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Pictorial review of cardiac sarcomas and their mimickers

Luba Frank, Jadranka Stojanovska
2014 Cancer Imaging  
• Research which is freely available for redistribution Submit your manuscript at this article as: Frank and Stojanovska: Pictorial review of cardiac sarcomas and their  ... 
doi:10.1186/1470-7330-14-s1-p36 fatcat:7q6lm2vsobgqhf75kmqtrfsrua


Jadranka Stojanovska, Thomas Chenevert, Alex Tsodikov, Carey Lumeng, Charles Burant
2017 Journal of Clinical and Translational Science  
Further staining and analysis of the complete patient cohort (n = 120) is ongoing. 2370 Understanding epicardial fat biology by imaging Jadranka Stojanovska, Thomas Chenevert, Alex Tsodikov, Carey Lumeng  ... 
doi:10.1017/cts.2017.225 fatcat:vbt5dvvowvg2dbcazdniftvhgm

Diastolic Cardiac Function by MRI—Imaging Capabilities and Clinical Applications

El-Sayed H. Ibrahim, Jennifer Dennison, Luba Frank, Jadranka Stojanovska
2021 Tomography  
Most cardiac studies focus on evaluating left ventricular (LV) systolic function. However, the assessment of diastolic cardiac function is becoming more appreciated, especially with the increasing prevalence of pathologies associated with diastolic dysfunction like heart failure with preserved ejection fraction (HFpEF). Diastolic dysfunction is an indication of abnormal mechanical properties of the myocardium, characterized by slow or delayed myocardial relaxation, abnormal LV distensibility,
more » ... d/or impaired LV filling. Diastolic dysfunction has been shown to be associated with age and other cardiovascular risk factors such as hypertension and diabetes mellitus. In this context, cardiac magnetic resonance imaging (MRI) has the capability for differentiating between normal and abnormal myocardial relaxation patterns, and therefore offers the prospect of early detection of diastolic dysfunction. Although diastolic cardiac function can be assessed from the ratio between early and atrial filling peaks (E/A ratio), measuring different parameters of heart contractility during diastole allows for evaluating spatial and temporal patterns of cardiac function with the potential for illustrating subtle changes related to age, gender, or other differences among different patient populations. In this article, we review different MRI techniques for evaluating diastolic function along with clinical applications and findings in different heart diseases.
doi:10.3390/tomography7040075 pmid:34941647 pmcid:PMC8706325 fatcat:bq6xpdxdpbeo5nqrjazfqu4kti

Virtual Reality Tool Simulates MRI Experience

Richard K J Brown, Sean Petty, Stephanie O'Malley, Jadranka Stojanovska, Matthew S Davenport, Ella A Kazerooni, Daniel Fessahazion
2018 Tomography  
Magnetic resonance imaging (MRI) is an extremely useful tool for the detection and characterization of numerous pathologic processes. Although patients can benefit from the use of MRI, claustrophobia is a major issue in some cases. This fear alone can lead to cancellation of the scanning procedure in some cases and the need for conscious sedation in others. Patient anxiety during the scan can also lead to increased motion-related artifacts on the images with associated degradation of the
more » ... tic quality of the study. To alleviate these problems, our team developed a virtual reality (VR) tool (app) to educate patients about MRI and simulate the experience of actually being scanned. The app is totally immersive and incorporates both the visual and auditory sensations that patients encounter during an MRI scan. Patients also learn about potential conditions and implanted devices that may preclude the safe performance of the examination. This VR tool not only educates patients about MRI and its importance in their care, but also allows them to virtually experience what it is like to have a MRI scan. This technology has the potential to decrease both claustrophobic cancellations and patient anxiety before a MRI scan.
doi:10.18383/j.tom.2018.00023 pmid:30320208 pmcid:PMC6173786 fatcat:rc6nhhl2pncp7gl7a5tfiprg6q

3266 Understanding epicardial adipose biology by imaging, transcriptomic, and lipidomic profiling

Jadranka Stojanovska, Alex Tsodikov, Carey Lumeng, Charles Burant, Thomas Chenevert
2019 Journal of Clinical and Translational Science  
Stojanovska 1 , Alex Tsodikov, Carey Lumeng, Charles Burant and Thomas Chenevert 1 University of Michigan School of Medicine OBJECTIVES/SPECIFIC AIMS: The study aims to understand if pro inflammatory  ...  activity and increasing adherence to the hemodialysis diet in patients with ESRD living in Puerto Rico. 3266 Understanding epicardial adipose biology by imaging, transcriptomic, and lipidomic profiling Jadranka  ... 
doi:10.1017/cts.2019.361 fatcat:z24xqq4kcnfn3kgyaxvszjornq

