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Pictorial review of cardiac sarcomas and their mimickers
2014
Cancer Imaging
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• Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit this article as: Frank and Stojanovska: Pictorial review of cardiac sarcomas and their ...
doi:10.1186/1470-7330-14-s1-p36
fatcat:7q6lm2vsobgqhf75kmqtrfsrua
2370
2017
Journal of Clinical and Translational Science
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Further staining and analysis of the complete patient cohort (n = 120) is ongoing.
2370 Understanding epicardial fat biology by imaging Jadranka Stojanovska, Thomas Chenevert, Alex Tsodikov, Carey Lumeng ...
doi:10.1017/cts.2017.225
fatcat:vbt5dvvowvg2dbcazdniftvhgm
Diastolic Cardiac Function by MRI—Imaging Capabilities and Clinical Applications
2021
Tomography
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Most cardiac studies focus on evaluating left ventricular (LV) systolic function. However, the assessment of diastolic cardiac function is becoming more appreciated, especially with the increasing prevalence of pathologies associated with diastolic dysfunction like heart failure with preserved ejection fraction (HFpEF). Diastolic dysfunction is an indication of abnormal mechanical properties of the myocardium, characterized by slow or delayed myocardial relaxation, abnormal LV distensibility,
doi:10.3390/tomography7040075
pmid:34941647
pmcid:PMC8706325
fatcat:bq6xpdxdpbeo5nqrjazfqu4kti
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... d/or impaired LV filling. Diastolic dysfunction has been shown to be associated with age and other cardiovascular risk factors such as hypertension and diabetes mellitus. In this context, cardiac magnetic resonance imaging (MRI) has the capability for differentiating between normal and abnormal myocardial relaxation patterns, and therefore offers the prospect of early detection of diastolic dysfunction. Although diastolic cardiac function can be assessed from the ratio between early and atrial filling peaks (E/A ratio), measuring different parameters of heart contractility during diastole allows for evaluating spatial and temporal patterns of cardiac function with the potential for illustrating subtle changes related to age, gender, or other differences among different patient populations. In this article, we review different MRI techniques for evaluating diastolic function along with clinical applications and findings in different heart diseases.
Virtual Reality Tool Simulates MRI Experience
2018
Tomography
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Magnetic resonance imaging (MRI) is an extremely useful tool for the detection and characterization of numerous pathologic processes. Although patients can benefit from the use of MRI, claustrophobia is a major issue in some cases. This fear alone can lead to cancellation of the scanning procedure in some cases and the need for conscious sedation in others. Patient anxiety during the scan can also lead to increased motion-related artifacts on the images with associated degradation of the
doi:10.18383/j.tom.2018.00023
pmid:30320208
pmcid:PMC6173786
fatcat:rc6nhhl2pncp7gl7a5tfiprg6q
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... tic quality of the study. To alleviate these problems, our team developed a virtual reality (VR) tool (app) to educate patients about MRI and simulate the experience of actually being scanned. The app is totally immersive and incorporates both the visual and auditory sensations that patients encounter during an MRI scan. Patients also learn about potential conditions and implanted devices that may preclude the safe performance of the examination. This VR tool not only educates patients about MRI and its importance in their care, but also allows them to virtually experience what it is like to have a MRI scan. This technology has the potential to decrease both claustrophobic cancellations and patient anxiety before a MRI scan.
3266 Understanding epicardial adipose biology by imaging, transcriptomic, and lipidomic profiling
2019
Journal of Clinical and Translational Science
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Stojanovska 1 , Alex Tsodikov, Carey Lumeng, Charles Burant and Thomas Chenevert 1 University of Michigan School of Medicine OBJECTIVES/SPECIFIC AIMS: The study aims to understand if pro inflammatory ...
activity and increasing adherence to the hemodialysis diet in patients with ESRD living in Puerto Rico.
3266 Understanding epicardial adipose biology by imaging, transcriptomic, and lipidomic profiling Jadranka ...
doi:10.1017/cts.2019.361
fatcat:z24xqq4kcnfn3kgyaxvszjornq
Validation of a New Physical Activity Questionnaire for a Sedentary Population
2011
Digestive Diseases and Sciences
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Background-Many available physical activity questionnaires (PAQs) are limited due to either focus on recreational activities or burdensome length. Aims-We sought to assess the reliability and validity of a new short PAQ that captures all activity types. Methods- The 12-item multiple-choice PAQ-M included eight activity domains, providing a total Physical Activity Score (PAS-M) in kcal/kg/week. The new PAQ-M was administered with the previously validated Paffenbarger PAQ to 426 men, ages 50-79,
doi:10.1007/s10620-011-1641-y
pmid:21409377
pmcid:PMC3371338
fatcat:3jtuxnngjjgcpatmjcyq4n2qqi
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... ndergoing colon-cancer screening. Results-The PAQ-M had excellent test-retest reliability (intraclass correlation = 0.87). The PAS-M was moderately correlated with the Paffenbarger Physical Activity Score (PAS-P) (r = 0.31) and inversely correlated with BMI (r = −0.14) and waist circumference (r = −0.17). Adenoma prevalence was inversely associated with the PAS-M (3rd vs. 1st tertile adjusted odds ratio, 0.46; 95% confidence interval, 0.26-0.84) but not with the PAS-P. Conclusions-Our new short physical activity questionnaire has excellent test-retest reliability, and was correlated moderately with a widely used physical activity questionnaire and obesity measures. Furthermore, the new PAQ was a better predictor of adenoma prevalence in the expected direction than the Paffenbarger questionnaire in this largely sedentary population.
