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Finite rigid sets in sphere complexes [article]

Edgar A. Bering IV, Christopher J. Leininger
<span title="2022-04-05">2022</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Define X i,j = (X i,j−1 ) Pi,j the complex obtained by applying Lemma 19 to X i,j−1 and P i,j . Finally set X i = X i,ki , this is rigid by induction.  ...  There exists a nested family of finite rigid simplicial complexes X j ⊆ S(M ) such that S(M ) = ∪ j X j . The restriction n ≥ 3 is necessary.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2204.02204v1">arXiv:2204.02204v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/w6cvmmwa4bdddduhth6omlsyoy">fatcat:w6cvmmwa4bdddduhth6omlsyoy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220606193532/https://arxiv.org/pdf/2204.02204v1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7e/32/7e327712e2fbe1d21cb9f38428fb00d241a317bf.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2204.02204v1" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Taschenbuch Literaturwissenschaft. Ein Studienbegleiter für Germanisten

Christopher J. Wickham, Edgar Papp
<span title="">1997</span> <i title="JSTOR"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5dddngiyhvc5vaabuj3jeaxzyi" style="color: black;">Die Unterrichtspraxis/Teaching German</a> </i> &nbsp;
Judith Ricker-Abderhalden University of Arkansas Papp, Edgar. Taschenbuch Literaturwissenschaft. Ein Studienbegleiter fiir Germanisten. Berlin: Erich Schmidt, 1995. Paper, 128 pp.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2307/3531228">doi:10.2307/3531228</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5oj34zzuuvamnf37csq5asa3gy">fatcat:5oj34zzuuvamnf37csq5asa3gy</a> </span>
<a target="_blank" rel="noopener" href="https://archive.org/details/sim_die-unterrichtspraxis_spring-1997_30_1/page/99" title="read fulltext microfilm" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Archive [Microfilm] <div class="menu fulltext-thumbnail"> <img src="https://archive.org/serve/sim_die-unterrichtspraxis_spring-1997_30_1/__ia_thumb.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2307/3531228"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> jstor.org </button> </a>

Magnetoencephalography and the infant brain

Yu-Han Chen, Joni Saby, Emily Kuschner, William Gaetz, J. Christopher Edgar, Timothy P.L. Roberts
<span title="2019-01-24">2019</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/sa477uo7lveh7hchpikpixop5u" style="color: black;">NeuroImage</a> </i> &nbsp;
J. Christopher Edgar, K01 MH108822 to Dr. Yuhan Chen), the National Institute of Child Health and Human Development (R01 HD093776 to Dr. J.  ...  Christopher Edgar), and the institutional IDDRC (U54 HD086984, especially the Neuroimaging and Neurocircuitry Core, Director Dr. Roberts).  ...  (Edgar et al., 2015a; Edgar et al., 2015b; Edgar et al., 2015c) ,).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2019.01.059">doi:10.1016/j.neuroimage.2019.01.059</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30685329">pmid:30685329</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6662211/">pmcid:PMC6662211</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/6ajfx33oybahdj2dvzawqere4i">fatcat:6ajfx33oybahdj2dvzawqere4i</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191013070756/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6662211&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/44/41/4441a87c73b49228fcb4d12a918fbac24c7faff9.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.neuroimage.2019.01.059"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662211" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Spherical Harmonic Residual Network for Diffusion Signal Harmonization [article]

Simon Koppers, Luke Bloy, Jeffrey I. Berman, Chantal M.W. Tax, J. Christopher Edgar, Dorit Merhof
<span title="2018-08-05">2018</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Diffusion imaging is an important method in the field of neuroscience, as it is sensitive to changes within the tissue microstructure of the human brain. However, a major challenge when using MRI to derive quantitative measures is that the use of different scanners, as used in multi-site group studies, introduces measurement variability. This can lead to an increased variance in quantitative metrics, even if the same brain is scanned. Contrary to the assumption that these characteristics are
more &raquo; ... parable and similar, small changes in these values are observed in many clinical studies, hence harmonization of the signals is essential. In this paper, we present a method that does not require additional preprocessing, such as segmentation or registration, and harmonizes the signal based on a deep learning residual network. For this purpose, a training database is required, which consist of the same subjects, scanned on different scanners. The results show that harmonized signals are significantly more similar to the ground truth signal compared to no harmonization, but also improve in comparison to another deep learning method. The same effect is also demonstrated in commonly used metrics derived from the diffusion MRI signal.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1808.01595v1">arXiv:1808.01595v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3lvebvg4cnfdzbwl6zzf235rs4">fatcat:3lvebvg4cnfdzbwl6zzf235rs4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200930184442/https://arxiv.org/pdf/1808.01595v1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/d6/67/d667b823b5d2efe106e1ea3e49d0ffef6421be2e.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1808.01595v1" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

