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A Taxometric Investigation of Unipolar Depression in the National Comorbidity Survey

James J. Prisciandaro, John E. Roberts
2005 Journal of Abnormal Psychology  
J. Ruscio et al.'  ...  Ruscio, 2004; J. Ruscio & Ruscio, 2000) .  ... 
doi:10.1037/0021-843x.114.4.718 pmid:16351392 fatcat:d72xbhpumngihlqqo4tnhrf5se

Brain activation to cocaine cues and motivation/treatment status

James J. Prisciandaro, Aimee L. McRae-Clark, Hugh Myrick, Scott Henderson, Kathleen T. Brady
2012 Addiction Biology  
Prisciandaro was supported by 1F32DA032250-01.  ... 
doi:10.1111/j.1369-1600.2012.00446.x pmid:22458561 pmcid:PMC3390439 fatcat:ydbx4alwxnhhbg52yl7weme6um

The relationship between years of cocaine use and brain activation to cocaine and response inhibition cues

James J. Prisciandaro, Jane E. Joseph, Hugh Myrick, Aimee L. McRae-Clark, Scott Henderson, James Pfeifer, Kathleen T. Brady
2014 Addiction  
Acknowledgments Declarations of Interest Funding for this study was provided by NIH grants F32 DA032250 (Prisciandaro) and R01 DA023188 (Brady); the NIH had no further role in study design; in the collection  ...  Prisciandaro et al.  ... 
doi:10.1111/add.12666 pmid:24938849 pmcid:PMC4229403 fatcat:qa3jtnx5vbegdjcwriap6bftae

Associations between behavioral disinhibition and cocaine use history in individuals with cocaine dependence

James J. Prisciandaro, Jeffrey E. Korte, Aimee L. McRae-Clark, Kathleen T. Brady
2012 Addictive Behaviours  
., 2007; Prisciandaro, McRae-Clark, Moran, Hartwell, & Brady, 2011; Tziortzis et al., 2011) , controlling for gender and age.  ... 
doi:10.1016/j.addbeh.2012.05.015 pmid:22710029 pmcid:PMC3626086 fatcat:yrvj3xabs5ewtlr6hv742pqnae

Psychoticism and neuroticism predict cocaine dependence and future cocaine use via different mechanisms

James J. Prisciandaro, Aimee L. McRae-Clark, Megan M. Moran-Santa Maria, Karen J. Hartwell, Kathleen T. Brady
2011 Drug and Alcohol Dependence  
Background-Personality characteristics have been associated with cocaine use. However, little is known about the mechanisms through which personality could impact drug use. The present study investigated the cross-sectional and prospective relationships between personality dimensions (i.e., impulsivity, neuroticism) and problematic cocaine use. Reactivity to a pharmacological stressor as a potential mediator of the relationship between neuroticism and future cocaine use was also examined.
more » ... s-Participants were 53 cocaine-dependent individuals and 47 non-dependent controls. Subjects completed the Eysenck Personality Questionnaire (EPQ) at baseline and were administered i.v. corticotrophin releasing hormone (CRH; 1 μg/kg). Cocaine use in the 30 days following CRH administration was measured. Results-Cocaine-dependent individuals had higher scores on the psychoticism (i.e., impulsivity, aggression; p = 0.02) and neuroticism (p < 0.01) scales of the EPQ than nondependent controls. Cocaine-dependent individuals also had a greater subjective stress response to CRH than controls (p < 0.01). Cocaine-dependent individuals with elevated psychoticism used significantly more cocaine over the follow-up period (p < 0.05), whereas individuals with elevated neuroticism trended towards using cocaine more frequently over the follow-up (p = 0.07). Finally, there was a trend for an indirect effect of neuroticism on frequency of cocaine use through subjective reactivity to CRH. Conclusions- The findings extend past research on the association between personality and cocaine use, and suggest that motives for cocaine use may systematically vary across personality characteristics. Moreover, tailoring therapeutic interventions to individuals' personalities may be an area that warrants further investigation.
doi:10.1016/j.drugalcdep.2010.11.028 pmid:21306838 pmcid:PMC3105212 fatcat:q6zua24amfhu5kknnyiyqflhwu

