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Inhibitory Interaction Between Calcium Channel Blocker and Clopidogrel

Seung-Pyo Lee, Jang-Whan Bae, Kyung Woo Park, Seung-Woon Rha, Jang-Ho Bae, Jung-Won Suh, In-Ho Chae, Myeong-Chan Cho, Hyo-Soo Kim
2011 Circulation Journal  
The clinical effect of, and additive measures to overcome the possible inhibitory calcium channel blocker (CCB) - clopidogrel interaction in Asian patients undergoing percutaneous coronary intervention is unknown. Methods and Results: A total of 900 Korean patients enrolled for the multicenter, prospective, randomized Influence of CILostazol-based triple antiplatelet therapy ON ischemic complication after drug-eluting stenT implantation (CILON-T) trial were divided into 4 groups depending on
more » ... prescription and type of anti-platelet therapy (dual [DAT] vs. triple [TAT; addition of cilostazol to DAT]) in a 2×2 factorial manner. The primary endpoint was a composite of cardiac death, non-fatal myocardial infarction and ischemic stroke at 6 months after PCI. On-treatment platelet reactivity (OPR) was assessed on VerifyNow P2Y12 assay. Concomitant CCB use increased OPR in the DAT group (mean ± SEM: 251.2±7.6 vs. 225.6±5.1; P=0.008), but not in the TAT group (214.5±9.1 vs. 203.4±5.6; P=0.294). Primary endpoint increased by use of CCB in patients with DAT (4.9% vs. 0.9%, P=0.016), but not in those with TAT (0% vs. 1.8%, P=0.346). Addition of cilostazol to DAT reduced OPR and clinical events in patients taking CCB (P=0.007 for P2Y12 reaction units; P=0.027 for thrombotic events). CCB without concomitant cilostazol use was a significant predictor of total thrombotic events. Conclusions: Concomitant use of CCB may weaken the anti-platelet effect of clopidogrel and increase subsequent thrombotic events in Asian subjects. This hazardous CCB - clopidogrel interaction may be overcome by addition of cilostazol. (Circ J 2011; 75: 2581 - 2589
doi:10.1253/circj.cj-11-0113 pmid:21857144 fatcat:sb7pmvinr5ahxje7gwtawn63iu

Morning Hypertension in Treated Hypertensives: Baseline Characteristics and Clinical Implications

Ju-Hee Lee, Jang-Whan Bae, Jung Bae Park, Chang Gyu Park, Ho-Joong Youn, Dong Ju Choi, Young Keun Ahn, Joon-Han Shin, Se-Joong Rim, Jang-Ho Bae, Dong-Woon Kim
2011 Korean Circulation Journal  
Morning hypertension is closely related to target organ damage and cardiovascular events. Little data is available concerning the baseline characteristics and comprehensive blood pressure analysis of hypertensive patients on treatment with morning hypertension. We evaluated 1,087 hypertensive patients who had taken stable anti-hypertensive medication at least 6 months. The enrolled patients measured their home blood pressure for 7 days. Baseline characteristics and the laboratory data were
more » ... zed. Morning hypertension was defined as a morning blood pressure ≥135/85 mm Hg and systolic or diastolic blood pressure difference between morning and evening exceeding 10 mm Hg. One hundred seventy three patients with morning hypertension showed a preponderance of males, older patients, alcohol consumers, and greater waist circumference and waist-to-hip ratio despite the same body mass index. Impaired fasting glucose and metabolic syndrome were more prevalent in the patients with morning hypertension. The morning hypertensives took more anti-hypertensive drugs and displayed higher blood pressure in the clinic and at home. The worse clinical variables and relatively poorly controlled blood pressure of those with morning hypertension supports a potential relationship of morning hypertension with poor cardiovascular outcome. Morning blood pressure should be monitored at home for the optimal treatment of hypertension.
doi:10.4070/kcj.2011.41.12.733 pmid:22259604 pmcid:PMC3257457 fatcat:xs4lbgluobbydphu6ldkd5ig3q

