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Pak-1 Expression Increases with Progression of Colorectal Carcinomas to Metastasis
2004
Clinical Cancer Research
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Purpose: The p21-activated kinase-1 (Pak-1) promotes cell motility and invasiveness. ...
Because Pak-1 plays a central role in regulating cell motility and invasiveness, we sought to determine whether Pak-1 may be involved in the malignant progression of colorectal carcinoma. ...
D. and J. H. C.) at a two-headed microscope. Stain intensity was given a numerical score on a scale of 0 -3, with 0 ϭ negative, 0.5 ϭ trace, 1 ϭ light, 2 ϭ moderate, and 3 ϭ intense. ...
doi:10.1158/1078-0432.ccr-03-0210
pmid:15161701
fatcat:zvpcucoxrbbf3jfllxppjxppqi
Performance of neural networks in materials science
2009
Materials Science and Technology
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A complete description of a typical network with i hidden units, connecting the inputs x j to the output y is given by y~X i w 2 ð Þ i h i zh 2 ð Þ (2) where h i~t anh X j w 1 ð Þ ij x j zh 1 ð Þ i " # ...
(3) where w and h represent weights. ...
doi:10.1179/174328408x311053
fatcat:gabkwflkqjhujbkvmtsufemhve
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate
2012
Proceedings of the National Academy of Sciences of the United States of America
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Fig. 1 . 1 PAK schematic and kinase assays for type II PAKs. (A) Schematic diagram for type I and type II PAK family members. ...
The type II PAKs, however, do not contain the conserved AID seen in type I PAKs, and are not regulated in a similar manner. ...
doi:10.1073/pnas.1214447109
pmid:22988085
pmcid:PMC3479536
fatcat:xqih7f5qzvfhxi4dlik4x3kune
Secretion of toxin A from Pseudomonas aeruginosa PAO1, PAK, and PA103 by Escherichia coli
1990
Infection and Immunity
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Toxin A proteins from P. aeruginosa PAO1, PA103, and PAK were compared for their secretion in E. coli. ...
Despite the differences in the amino acid sequences of their leader peptides, toxin A proteins from strains PAO1, PA103, and PAK were processed and secreted to the periplasm of E. coli. ...
P, Toxin A precursor; M, mature toxin A.VOL. 58, 1990 %J %J ---r_. on March 21, 2020 by guest http://iai.asm.org/ Downloaded from
INFECT. ...
pmid:2108926
pmcid:PMC258600
fatcat:ewmjpa2rmjeebgzaoxugsdzhxm
Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer
2018
Nature Communications
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p21-activated kinases (Paks) play an important role in oncogenic signaling pathways and have been considered as potential therapeutic targets in various cancers. ...
Here we use a transgenic mouse model in which a specific peptide inhibitor of Group I Paks is conditionally expressed in response to Cre recombinase. ...
Cells were allowed to migrate for 19 h. ...
doi:10.1038/s41467-018-05935-6
pmid:30150766
pmcid:PMC6110733
fatcat:l4iulid5onhejpxw6n5rvy2eni
Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes
1997
Molecular and Cellular Biology
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Recently we have shown that a Drosophila PAK is enriched in the leading edge of embryonic epithelial cells undergoing dorsal closure (N. Harden, J. Lee, H.-Y. Loh, Y.-M. Ong, I. Tan, T. Leung, E. ...
Cdc42 and Rac1 cause alpha-PAK autophosphorylation and kinase activation. Mapping alpha-PAK autophosphorylation sites has allowed generation of a constitutively active kinase mutant. ...
The remainder was resuspended in 6 M HCl and heated to 110ЊC for 2 h. ...
doi:10.1128/mcb.17.3.1129
pmid:9032240
pmcid:PMC231838
fatcat:l77e26sg3vdhjdaa542mpxpxlq
Rational Synthesis Pathway for Ordered Mesoporous Carbon with Controllable 30- to 100-Angstrom Pores
2008
Advanced Materials
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A 2D hexagonal mesoporous silica, MSU-H, was synthesized following procedures reported elsewhere with slight modifications, [6g,14] and used as the silica template. ...
The composite material was then dried at 100°C for 6 h and at 160°C for 6 h thereafter. ...
Sample H was prepared by refluxing sample G in boiling water for 6 h, which selectively removed boron oxide species from the silica/boron composite. ...
doi:10.1002/adma.200702209
fatcat:22apdsei5jglph5gvt4cn7qxni
KDM3B Is the H3K9 Demethylase Involved in Transcriptional Activation of lmo2 in Leukemia
2012
Molecular and Cellular Biology
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After 48 h, real-time PCR was performed to compare the expression levels of the target genes. ...
