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Primary hepatic choriocarcinoma in a female patient

Makhmud Malikov, Eun Shin, Jai Young Cho, Ho-Seong Han, You-Seok Yoon, Young Rok Choi, Jae Yool Jang, Hanlim Choi, Jae Seong Jang, Seong Uk Kwon, Haeryoung Kim
2015 Korean Journal of Clinical Oncology  
Choriocarcinoma is a germ cell tumor belonging to the spectrum of gestational trophoblastic diseases [1, 2] . It is characterized by wide and rapid hematogenous metastases, usually to the lungs and vagina [3] . It mostly occurs in the gonads and less frequently in extrag-onadal locations, including the mediastinum, retroperitoneum, stomach, or liver as a primary tumor. Primary choriocarcinoma of the mediastinum or stomach is more frequently reported than primary hepatic choriocarcinoma. To our
more » ... nowledge, nine case reports of primary hepatic choriocarcinoma have been published in international journals [4] [5] [6] [7] [8] . In this case report, we describe a patient with primary liver choriocarcinoma and lung metastases. CASE REPORT A 59-year-old woman was referred to our clinic with a history of upper right quadrant pain lasting 1 month. The patient's medical history was unremarkable. Computed tomography (CT) revealed a large hypervascular mass in the right liver (Fig. 1) . Magnetic resonance imaging revealed large masses with tiny daughter nodules in the right lobe of the liver, characteristic of angiosarcoma (Fig. 2) . Cervicovaginal smear was negative for intraepithelial lesions and malignancy. Blood tests on admission revealed a low hemoglobin level (6.5 g/dL). Choriocarcinoma is a germ cell tumor belonging to the spectrum of gestational trophoblastic diseases, and occurs most commonly in the gonads. Primary hepatic choriocarcinoma is very rare, especially in females. A 59-year-old woman was referred to our clinic with a history of upper right quadrant pain lasting 1 month. Computed tomography and magnetic resonance imaging revealed a large hypervascular mass in the right liver, characteristic of angiosarcoma. The patient underwent right hemihepatectomy without unexpected events. Histopathology revealed the tumor as a choriocarcinoma, with numerous syncytiotrophoblasts. Immunohistochemistry was positive for β-human chorionic gonadotropin and CK-19, with a Ki-67 labeling index of 90%. The tumor showed focal positivity for CD31 and human placental lactogen. The patient started chemotherapy (vincristine and cyclophosphamide) on postoperative day 16. The patient's clinical condition improved and she was discharged on postoperative day 17. Primary hepatic choriocarcinoma in female adults is a rare aggressive tumor, and further studies are needed to improve its diagnosis and treatment.
doi:10.14216/kjco.15007 fatcat:u5jffnhvn5gz5gidvx5wlxe3iq

Evaluation of the Mechanical Properties of a 3D-Printed Mortar

Hojae Lee, Jang-Ho Jay Kim, Jae-Heum Moon, Won-Woo Kim, Eun-A Seo
2019 Materials  
The mechanical properties of 3D-printed mortars are determined in terms of their compressive and direct tensile bond strengths. To determine such properties using existing methods, a preliminary experiment was conducted. The compressive strength of the printed mortar was compared to mold-casted specimens and it was found that the compressive strength decreased by ~30%. Among the fabrication variables, an increase in nozzle height negatively influenced the direct tensile bond strength. For the
more » ... me conditions and age, the direct tensile strength decreased by as much as 16–29% when the number of layers increased from 2 to 6. When the specimens were fabricated using a specially designed stainless steel frame and core drill, followed by extraction and the application of physical impact, the 28 days compressive strength of the specimen decreased by ~50%.
doi:10.3390/ma12244104 pmid:31817981 pmcid:PMC6947545 fatcat:473zd4mypnem7pl7xvzfvhsw3i

Minimal Change in Nephrotic Syndrome Associated with Mixed Connective Tissue Disease