Arterial stiffness in geriatric medicine

Jeong Bae Park, Kee Sik Kim, Ho Joong Youn, Sang Hong Baek, Kyu Hyung Ryu, Shung Chull Chae, Jang Ho Bae, Jang Ho Bae, Chang Gyu Park, Moo Yong Rhee, Soo Yeun Choi, Dong Ju Choi (+15 others)
2009 Artery Research  
ARTERIAL STIFFNESS IN GERIATRIC MEDICINE Jeong Bae Park, Kee Sik Kim, Ho Joong Youn, Sang Hong Baek, Kyu Hyung Ryu, Shung Chull Chae, Jang Ho Bae, Jang Ho Bae, Chang Gyu Park, Moo Yong Rhee, Soo Yeun Choi  ...  Ahn, Myung Ho Jeong, Jung Gwan Cho, Jung Chaee Kang, Jong Chun Park.  ... 
doi:10.1016/j.artres.2009.06.032 fatcat:7wltlrucvfcexgldteo6jr3kci

Clinical Effects of Hypertension on the Mortality of Patients with Acute Myocardial Infarction

Dong Goo Kang, Myung Ho Jeong, Yongkeun Ahn, Shung Chull Chae, Seung Ho Hur, Taek Jong Hong, Young Jo Kim, In Whan Seong, Jei Keon Chae, Jay Young Rhew, In Ho Chae, Myeong Chan Cho (+7 others)
2009 Journal of Korean medical science  
doi:10.3346/jkms.2009.24.5.800 pmid:19794974 pmcid:PMC2752759 fatcat:ualeqqv7nnhbdf7kh4comma4cu

Cilostazol Eliminates Adverse Smoking Outcome in Patients With Drug-Eluting Stent Implantation

Hack-Lyoung Kim, Jung-Won Suh, Seung-Pyo Lee, Hyun-Jae Kang, Bon-Kwon Koo, Young-Seok Cho, Tae-Jin Youn, In-Ho Chae, Dong-Ju Choi, Seung-Woon Rha, Jang-Ho Bae, Taek-Geun Kwon (+3 others)
2014 Circulation Journal  
The present study investigated whether cilostazol can eliminate adverse smoking outcome after percutaneous coronary intervention (PCI). Methods and Results: A total of 914 patients with successful drug-eluting stent (DES) implantation were randomly assigned to dual antiplatelet therapy (DAT; aspirin and clopidogrel, n=457) or to triple antiplatelet therapy (TAT; DAT with cilostazol, n=457). The effect of smoking on 2-year major adverse cardio/cerebrovascular events (MACCE) in both the TAT and
more » ... T groups was evaluated. Total MACCE were not significantly different between the 2 anti-platelet regimens (9.8% in TAT vs. 11.4% in DAT groups, P=0.45), but the adverse effects of smoking on clinical outcome were different between DAT vs. TAT. Current smokers had a higher prevalence of MACCE than non-smokers in the DAT group (16.7% vs. 9.5%, P=0.04). In the TAT group, however, the adverse effect of smoking was abolished (9.2% vs. 10.1%, P=0.85). Regarding the effects of smoking on the antiplatelet effects of DAT or TAT, post-treatment platelet reactivity (in P2Y12 reaction units; PRU) in current smokers was not significantly lower than that in non-smokers in the DAT group, whereas, in the TAT group, it was significantly lower than that of non-smokers (189±88 vs. 216±89 PRU, P=0.01). Conclusions: Adverse clinical effects of smoking may be eliminated by the addition of cilostazol to DAT after DES implantation. This may be due to the stimulation of cilostazol's antiplatelet effects by smoking. (Circ J 2014; 78: 1420 -1427
doi:10.1253/circj.cj-13-1394 pmid:24694769 fatcat:ompc7l2pvnbtpczjo3citjprwa

Ten-year clinical outcomes in patients with intermediate coronary stenosis according to the combined culprit lesion

Yong Kyun Kim, Chae Won Jang, Soon Ho Kwon, Jae Hoon Kim, Amir Lerman, Jang-Ho Bae
2021 Clinical Cardiology  
We assessed the long-term clinical outcomes of an intermediate lesion (IL) according to the presence of a combined culprit lesion (CCL). Long-term clinical outcomes of IL may be affected by the presence of a CCL. Angiographic findings (n = 1096) and medical chart were reviewed. Patients with IL were divided into two groups: IL without CCL group (n = 383, 64.5%) and IL with CCL group (n = 211, 35.5%). The major adverse cardiovascular events (MACE) in the IL with CCL group were significantly
more » ... r than those in the IL without CCL group (death: 12.3% vs. 7.0%, myocardial infarction: 3.3%vs. 0.5%, stroke: 6.6% vs. 2.6%, and revascularization [RVSC]: 25.1% vs. 7.6%) during a mean follow up period of 118.4 ± 5.5 months. IL related RVSC rate in the IL with CCL group was higher than that in the IL without CCL group (5.7% vs. 2.1%, p = 0.020). RVSC rate related to IL in total subjects was lower than that related to stented lesion (3.4% vs. 6.4%). The important predictors of total MACE in total subjects were the presence of CCL, IL percent diameter stenosis, hypertension, history of percutaneous coronary intervention, blood glucose and ejection fraction. The predictors of IL related RVSC were IL percent diameter stenosis and IL located in the right coronary artery. 10-year clinical outcomes of an IL (especially IL without CCL) were better than those of stented lesions. This study suggests that the IL can be safely followed up in sites that do not have ability to assess functional study.
doi:10.1002/clc.23668 pmid:34133033 fatcat:gtpcbizwzfacrnwji3rh37gm7u