Validation of a New Physical Activity Questionnaire for a Sedentary Population

Joel H. Rubenstein, Hal Morgenstern, Joan Kellenberg, Tal Kalish, Jena Donovan, John Inadomi, Daniel McConnell, Jadranka Stojanovska, Philip Schoenfeld
2011 Digestive Diseases and Sciences  
Background-Many available physical activity questionnaires (PAQs) are limited due to either focus on recreational activities or burdensome length. Aims-We sought to assess the reliability and validity of a new short PAQ that captures all activity types. Methods- The 12-item multiple-choice PAQ-M included eight activity domains, providing a total Physical Activity Score (PAS-M) in kcal/kg/week. The new PAQ-M was administered with the previously validated Paffenbarger PAQ to 426 men, ages 50-79,
more » ... ndergoing colon-cancer screening. Results-The PAQ-M had excellent test-retest reliability (intraclass correlation = 0.87). The PAS-M was moderately correlated with the Paffenbarger Physical Activity Score (PAS-P) (r = 0.31) and inversely correlated with BMI (r = −0.14) and waist circumference (r = −0.17). Adenoma prevalence was inversely associated with the PAS-M (3rd vs. 1st tertile adjusted odds ratio, 0.46; 95% confidence interval, 0.26-0.84) but not with the PAS-P. Conclusions-Our new short physical activity questionnaire has excellent test-retest reliability, and was correlated moderately with a widely used physical activity questionnaire and obesity measures. Furthermore, the new PAQ was a better predictor of adenoma prevalence in the expected direction than the Paffenbarger questionnaire in this largely sedentary population.
doi:10.1007/s10620-011-1641-y pmid:21409377 pmcid:PMC3371338 fatcat:3jtuxnngjjgcpatmjcyq4n2qqi

Value CMR: Towards a Comprehensive, Rapid, Cost-Effective Cardiovascular Magnetic Resonance Imaging [article]

El-Sayed H Ibrahim, Luba Frank, Dhiraj Baruah, Jason Rubenstein, V Emre Arpinar, Andrew Nencka, Kevin Koch, L Tugan Muftuler, Orhan Unal, Jadranka Stojanovska, John Charlson, Elizabeth Gore (+1 others)
2020 medRxiv   pre-print
CMR is considered the gold standard for measuring heart function, including cardiac volumes and mass. Further, in a single CMR exam, information about cardiac function, structure, tissue composition, and blood flow could be obtained. Nevertheless, CMR is underutilized due to long scanning times, the need for multiple breath-holds, use of a contrast agent, and relatively higher cost compared to echocardiography. In this study, we propose a rapid CMR exam based on recent developments in imaging
more » ... quences. The proposed exam is both rapid and provides comprehensive cardiovascular information without the need for a contrast agent or multiple breath-holds. The developed exam includes advanced sequences for evaluating global and regional cardiac functions, myocardial tissue characterization, and flow hemodynamics in the heart, valves, and large vessels. Time-consuming conventional sequences have been replaced by advanced sequences, which resulted in reducing scan time from > 1 hour with conventional CMR exam to <20 minutes with the proposed rapid CMR exam. Specifically, conventional two-dimensional (2D) cine and phase-contrast (PC) sequences have been replaced by optimized three-dimensional (3D)-cine and four-dimensional (4D)-flow sequences, respectively. Compared to 2D cine imaging that requires 12-16 separate breath-holds, the implemented 3D-cine sequence allows for whole heart coverage in 1-2 breath-holds; thus, reducing scan time by 80-90%. Similarly, compared to 2D PC flow imaging that requires multiple breath-holds and the presence of an experienced cardiac operator for precise prescription of the imaging planes, the implemented 4D-flow sequence allows for whole-chest coverage in ~10-minute, free-breathing acquisition without the need for a navigator echo, which makes scan time independent of the patient breathing pattern. Furthermore, conventional myocardial tagging has been replaced by the fast strain-encoding (SENC) sequence, which reduces scan time from one slice per breath-hold to only one slice per heartbeat (~1 second). Finally, T1 and T2 mapping sequences are included in this proposed exam, which allow for myocardial tissue characterization without the need for contrast. The proposed rapid exam has been tested on volunteers and measurements showed good agreement with those from conventional sequences despite the significant reduction in scan time. In conclusion, we propose a rapid, contrast-free, and comprehensive cardiovascular exam that does not require repeated breath-holds or a cardiac experienced operator to run the exam, which would result in improving cost effectiveness of CMR and increasing its adoption in clinical practice.
doi:10.1101/2020.10.09.20204305 fatcat:aug6azgwgbcp3msacr5uen3o3y