Jung A Yoon, Mun Jang, Jai Won Chang, Eun Kyoung Lee
2020 Korean Journal of Medicine  
Mixed connective tissue disease (MCTD) is a rheumatologic disorder that has combined features of systemic lupus erythematosus, systemic sclerosis, and rheumatoid arthritis with the anti-U1 ribonucleoprotein (RNP) antibody. Although renal involvement is not included in any of the diagnostic criteria, it has been observed in 20% of MCTD patients. The most common renal disease is immune complex nephropathy, histologically classified as membranous glomerulonephritis, but minimal change disease
more » ... is very rare and has only been reported once previously. A previously healthy 33-year-old woman presented with generalized edema, puffy hands, arthralgia, and Raynaud's phenomenon. We diagnosed MCD with proteinuria (> 9 g/day) and hypoalbuminemia (< 1.0 g/dL) by renal biopsy, and MCTD with a simultaneously high titer of the anti-U1 RNP antibody. The patient was treated with 200 mg/day cyclosporine and 30 mg/day prednisolone. The proteinuria and hypoalbuminemia normalized 2 months later. We report a patient with severe MCD associated with MCTD.
doi:10.3904/kjm.2020.95.6.409 fatcat:wtbzqz26ozh3hg4qaiumd4hyha

Neurotoxic and Neuroprotective Actions of Catecholamines in Cortical Neurons

Jai Sung Noh, Eun Young Kim, Jang Sook Kang, Hyung Ryong Kim, Young J. Oh, Byoung Joo Gwag
1999 Experimental Neurology  
We examined the possibility that catecholamines (CA) could act as endogenous modulators of neuronal death. Exposure to high doses (G100 M) of dopamine (DA) caused widespread neuronal death within 24 h in mouse cortical cell cultures and was accompanied by cell body shrinkage, aggregation and condensation of nuclear chromatin, and prominent internucleosomal DNA fragmentation. Epinephrine, but not norepinephrine (NE), was slightly toxic to neurons at doses higher than 1 mM. DA-induced death was
more » ... tenuated by the addition of three different anti-apoptosis agents, 1 g/ml cycloheximide, 25 mM K ؉ , or 100 ng/ml brainderived neurotrophic factor (BDNF). While treatment with 100 M N-acetyl-L-cysteine attenuated DA neurotoxicity, neither the glutamate antagonists (10 M MK-801 plus 50 M CNQX) nor several antioxidants [trolox, 100 M; Mn (III) tetrakis (4-benzoic acid) porphyrin chloride, 100 M; Mn (III) tetrakis (1-methyl-4pyridyl) prophyrin pentachloride, 100 M; N-tert-butyl-␣-phenylnitrone, 3 mM] prevented the CA-induced apoptosis. Interestingly, all CA at 1-30 M attenuated free radical-mediated neuronal necrosis following exposure to 30 M Fe 2؉ or 200 M H 2 O 2 , which was insensitive to DA or NE antagonists. Like trolox, CA reduced levels of the stable free radical 1,1-diphenyl-2picrylhydrazyl under cell-free conditions, raising the possibility that CA as an antioxidant protects neurons. We also found that the neuroprotective effect of CA prolonged the protective effects of BDNF against serum deprivation. The present findings suggest that CA induces apoptosis at high doses but prevents free radical-mediated neurotoxicity as an anti-oxidant without being coupled to the receptors. 1999 Academic Press
doi:10.1006/exnr.1999.7144 pmid:10486189 fatcat:2sfooum5kfdo5ok5oken357qqa

Primary Pulmonary T-Cell Lymphoma: a Case Report

Chung Hee Shin, Sang Hyun Paik, Jai Soung Park, Hee Kyung Kim, Sung Il Park, Jang Gyu Cha, Eun Suk Koh
2010 Korean Journal of Radiology  
Primary pulmonary T-cell lymphoma is an extremely rare malady, and we diagnosed this in a 52-year-old male who was admitted to our hospital with cough for the previous two weeks. The chest CT demonstrated multiple variable sized mass-like consolidations with low density central necrosis in the peripheral portion of both the upper and lower lobes. Positron emission tomography (PET) showed multiple areas of hypermetabolic fluorodeoxyglucose (FDG) uptake in both lungs with central metabolic
more » ... , which correlated with central necrosis seen on CT. The histological sample showed peripheral T-cell lymphoma of the not otherwise specified form. The follow-up CT scan showed an increased extent of the multifocal consolidative lesions despite that the patient had undergone chemotherapy. rimary lymphoma of the lung is a rare disorder, and primary pulmonary lymphoma represents only 0.5-1% of all primary pulmonary malignancies, less than 1% of all the cases of non-Hodgkin's lymphoma (NHL) and 3-4% of all the extranodal manifestations of NHL (1). Most of the cases of the primary lymphoma of the lung originate from the B-cell lineage, and the disease is frequently located in the bronchus-associated lymphoid tissue. Very few cases of pulmonary T-cell lymphoma have been reported and the imaging features of this rare cancer have not been well characterized. We report here on an extremely rare case of primary pulmonary peripheral T-cell lymphoma not otherwise specified (PTCLN), and we present the CT and positron emission tomography (PET) images. CASE REPORT A 52-year-old male was admitted to our hospital suffering with cough, fever and sweating for the previous two weeks. There was no history of treatment or medication for diabetes mellitus and hypertension. The patient was a smoker (45 pack-years) and he drank alcohol. On the posteroanterior chest radiograph, variable sized nodules and masses were seen in both lower lobes and the right upper lobe (Fig. 1A) . The contrast enhanced chest CT scan revealed variable sized masses in the right upper lobe and both lower lobes, and the masses displayed central necrosis (Fig. 1B-D) . A small fluid collection was seen in the left hemithorax. No endobronchial lesion was visualized on bronchoscopy. A CT-guided percutaneous transthoracic needle biopsy (PTNB) was done for the mass in the left lower lobe. The histologic examination of the percutaneous transthoracic needle biopsy
doi:10.3348/kjr.2010.11.2.234 pmid:20191072 pmcid:PMC2827788 fatcat:ctsuqh3xfjfbrlnol5pv6cn3nm

