However, genomic data are often held by different stakeholders (e.g. hospitals, universities, and healthcare companies) who consider the data as sensitive information, even though they desire to collaborate. To address this issue, recent works have proposed solutions using Secure Multi-party Computation (MPC), which train on the decentralized data in a way that the participants could learn nothing from each other beyond the
more &raquo; ... final trained model. We design and implement several MPC-friendly ML primitives, including class weight adjustment and parallelizable approximation of activation function. In addition, we develop the solution as an extension to TF Encrypted , enabling us to quickly experiment with enhancements of both machine learning techniques and cryptographic protocols while leveraging the advantages of TensorFlow's optimizations. Our implementation compares favorably with state-of-the-art methods, winning first place in Track IV of the iDASH2019 secure genome analysis competition.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2002.04344v2">arXiv:2002.04344v2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/dyiaoxewvfa3pcdcyn5yd2fh7i">fatcat:dyiaoxewvfa3pcdcyn5yd2fh7i</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200322043111/https://arxiv.org/pdf/2002.04344v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2002.04344v2" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Genetic control of gene expression and splicing in the developing human brain [article]

Rebecca L. Walker, Gokul Ramaswami, Christopher Hartl, Nicholas Mancuso, Michael J. Gandal, Luis de la Torre-Ubieta, Bogdan Pasaniuc, Jason L. Stein, Daniel H. Geschwind
<span title="2018-11-16">2018</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
To prioritize candidate susceptibility genes in our TWAS we performed statistical finemapping using FOCUS (Mancuso et al., 2017) .  ...  We applied FOCUS (Mancuso et al., 2017) to our fetalgene TWAS results that lie within a GWAS region to identify a credible set of causal genes at .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/471193">doi:10.1101/471193</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/oxxk7m3s7bgsvl6ymbay77l7ba">fatcat:oxxk7m3s7bgsvl6ymbay77l7ba</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190501050449/https://www.biorxiv.org/content/biorxiv/early/2018/11/16/471193.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b0/e7/b0e7b73a0769c7f73e467db91ce1cd567185e045.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/471193"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

X-ray phase vortices: theory and experiment

Andrew G. Peele, Keith A. Nugent, Adrian P. Mancuso, David Paterson, Ian McNulty, Jason P. Hayes
<span title="2004-08-01">2004</span> <i title="The Optical Society"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/x7beftam25dklnfekgui7ayivu" style="color: black;">Optical Society of America. Journal A: Optics, Image Science, and Vision</a> </i> &nbsp;
We review the current work on x-ray phase vortices. We explain the role of an x-ray vortex in phase recovery and speculate on its possible applications in other fields of x-ray optical research. We present our theoretical understanding of the structure of phase vortices and test these predictions against experiment. We present experimental observations of phase vortices with charge greater than 3 and observe that their propagation appears to be consistent with our theoretical models.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1364/josaa.21.001575">doi:10.1364/josaa.21.001575</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/15330486">pmid:15330486</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/zxo6lmmxofhzxhdzzuvum4uxse">fatcat:zxo6lmmxofhzxhdzzuvum4uxse</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190228131854/http://pdfs.semanticscholar.org/a353/625e27a3d7f63e1b7d33d5f42fedd5eef241.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a3/53/a353625e27a3d7f63e1b7d33d5f42fedd5eef241.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1364/josaa.21.001575"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

HIV Care Continuum and Meeting 90-90-90 Targets: Cascade of Care Analyses of a U.S. Military Cohort