Value CMR: Towards a Comprehensive, Rapid, Cost-Effective Cardiovascular Magnetic Resonance Imaging
[article]
2020
medRxiv
pre-print
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CMR is considered the gold standard for measuring heart function, including cardiac volumes and mass. Further, in a single CMR exam, information about cardiac function, structure, tissue composition, and blood flow could be obtained. Nevertheless, CMR is underutilized due to long scanning times, the need for multiple breath-holds, use of a contrast agent, and relatively higher cost compared to echocardiography. In this study, we propose a rapid CMR exam based on recent developments in imaging
doi:10.1101/2020.10.09.20204305
fatcat:aug6azgwgbcp3msacr5uen3o3y
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... quences. The proposed exam is both rapid and provides comprehensive cardiovascular information without the need for a contrast agent or multiple breath-holds. The developed exam includes advanced sequences for evaluating global and regional cardiac functions, myocardial tissue characterization, and flow hemodynamics in the heart, valves, and large vessels. Time-consuming conventional sequences have been replaced by advanced sequences, which resulted in reducing scan time from > 1 hour with conventional CMR exam to <20 minutes with the proposed rapid CMR exam. Specifically, conventional two-dimensional (2D) cine and phase-contrast (PC) sequences have been replaced by optimized three-dimensional (3D)-cine and four-dimensional (4D)-flow sequences, respectively. Compared to 2D cine imaging that requires 12-16 separate breath-holds, the implemented 3D-cine sequence allows for whole heart coverage in 1-2 breath-holds; thus, reducing scan time by 80-90%. Similarly, compared to 2D PC flow imaging that requires multiple breath-holds and the presence of an experienced cardiac operator for precise prescription of the imaging planes, the implemented 4D-flow sequence allows for whole-chest coverage in ~10-minute, free-breathing acquisition without the need for a navigator echo, which makes scan time independent of the patient breathing pattern. Furthermore, conventional myocardial tagging has been replaced by the fast strain-encoding (SENC) sequence, which reduces scan time from one slice per breath-hold to only one slice per heartbeat (~1 second). Finally, T1 and T2 mapping sequences are included in this proposed exam, which allow for myocardial tissue characterization without the need for contrast. The proposed rapid exam has been tested on volunteers and measurements showed good agreement with those from conventional sequences despite the significant reduction in scan time. In conclusion, we propose a rapid, contrast-free, and comprehensive cardiovascular exam that does not require repeated breath-holds or a cardiac experienced operator to run the exam, which would result in improving cost effectiveness of CMR and increasing its adoption in clinical practice.
CMR for evaluation of cardiac function in Type-1 diabetes
2016
Journal of Cardiovascular Magnetic Resonance
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Sodium magnetic resonance imaging of chemotherapeutic response in a rat glioma
2004
Magnetic Resonance in Medicine
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This study investigates the comparative changes in the sodium MRI signal and proton diffusion following treatment using a 9L rat glioma model to develop markers of earliest response to cancer therapy. Sodium MRI and proton diffusion mapping were performed on untreated (n ؍ 5) and chemotherapy 1,3bis(2-chloroethyl)-1-nitrosourea-treated rats (n ؍ 5). Animals were scanned serially at 2-to 3-day intervals for up to 30 days following therapy. The time course of Na concentration in a tumor
doi:10.1002/mrm.20332
pmid:15690506
pmcid:PMC3121241
fatcat:osabmp5agjeklgyynebyalm54y
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... a dramatic increase in the treated brain tumor compared to the untreated tumor, which correlates in time with an increase in tumor water diffusion. The largest posttreatment increase in sodium signal occurred 7-9 days following treatment and correlated to the period of the greatest chemotherapy-induced cellular necrosis based on diffusion and histopathology. Both Na MRI and proton ADC mapping revealed early changes in tumor sodium content and cellularity. This study demonstrates the possibility of Na MRI to function as a biomarker for monitoring early tumor treatment and validates the use of monitoring changes in diffusion MRI values for assessing tumor cellularity. Magn Reson Med 53:85-92, 2005.