(J) sh-CTL or sh-KDM3B knockdown stable cells were lysed and immunoblotted with anti-lmo2 and anti-KDM3B antibodies. -Actin was used as a loading control. ...
(D to G) ATRA-treated HL-60 cells were differentiated for 48 h. ...
doi:10.1128/mcb.00133-12
pmid:22615488
pmcid:PMC3416203
fatcat:qz4t4lnmpva6tfe36ycpwwwfvm
Disrupted-in-Schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling
2011
Proceedings of the National Academy of Sciences of the United States of America
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In vivo genetic interaction studies revealed that the UNC-73/TRIO-RAC-PAK signaling pathway is activated by ectopic DISC1 in C. elegans motor axons. ...
These results together indicate that the TRIO-RAC-PAK signaling pathway can be exploited and modulated by DISC1 to regulate axonal connectivity in the developing brain. genetic model | rolipram ...
(H) The RAC1 activities in COS cells are significantly increased when hTRIO is coexpressed with mDISC1. ...
doi:10.1073/pnas.1018128108
pmid:21422296
pmcid:PMC3078365
fatcat:4kh5rhhjxra2hbovfnsuou5opq
Closed-loop, ultraprecise, automated craniotomies
2015
Journal of Neurophysiology
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Proc Inst Mech Eng H. A., Bonhoeffer T., Chow D. K., Chuckowree J., De Paola V., Hofer S. ...
., Pei, H., Kesner, S.B., Thomas, A.J., and Walsh, C. Edwin M., Craig T. Nordhausen, and Richard A. Normann. ...
doi:10.1152/jn.01055.2014
pmid:25855700
pmcid:PMC4480624
fatcat:qwszkhe3yfbtvdzxkadn3yrfhq
Clinical Applications of Platelet-Rich Plasma in Patellar Tendinopathy
2014
BioMed Research International
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Platelet-rich plasma (PRP), a blood derivative with high concentrations of platelets, has been found to have high levels of autologous growth factors (GFs), such as transforming growth factor-β(TGF-β), platelet-derived growth factor (PDGF), fibroblastic growth factor (FGF), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF). These GFs and other biological active proteins of PRP can promote tissue healing through the regulation of fibrosis and angiogenesis. Moreover,
doi:10.1155/2014/249498
pmid:25136568
pmcid:PMC4127290
fatcat:sq65vrmfcjfljgh4n5mfyin6ku
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... is considered to be safe due to its autologous nature and long-term usage without any reported major complications. Therefore, PRP therapy could be an option in treating overused tendon damage such as chronic tendinopathy. Here, we present a systematic review highlighting the clinical effectiveness of PRP injection therapy in patellar tendinopathy, which is a major cause of athletes to retire from their respective careers.
Recent Perturbative Results on Heavy Quark Decays
2008
Continuous Advances in QCD 2008
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Cytotype diversity and genome size variation in eastern Asian polyploid Cardamine (Brassicaceae) species
2009
Annals of Botany
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Finally, considering the overall morphological similarity (J. Lihová, H. Kudoh and K. Marhold, unpubl. res.) ...
On the basis of morphometric analyses, and thorough field and herbarium studies, a new taxonomic concept for this group was recently developed (J. Lihová, H. Kudoh and K. ...
doi:10.1093/aob/mcp282
pmid:20007978
pmcid:PMC2814755
fatcat:uqzbper2erdlplp46jq6r6vqk4
The Arabidopsis GRF-INTERACTING FACTOR Gene Family Performs an Overlapping Function in Determining Organ Size as Well as Multiple Developmental Properties
2009
Plant Physiology
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Plants were grown under short days (8 h of light/16 h of darkness). Organ Growth by GIF Genes Plant Physiol. ...
For measurement of leaf plastochron, plants were grown under the short-day conditions of 8 h of light/16 h of darkness. ...
doi:10.1104/pp.109.141838
pmid:19648231
pmcid:PMC2754652
fatcat:btxojzdmtzbbphatk2dguxyhki
Space‐charge‐limited injection in n+‐i‐n+ structures fabricated by a focused ion beam
1995
Applied Physics Letters
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J. Appl. Phys. 24, L903 ͑1985͒. 2 Y. Hirayama and H. Okamoto, Jpn. J. Appl. Phys. 24, L965 ͑1985͒. 3 Y. Hirayama, A. D. Wieck, and K. Ploog, J. Appl. ...
H. Rangu, J. Sone, S. Matsui, J. Tsai, T. Baba, Y. Ochiai, and F. Nihey for useful discussions and constant encouragement throughout the work. ...
doi:10.1063/1.115148
fatcat:klacgnis5nevbpinqxfenm7ihi
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