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About 3% of people will be diagnosed with epilepsy during their lifetime, but about 70% of people with epilepsy eventually go into remission. We conducted a systematic review and aimed to answer the following clinical question: What are the effects of additional treatments in people with drug-resistant epilepsy characterised by generalised seizures? We searched: Medline, Embase, The Cochrane Library, and other important databases up to April 2014 (Clinical Evidence reviews are updatedpmid:25882687 pmcid:PMC4400652 fatcat:z4nhlqogobd53kmfajbingjxpy
more »... ly; please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA). We found four studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions. In this systematic review we present information relating to the effectiveness and safety on the addition of the following interventions: lacosamide, lamotrigine, levetiracetam, perampanel, and zonisamide versus the addition of placebo.
We confirm we have read the Journal's position on issues involved in ethical publication and affirm that this report consistent with those guidelines Disclosures Professor JH Cross has participated in ...doi:10.1111/epi.13758 pmid:28591485 fatcat:3u4y3tteqjfy7deeb7copiwk6m
Collaborative Cross (CC) mice have proven to be a valuable system for developing new mouse pathogenesis models for viral infections that are not well modeled in conventional laboratory mouse lines. ... A p value of < 0.05 was considered statistically significant. 141 Zika virus infection does not induce weight loss in 13 Collaborative Cross lines. ... Following fixation with 2% paraformaldehyde for 1 hr at room temperate, plates were 109 incubated with 500 ng/ml of flavivirus cross-reactive mouse MAb E60 (19) for 2 hr at room 110 temperature or overnight ...doi:10.1101/695510 fatcat:ojdhgkra2zhoxg2kss3kaeqhfq
A cross-sectional survey was undertaken using an online questionnaire distributed by a maternity user group representative via social media. ... We thank South Yorkshire Collaboration for Leadership in Applied Health Research and Care (CLAHRC-SY) for funding Helen Watson's involvement in the project, and Jo Cooke for facilitating this involvement ... Discussion This cross-sectional study has provided insight into women's knowledge and practices surrounding ABE and the acceptability of ABE to mothers. ...doi:10.1186/s12978-018-0497-4 pmid:29618359 pmcid:PMC5885364 fatcat:jse4qksh5jb2lcxttnlemi63ru
The Cochrane library
We found seven RCTs, but were unable to perform any meta-analysis, because each trial looked at different populations, different therapies and considered different outcomes.doi:10.1002/14651858.cd003277.pub3 pmid:23450537 fatcat:wwdny5rwzfaptejwaxax22vvqm
Acrolein acetals, including asymmetric derivatives, are robust cross-metathesis substrates as evidenced by reaction yields of 80-90% at catalyst loadings of 2-5 mol % (PCy3)zCI2Ru=CHPh (1). ... However, attempts at Ru-catalyzed cross-metathesis of 3 with orthoester 6 ~5 or ketal 716 proved unsuccessful. ... Extending the methodology to the construction of 13,y-unsaturated aldehydes via cross-metathesis was also explored. ...doi:10.1016/s0040-4039(98)02641-0 fatcat:4cemccculve6po6xfqmse4ow6m
J. Scriba, unpublished observations). ... The discordance between these findings might have resulted from the cross-sectional designs, in which infection with M. tuberculosis was defined using a single IFN-␥ release assay or TST, and it is not ...doi:10.1128/cvi.00142-17 pmid:28701467 pmcid:PMC5585695 fatcat:i5wspy7nsvefdn33iodq6fsfva