Effectiveness and Safety of Biolimus A9™-Eluting stEnt in Patients with AcUTe Coronary sYndrome; A Multicenter, Observational Study (BEAUTY Study)

Keun-Ho Park, Myung Ho Jeong, Young Joon Hong, Youngkeun Ahn, Hyun Kuk Kim, Young Yub Koh, Doo Il Kim, Sang Wook Kim, Weon Kim, Seung Woon Rha, Jay Young Rhew, Jong Seon Park (+14 others)
2018 Yonsei medical journal  
ORCID Keun-Ho Park Myung Ho Jeong  ... 
doi:10.3349/ymj.2018.59.1.72 pmid:29214779 pmcid:PMC5725367 fatcat:wgaohih5ozevpfjcrrpt2qrc6q

Comparison of Clinical Outcomes Following Acute Myocardial Infarctions in Hypertensive Patients With or Without Diabetes

Min Goo Lee, Myung Ho Jeong, Youngkeun Ahn, Shung Chull Chae, Seung Ho Hur, Taek Jong Hong, Young Jo Kim, In Whan Seong, Jei Keon Chae, Jay Young Rhew, In Ho Chae, Myeong Chan Cho (+10 others)
2009 Korean Circulation Journal  
and Objectives: It is thought that patients with diabetes mellitus (DM) have a poor prognosis after an acute myocardial infarction (AMI), but the effect of diabetes on the outcomes of hypertensive patients with AMIs has not been elucidated in the Korean population. The aim of this study was to investigate the effects of diabetes on longterm clinical outcomes following AMIs in patients with hypertension. Subjects and Methods: Using data from the Korea Acute Myocardial Infarction Registry
more » ... r 2005 to December 2006), 2,233 hypertensive patients with AMIs were grouped as follows based on the presence of DM: group I, diabetic hypertension (n=892, 544 men, mean age=66.2±10.9 years); and group II, non-diabetic hypertension (n=1341, 938 men, mean age=63.9±12.8 years). The primary study outcomes included in-hospital death and major adverse cardiac events (MACE ; cardiac death, myocardial infarction (MI), repeat percutaneous coronary intervention, and coronary artery bypass surgery) at the 1 year follow-up. Results: Hypertensive patients with DM were older and more likely to be women. The diabetic group had lower blood pressure (p<0.001), a lower left ventricular ejection fraction (p<0.001), a more severe degree of heart failure (p<0.001), a longer duration of coronary care unit admission (p<0.001), and a higher incidence of hyperlipidemia (p=0.007). The N-terminal pro-brain natriuretic peptide level (4602.5±8710.6 pg/mL vs. 2320.8 ±5837.9 pg/mL, p<0.001) was higher and the creatinine clearance (62.4±29.9 mL/min vs. 73.0±40.8 mL/min, p<0.001) was lower in the diabetic group than the non-diabetic group. Coronary angiographic findings revealed more frequent involvement of the left main stem (p=0.002) and multiple vessels (p<0.001) in the diabetic group. The rate of in-hospital death was higher in the diabetic group (p<0.001). During follow-up, the rates of composite MACE at 1 month, 6 months, and 12 months were higher in the diabetic group (p<0.001). Conclusion: In hypertensive patients with AMI, DM was associated with worse clinical and angiographic features, with a higher risk of development of severe heart failure, and an increased risk of MACE on long-term clinical follow-up. (Korean Circ J 2009; 39:243-250)
doi:10.4070/kcj.2009.39.6.243 pmid:19949630 pmcid:PMC2771834 fatcat:hwsp4nvy65ez3jmoilfi7j7cma

Clinical outcomes of acute myocardial infarction with occluded left circumflex artery