SA76. Open Board

J. Christopher Edgar, Charlie L. Fisk, Breannan Howell, Michael A. Hunter, Mingxiong Huang, Jose M. Canive, Gregory A. Miller
<span title="2017-03-01">2017</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/o67mrs6u45fmrmhkxo62gcvrli" style="color: black;">Schizophrenia Bulletin</a> </i> &nbsp;
BY OUR BOOTSTRAPS: IDENTIFYING BEST PRACTICES FOR MEASURING AUDITORY 40 HZ STEADY STATE NEURAL ACTIVITY J. Christopher Edgar* ,1 , Charlie L. Fisk IV 1 , Yuhan Chen 1 , Breannan Howell 2 , Michael A.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/schbul/sbx023.075">doi:10.1093/schbul/sbx023.075</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/aw3s72vnwjeyhce2n4lsnnynje">fatcat:aw3s72vnwjeyhce2n4lsnnynje</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190503133802/https://watermark.silverchair.com/sbx023.075.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAnMwggJvBgkqhkiG9w0BBwagggJgMIICXAIBADCCAlUGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM12T0ZwXNhEAQIvdEAgEQgIICJroSBnt0iPH0Y18dwvvXmo_2ogKm3Mx5uGMYUudXGcykc2S5NNEL5dYsm8JtB56HmtKqbcyq3OREmFDynyJaT9LHeMY4TeHpsQ3ogOEZrzP-3sPSAtUJNnSwH-CHZqPHrBmrh8xHx2QbEcbu92esykSLBGUn4HuCWlIDWh0lowG4blqXVLroJ0vHdOTqauJaLR8kEETamCdEZ3icRw0Wq3CKIntHfMikwPnU7T61u225_8t51g7nrMNOsUAGBqhN2OkFcCpbCLVD_ivpTLNQO2537s7dyY-6YVlVmlv02DxL526QpuIfLXjOIQ_mA1fF6wacLRrGD7fR_4NvdPOBDDbSgHYPofQNTUMSb32CjbHC4OIREmldPl0dF5XMMuuIcc5sz1C721X2R6HEHnQcbBxIaeHnGXkMJnWyw4J8Bs-YGjEnGtZWfIVCFrNsXEzpsj3Eg6KcIeUDPE8ZnHWOEh4qEgnk_vRwKRSmU4KcqSPsyMl5s38BtlP6bkQBuBSuMq8Pd9bjdToOLHMfptGE2YBzvGq6xQLEzpiVecJ24bHCrwbveeUye8a95MEi1VOw3FXzqdc0nS7mIeT56GdS0GhxCifTXJ-0lG2s4ghLcYnZVi69eF4Ut_29mBxOCXUQYN2fiMsJrvIXG0r2hfS9avkL703oVcTSL-U1sv_pi3LP5rwYIkTSPxDyepSHAFg6Mdf0PVq1ZPBai1QixZ-z4fcO3sN8sy8" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/18/41/184120d8845135508c56f4cf8d941a750834245d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/schbul/sbx023.075"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a>