It is shown here that Cu(II), and to a lesser extent Fe(III), enhance oxidation of free 3OHKyn, 3OHAA and 3OHKyn bound to specific amino acids and lens proteins, with this resulting in increased cross-linking ... It should be noted that this gel has been stained for a much longer time compared to other figures in order to detect any potential Kyn-mediated cross-links. ... Supplementary Figure 1 Extent of protein cross-linking (as detected by SDS-PAGE gels with silver staining) over time on incubation of mixtures containing 3OHKyn (10 µM) and BLP (ca. 6 µM) (present ...doi:10.6084/m9.figshare.4569748.v1 fatcat:w5zg2vqqrncb3li2cfqjgiihem
A new method for the cross-metathesis of terminal olefins is described. ... Treatment of terminal olefins with 1-2 equivalents of a symmetric disubstituted cis or trans olefin and 5 mol% C12(PCy3)2Ru=CHPh (1) in dichloromethane generates the desired cross-metathesis products in ... yne-ene s and ring-opening cross-metathesis reactions using Ru and Mo catalysis have been demonstrated. 9''° Outlined herein is a new method for the selective cross-metathesis of unhindered alkyl-substituted ...doi:10.1016/s0040-4039(98)01647-5 fatcat:t3qahxcxyfbbdjfvfinfi5ndh4
E57, o992-o993 [doi:10.1107/S1600536801015872] (1R,2R)-1,2-Diammoniocyclohexane dichloride Louis J. Farrugia, Ronald J. Cross and Helen R. L. Barley S1. ...doi:10.1107/s1600536801015872 fatcat:rvyeiml55va3hibiepvlf7ddsm
J. Prev. Med. 2019; 56: e55-63. ... Sample size We used an analytical cross-sectional design with children who received no influenza vaccine. ...doi:10.1111/jpc.15235 pmid:33094543 fatcat:q634rhzplncfbpyyryrwov77om
Fenfluramine hydrochloride has classically been described as acting pharmacologically through a serotonergic mechanism. Therefore, it was initially used as an anorectic drug, given that impaired serotonin homeostasis may be associated with increased food intake. Although positive results were documented, cardiovascular concerns resulted in its temporary withdrawal. Nevertheless, a novel role in patients with epilepsy was later suggested by isolated clinical observations. The wide application ofdoi:10.1111/dmcn.14822 pmid:33565102 fatcat:7dujxdzjd5aydgj5k5obis7yei
more »... genetic testing allowed the classification (predominantly as Dravet syndrom) of patients in whom benefit was seen, while with the development of zebrafish models, its antiepileptic properties were confirmed at a molecular level. Data from randomized clinical trials have shown a beneficial effect of fenfluramine, as an adjunct therapy, on seizure control for children with Dravet syndrome, though there is still uncertainty about the impact on neurodevelopment in these patients. No signs of heart valve disease have been documented to date. Long-term and appropriately designed clinical studies will verify whether fenfluramine is a therapeutic agent of high importance, living up to the promise shown so far.
Cross at Neurosciences Unit, Institute of Child Health, The Wolfson Centre, Mecklenburgh Square, London WC1N 2AP, U.K. E-mail: firstname.lastname@example.org synonymous with the condition. ...doi:10.1111/j.1528-1167.2005.00353.x pmid:16359466 fatcat:lh2ndkfszjfkbpdayihylg6pji
Cross and E.izapetH Lenr. UNDER- STANDING LITERATURE. By E. A. Cross, Dorotuy Dakin, and HELEN J. Hanton. INTERPRETING LITERA- TURE. By E. A. Cross, FLorENcCE M. MEyer, and Emma L. REpPERT. ... Gates, AL- THEA BEERY, and HELEN CRosSEN. (“‘Mac- millan Readers,” Grades VII and VIII.) Macmillan. Pp. 472 each. ...doi:10.2307/809222 fatcat:4t63qvaog5gnpdskoj2dduwpcy
J. ... Helen Cross has a patent for C10 in the treatment of epilepsy; has received royalties for a chapter on childhood epilepsy in Brain Diseases of the Nervous System, and as editor of Paediatric Epilepsy; ...doi:10.1007/s11940-016-0407-4 pmid:27154366 pmcid:PMC4859845 fatcat:7ujzz7auvzcqtm4rq7prx3k5ou
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