CMR for evaluation of cardiac function in Type-1 diabetes

El-Sayed H Ibrahim, Jadranka Stojanovska, Scott Swanson, Claire Duvernoy, Rodica Pop-Busui
2016 Journal of Cardiovascular Magnetic Resonance  
doi:10.1186/1532-429x-18-s1-p150 fatcat:5xc33weopfgyzeg4kln7pe4dh4

Sodium magnetic resonance imaging of chemotherapeutic response in a rat glioma

Victor D. Schepkin, Brian D. Ross, Thomas L. Chenevert, Alnawaz Rehemtulla, Surabhi Sharma, Mahesh Kumar, Jadranka Stojanovska
2004 Magnetic Resonance in Medicine  
This study investigates the comparative changes in the sodium MRI signal and proton diffusion following treatment using a 9L rat glioma model to develop markers of earliest response to cancer therapy. Sodium MRI and proton diffusion mapping were performed on untreated (n ‫؍‬ 5) and chemotherapy 1,3bis(2-chloroethyl)-1-nitrosourea-treated rats (n ‫؍‬ 5). Animals were scanned serially at 2-to 3-day intervals for up to 30 days following therapy. The time course of Na concentration in a tumor
more » ... a dramatic increase in the treated brain tumor compared to the untreated tumor, which correlates in time with an increase in tumor water diffusion. The largest posttreatment increase in sodium signal occurred 7-9 days following treatment and correlated to the period of the greatest chemotherapy-induced cellular necrosis based on diffusion and histopathology. Both Na MRI and proton ADC mapping revealed early changes in tumor sodium content and cellularity. This study demonstrates the possibility of Na MRI to function as a biomarker for monitoring early tumor treatment and validates the use of monitoring changes in diffusion MRI values for assessing tumor cellularity. Magn Reson Med 53:85-92, 2005.
doi:10.1002/mrm.20332 pmid:15690506 pmcid:PMC3121241 fatcat:osabmp5agjeklgyynebyalm54y

Increased Epicardial Fat Volume Is Independently Associated with the Presence and Severity of Systemic Sclerosis

Benjamin D. Long, Jadranka Stojanovska, Richard K.J. Brown, Anil K. Attili, Eizabeth A. Jackson, Vladimir Ognenovski
2017 Academic Radiology  
Stojanovska is funded by NIH Post-doctoral translational science program training grant UL1TR000433 and F043322. We acknowledge Aishwarya Parameswaran M.S. from MICHR for statistical support.  ... 
doi:10.1016/j.acra.2017.07.003 pmid:28847640 pmcid:PMC5725270 fatcat:zhilzkhx2zgbjo6cgruatglbiy

Congenital and Hereditary Causes of Sudden Cardiac Death in Young Adults: Diagnosis, Differential Diagnosis, and Risk Stratification

Jadranka Stojanovska, Anubhav Garg, Smita Patel, David M. Melville, Ella A. Kazerooni, Gisela C. Mueller
2013 Radiographics  
doi:10.1148/rg.337125073 pmid:24224591 fatcat:dktbk6kkkzhyxkvnoehdod55py

Computer-Aided Diagnosis of Lung Nodules on CT Scans:

Ted Way, Heang-Ping Chan, Lubomir Hadjiiski, Berkman Sahiner, Aamer Chughtai, Thomas K. Song, Chad Poopat, Jadranka Stojanovska, Luba Frank, Anil Attili, Naama Bogot, Philip N. Cascade (+1 others)
2010 Academic Radiology  
Rationale and Objectives-The aim of this study was to evaluate the effect of computer-aided diagnosis (CAD) on radiologists' estimates of the likelihood of malignancy of lung nodules on computed tomographic (CT) imaging. Methods and Materials-A total of 256 lung nodules (124 malignant, 132 benign) were retrospectively collected from the thoracic CT scans of 152 patients. An automated CAD system was developed to characterize and provide malignancy ratings for lung nodules on CT volumetric
more » ... An observer study was conducted using receiver-operating characteristic analysis to evaluate the effect of CAD on radiologists' characterization of lung nodules. Six fellowshiptrained thoracic radiologists served as readers. The readers rated the likelihood of malignancy on a scale of 0% to 100% and recommended appropriate action first without CAD and then with CAD. The observer ratings were analyzed using the Dorfman-Berbaum-Metz multireader, multicase method. Results-The CAD system achieved a test area under the receiver-operating characteristic curve (A z ) of 0.857 ± 0.023 using the perimeter, two nodule radii measures, two texture features, and two gradient field features. All six radiologists obtained improved performance with CAD. The average A z of the radiologists improved significantly (P < .01) from 0.833 (range, 0.817-0.847) to 0.853 (range, 0.834-0.887). Conclusion-CAD has the potential to increase radiologists' accuracy in assessing the likelihood of malignancy of lung nodules on CT imaging. Keywords Computer-aided diagnosis; pulmonary nodule; observer study; computed tomography The use of computed tomographic (CT) imaging for lung cancer screening is an area of active research. CT imaging has been shown to be more sensitive for lung nodule detection than chest x-ray, especially for smaller nodules (1-4). Henschke et al (5) reported a 92% survival rate among patients who underwent surgical resection for detected stage I lung cancers. Sobue et al (6) reported an almost 100% 5-year survival rate for patients with nodules < 9 mm in size. These data suggest the benefits of earlier intervention with early
doi:10.1016/j.acra.2009.10.016 pmid:20152726 pmcid:PMC3767437 fatcat:2fvi36hpwrab7mrcmk4beoxxvm

Thoracic central venous evaluation: comparison of first-pass direct versus delayed-phase indirect multidetector CT venography

Baskaran Sundaram, Jean W. Kuriakose, Jadranka Stojanovska, Kuanwong Watcharotone, Robert A. Parker, Ella A. Kazerooni
2015 Clinical imaging  
Purpose-To compare first pass and delayed phase thoracic Computed Tomography (CT) venography for the evaluation of suspected central thoracic venous pathology. Material and methods-CT images and medical records of all patients who underwent thoracic CT venography over a five year period were retrospectively reviewed. Both first pass (18 seconds) and delayed phase (60 seconds) venous images were obtained in all patients. The images were reviewed in random order by three readers using a
more » ... itative visual grading scheme for image quality, including artifacts and the uniformity of venous enhancement. In addition, enhancement was quantitatively evaluated. The presence and type of venous pathology, and overall diagnostic confidence were recorded and compared. Reference verification was performed when available. Results-18 patients formed the study group, mean age 49.5 years and 28% male. Dual arm injection was successful in 72% of exams. All readers reported more streak artifacts on first pass imaging than delayed imaging (72-94% vs. 27-44% respectively; p < 0.05). First pass imaging had significantly higher measured enhancement across all central venous segments than delayed imaging (mean HU range: 212-906 HU vs. 173-414 HU; p < 0.05), but also had significantly more heterogeneous enhancement (mean SD range 75-1058 HU vs. 67-378 HU; p <0.05). For overall diagnosis, reader agreement, accuracy and confidence levels were higher for delayed phase images (p < 0.05). Conclusion-Indirect thoracic CT venography using delayed phase imaging alone may be sufficient for evaluating clinically suspected central venous abnormality.
doi:10.1016/j.clinimag.2015.02.005 pmid:25724223 pmcid:PMC4412308 fatcat:qw5xfgikazg2xgk3tdmrllc6dy

Safety of CMR in patients with cardiac implanted electronic devices

El-Sayed H Ibrahim, Laura Horwood, Jadranka Stojanovska, Anil Attili, Luba Frank, Hakan Oral, Frank Bogun
2016 Journal of Cardiovascular Magnetic Resonance  
Safety of CMR in patients with cardiac implanted electronic devices El-Sayed H Ibrahim 1* , Laura Horwood 1 , Jadranka Stojanovska 1 , Anil Attili 1 , Luba Frank 2 , Hakan Oral 1 , Frank Bogun 1 From 19th  ... 
doi:10.1186/1532-429x-18-s1-o123 fatcat:3vwrzts6hbby3fonvxcwtdrsym

HARP Versus SinMod for measuring regional heart function from tagged CMR images

El-Sayed H Ibrahim, Scott Swanson, Jadranka Stojanovska, Claire Duvernoy, Rodica Pop-Busui
2016 Journal of Cardiovascular Magnetic Resonance  
doi:10.1186/1532-429x-18-s1-p60 fatcat:773uf42wfrg5vfe66w3qjlpmqe
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