Paraoxonase-1 is a major determinant of clopidogrel efficacy

Heleen J Bouman, Edgar Schömig, Jochem W van Werkum, Janna Velder, Christian M Hackeng, Christoph Hirschhäuser, Christopher Waldmann, Hans-Günther Schmalz, Jurriën M ten Berg, Dirk Taubert
<span title="2010-12-19">2010</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/aowhseoqprea3b5rljynk52q4m" style="color: black;">Nature Medicine</a> </i> &nbsp;
1 1 0 VOLUME 17 | NUMBER 1 | JANUARY 2011 nature medicine Clinical efficacy of the antiplatelet drug clopidogrel is hampered by its variable biotransformation into the active metabolite 1,2 . The variability in the clinical response to clopidogrel treatment has been attributed to genetic factors, but the specific genes and mechanisms underlying clopidogrel bioactivation remain unclear. Using in vitro metabolomic profiling techniques, we identified paraoxonase-1 (PON1) as the crucial enzyme for
more &raquo; ... lopidogrel bioactivation, with its common Q192R polymorphism determining the rate of active metabolite formation. We tested the clinical relevance of the PON1 Q192R genotype in a population of individuals with coronary artery disease who underwent stent implantation and received clopidogrel therapy. PON1 QQ192 homozygous individuals showed a considerably higher risk than RR192 homozygous individuals of stent thrombosis, lower PON1 plasma activity, lower plasma concentrations of active metabolite and lower platelet inhibition. Thus, we identified PON1 as a key factor for the bioactivation and clinical activity of clopidogrel. These findings have therapeutic implications and may be exploited to prospectively assess the clinical efficacy of clopidogrel. Antiplatelet therapy with the ADP P2Y12 receptor antagonist clopidogrel is recommended by current clinical practice guidelines to prevent atherothrombotic events in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI) with stent implantation. The main drawback of clopidogrel is a high interindividual variability in antiplatelet response 3 . Low platelet responsiveness to clopidogrel has been found to translate into a high incidence of atherothrombotic events, including stent thrombosis as the most serious and often fatal clinical event 4 . However, the biological mechanisms underlying the response variability remain largely unclear. In a recent genome-wide association analysis, it was estimated that 83% of individual variance in response to clopidogrel was attributable to genetic effects 5 , but the gene variants investigated thus far explain only a minor proportion of the response variability 6,7 . Clopidogrel is a thienopyridine prodrug that requires enzymatic conversion into its active thiol metabolite. Pharmacokinetic-pharmacodynamic analyses suggest that the majority of the variability in platelet response is explained by the variability in plasma concentrations of the active metabolite 8,9 . We postulated that genetic variants of drug-metabolizing enzymes would affect the response to clopidogrel. Using a validated microsomal expression system of metabolizing enzymes, we identified PON1, an esterase synthesized in the liver and associated with HDL in blood, as the rate-determining enzyme for the formation of the thiol active metabolite from clopidogrel. We found that the common functional PON1 Q192R gene polymorphism resulted in a more efficient clopidogrel bioactivation. On the basis of this mechanistic information, we performed a case-cohort study in individuals with CAD who underwent PCI and received clopidogrel therapy to comprehensively assess the relationships between the PON1 Q192R polymorphism, PON1 enzyme activity, clopidogrel pharmacokinetics, platelet response and the risk of stent thrombosis. Subsequently, we conducted an independent replication study evaluating the reliability and validity of the association between PON1 and clinical end points. We functionally expressed cytochrome P450 oxidoreductase isozymes (CYPs) and esterases in a human embryonic kidney cell line and monitored conversion of clopidogrel or potential metabolic clopidogrel intermediates in microsome preparations ( Fig. 1 and Supplementary Fig. 1) . We identified bioactivation of clopidogrel as a two-step process. The first step was an oxidation of clopidogrel to 2-oxo-clopidogrel catalyzed by CYP3A4, CY3A5, CYP2B6, CYP1A2, CYP1A1, CYP2E1 and CYP2A6 at enzymatic efficiencies (V max / K m ) of 16.02, 8.67, 2.61, 1.87, 0.88, 0.72 and 0.70 µl mg −1 min −1 , respectively. The second step was a hydrolytic cleavage of the γ-thiobutyrolactone ring of 2-oxo-clopidogrel to the pharmacologically active thiol metabolite catalyzed by the esterases PON1 and PON3 at enzymatic efficiencies of 0.36 and 0.030 µl mg −1 min −1 , respectively. This bioactivation step competed with the hydrolysis of the methyl ester in clopidogrel, 2-oxo-clopidogrel and the thiol metabolite to form inactive carboxylic acid metabolites at considerably higher conversion rates catalyzed by the esterases carboxylesterase-1, carboxylesterase-2 and butyrylcholinesterase (Supplementary Table 1 and Supplementary Fig. 2) . To further exclude that oxidative biotransformation was involved in the second step of active metabolite formation, as suggested previously 10-12 , we incubated 2-oxo-clopidogrel with human liver microsomes or with human serum, with equal paraoxonase activity in both preparations. There were no differences in the conversion rates to the thiol metabolite (Supplementary Fig. 3) . Moreover, pharmacological
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/nm.2281">doi:10.1038/nm.2281</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/21170047">pmid:21170047</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gi3sg2xqhffpvfk5busv6mhutm">fatcat:gi3sg2xqhffpvfk5busv6mhutm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200709233623/https://www.recherchecliniquepariscentre.fr/wp-content/uploads/2012/03/TD-UE7-3a-Clopido.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/bb/7c/bb7c20ce49138102d5f3987a50066dbf1fbc8a3c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/nm.2281"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> nature.com </button> </a>