Sung Soo Kim, Hong Sang Choi, Myung Ho Jeong, Jeong Gwan Cho, Young Keun Ahn, Jong Hyun Kim, Shung Chull Chae, Young Jo Kim, Seung Ho Hur, In Whan Seong, Taek Jong Hong, Donghoon Choi (+8 others)
2011 Journal of Cardiology  
Clinical outcomes of acute myocardial infarction with occluded left circumflex artery 291 Summary: Left circumflex artery (LCX) related acute myocardial infarction (AMI) has been known to be under diagnosed with 12-lead electrocardiogram (ECG). However, there were only a few studies that have focused on the clinical characteristics of LCX-related AMI. We studied the clinical characteristics and hospital mortality in patients with angiographically confirmed LCXrelated AMI. A total of 2281 AMI
more » ... ients with single acutely occluded culprit vessel in coronary angiography (pre-Thrombolysis In Myocardial Infarction flow: 0) were enrolled in the Korea Acute Myocardial Infarction Registry (KAMIR) from November 2005 to January 2008. These patients were divided into three groups according to culprit vessel [left anterior descending artery (LAD), right coronary artery (RCA), and LCX]. This study showed the patients with LCX-related AMI were less likely to present with ST elevation in ECG (46.3%, 87.0%, and 82.3%; p < 0.001) and primary percutaneous coronary intervention (PCI) (43.4%, 78.9%, and 74.5%; p < 0.001) and door to balloon time <90 min (31.3%, 52.8%, and 51.0%; p < 0.001), compared with LAD and RCA. However, no statistical difference was found in hospital mortality among the three groups. Multivariate analysis showed primary PCI decreased the hospital mortality in patients with occluded coronary artery. In conclusion, AMI patients with an occluded LCX presented with less ST elevation and primary PCI. These results suggest that clinical physicians should be careful with patients presenting with chest pain but apparently normal ECG and must rule out LCX occlusion. KEYWORDS 12-Lead surface electrocardiogram; Acute myocardial infarction; Left circumflex coronary artery
doi:10.1016/j.jjcc.2011.01.014 pmid:21388789 fatcat:xjnwarm5zzfktdqftj2bavovlu

Intracardiac Electrogram at Successful Site of Radiofrequency Catheter Ablation in Patients with Atrioventricular Nodal Reentrant Tachycardia

Jang Ho Bae, Yoon Nyun Kim, Kee Sik Kim, Kwon Bae Kim, Jae Ho Park, Sang Min Lee
1998 Korean Circulation Journal  
and Objectives Ablation of the slow pathway in patients with atrioventricular nodal reentrant tachycardia AVNRT can be performed by using a specific intracardiac electrogram findings predicting a successful radiofrequency catheter ablation. The purpose of the present study is to recognize a specific intracardiac electrogram findings predicting a successful sites of radiofrequency catheter ablation in patients with AVNRT. Materials and Methods The study population consisted of the 18 patients 7
more » ... ales, mean age 46 yr to undergo successful catheter ablation using radiofrequency current in order to eliminate AVNRT from January 1993 to september 1994. We have analyzed local intracardiac electrogram at successful and unsuccessful sites of radiofrequency catheter ablation before the radiofrequency application: Atrial electrogram amplitude, duration, number of peaks in atrial electrogram, atrial/ventricular A/V electrogram amplitude ratio, and presence of His potential and/or slow potential. Results Of 18 patients, 16 patients underwent a slow pathway ablation, the other 2 patients a fast pathway ablation. The mean A/V electrogram amplitude ratio at successful and unsuccessful sites was 0.69 0.91 and 1.86 2.03, respectively. The mean atrial electrogram duration and number of peaks at successful and unsuccessful sites was 57 16 msec vs 69 16 msec and 1.7 0.5 vs 2.2 0.7, respectively. His bundle electrogram was seen in one slow pathway ablated and one fast pathway ablated patient. No slow potential could be identified in any of these 18 patients. Conclusion We think that A/V electrocardiogram amplitude ratio below 0.5 at posterior interatrial septum along tricuspid annulus is important marker indicating a successful ablation sites. Korean Circulation J 1998 ; 28 11 : 1852-1860 KEY WORDS Slow pathway·Atrioventricular nodal reentrant tachycardia·Radiofrequency catheter ablation.
doi:10.4070/kcj.1998.28.11.1852 fatcat:4s5ysg73prgufcjar4e4n4mimm

