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Epilepsy (generalised seizures)

J Helen Cross
2015 Clinical evidence  
About 3% of people will be diagnosed with epilepsy during their lifetime, but about 70% of people with epilepsy eventually go into remission. We conducted a systematic review and aimed to answer the following clinical question: What are the effects of additional treatments in people with drug-resistant epilepsy characterised by generalised seizures? We searched: Medline, Embase, The Cochrane Library, and other important databases up to April 2014 (Clinical Evidence reviews are updated
more » ... ly; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). We found four studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. In this systematic review we present information relating to the effectiveness and safety on the addition of the following interventions: lacosamide, lamotrigine, levetiracetam, perampanel, and zonisamide versus the addition of placebo.
pmid:25882687 pmcid:PMC4400652 fatcat:z4nhlqogobd53kmfajbingjxpy

Medical management and antiepileptic drugs in hypothalamic hamartoma

J. Helen Cross, Helen Spoudeas
2017 Epilepsia  
We confirm we have read the Journal's position on issues involved in ethical publication and affirm that this report consistent with those guidelines Disclosures Professor JH Cross has participated in  ... 
doi:10.1111/epi.13758 pmid:28591485 fatcat:3u4y3tteqjfy7deeb7copiwk6m

Zika virus infection in Collaborative Cross mice [article]

Melissa D Mattocks, Kenneth S Plante, Ethan J Fritch, Ralph S Baric, Martin T Ferris, Mark T Heise, Helen M Lazear
2019 bioRxiv   pre-print
Collaborative Cross (CC) mice have proven to be a valuable system for developing new mouse pathogenesis models for viral infections that are not well modeled in conventional laboratory mouse lines.  ...  A p value of < 0.05 was considered statistically significant. 141 Zika virus infection does not induce weight loss in 13 Collaborative Cross lines.  ...  Following fixation with 2% paraformaldehyde for 1 hr at room temperate, plates were 109 incubated with 500 ng/ml of flavivirus cross-reactive mouse MAb E60 (19) for 2 hr at room 110 temperature or overnight  ... 
doi:10.1101/695510 fatcat:ojdhgkra2zhoxg2kss3kaeqhfq

Women's perspectives on antenatal breast expression: a cross-sectional survey

Frankie J. Fair, Helen Watson, Rachel Gardner, Hora Soltani
2018 Reproductive Health  
A cross-sectional survey was undertaken using an online questionnaire distributed by a maternity user group representative via social media.  ...  We thank South Yorkshire Collaboration for Leadership in Applied Health Research and Care (CLAHRC-SY) for funding Helen Watson's involvement in the project, and Jo Cooke for facilitating this involvement  ...  Discussion This cross-sectional study has provided insight into women's knowledge and practices surrounding ABE and the acceptability of ABE to mothers.  ... 
doi:10.1186/s12978-018-0497-4 pmid:29618359 pmcid:PMC5885364 fatcat:jse4qksh5jb2lcxttnlemi63ru

Treatment of Lennox-Gastaut syndrome

Eleanor C Hancock, J Helen Cross
2013 The Cochrane library  
We found seven RCTs, but were unable to perform any meta-analysis, because each trial looked at different populations, different therapies and considered different outcomes.
doi:10.1002/14651858.cd003277.pub3 pmid:23450537 fatcat:wwdny5rwzfaptejwaxax22vvqm

Terminal olefin cross-metathesis with acrolein acetals

Daniel J. O'Leary, Helen E. Blackwell, Rebecca A. Washenfelder, Katsukiyo Miura, Robert H. Grubbs
1999 Tetrahedron Letters  
Acrolein acetals, including asymmetric derivatives, are robust cross-metathesis substrates as evidenced by reaction yields of 80-90% at catalyst loadings of 2-5 mol % (PCy3)zCI2Ru=CHPh (1).  ...  However, attempts at Ru-catalyzed cross-metathesis of 3 with orthoester 6 ~5 or ketal 716 proved unsuccessful.  ...  Extending the methodology to the construction of 13,y-unsaturated aldehydes via cross-metathesis was also explored.  ... 
doi:10.1016/s0040-4039(98)02641-0 fatcat:4cemccculve6po6xfqmse4ow6m

The Cross-Species Mycobacterial Growth Inhibition Assay (MGIA) Project, 2010–2014

Michael J. Brennan, Rachel Tanner, Sheldon Morris, Thomas J. Scriba, Jacqueline M. Achkar, Andrea Zelmer, David A. Hokey, Angelo Izzo, Sally Sharpe, Ann Williams, Adam Penn-Nicholson, Mzwandile Erasmus (+5 others)
2017 Clinical and Vaccine Immunology  
J. Scriba, unpublished observations).  ...  The discordance between these findings might have resulted from the cross-sectional designs, in which infection with M. tuberculosis was defined using a single IFN-␥ release assay or TST, and it is not  ... 
doi:10.1128/cvi.00142-17 pmid:28701467 pmcid:PMC5585695 fatcat:i5wspy7nsvefdn33iodq6fsfva

Cross-linking of lens crystallin proteins induced by tryptophan metabolites and metal ions: implications for cataract development