Validating γ Oscillations and Delayed Auditory Responses as Translational Biomarkers of Autism

Michael J. Gandal, J. Christopher Edgar, Richard S. Ehrlichman, Mili Mehta, Timothy P.L. Roberts, Steven J. Siegel
<span title="">2010</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/z5ukx73avrb57kufzzr36timya" style="color: black;">Biological Psychiatry</a> </i> &nbsp;
Background-Difficulty modeling complex behavioral phenotypes in rodents (e.g., language) has hindered pathophysiological investigation and treatment development for autism spectrum disorders (ASD). Recent human neuroimaging studies, however, have identified functional biomarkers that can be more directly related to the abnormal neural dynamics of ASD. This study assessed the translational potential of auditory evoked-response endophenotypes of autism in parallel mouse and human studies of
more &raquo; ... . Methods-Whole-cortex magnetoencephalography was recorded in 17 typically developing and 25 autistic children during auditory pure-tone presentation. Superior temporal gyrus activity was analyzed in time and frequency domains. Auditory evoked potentials were recorded in mice prenatally exposed to valproic acid (VPA) and analyzed with analogous methods. Results-VPA-exposed mice demonstrated selective behavioral alterations related to autism, including reduced social interactions and ultrasonic vocalizations, increased repetitive selfgrooming, and prepulse inhibition deficits. Autistic subjects and VPA-exposed mice showed a similar 10% latency delay in the N1/M100 evoked response and a reduction in gamma frequency (30-50 Hz) phase-locking factor (PLF). Electrophysiological measures were associated with mouse behavioral deficits. In mice, gamma PLF was correlated with expression of the autism risk gene neuroligin-3 and neural deficits were modulated by the mGluR5-receptor antagonist MPEP. Conclusion-Results demonstrate a novel preclinical approach toward mechanistic understanding and treatment development for autism.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.biopsych.2010.09.031">doi:10.1016/j.biopsych.2010.09.031</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/21130222">pmid:21130222</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5070466/">pmcid:PMC5070466</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/i53morhao5gffizlyhwtqugpsa">fatcat:i53morhao5gffizlyhwtqugpsa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200429110644/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5070466&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ce/08/ce08d57a16a2911ea657dba863f3c30572fbd15a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.biopsych.2010.09.031"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070466" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Superior temporal gyrus spectral abnormalities in schizophrenia

J. Christopher Edgar, Faith M. Hanlon, Ming-Xiong Huang, Michael P. Weisend, Robert J. Thoma, Bruce Carpenter, Karsten Hoechstetter, José M. Cañive, Gregory A. Miller
<span title="">2008</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/egv6blesqvadjolgihukbwgnna" style="color: black;">Psychophysiology</a> </i> &nbsp;
Address reprint requests to: J.  ...  ., Edgar et al., 2003; Huang et al., 2003; Ligeois-Chauvel, Musolino, Badier, Marquis, & Chauvel, 1994) ; (2) the paired-click 50-ms ratio score deficit is observed in left but not always in right STG  ...  Although Edgar et al. (2003) found relatively weak associations between P50 and M50 suppression ratios, the weak correlations may simply reflect the fact that, because P50 gating does not correlate with  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/j.1469-8986.2008.00682.x">doi:10.1111/j.1469-8986.2008.00682.x</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/18665866">pmid:18665866</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC2685182/">pmcid:PMC2685182</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/na4m2fzypjbt7jyp7xtuslfaju">fatcat:na4m2fzypjbt7jyp7xtuslfaju</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200208064458/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2685182&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/2b/e6/2be64501023efea49dfca3ff71ea87265858dba1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/j.1469-8986.2008.00682.x"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685182" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Biomarkers for autism spectrum disorder: opportunities for magnetoencephalography (MEG)