Impact of diabetes mellitus on mortality in patients with acute heart failure: a prospective cohort study

Min Gyu Kong, Se Yong Jang, Jieun Jang, Hyun-Jai Cho, Sangjun Lee, Sang Eun Lee, Kye Hun Kim, Byung-Su Yoo, Seok-Min Kang, Sang Hong Baek, Dong-Ju Choi, Eun-Seok Jeon (+7 others)
2020 Cardiovascular Diabetology  
Although more than one-third of the patients with acute heart failure (AHF) have diabetes mellitus (DM), it is unclear if DM has an adverse impact on clinical outcomes. This study compared the outcomes in patients hospitalized for AHF stratified by DM and left ventricular ejection fraction (LVEF). The Korean Acute Heart Failure registry prospectively enrolled and followed 5625 patients from March 2011 to February 2019. The primary endpoints were in-hospital and overall all-cause mortality. We
more » ... aluated the impact of DM on these endpoints according to HF subtypes and glycemic control. During a median follow-up of 3.5 years, there were 235 (4.4%) in-hospital mortalities and 2500 (46.3%) overall mortalities. DM was significantly associated with increased overall mortality after adjusting for potential confounders (adjusted hazard ratio [HR] 1.11, 95% confidence interval [CI] 1.03-1.22). In the subgroup analysis, DM was associated with higher a risk of overall mortality in heart failure with reduced ejection fraction (HFrEF) only (adjusted HR 1.14, 95% CI 1.02-1.27). Inadequate glycemic control (HbA1c ≥ 7.0% within 1 year after discharge) was significantly associated with a higher risk of overall mortality compared with adequate glycemic control (HbA1c < 7.0%) (44.0% vs. 36.8%, log-rank p = 0.016). DM is associated with a higher risk of overall mortality in AHF, especially HFrEF. Well-controlled diabetes (HbA1c < 7.0%) is associated with a lower risk of overall mortality compared to uncontrolled diabetes. Trial registration, NCT01389843. Registered July 6, 2011.
doi:10.1186/s12933-020-01026-3 pmid:32359358 fatcat:n2llznhp2na6rmhxlb53gi63im

Schwannoma of the Appendix: A Case Report

Sung Hwa Jung, Won Kyu Park, Jae Woon Kim, Jay Chun Chang, Han Won Jang, Young Jin Jung, Young Kyoung Bae, Jong Ryul Eun
2006 Journal of the Korean Radiological Society  
Schwannoma is a benign neurogenic tumor arising from the nerve sheath, and it presents as a well defined mass. Isolated gastrointestinal schwannoma is a relatively rare finding and schwannoma of the appendix is extremely rare. We report here on a case of schwannoma that arose from the appendix, and this lesion was pathologically confirmed.
doi:10.3348/jkrs.2006.54.2.127 fatcat:exzvj5fxm5hn7gqnxscaqafnfq

Lumbar Actinomycosis: A Case Report

Min Hee Lee, Jang Gyu Cha, Eun Ju Choo, Kyeong Cheon Jung, Jai Soung Park, Sung Il Park, Sang Hyun Paik, Hae Kyung Lee
2009 Journal of the Korean Society of Radiology  
doi:10.3348/jksr.2009.60.1.41 fatcat:x5xez4elmfgqpcq6uqbgm7nyry