Alcohol-Induced Stimulation Mediates the Effect of aGABRA2SNP on Alcohol Self-Administrated among Alcohol-Dependent Individuals

Stephen J. Boyd, Joseph P. Schacht, James J. Prisciandaro, Konstantin Voronin, Raymond F. Anton
2016 Alcohol and Alcoholism  
A single-nucleotide polymorphism (SNP) in GABRA2 (rs279858) may moderate subjective response (SR) to alcohol. Results of studies in non-dependent drinkers examining this GABRA2 SNP on SR have been equivocal. This study examined this SNP's direct and indirect effects on alcohol self-administration in dependent drinkers. Method: The sample consisted of 63 Caucasian, non-treatment-seeking individuals with alcohol dependence. Subjective stimulation was assessed using the Biphasic Alcohol Effects
more » ... le following consumption of an alcoholic priming drink (target breath alcohol content = 0.02 g%). Participants were subsequently offered the opportunity to self-administer up to eight additional drinks. Results: Controlling for baseline stimulation, T-allele homozygotes, relative to individuals with at least one copy of the C-allele, reported greater initial stimulation, t(58) = 2.011, p = 0.049. Greater stimulation predicted greater subsequent alcohol self-administration, t(57) = 2.522, p = 0.015. Although rs279858 genotype did not directly impact self-administration (t(57) = −0.674, p = 0.503), it did have an indirect effect (95% confidence interval [0.068, 1.576]), such that T-allele homozygotes reported greater stimulation, which in turn predicted greater self-administration. Conclusion: These results suggest that the influence of this SNP on SR differs depending on dose or stage of dependence. This study is the first to demonstrate an indirect effect of rs279858 genotype on drinking through SR. Although C-allele carriers have been shown to have an increased risk for alcohol dependence, in our dependent sample, greater stimulation was found among T-allele homozygotes, suggesting that the influence of SR on developing and maintaining dependence differs based on rs279858 genotype. This study demonstrates an indirect effect of rs279858 genotype on drinking through SR. Although C-allele carriers have an increased risk for alcohol dependence, in our dependent sample, greater stimulation was found among T-allele homozygotes, suggesting that the influence of SR on developing dependence differs based on rs279858 genotype.
doi:10.1093/alcalc/agw024 pmid:27117237 pmcid:PMC5004744 fatcat:yrwiurmy3rdrncvvy6aedx7k4i

Real-time fMRI in the treatment of nicotine dependence: A conceptual review and pilot studies

Karen J. Hartwell, James J. Prisciandaro, Jeffery Borckardt, Xingbao Li, Mark S. George, Kathleen T. Brady
2013 Psychology of Addictive Behaviors  
Technical advances allowing for the analysis of fMRI results in real-time have led to studies exploring the ability of individuals to use neural feedback signals to modify behavior and regional brain activation. The use of real-time fMRI (rtfMRI) feedback has been explored for therapeutic benefit in a number of disease states, but to our knowledge the potential therapeutic benefit of rtfMRI feedback in the treatment of addictive disorders has not been explored. This manuscript will provide an
more » ... erview of the development of rtfMRI and discussion of its potential uses in the treatment of addictions. We also describe a series of pilot studies that highlight some of the technical challenges in developing a rtfMRI feedback paradigm for use in addictions, specifically in nicotine dependence. Because the use of rtfMRI feedback is in its infancy, the work described is focused on establishing some of the basic parameters in optimizing the rtfMRI feedback, such as the type of feedback signal, region of interest for feedback and predicting which subjects are most likely to respond well to training. While rtfMRI feedback remains an intriguing possibility for the treatment of addictions, much work remains to be done in establishing its efficacy. Development of Real-time fMRI Feedback: An Overview For the past decade, magnetic resonance imaging (MRI) has been the dominant imaging tool for brain research. Unlike older brain imaging techniques such as positron emission tomography (PET) or single photon emission computed tomography (SPECT), MRI does not use ionizing radiation so it is a relatively low-risk procedure that can be conducted repeatedly without fear of increasing radiation load. In addition, MRI has high spatial resolution and allows for imaging the entire brain in only a few seconds. Initially, MRI was used to examine the structure of the brain, and PET or SPECT were the "tools of choice" for imaging the brain function. However, in the mid-1990's using a technique called blood oxygen level dependent imaging (BOLD), researchers discovered that they could use MRI to image a variant of hemoglobin that changed locally reflecting different activity of the brain. This finding allowed MRI studies to gather information about brain function (fMRI) as well as structure. Because BOLD changes are not very large (approximately 0.5-3% of baseline), early functional MRI studies (fMRI) could not make statements about a single individual. It
doi:10.1037/a0028215 pmid:22564200 pmcid:PMC3646943 fatcat:de5m7yeijnfznhlh2khffvid3e

