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Pak-1 Expression Increases with Progression of Colorectal Carcinomas to Metastasis

J. H. Carter
2004 Clinical Cancer Research  
Purpose: The p21-activated kinase-1 (Pak-1) promotes cell motility and invasiveness.  ...  Because Pak-1 plays a central role in regulating cell motility and invasiveness, we sought to determine whether Pak-1 may be involved in the malignant progression of colorectal carcinoma.  ...  D. and J. H. C.) at a two-headed microscope. Stain intensity was given a numerical score on a scale of 0 -3, with 0 ϭ negative, 0.5 ϭ trace, 1 ϭ light, 2 ϭ moderate, and 3 ϭ intense.  ... 
doi:10.1158/1078-0432.ccr-03-0210 pmid:15161701 fatcat:zvpcucoxrbbf3jfllxppjxppqi

Performance of neural networks in materials science

H. K. D. H. Bhadeshia, R. C. Dimitriu, S. Forsik, J. H. Pak, J. H. Ryu
2009 Materials Science and Technology  
A complete description of a typical network with i hidden units, connecting the inputs x j to the output y is given by y~X i w 2 ð Þ i h i zh 2 ð Þ (2) where h i~t anh X j w 1 ð Þ ij x j zh 1 ð Þ i " #  ...  (3) where w and h represent weights.  ... 
doi:10.1179/174328408x311053 fatcat:gabkwflkqjhujbkvmtsufemhve

Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate

B. H. Ha, M. J. Davis, C. Chen, H. J. Lou, J. Gao, R. Zhang, M. Krauthammer, R. Halaban, J. Schlessinger, B. E. Turk, T. J. Boggon
2012 Proceedings of the National Academy of Sciences of the United States of America  
Fig. 1 . 1 PAK schematic and kinase assays for type II PAKs. (A) Schematic diagram for type I and type II PAK family members.  ...  The type II PAKs, however, do not contain the conserved AID seen in type I PAKs, and are not regulated in a similar manner.  ... 
doi:10.1073/pnas.1214447109 pmid:22988085 pmcid:PMC3479536 fatcat:xqih7f5qzvfhxi4dlik4x3kune

Secretion of toxin A from Pseudomonas aeruginosa PAO1, PAK, and PA103 by Escherichia coli

A N Hamood, M J Wick, B H Iglewski
1990 Infection and Immunity  
Toxin A proteins from P. aeruginosa PAO1, PA103, and PAK were compared for their secretion in E. coli.  ...  Despite the differences in the amino acid sequences of their leader peptides, toxin A proteins from strains PAO1, PA103, and PAK were processed and secreted to the periplasm of E. coli.  ...  P, Toxin A precursor; M, mature toxin A.VOL. 58, 1990 %J %J ---r_. on March 21, 2020 by guest Downloaded from INFECT.  ... 
pmid:2108926 pmcid:PMC258600 fatcat:ewmjpa2rmjeebgzaoxugsdzhxm

Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer

H. Y. Chow, B. Dong, C. A. Valencia, C. T. Zeng, J. N. Koch, T. Y. Prudnikova, J. Chernoff
2018 Nature Communications  
p21-activated kinases (Paks) play an important role in oncogenic signaling pathways and have been considered as potential therapeutic targets in various cancers.  ...  Here we use a transgenic mouse model in which a specific peptide inhibitor of Group I Paks is conditionally expressed in response to Cre recombinase.  ...  Cells were allowed to migrate for 19 h.  ... 
doi:10.1038/s41467-018-05935-6 pmid:30150766 pmcid:PMC6110733 fatcat:l4iulid5onhejpxw6n5rvy2eni

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

E Manser, H Y Huang, T H Loo, X Q Chen, J M Dong, T Leung, L Lim
1997 Molecular and Cellular Biology  
Recently we have shown that a Drosophila PAK is enriched in the leading edge of embryonic epithelial cells undergoing dorsal closure (N. Harden, J. Lee, H.-Y. Loh, Y.-M. Ong, I. Tan, T. Leung, E.  ...  Cdc42 and Rac1 cause alpha-PAK autophosphorylation and kinase activation. Mapping alpha-PAK autophosphorylation sites has allowed generation of a constitutively active kinase mutant.  ...  The remainder was resuspended in 6 M HCl and heated to 110ЊC for 2 h.  ... 
doi:10.1128/mcb.17.3.1129 pmid:9032240 pmcid:PMC231838 fatcat:l77e26sg3vdhjdaa542mpxpxlq

Rational Synthesis Pathway for Ordered Mesoporous Carbon with Controllable 30- to 100-Angstrom Pores

H. I. Lee, J. H. Kim, D. J. You, J. E. Lee, J. M. Kim, W. S. Ahn, C. Pak, S. H. Joo, H. Chang, D. Seung
2008 Advanced Materials  
A 2D hexagonal mesoporous silica, MSU-H, was synthesized following procedures reported elsewhere with slight modifications, [6g,14] and used as the silica template.  ...  The composite material was then dried at 100°C for 6 h and at 160°C for 6 h thereafter.  ...  Sample H was prepared by refluxing sample G in boiling water for 6 h, which selectively removed boron oxide species from the silica/boron composite.  ... 
doi:10.1002/adma.200702209 fatcat:22apdsei5jglph5gvt4cn7qxni

KDM3B Is the H3K9 Demethylase Involved in Transcriptional Activation of lmo2 in Leukemia