Parameteric Assessment of Water Use Vulnerability of South Korea using SWAT model and TOPSIS

Won Kwyang Jai, Sung Jang Hyun, Chung Eun-Sung
2015 Journal of Korea Water Resources Association  
This study assessed the water use vulnerability for 12 basins of South Korea. The annual runoff of 12 basins are derived using a Soil and Water Assessment Tool (SWAT) and the calculated runoff per unit area and population are compared with each basin. The 18 indicators are selected in order to assess the vulnerability. Those are classified by aspects of demand, loss and supply of water use. Their weighting values used Entropy method to determine objective weights. To quantitatively assess the
more » ... ter use vulnerability, the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) based on multi-criteria decision making are applied. The results show that the water availability vulnerability of Hyeongsan River has the highest value followed by Sapgyo River; Dongjin River; Seomjin River; Anseong River; Mangyung River; Nakdong River; Tamjin River; Youngsan River, Geum River; Taehwa River; and Han River. The result of this study has a capability to provide references for the index deveopment of climate change vulnerability assessment.
doi:10.3741/jkwra.2015.48.8.647 fatcat:ixbtiysfnfc4vgl3gzoq6e6y6q

Proposed Treatment Protocol for Frostbite: A Retrospective Analysis of 17 Cases Based on a 3-Year Single-Institution Experience

Eun-Kyung Woo, Jong Wook Lee, Gi-Yeun Hur, Jang-Hyu Koh, Dong-Kook Seo, Jai-Ku Choi, Young-Chul Jang
2013 Archives of Plastic Surgery  
Woo, Jong Wook Lee, Gi-Yeun Hur, Jang-Hyu Koh, Dong-Kook Seo, Jai-Ku Choi, Young-Chul Jang Department of Plastic and Reconstructive Surgery, Hallym University Hangang Sacred Heart Hospital, Hallym University  ...  frequently climb mountains and are thus more often exposed to extremely cold Proposed Treatment Protocol for Frostbite: A Retrospective Analysis of 17 Cases Based on a 3-Year Single-Institution Experience Eun-Kyung  ... 
doi:10.5999/aps.2013.40.5.510 pmid:24086802 pmcid:PMC3785582 fatcat:q64wzy2frvbvre6wryluezcdvu

Protective role of endogenous plasmalogens against hepatic steatosis and steatohepatitis in mice

Jung Eun Jang, Han-Sol Park, Hyun Ju Yoo, In-Jeoung Baek, Ji Eun Yoon, Myoung Seok Ko, Ah-Ram Kim, Hyoun Sik Kim, Hye-Sun Park, Seung Eun Lee, Seung-Whan Kim, Su Jung Kim (+11 others)
2017 Hepatology  
Ki-Up Lee # These authors contributed equally to this work.
doi:10.1002/hep.29039 pmid:28073164 pmcid:PMC5503808 fatcat:tg2plr5l6ng6pjdwpxlwobqwda

Primary Pleural Synovial Sarcoma with Metastatic Cardiac Involvement: A Case Report

Ji-Hye Won, Susie Chin, Jai Soung Park, Sang Hyun Paik, Heon Lee, Jang Gyu Cha, Hwa Kyoon Shin, Eun Suk Koh
2016 Iranian Journal of Radiology  
Paik, Susie Chin and Ji-Hye Won; drafting of the manuscript: Heon Lee and Ji-Hye Won; critical revision of the manuscript for important intellectual content: Jai Soung Park, Jang Gyu Cha and Sang Hyun  ...  Paik; administrative, technical and material support: Eun Suk Koh, Shin and Susie Chin; study supervision: Jai Soung Park, Sang Hyun Paik and Heon Lee Financial Disclosure: There is nothing to disclose  ... 
doi:10.5812/iranjradiol.41066 pmid:27895882 pmcid:PMC5118976 fatcat:rll65esrtvfvlfvoedv34o62xe