Andrew Anglemyer, Noah Haber, Adi Noiman, George Rutherford, Anuradha Ganesan, Jason Blaylock, Jason Okulicz, Ryan C Maves, Tahaniyat Lalani, Christina Schofield, James Mancuso, Brian K Agan (+1 others)
<span title="2020-03-24">2020</span> <i title="Oxford University Press"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/p2g77rcmcjaozgihldxgdylqs4" style="color: black;">Military medicine</a> </i> &nbsp;
The new initiative by the Department of Health and Human Services (DHHS) aims to decrease new HIV infections in the U.S. by 75% within 5 years and 90% within 10 years. Our objective was to evaluate whether the U.S. military provides a good example of the benefits of such policies. We conducted an analysis of a cohort of 1,405 active duty military personnel with HIV enrolled in the Natural History Study who were diagnosed between 2003 and 2015 at six U.S. military medical centers. The study was
more &raquo; ... pproved by institutional review boards at the Uniformed Services University of the Health Sciences and each of the sites. We evaluated the impact of Department of Defense (DoD) HIV care policies, including screening, linkage to care, treatment eligibility, and combined antiretroviral therapy (cART) initiation on achieving viral suppression (VS) within 3 years of diagnosis. As a secondary outcome, we evaluated the DoD's achievement of UNAIDS 90-90-90 targets. Nearly all (99%) were linked to care within 60 days. Among patients diagnosed in 2003-2009, 77.5% (95% confidence intervals (CI) 73.9-80.6%) became eligible for cART within 3 years of diagnosis, 70.6% (95% CI 66.6-74.1%) overall initiated cART, and 64.2% (95% CI 60.1-68.0%) overall achieved VS. Among patients diagnosed in 2010-2015, 98.7% (95% CI 96.7-99.5%) became eligible for cART within 3 years of diagnosis, 98.5% (95% CI 96.4-99.4%) overall initiated cART, and 89.8% (95% CI 86.0-92.5%) overall achieved VS. U.S. military HIV policies have been highly successful in achieving VS goals, exceeding the UNAIDS 90-90-90 targets. In spite of limitations, including generalizability, this example demonstrates the feasibility of the DHHS initiative to decrease new infections through testing, early treatment, and retention in care.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/milmed/usaa021">doi:10.1093/milmed/usaa021</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32207528">pmid:32207528</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7429920/">pmcid:PMC7429920</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/huj4x3rez5di3epiorfag5o52m">fatcat:huj4x3rez5di3epiorfag5o52m</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210702192528/https://watermark.silverchair.com/usaa021.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAs4wggLKBgkqhkiG9w0BBwagggK7MIICtwIBADCCArAGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMJusbM5CY3m4euPNVAgEQgIICgRmL_8Ez2rf8OlKNkJy1K-a3WxtmrdsDXkjImyEHQ57SBlSpqvAl0BxOtSxhxrYpqOYkFzAYyDSZyhOg_CA2izCjaA_HDqLLClGOiCKMbpGSUiy0PXZj4lvg51595XBubqgHs3XxD7cW0L9j5ut95rcIvbfQNe0VDgFAyzxnWJB7k3gouUNQLm-2Hcn8hDxKOe3iiOvg0emsgckL9Pn4km-gvUwdycXJNFt0q9JTZvbtOwhH6syRMJEUnw-j3IuwUX6Ewb50FoRp-paKioCiC9Ni-uffixSSfGPYtwqtLHOTOGfOPAGtlW09wovggpSRNoUpEdgP1A0X1DQShKwrTOHfpmatxwg_RIK1QGtttP0UIPOwgB2z-i8f7UX5BQn6zNWkTPhKkqaoXcrY6zjZYgpnIJgamUyVKhZWgFc4zv-fx5vc4Y5lTAgtgkaEZwY3wEldYulenK8cFLBWpWlnzVc6QxnVmTI_PXHa44oaq-BSHo_GzdhJKWnh64bm-oDk48kGhesNqHEOLUQoAL3DkX5ikvBfaFci1h2Twj1oQLJiWFkhs4x7-R6hh6w3A7w8LhJOYxKaFtdVACk7ItZZrIpbYnBSpc5B-leBk4I0BEQ1lbJ9R6-aAEqAGKV6TIiRS-aTnvQRoHTk7uzMtwmRqRpVTaPrOkv_PGKE1dBt3FTVyIBd8-Zq4OVq6_1ax5pjhcBDWsI_NXkTBPNIgAwKqhjGcuI-3by31ZElW52urdbrpK2p_BkA-F7RfFf4RPp3S4SxfoKy4J3gPiB57jPQmMc0fvnW4ILZUEr4gxgJVruGTamtVdISqXoEfbkc-5zaXmvgwa0jNucQTOF7yN4UgdJG" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/2d/7f/2d7f517406e855f0f4dc50df4eae21a6da607ec8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/milmed/usaa021"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7429920" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Forensic microbial system for high-resolution object provenance [article]