J.-Y. Kim, K.-B. Kim, G. H. Eom, N. Choe, H. J. Kee, H.-J. Son, S.-T. Oh, D.-W. Kim, J. H. Pak, H. J. Baek, H. Kook, Y. Hahn (+3 others)
2012 Molecular and Cellular Biology  
After 48 h, real-time PCR was performed to compare the expression levels of the target genes.  ...  (J) sh-CTL or sh-KDM3B knockdown stable cells were lysed and immunoblotted with anti-lmo2 and anti-KDM3B antibodies. ␤-Actin was used as a loading control.  ...  (D to G) ATRA-treated HL-60 cells were differentiated for 48 h.  ... 
doi:10.1128/mcb.00133-12 pmid:22615488 pmcid:PMC3416203 fatcat:qz4t4lnmpva6tfe36ycpwwwfvm

Disrupted-in-Schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling

S.-Y. Chen, P.-H. Huang, H.-J. Cheng
2011 Proceedings of the National Academy of Sciences of the United States of America  
In vivo genetic interaction studies revealed that the UNC-73/TRIO-RAC-PAK signaling pathway is activated by ectopic DISC1 in C. elegans motor axons.  ...  These results together indicate that the TRIO-RAC-PAK signaling pathway can be exploited and modulated by DISC1 to regulate axonal connectivity in the developing brain. genetic model | rolipram  ...  (H) The RAC1 activities in COS cells are significantly increased when hTRIO is coexpressed with mDISC1.  ... 
doi:10.1073/pnas.1018128108 pmid:21422296 pmcid:PMC3078365 fatcat:4kh5rhhjxra2hbovfnsuou5opq

Closed-loop, ultraprecise, automated craniotomies

Nikita Pak, Joshua H. Siegle, Justin P. Kinney, Daniel J. Denman, Timothy J. Blanche, Edward S. Boyden
2015 Journal of Neurophysiology  
Proc Inst Mech Eng H. A., Bonhoeffer T., Chow D. K., Chuckowree J., De Paola V., Hofer S.  ...  ., Pei, H., Kesner, S.B., Thomas, A.J., and Walsh, C. Edwin M., Craig T. Nordhausen, and Richard A. Normann.  ... 
doi:10.1152/jn.01055.2014 pmid:25855700 pmcid:PMC4480624 fatcat:qwszkhe3yfbtvdzxkadn3yrfhq

Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy

D. U. Jeong, C.-R. Lee, J. H. Lee, J. Pak, L.-W. Kang, B. C. Jeong, S. H. Lee
2014 BioMed Research International  
Platelet-rich plasma (PRP), a blood derivative with high concentrations of platelets, has been found to have high levels of autologous growth factors (GFs), such as transforming growth factor-β(TGF-β), platelet-derived growth factor (PDGF), fibroblastic growth factor (FGF), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF). These GFs and other biological active proteins of PRP can promote tissue healing through the regulation of fibrosis and angiogenesis. Moreover,
more » ... is considered to be safe due to its autologous nature and long-term usage without any reported major complications. Therefore, PRP therapy could be an option in treating overused tendon damage such as chronic tendinopathy. Here, we present a systematic review highlighting the clinical effectiveness of PRP injection therapy in patellar tendinopathy, which is a major cause of athletes to retire from their respective careers.
doi:10.1155/2014/249498 pmid:25136568 pmcid:PMC4127290 fatcat:sq65vrmfcjfljgh4n5mfyin6ku

Recent Perturbative Results on Heavy Quark Decays

J. H. Piclum, M. Dowling, A. Pak
2008 Continuous Advances in QCD 2008  
doi:10.1142/9789812838667_0002 fatcat:3lhfsle4xzgkpdb6zoi37q3qii

Cytotype diversity and genome size variation in eastern Asian polyploid Cardamine (Brassicaceae) species

K. Marhold, H. Kudoh, J.-H. Pak, K. Watanabe, S. Spaniel, J. Lihova
2009 Annals of Botany  
Finally, considering the overall morphological similarity (J. Lihová, H. Kudoh and K. Marhold, unpubl. res.)  ...  On the basis of morphometric analyses, and thorough field and herbarium studies, a new taxonomic concept for this group was recently developed (J. Lihová, H. Kudoh and K.  ... 
doi:10.1093/aob/mcp282 pmid:20007978 pmcid:PMC2814755 fatcat:uqzbper2erdlplp46jq6r6vqk4

The Arabidopsis GRF-INTERACTING FACTOR Gene Family Performs an Overlapping Function in Determining Organ Size as Well as Multiple Developmental Properties

B. H. Lee, J.-H. Ko, S. Lee, Y. Lee, J.-H. Pak, J. H. Kim
2009 Plant Physiology  
Plants were grown under short days (8 h of light/16 h of darkness). Organ Growth by GIF Genes Plant Physiol.  ...  For measurement of leaf plastochron, plants were grown under the short-day conditions of 8 h of light/16 h of darkness.  ... 
doi:10.1104/pp.109.141838 pmid:19648231 pmcid:PMC2754652 fatcat:btxojzdmtzbbphatk2dguxyhki

Space‐charge‐limited injection in n+‐i‐n+ structures fabricated by a focused ion beam

S. W. Hwang, H. J. Lezec, T. Sakamoto, N. Nakamura, J. H. Pak
1995 Applied Physics Letters  
J. Appl. Phys. 24, L903 ͑1985͒. 2 Y. Hirayama and H. Okamoto, Jpn. J. Appl. Phys. 24, L965 ͑1985͒. 3 Y. Hirayama, A. D. Wieck, and K. Ploog, J. Appl.  ...  H. Rangu, J. Sone, S. Matsui, J. Tsai, T. Baba, Y. Ochiai, and F. Nihey for useful discussions and constant encouragement throughout the work.  ... 
doi:10.1063/1.115148 fatcat:klacgnis5nevbpinqxfenm7ihi
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