Increased Epicardial Fat Volume Is Independently Associated with the Presence and Severity of Systemic Sclerosis
2017
Academic Radiology
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Stojanovska is funded by NIH Post-doctoral translational science program training grant UL1TR000433 and F043322. We acknowledge Aishwarya Parameswaran M.S. from MICHR for statistical support. ...
doi:10.1016/j.acra.2017.07.003
pmid:28847640
pmcid:PMC5725270
fatcat:zhilzkhx2zgbjo6cgruatglbiy
Congenital and Hereditary Causes of Sudden Cardiac Death in Young Adults: Diagnosis, Differential Diagnosis, and Risk Stratification
2013
Radiographics
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Computer-Aided Diagnosis of Lung Nodules on CT Scans:
2010
Academic Radiology
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Rationale and Objectives-The aim of this study was to evaluate the effect of computer-aided diagnosis (CAD) on radiologists' estimates of the likelihood of malignancy of lung nodules on computed tomographic (CT) imaging. Methods and Materials-A total of 256 lung nodules (124 malignant, 132 benign) were retrospectively collected from the thoracic CT scans of 152 patients. An automated CAD system was developed to characterize and provide malignancy ratings for lung nodules on CT volumetric
doi:10.1016/j.acra.2009.10.016
pmid:20152726
pmcid:PMC3767437
fatcat:2fvi36hpwrab7mrcmk4beoxxvm
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... An observer study was conducted using receiver-operating characteristic analysis to evaluate the effect of CAD on radiologists' characterization of lung nodules. Six fellowshiptrained thoracic radiologists served as readers. The readers rated the likelihood of malignancy on a scale of 0% to 100% and recommended appropriate action first without CAD and then with CAD. The observer ratings were analyzed using the Dorfman-Berbaum-Metz multireader, multicase method. Results-The CAD system achieved a test area under the receiver-operating characteristic curve (A z ) of 0.857 ± 0.023 using the perimeter, two nodule radii measures, two texture features, and two gradient field features. All six radiologists obtained improved performance with CAD. The average A z of the radiologists improved significantly (P < .01) from 0.833 (range, 0.817-0.847) to 0.853 (range, 0.834-0.887). Conclusion-CAD has the potential to increase radiologists' accuracy in assessing the likelihood of malignancy of lung nodules on CT imaging. Keywords Computer-aided diagnosis; pulmonary nodule; observer study; computed tomography The use of computed tomographic (CT) imaging for lung cancer screening is an area of active research. CT imaging has been shown to be more sensitive for lung nodule detection than chest x-ray, especially for smaller nodules (1-4). Henschke et al (5) reported a 92% survival rate among patients who underwent surgical resection for detected stage I lung cancers. Sobue et al (6) reported an almost 100% 5-year survival rate for patients with nodules < 9 mm in size. These data suggest the benefits of earlier intervention with early
Thoracic central venous evaluation: comparison of first-pass direct versus delayed-phase indirect multidetector CT venography
2015
Clinical imaging
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Purpose-To compare first pass and delayed phase thoracic Computed Tomography (CT) venography for the evaluation of suspected central thoracic venous pathology. Material and methods-CT images and medical records of all patients who underwent thoracic CT venography over a five year period were retrospectively reviewed. Both first pass (18 seconds) and delayed phase (60 seconds) venous images were obtained in all patients. The images were reviewed in random order by three readers using a
doi:10.1016/j.clinimag.2015.02.005
pmid:25724223
pmcid:PMC4412308
fatcat:qw5xfgikazg2xgk3tdmrllc6dy
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... itative visual grading scheme for image quality, including artifacts and the uniformity of venous enhancement. In addition, enhancement was quantitatively evaluated. The presence and type of venous pathology, and overall diagnostic confidence were recorded and compared. Reference verification was performed when available. Results-18 patients formed the study group, mean age 49.5 years and 28% male. Dual arm injection was successful in 72% of exams. All readers reported more streak artifacts on first pass imaging than delayed imaging (72-94% vs. 27-44% respectively; p < 0.05). First pass imaging had significantly higher measured enhancement across all central venous segments than delayed imaging (mean HU range: 212-906 HU vs. 173-414 HU; p < 0.05), but also had significantly more heterogeneous enhancement (mean SD range 75-1058 HU vs. 67-378 HU; p <0.05). For overall diagnosis, reader agreement, accuracy and confidence levels were higher for delayed phase images (p < 0.05). Conclusion-Indirect thoracic CT venography using delayed phase imaging alone may be sufficient for evaluating clinically suspected central venous abnormality.
Safety of CMR in patients with cardiac implanted electronic devices
2016
Journal of Cardiovascular Magnetic Resonance
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Safety of CMR in patients with cardiac implanted electronic devices El-Sayed H Ibrahim 1* , Laura Horwood 1 , Jadranka Stojanovska 1 , Anil Attili 1 , Luba Frank 2 , Hakan Oral 1 , Frank Bogun 1 From 19th ...
doi:10.1186/1532-429x-18-s1-o123
fatcat:3vwrzts6hbby3fonvxcwtdrsym
HARP Versus SinMod for measuring regional heart function from tagged CMR images
2016
Journal of Cardiovascular Magnetic Resonance
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