Relationship between arterial stiffness and circadian pattern of blood pressure

Jin-Sun Park, Joon-Han Shin, Jeong-Bae Park, Dong-Ju Choi, Ho-Joong Youn, Chang-Gyu Park, Jun Kwan, Youngkeun Ahn, Dong-Woon Kim, Se-Joong Rim, Seung-Woo Park, Jidong Sung (+1 others)
2019 Medicine  
Conceptualization: Joon-Han Shin, Jeong-Bae Park, Jun Kwan, Jang-Ho Bae.  ...  Data curation: Jeong-Bae Park, Dong-Ju Choi, Ho-Joong Youn, Chang-Gyu Park, Jun Kwan, Youngkeun Ahn, Dong-Woon Kim, Se-Joong Rim, Seung-Woo Park, Jidong Sung, Jang-Ho Bae.  ... 
doi:10.1097/md.0000000000014953 pmid:30896666 pmcid:PMC6709131 fatcat:s4dvrcskyncs7lpsts454wkrva

Naturally formed epitaxial diamond crystals in rubies

Gyeong-Su Park, Sung Chul Bae, Steve Granick, Jang-Ho Lee, Sang-Duk Bae, Taekyung Kim, J.M. Zuo
2007 Diamond and related materials  
Materials inspired by nature comprise a running theme of modern science. Among the crystals that can be formed, diamond is perhaps most emblematic. In the conventional thinking, natural diamonds form only under high-pressure and high-temperature conditions. Here we show a new, natural form of diamond crystals of high quality that are epitaxial with their ruby substrate. Diamonds in rubies are rare; heteroepitaxial diamonds are twice as unexpected. Epitaxy suggests that the natural diamonds in
more » ... e rubies were formed after ruby crystallization in a thermodynamically diamond stable region. This striking natural control over diamond epitaxy suggests a general strategy by which to form naturally-inspired, gemquality crystals.
doi:10.1016/j.diamond.2006.08.031 fatcat:3avvfwxh3jg6xfsjppc4oha644

Development of a bio-electrospray system for cell and non-viral gene delivery

Myung Chul Lee, Hoon Seonwoo, Pankaj Garg, Kyoung Je Jang, Shambhavi Pandey, Hong Bae Kim, Sang Bae Park, Jong Beom Ku, Jang Ho Kim, Ki Taek Lim, Jong Hoon Chung
2018 RSC Advances  
The NVG-BES system facilitated to introduce DNA to cells and delivered cells to a target simultaneously. In this method, a cationic polymer was used as non-viral carrier with electric force by bio-electrospray (BES) system to electrospray living cells onto a target.
doi:10.1039/c7ra12477e pmid:35540421 pmcid:PMC9078360 fatcat:ahutp6dotjbdvhtjnj2goirgem

Enhancing of Osseointegration with Propolis-Loaded TiO2 Nanotubes in Rat Mandible for Dental Implants