Impact of Psychiatric Comorbidity on Mortality in Veterans with Type 2 Diabetes

James J. Prisciandaro, Mulugeta Gebregziabher, Anouk L. Grubaugh, Gregory E. Gilbert, Carrae Echols, Leonard E. Egede
2011 Diabetes Technology & Therapeutics  
The reliability of VA mortality data is well supported. 20 74 PRISCIANDARO ET AL.  ...  9 codes in administrative VA databases. 25, 26 One recent study found that using a conceptual approach to grouping diagnoses, similar to the one taken by the present study, provided positive/ 76 PRISCIANDARO  ... 
doi:10.1089/dia.2010.0092 pmid:21175275 pmcid:PMC3025763 fatcat:jjbl36jqxjfeflrh2elolplzci

D-cycloserine combined with cue exposure therapy fails to attenuate subjective and physiological craving in cocaine dependence

Elizabeth J. Santa Ana, James J. Prisciandaro, Michael E. Saladin, Aimee L. McRae-Clark, Stephanie R. Shaftman, Paul J. Nietert, Kathleen T. Brady
2015 American Journal on Addictions  
The authors thank Lisa Jenkins, James Pfeifer, Colleen Reed, and Kate Macia at MUSC for their assistance with study participants.  ...  Am J Addict. Author manuscript; available in PMC 2016 April 01.Demographic and Clinical Characteristics Santa Ana et al. Page 12 Santa Ana et al.  ...  #1 • • craving assessment 2:31 • Biopac heart rate assessment 5 minutes • COC cue manipulation/urge surfing practice • craving assessment 2:48 • craving assessment 3:10 Am J  ... 
doi:10.1111/ajad.12191 pmid:25808169 pmcid:PMC4409457 fatcat:irby67q3rvcelpn37xfmv5owei

Individualized real-time fMRI neurofeedback to attenuate craving in nicotine-dependent smokers
EN

Karen J. Hartwell, Colleen A. Hanlon, Xingbao Li, Jeffrey J. Borckardt, Melanie Canterberry, James J. Prisciandaro, Megan M. Moran-Santa Maria, Todd LeMatty, Mark S. George, Kathleen T. Brady
2016 Journal of Psychiatry & Neuroscience  
Participants were given several J Psychiatry Neurosci 2016;41(1) general suggestions to help reduce their cravings; for example, we instructed them to "try thinking about other things (dinner, what you  ... 
doi:10.1503/jpn.140200 pmid:26505139 pmcid:PMC4688028 fatcat:swjxt72lyjbnngy26xjte3w7pm

Modeling longitudinal drinking data in clinical trials: An application to the COMBINE study

Stacia M. DeSantis, Dipankar Bandyopadhyay, Nathaniel L. Baker, Patrick K. Randall, Raymond F. Anton, James J. Prisciandaro
2013 Drug and Alcohol Dependence  
The hurdle for the observed number of drinks consumed, denoted y ij for person i at week j is written as P(Y ij = y ij ) = p ij if y ij = 0 and if Y ij > 0 where f(y ij )denotes the standard Poisson distribution  ...  ., 2010; Prisciandaro et al., 2012) and Cochrane reviews have demonstrated a lack of consensus in primary outcome definitions across alcohol trials (Srisurapanont and Jarusuraisin, 2008; Rosner et al  ... 
doi:10.1016/j.drugalcdep.2013.02.013 pmid:23566774 pmcid:PMC4025907 fatcat:y77sxp7qcvclvkr3jgfmeuhsn4

Prospective associations between brain activation to cocaine and no-go cues and cocaine relapse