Timothy P. L. Roberts, Emily S. Kuschner, J. Christopher Edgar
<span title="2021-09-15">2021</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zrapiew6nvbnbji3y2lmvg55nu" style="color: black;">Journal of Neurodevelopmental Disorders</a> </i> &nbsp;
Roberts, Kuschner, and Edgar contributed equally to the design and preparation of this manuscript. Dr. Roberts wrote the first draft; Drs. Edgar and Kuschner contributed significant editing.  ...  Edgar also declare intellectual property relating to the potential use of electrophysiological markers for treatment planning in clinical ASD. Dr. Edgar declares no other financial conflict. Dr.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s11689-021-09385-y">doi:10.1186/s11689-021-09385-y</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34525943">pmid:34525943</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8442415/">pmcid:PMC8442415</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ztqlmimi5jcv3n4vb5mdtvvkj4">fatcat:ztqlmimi5jcv3n4vb5mdtvvkj4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210929084339/https://jneurodevdisorders.biomedcentral.com/track/pdf/10.1186/s11689-021-09385-y.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/65/6b/656be1ca755eb2c9243e4d902c6c3a2141de6883.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s11689-021-09385-y"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8442415" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Extraformational sediment recycling on Mars

Kenneth S. Edgett, Steven G. Banham, Kristen A. Bennett, Lauren A. Edgar, Christopher S. Edwards, Alberto G. Fairén, Christopher M. Fedo, Deirdra M. Fey, James B. Garvin, John P. Grotzinger, Sanjeev Gupta, Marie J. Henderson (+11 others)
<span title="2020-10-06">2020</span> <i title="Geological Society of America"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/btagb6sahfeurofrj4reh4msla" style="color: black;">Geosphere</a> </i> &nbsp;
., , 2015 Edgar et al., 2018 Banham et al., 2018a; Stack et al., 2019) .  ...  Edgar et al., 2018 . Thus, the stratified clasts are interpreted to be sandstone fragments. Their size and angularity suggest minimal transport.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1130/ges02244.1">doi:10.1130/ges02244.1</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33304202">pmid:33304202</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7116455/">pmcid:PMC7116455</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4cvbkvmo2fbava46nyndprnxqa">fatcat:4cvbkvmo2fbava46nyndprnxqa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210717011009/https://digital.csic.es/bitstream/10261/234035/1/1508.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/0a/10/0a10921ae109b899c79e2921e97fed77f3c21589.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1130/ges02244.1"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7116455" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Resting-State Oscillatory Activity in Autism Spectrum Disorders

Lauren Cornew, Timothy P. L. Roberts, Lisa Blaskey, J. Christopher Edgar
<span title="2011-12-30">2011</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/rww2glc3bbfr3pqwz5ihdrbyb4" style="color: black;">Journal of Autism and Developmental Disorders</a> </i> &nbsp;
* Occipital ** Low gamma 60.92 <.001 Parietal * Occipital ** High gamma 38.49 <.001 Anterior temporal ** Posterior temporal ** Occipital * VFO 30.97 <.001 Anterior temporal ** J  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s10803-011-1431-6">doi:10.1007/s10803-011-1431-6</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22207057">pmid:22207057</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3638261/">pmcid:PMC3638261</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/rlvosldnnbhkjecpax7l55p35q">fatcat:rlvosldnnbhkjecpax7l55p35q</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191023004732/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3638261&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/93/d3/93d39b4d08c865a5ae8473e1002a00413cdcb508.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s10803-011-1431-6"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638261" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

G-baToN: a versatile cell-cell interaction reporter system [article]

Rui Tang, Christopher W. Murray, Ian Linde, Nicholas J. Kramer, Min K. Tsai, Leo Chen, Hongchen Cai, Aaron D. Gitler, Edgar Engleman, Monte M Winslow
<span title="2020-02-02">2020</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Shue for critical reagents; D. 578 Feldser, J. Sage, Y. Chien, N. Kipniss and members of the Winslow laboratory for helpful 579 comments.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.02.01.929877">doi:10.1101/2020.02.01.929877</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5ls3walqoze3dmifgwvsqdimiq">fatcat:5ls3walqoze3dmifgwvsqdimiq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200711182308/https://www.biorxiv.org/content/biorxiv/early/2020/05/22/2020.02.01.929877.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/bd/05/bd05be6dd4de8bb121bc78938e35e7bcb2944939.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.02.01.929877"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