Jason Qian, Zhi-xiang Lu, Christopher P Mancuso, Han-Ying Jhuang, Rocío del Carmen Barajas-Ornelas, Sarah Boswell, Fernando H Ramírez-Guadiana, Victoria Jones, Akhila Sonti, Kole Sedlack, Lior Artzi, Giyoung Jung (+9 others)
<span title="2020-03-16">2020</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Mapping where an object has been is a fundamental challenge for human health, commerce, and food safety. Location-specific microbes offers the potential to cheaply and sensitively determine object provenance. We created a synthetic, scalable microbial spore system that identifies object provenance in under one hour at meter-scale resolution and near single spore sensitivity, and that can be safely introduced into and recovered from the environment. This system solves the key challenges in
more &raquo; ... provenance: persistence in the environment, scalability, rapid and facile decoding, and biocontainment. Our system is compatible with SHERLOCK, facilitating its implementation in a wide range of applications.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.03.14.990804">doi:10.1101/2020.03.14.990804</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/qzg4b5ycsbgqdkkqwkv7r4x3xq">fatcat:qzg4b5ycsbgqdkkqwkv7r4x3xq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200317213651/https://www.biorxiv.org/content/biorxiv/early/2020/03/16/2020.03.14.990804.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.03.14.990804"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

Assessment of the QuantiFERON-TB Gold In-Tube test for the detection of Mycobacterium tuberculosis infection in United States Navy recruits

Jason M. Lempp, Margan J. Zajdowicz, Arlene L. Hankinson, Sean R. Toney, Lisa W. Keep, James D. Mancuso, Gerald H. Mazurek, Katalin Andrea Wilkinson
<span title="2017-05-17">2017</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3gm7274mfe6fcs7e3jterqlri" style="color: black;">PLoS ONE</a> </i> &nbsp;
Immunologic tests such as the tuberculin skin test (TST) and QuantiFERON ® -TB Gold In-Tube test (QFT-GIT) are designed to detect Mycobacterium tuberculosis infection, both latent M. tuberculosis infection (LTBI) and infection manifesting as active tuberculosis disease (TB). These tests need high specificity to minimize unnecessary treatment and high sensitivity to allow maximum detection and prevention of TB. Methods Estimate QFT-GIT specificity, compare QFT-GIT and TST results, and assess
more &raquo; ... or associations with test discordance among U.S. Navy recruits. Results Among 792 subjects with completed TST and QFT-GIT, 42(5.3%) had TST indurations !10mm, 23(2.9%) had indurations !15mm, 14(1.8%) had positive QFT-GIT results, and 5 (0.6%) had indeterminate QFT-GITs. Of 787 subjects with completed TST and determinate QFT-GIT, 510(64.8%) were at low-risk for infection, 277(35.2%) were at increased risk, and none had TB. Among 510 subjects at low-risk (presumed not infected), estimated TST specificity using a 15mm cutoff, 99.0% (95%CI: 98.2-99.9%), and QFT-GIT specificity, 98.8% (95%CI: 97.9-99.8%), were not significantly different (p>0.99). Most discordance was PLOS ONE | https://doi.among recruits at increased risk of infection, and most was TST-positive but QFT-GIT-negative discordance. Of 18 recruits with TST !15mm but QFT-GIT negative discordance, 14 (78%) were at increased risk. TB prevalence in country of birth was the strongest predictor of positive TST results, positive QFT-GIT results, and TST-positive but QFT-GIT-negative discordance. Reactivity to M. avium purified protein derivative (PPD) was associated with positive TST results and with TST-positive but QFT-GIT-negative discordance using a 10 mm cutoff, but not using a 15 mm cutoff or with QFT-GIT results. Conclusions M. tuberculosis infection prevalence was low, with the vast majority of infection occurring in recruits with recognizable risks. QFT-GIT and TST specificities were high and not significantly different. Negative QFT-GIT results among subjects with TST induration !15 mm who were born in countries with high TB prevalence, raise concerns. were used to measure interferon gamma. CDC, USN, and Cellestis representatives reviewed the study design, data collection methods, and analysis plans prior to startup. CDC and USN representatives cleared the manuscript for publication according to established guidelines.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0177752">doi:10.1371/journal.pone.0177752</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28545136">pmid:28545136</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5435309/">pmcid:PMC5435309</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/lzrfmdi63vaupdhjwajxwtbth4">fatcat:lzrfmdi63vaupdhjwajxwtbth4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190226113436/http://pdfs.semanticscholar.org/70a9/e0c1ff6a4f6e8a9a0a27448b1f89a53e8a22.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/70/a9/70a9e0c1ff6a4f6e8a9a0a27448b1f89a53e8a22.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0177752"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435309" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Prostaglandin E2 Induction during Mouse Adenovirus Type 1 Respiratory Infection Regulates Inflammatory Mediator Generation but Does Not Affect Viral Pathogenesis