Nithideth Somsanith, Yu-Kyoung Kim, Young-Seok Jang, Young-Hee Lee, Ho-Keun Yi, Jong-Hwa Jang, Kyoung-A Kim, Tae-Sung Bae, Min-Ho Lee
2018 Materials  
TiO 2 nanotubes (TNT) formation is beneficial for improving bone cell-material interaction and drug delivery for Ti dental implants. Among the natural drugs to be installed in TNT, selected propolis has antibacterial and anti-inflammatory properties. It is a resinous natural product which is collected by the honeybees from the various types of plants with their salivary enzymes. This study concludes that TNT loaded with a propolis (PL-TNT-Ti) dental implant has the ability to improve
more » ... ation. The propolis particles were embedded within the TNT or adhered to the top. In a cytotoxicity test using osteoblast, PL-TNT-Ti group exhibited an increased cell proliferation and differentiation. A Sprague Dawley rat mandibular model was used to evaluate the osseointegration and bone bonding of TNT or PL-TNT-Ti. From the µ-CT and hematoxylin and eosin (HE) histological results after implantation at 1 and 4 weeks to rat mandibular, an increase in the extent of new bone formation and mineral density around the PL-TNT-Ti implant was confirmed. The Masson's trichrome staining showed the expression of well-formed collagenous for bone formation on the PL-TNT-Ti. Immunohistochemistry staining indicate that bone morphogenetic proteins (BMP-2 and BMP-7) around the PL-TNT-Ti increased the expression of collagen fibers and of osteogenic differentiation whereas the expression of inflammatory cytokine such as interleukin-1 beta (IL-1ß) and tumor necrosis factor-alpha (TNF-α) is decreased. Materials 2018, 11, 61 2 of 14 implantation. Titanium (Ti) is widely used as dental implant materials owing to its low density, good biocompatibility, high corrosion resistance and appropriate mechanical properties [3] . Nevertheless, its bioinert nature warrants more time to achieve complete osseointegration [4] . To overcome this limitation, various physical, chemical, and biochemical treatments are explored to modify the surface of the Ti implant [5] [6] [7] [8] . Anodic oxidation, commonly referred as anodizing, is a simple, versatile and cost-effective surface treatment process to generate nanostructures on Ti and its alloys [9] . It involves electrochemically induced dissolution of titanium along with the formation of oxides of titanium. Depending on the type of electrolytes and treatment conditions, the resultant oxide could be a compact layer or porous layer or in the form of nanotubes [10, 11] . Recent studies on the interaction between bone cells and TiO 2 nanotubes (TNT) have shown that osteoblast adhesion, proliferation and migration are significantly influenced by the nanotube structure [12] . The TiO 2 nanotubes generated by anodizing could promote interaction with osteoblasts by enhancing the bone cell-implant contact area [13] . Furthermore, the nanotube structure has demonstrated benefits for drug delivery and selective release of biomolecules from the implant surface to the surrounding bone as a means of achieving successful dental implantation [14] . One of the major barriers faced after implantation is the possibility of inflammation and its subsequent effects on wound healing and bone bonding. In the expression of macrophages due to external stimuli such as implantation, gram-negative bacteria stimulate the release of lipopolysaccharide (LPS), which is counteracted by the host's immune cells forcing the release of interferon gamma (IFN-γ). In this process, the LPS activates the macrophages resulting in the release of large amounts of reactive oxygen, nitric oxide, and various cytokines [15] . Hence, it is imperative to prevent the acute or chronic inflammatory responses after implantation so that a better healing around the implant as well as improved osseointegration could be achieved [16] . Propolis is a resinous natural product, which contains a mixture of different plant exudates collected by the honeybees from the buds and leaves of various types of trees and plants and the honeybee's salivary enzymes [17] . Its composition is quite complex and the main components of propolis been identified as flavonoids and phenolic esters as caffeic acid phenethyl ester [18, 19] . The biological activity of propolis primarily depends on the compounds from the polyphenolic fractions, particularly the flavonoids, followed by aromatic acids, phenolic acid esters, etc. [18] . The flavonoids isolated from propolis exhibit anti-microbial and antiprotozoal [20] , anti-inflammatory [21], and immunomodulatory [22] activities. The use of propolis is also explored in dental treatment which includes aphthous ulcers, candidiasis, gingivitis, periodontitis and pulpitis [23, 24] . Earlier studies using animal models have shown a significant reduction of acute and chronic inflammation with Ethanolic Extract of Propolis (EEP) [25] [26] [27] [28] [29] . Hence, it is believed that surface modification of Ti based dental implants with propolis might reduce implant-induced inflammations but also enhance osseointegration. Since the use of TNT formed on dental implants has already been established to display better bone cell-material interactions and drug delivery, the present study aims to load propolis on TNT as a drug-delivery system. For in vitro studies the TNT were prepared on Ti plates whereas for in vivo studies using a rat model, the TNT were prepared on a Ti dental implant. Both were loaded with propolis to study the effect of propolis on osseointegration.
doi:10.3390/ma11010061 pmid:29301269 pmcid:PMC5793559 fatcat:c2v4ulqygzfz7ccxfegfcj3xqe

Early Life History of Coreoperca herzi in Han River, Korea

Jae-Min Park, Hyung-Bae Jeon, Ho Young Suk, Seong-Jang Cho, Kyeong-Ho Han
2020 Development & Reproduction  
This study aimed to investigate early life of Coreoperca herzi living in Han River and compare morphological differences between different groups during the development in order to provide basic data for relevant taxonomic research. On average, one female individual spawned 541 to 861 eggs (average 701) at once. After 259 hours, the tail broke out of the egg membrane and hatching began. Immediately after hatching, the larvae were average 7.81±0.10 mm (n=5) in total length. 60 days the juvenile
more » ... as average 35.9±1.30 mm (n=5) in total length. The white spots spread to the rest of the body, rending the same pattern as that on the body of their broodstock fish.
doi:10.12717/dr.2020.24.1.63 pmid:32411919 pmcid:PMC7201061 fatcat:l67pbllutbehxj54ododwuv7vq
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