James J. Prisciandaro, Hugh Myrick, Scott Henderson, Aimee L. McRae-Clark, Kathleen T. Brady
2013 Drug and Alcohol Dependence  
Prisciandaro was supported by NIDA F32 DA032250. Addict Biol. 2009; 14:22-31. [PubMed: 18855805] Epstein DH, Willner-Reid J, Vahabzadeh M, Mezghanni M, Lin JL, Preston KL.  ...  Cocaine cue-reactivity paradigm The present investigation utilized a visual cocaine cue-reactivity fMRI paradigm (Prisciandaro et al., 2012) .  ... 
doi:10.1016/j.drugalcdep.2013.04.008 pmid:23683790 pmcid:PMC3703628 fatcat:z6f5be7wb5g6zgjof3vg52s3uq

Dosimetric review of cardiac implantable electronic device patients receiving radiotherapy

Joann I. Prisciandaro, Akash Makkar, Colleen J. Fox, James A. Hayman, Laura Horwood, Frank Pelosi, Jean M. Moran
2015 Journal of Applied Clinical Medical Physics  
Estimated Total Dose Estimated Total Point Dose Journal of Applied Clinical Medical Physics, Vol. 16, No. 1, 2015 Prisciandaro et al.: Assessment of RT patients with CIEDs  ... 
doi:10.1120/jacmp.v16i1.5189 pmid:25679176 fatcat:ryonrhfkmrgrbjrvegtdolqcgm

Impact of DCS-facilitated cue exposure therapy on brain activation to cocaine cues in cocaine dependence

James J. Prisciandaro, Hugh Myrick, Scott Henderson, Aimee L. McRae-Clark, Elizabeth J. Santa Ana, Michael E. Saladin, Kathleen T. Brady
2013 Drug and Alcohol Dependence  
Prisciandaro was supported by NIDA F32 DA032250.  ...  Prisciandaro et al.  ...  of the association between motivation/ treatment status and brain activation to cocaine cues utilizing the present fMRI cocaine cue paradigm provided further support for the validity of the paradigm (Prisciandaro  ... 
doi:10.1016/j.drugalcdep.2013.02.009 pmid:23497788 pmcid:PMC3716842 fatcat:z6fcepl3rbhz3fq2fgxit5qrju

Sustained Reduction of Nicotine Craving With Real-Time Neurofeedback: Exploring the Role of Severity of Dependence

Melanie Canterberry, Colleen A. Hanlon, Karen J. Hartwell, Xingbao Li, Max Owens, Todd LeMatty, James J. Prisciandaro, Jeffrey Borckardt, Michael E. Saladin, Kathleen T. Brady, Mark S. George
2013 Nicotine & Tobacco Research  
Neurofeedback delivered via real-time functional magnetic resonance imaging (rtfMRI) is a promising therapeutic technique being explored to facilitate self-regulation of craving in nicotine-dependent cigarette smokers. The current study examined the role of nicotine-dependence severity and the efficacy of multiple visits of neurofeedback from a single region of interest (ROI) in the anterior cingulate cortex (ACC) on craving reduction. Methods: Nine nicotine-dependent cigarette smokers
more » ... ted in three rtfMRI visits that examined cue-induced craving and brain activation. Severity of nicotine dependence was assessed with the Fagerström Test for Nicotine Dependence. When viewing smoking-related images with instructions to "crave," patient-tailored ROIs were generated in the vicinity of the ACC. Activity levels from the ROI were fed back while participants viewed smoking cues with the instruction to reduce craving. results: Neurofeedback from a single ROI in the ACC led to consistent decreases in self-reported craving and activation in the ACC across the three visits. Dependence severity predicted response to neurofeedback at Visit 3. Conclusions: This study builds upon previous rtfMRI studies on the regulation of nicotine craving in demonstrating that feedback from the ACC can reduce activation to smoking cues across three separate visits. Individuals with lower nicotine-dependence severity were more successful in reducing ACC activation over time. These data highlight the need to consider dependence severity in developing more individualized neurofeedback methods.
doi:10.1093/ntr/ntt122 pmid:23935182 pmcid:PMC3819983 fatcat:x4rcqmyakfhnbls4emnblzdb2y
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