Mary K. McCarthy, Rachael E. Levine, Megan C. Procario, Peter J. McDonnell, Lingqiao Zhu, Peter Mancuso, Leslie J. Crofford, David M. Aronoff, Jason B. Weinberg, Jane C. Deng
<span title="2013-10-16">2013</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3gm7274mfe6fcs7e3jterqlri" style="color: black;">PLoS ONE</a> </i> &nbsp;
in mPGES-1 -/-mice is likely due to a decrease in IFNγ production by CD4 + and CD8 + T cells, as these cell types are the major producers of IFN-γ during MAV-1 respiratory infection (Mary McCarthy and Jason  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0077628">doi:10.1371/journal.pone.0077628</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24147040">pmid:24147040</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3797793/">pmcid:PMC3797793</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wxipwpzravhhhfrkfo265d74km">fatcat:wxipwpzravhhhfrkfo265d74km</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171008201114/http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0077628&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b7/ae/b7aeba76d60941483669bcec695bb6795ebfe8d5.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0077628"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797793" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Ablation of the leptin receptor in myeloid cells impairs pulmonary clearance of Streptococcus pneumoniae and alveolar macrophage bactericidal function

Peter Mancuso, Jeffrey L. Curtis, Christine M. Freeman, Marc Peters-Golden, Jason B. Weinberg, Martin G. Myers
<span title="">2018</span> <i title="American Physiological Society"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ok5lktf725bsfiv2ygtooufz74" style="color: black;">American Journal of Physiology - Lung cellular and Molecular Physiology</a> </i> &nbsp;
Mancuso P, Curtis JL, Freeman CM, Peters-Golden M, Weinberg JB, Myers MG, Jr.  ...  Mancuso) and R01-AI-083334 (to J. Weinberg) and the Department of Veterans Affairs via Merit Review Awards I01 BX001389 (to C. Freeman) and I01 CX000911 (to J. Curtis).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1152/ajplung.00447.2017">doi:10.1152/ajplung.00447.2017</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29565180">pmid:29565180</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/j3sp42tusvdutlaxomljezyweu">fatcat:j3sp42tusvdutlaxomljezyweu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200319184709/https://journals.physiology.org/doi/pdf/10.1152/ajplung.00447.2017" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/66/8f/668f797e022863bbb6ca600ab7a434f0b67bcffb.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1152/ajplung.00447.2017"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Alveolar Epithelial Cell–Derived Prostaglandin E2Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation

Jennifer M. Speth, Emilie Bourdonnay, Loka Raghu Kumar Penke, Peter Mancuso, Bethany B. Moore, Jason B. Weinberg, Marc Peters-Golden
<span title="2016-05-13">2016</span> <i title="The American Association of Immunologists"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/pbkbyur74rdkdgx2mbqyooa75e" style="color: black;">Journal of Immunology</a> </i> &nbsp;
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4049/jimmunol.1502153">doi:10.4049/jimmunol.1502153</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27183597">pmid:27183597</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4893973/">pmcid:PMC4893973</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/6hxscsjbbff5taxn6bnls2j5hq">fatcat:6hxscsjbbff5taxn6bnls2j5hq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190502032725/http://www.jimmunol.org/content/jimmunol/196/12/5112.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/44/9c/449c4ef6cb229495dc80d05cbd188a62a1dca84d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4049/jimmunol.1502153"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893973" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice

Jennifer M. Dolan, Jason B. Weinberg, Edmund O'Brien, Anya Abashian, Megan C. Procario, David M. Aronoff, Leslie J. Crofford, Marc Peters-Golden, Lindsay Ward, Peter Mancuso
<span title="">2016</span> <i title="American Physiological Society"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ok5lktf725bsfiv2ygtooufz74" style="color: black;">American Journal of Physiology - Lung cellular and Molecular Physiology</a> </i> &nbsp;
Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice. The production of prostaglandin E2 (PGE2) increases dramatically during pneumococcal pneumonia, and this lipid mediator impairs alveolar macrophage (AM)-mediated innate immune responses. Microsomal prostaglandin E synthase-1 (mPGES-1) is a key enzyme involved in the synthesis of PGE2, and its expression is enhanced during bacterial infections. Genetic
more &raquo; ... of mPGES-1 in mice results in diminished PGE2 production and elevated levels of other prostaglandins after infection. Since PGE2 plays an important immunoregulatory role during bacterial pneumonia we assessed the impact of mPGES-1 deletion in the host defense against pneumococcal pneumonia in vivo and in AMs in vitro. Wild-type (WT) and mPGES-1 knockout (KO) mice were challenged with Streptococcus pneumoniae via the intratracheal route. Compared with WT animals, we observed reduced survival and increased lung and spleen bacterial burdens in mPGES-1 KO mice 24 and 48 h after S. pneumoniae infection. While we found modest differences between WT and mPGES-1 KO mice in pulmonary cytokines, AMs from mPGES-1 KO mice exhibited defective killing of ingested bacteria in vitro that was associated with diminished inducible nitric oxide synthase expression and reduced nitric oxide (NO) synthesis. Treatment of AMs from mPGES-1 KO mice with an NO donor restored bacterial killing in vitro. These results suggest that mPGES-1 plays a critical role in bacterial pneumonia and that genetic ablation of this enzyme results in diminished pulmonary host defense in vivo and in vitro. These results suggest that specific inhibition of PGE2 synthesis by targeting mPGES-1 may weaken host defense against bacterial infections. bacterial pneumonia; lung; host defense; Streptococcus pneumoniae; microsomal prostaglandin E synthase; prostaglandins
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1152/ajplung.00220.2015">doi:10.1152/ajplung.00220.2015</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27059285">pmid:27059285</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4935474/">pmcid:PMC4935474</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/c65bqjawj5grdf2b43j7iaudha">fatcat:c65bqjawj5grdf2b43j7iaudha</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20181030093645/https://www.physiology.org/doi/pdf/10.1152/ajplung.00220.2015" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/01/c2/01c24160428e5667b44630ed0ed49c2ccd1f0f95.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1152/ajplung.00220.2015"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935474" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Page 381 of Florida Bar Journal Vol. 81, Issue 8 [page]

<span title="">2007</span> <i title="Florida Bar Journal"> <a target="_blank" rel="noopener" href="https://archive.org/details/pub_florida-bar-journal" style="color: black;">Florida Bar Journal</a> </i> &nbsp;
. 407/681-9494 Joseph J Mancuso Pa 262 Wilshire Blvd Casselberry 32707-5355 jmancuso29cfl.rr.com Fax: 407/673-3547 MANCUSO, LauranceL . 407/688-1913 PO Box 952735 Lake Mary 327982735 llmancuso 9 mancuso-mediation.com  ...  1606 NW 102ND DR CORAL SPRINGS 33071-3921 smankodi9aol.com MANXOFF.GeriLyrvi . 305/4191437 Perry Ellis intematxjnal Inc 3000 NW lOTIh Ave Miami 33172-2133 glmankoff9yahoo.com Fax: 305/357-1437 MANXOFF, Jason  ... 
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