Helen J. Tweeddale, Clare L. Hawkins, Joane F. Janmie, Roger J. W. Truscott, Michael J. Davies
2017 Figshare  
It is shown here that Cu(II), and to a lesser extent Fe(III), enhance oxidation of free 3OHKyn, 3OHAA and 3OHKyn bound to specific amino acids and lens proteins, with this resulting in increased cross-linking  ...  It should be noted that this gel has been stained for a much longer time compared to other figures in order to detect any potential Kyn-mediated cross-links.  ...   Supplementary Figure 1 Extent of protein cross-linking (as detected by SDS-PAGE gels with silver staining) over time on incubation of mixtures containing 3OHKyn (10 µM) and BLP (ca. 6 µM) (present  ... 
doi:10.6084/m9.figshare.4569748.v1 fatcat:w5zg2vqqrncb3li2cfqjgiihem

A new method for cross-metathesis of terminal olefins

Daniel J O'Leary, Helen E Blackwell, Rebecca A Washenfelder, Robert H Grubbs
1998 Tetrahedron Letters  
A new method for the cross-metathesis of terminal olefins is described.  ...  Treatment of terminal olefins with 1-2 equivalents of a symmetric disubstituted cis or trans olefin and 5 mol% C12(PCy3)2Ru=CHPh (1) in dichloromethane generates the desired cross-metathesis products in  ...  yne-ene s and ring-opening cross-metathesis reactions using Ru and Mo catalysis have been demonstrated. 9''° Outlined herein is a new method for the selective cross-metathesis of unhindered alkyl-substituted  ... 
doi:10.1016/s0040-4039(98)01647-5 fatcat:t3qahxcxyfbbdjfvfinfi5ndh4

(1R,2R)-1,2-Diammoniocyclohexane dichloride

Louis J. Farrugia, Ronald J. Cross, Helen R. L. Barley
2001 Acta Crystallographica Section E  
E57, o992-o993 [doi:10.1107/S1600536801015872] (1R,2R)-1,2-Diammoniocyclohexane dichloride Louis J. Farrugia, Ronald J. Cross and Helen R. L. Barley S1.  ... 
doi:10.1107/s1600536801015872 fatcat:rvyeiml55va3hibiepvlf7ddsm

Barriers to influenza vaccination of children hospitalised for acute respiratory illness: A cross‐sectional survey

Samantha J Carlson, Helen E Quinn, Christopher C Blyth, Allen Cheng, Julia Clark, Joshua R Francis, Helen S Marshall, Kristine Macartney, Julie Leask
2020 Journal of Paediatrics and Child Health  
J. Prev. Med. 2019; 56: e55-63.  ...  Sample size We used an analytical cross-sectional design with children who received no influenza vaccine.  ... 
doi:10.1111/jpc.15235 pmid:33094543 fatcat:q634rhzplncfbpyyryrwov77om

Fenfluramine as antiseizure medication for epilepsy

Maria Gogou, J Helen Cross
2021 Developmental Medicine & Child Neurology  
Fenfluramine hydrochloride has classically been described as acting pharmacologically through a serotonergic mechanism. Therefore, it was initially used as an anorectic drug, given that impaired serotonin homeostasis may be associated with increased food intake. Although positive results were documented, cardiovascular concerns resulted in its temporary withdrawal. Nevertheless, a novel role in patients with epilepsy was later suggested by isolated clinical observations. The wide application of
more » ... genetic testing allowed the classification (predominantly as Dravet syndrom) of patients in whom benefit was seen, while with the development of zebrafish models, its antiepileptic properties were confirmed at a molecular level. Data from randomized clinical trials have shown a beneficial effect of fenfluramine, as an adjunct therapy, on seizure control for children with Dravet syndrome, though there is still uncertainty about the impact on neurodevelopment in these patients. No signs of heart valve disease have been documented to date. Long-term and appropriately designed clinical studies will verify whether fenfluramine is a therapeutic agent of high importance, living up to the promise shown so far.
doi:10.1111/dmcn.14822 pmid:33565102 fatcat:7dujxdzjd5aydgj5k5obis7yei

Neurocutaneous Syndromes and Epilepsy-Issues in Diagnosis and Management

J. Helen Cross
2005 Epilepsia  
Cross at Neurosciences Unit, Institute of Child Health, The Wolfson Centre, Mecklenburgh Square, London WC1N 2AP, U.K. E-mail: synonymous with the condition.  ... 
doi:10.1111/j.1528-1167.2005.00353.x pmid:16359466 fatcat:lh2ndkfszjfkbpdayihylg6pji

Appreciating Literature

E. A. Cross, Elizabeth Lehr, Dorothy Dakin, Helen J. Hanlon, Florence M. Meyer, Emma L. Reppert
1952 English Journal  
Cross and E.izapetH Lenr. UNDER- STANDING LITERATURE. By E. A. Cross, Dorotuy Dakin, and HELEN J. Hanton. INTERPRETING LITERA- TURE. By E. A. Cross, FLorENcCE M. MEyer, and Emma L. REpPERT.  ...  Gates, AL- THEA BEERY, and HELEN CRosSEN. (“‘Mac- millan Readers,” Grades VII and VIII.) Macmillan. Pp. 472 each.  ... 
doi:10.2307/809222 fatcat:4t63qvaog5gnpdskoj2dduwpcy

Targeted Treatment in Childhood Epilepsy Syndromes

Katharina Vezyroglou, J. Helen Cross
2016 Current Treatment Options in Neurology  
J.  ...  Helen Cross has a patent for C10 in the treatment of epilepsy; has received royalties for a chapter on childhood epilepsy in Brain Diseases of the Nervous System, and as editor of Paediatric Epilepsy;  ... 
doi:10.1007/s11940-016-0407-4 pmid:27154366 pmcid:PMC4859845 fatcat:7ujzz7auvzcqtm4rq7prx3k5ou
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