Dependency on Smartphone Use and its Association with Anxiety in Korea

Kyung Eun Lee, Si-Heon Kim, Tae-Yang Ha, Young-Myong Yoo, Jai-Jun Han, Jae-Hyuk Jung, Jae-Yeon Jang
2016 Public health reports (1974)  
Objective. South Korea has the highest rate of smartphone ownership worldwide, which is a potential concern given that smartphone dependency may have deleterious effects on health. We investigated the relationship between smartphone dependency and anxiety. Methods. Participants included 1,236 smartphone-using students (725 men and 511 women) from six universities in Suwon, South Korea. Participants completed measures of smartphone use, smartphone dependency, anxiety, and general characteristics
more » ... (i.e., demographic, health-related, and socioeconomic characteristics). To measure smartphone dependency and anxiety, we used questionnaires of Yang's test developed from Young's Internet Addiction Test and Zung's Self-Rating Anxiety Scale. We used multiple logistic regression to determine the association between smartphone dependency and anxiety after adjusting for relevant factors. Results. On a scale from 25 to 100, with higher scores on the smartphone dependency test indicating greater dependency, women were significantly more dependent on smartphones than were men (mean smartphone dependency score: 50.7 vs. 56.0 for men and women, respectively, p,0.001). However, the amount of time spent using smartphones and the purpose of smartphone use affected smartphone dependency in both men and women. Particularly, when daily use time increased, smartphone dependency showed an increasing trend. Compared with times of use ,2 hours vs. $6 hours, men scored 46.2 and 56.0 on the smartphone dependency test, while women scored 48.0 and 60.4, respectively (p,0.001). Finally, for both men and women, increases in smartphone dependency were associated with increased anxiety scores. With each one-point increase in smartphone dependency score, the risk of abnormal anxiety in men and women increased by 10.1% and 9.2%, respectively (p,0.001). Conclusion. Among this group of university students in South Korea, smartphone dependency appeared to be associated with increased anxiety. Standards for smartphone use might help prevent deleterious health effects.
doi:10.1177/003335491613100307 pmid:27252561 pmcid:PMC4869088 fatcat:uptbkj5dyvegrncwil5iadeohq

Duodenal Metastasis of Pulmonary Pleomorphic Carcinoma: A Case Report

Sun Hye Jeong, Sang Hyun Paik, Nam Seok Lee, Eun Suk Koh, Hwa Kyoon Shin, Jang Gyu Cha, Jai Soung Park
2016 Journal of the Korean Society of Radiology  
4 , Jang Gyu Cha, MD 1 , Jai Soung Park, MD 1 * Departments of 1 Radiology, 3 Pathology, 4 Thoracic Surgery, Soonchunhyang University Bucheon Hospital, Bucheon, Korea Purun Radiologic Clinic, Yesan, Korea  ...  The Duodenal Metastasis of Pulmonary Pleomorphic Carcinoma: A Case Report 십이지장으로 전이된 폐의 다형성 암종 1예 Sun Hye Jeong, MD 1 , Sang Hyun Paik, MD 1 , Nam Seok Lee, MD 2 , Eun Suk Koh, MD 3 , Hwa Kyoon Shin, MD  ... 
doi:10.3348/jksr.2016.74.2.91 fatcat:pjvcrjuhxvhmlaik5dqlhcpt34

Polypoid Endobronchial Lung Cyst with Bronchoscopic Removal : A Case Report

Jung-Hoon Kim, An-Soo Jang, Jong-Sook Park, June-Hyuk Lee, Sung-Woo Park, Eun-Suk Koh, Jai-Soung Park, Choon-Sik Park
2005 Journal of Korean medical science  
Pulmonary bronchogenic cyst in adults is rare and the typical appearance is a sharply circumscribed, round or oval nodule or mass, usually in the medial third of the lungs. Bronchial polyps are rare histopathologically distinct nonneoplastic endobronchial lesions and are classified as multiple papillomas, solitary papillomas, and inflammatory polyps. We herein report a patient with polypoid endobronchial lung cyst. A 68-yr-old woman presented with a discomfort and pain in the right upper chest
more » ... f four weeks' duration. Chest radiography revealed a cystic lesion in the right upper lung. Computed tomography revealed a 4× ×5 cm sized large cyst. Neither enlarged mediastinal lymph nodes nor extrabronchial involvements were observed. Flexible bronchoscopy revealed a peduncular polyp about 2 cm in length originating from the anterior segment of right upper lung. After bronchoscopic removal of polyp, cystic lesion of the right upper lung disappeared.
doi:10.3346/jkms.2005.20.5.892 pmid:16224170 pmcid:PMC2779293 fatcat:kddfonlbqvcdfnaca77um2biqe
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