Molecular Mechanisms of Bortezomib Resistant Adenocarcinoma Cells

Erika Suzuki, Susan Demo, Edgar Deu, Jonathan Keats, Shirin Arastu-Kapur, P. Leif Bergsagel, Mark K. Bennett, Christopher J. Kirk, Susheela Tridandapani
<span title="2011-12-22">2011</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3gm7274mfe6fcs7e3jterqlri" style="color: black;">PLoS ONE</a> </i> &nbsp;
Bortezomib (Velcade TM ) is a reversible proteasome inhibitor that is approved for the treatment of multiple myeloma (MM). Despite its demonstrated clinical success, some patients are deprived of treatment due to primary refractoriness or development of resistance during therapy. To investigate the role of the duration of proteasome inhibition in the anti-tumor response of bortezomib, we established clonal isolates of HT-29 adenocarcinoma cells adapted to continuous exposure of bortezomib.
more &raquo; ... cells were ,30-fold resistant to bortezomib. Two novel and distinct mutations in the b5 subunit, Cys63Phe, located distal to the binding site in a helix critical for drug binding, and Arg24Cys, found in the propeptide region were found in all resistant clones. The latter mutation is a natural variant found to be elevated in frequency in patients with MM. Proteasome activity and levels of both the constitutive and immunoproteasome were increased in resistant cells, which correlated to an increase in subunit gene expression. These changes correlated with a more rapid recovery of proteasome activity following brief exposure to bortezomib. Increased recovery rate was not due to increased proteasome turnover as similar findings were seen in cells co-treated with cycloheximide. When we exposed resistant cells to the irreversible proteasome inhibitor carfilzomib we noted a slower rate of recovery of proteasome activity as compared to bortezomib in both parental and resistant cells. Importantly, carfilzomib maintained its cytotoxic potential in the bortezomib resistant cell lines. Therefore, resistance to bortezomib, can be overcome with irreversible inhibitors, suggesting prolonged proteasome inhibition induces a more potent anti-tumor response.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0027996">doi:10.1371/journal.pone.0027996</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22216088">pmid:22216088</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3245226/">pmcid:PMC3245226</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bdjyqz36dzcydge5nk3bkhp3pu">fatcat:bdjyqz36dzcydge5nk3bkhp3pu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171002145055/http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0027996&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/2d/e8/2de8e6b4bbc4d91e3736436b41fb1fe95ee92501.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0027996"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245226" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

UCHIME improves sensitivity and speed of chimera detection

Robert C. Edgar, Brian J. Haas, Jose C. Clemente, Christopher Quince, Rob Knight
<span title="2011-06-23">2011</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4r72gbmtcrde5no3fwwogjs3cu" style="color: black;">Computer applications in the biosciences : CABIOS</a> </i> &nbsp;
The stand-alone UCHIME program is tested and also an implementation of the same algorithm in the USEARCH package (Edgar, 2010) .  ...  Two versions of UCHIME are tested: a stand-alone program and a second implementation of the UCHIME algorithm in the USEARCH package (Edgar, 2010) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/bioinformatics/btr381">doi:10.1093/bioinformatics/btr381</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/21700674">pmid:21700674</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3150044/">pmcid:PMC3150044</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/iqumpamaafdmpgaghhkaiuepsi">fatcat:iqumpamaafdmpgaghhkaiuepsi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190225234559/http://pdfs.semanticscholar.org/6960/bf08825bfab78f7f1ce7301d5c23cfbbdea6.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/69/60/6960bf08825bfab78f7f1ce7301d5c23cfbbdea6.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/bioinformatics/btr381"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150044" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Selection of Apoptotic Cell Specific Human Antibodies from Adult Bone Marrow

Caroline Grönwall, Edgar D. Charles, Lynn B. Dustin, Christoph Rader, Gregg J. Silverman, Srinivas Kaveri
<span title="2014-04-23">2014</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3gm7274mfe6fcs7e3jterqlri" style="color: black;">PLoS ONE</a> </i> &nbsp;
IgM expression system To express recombinant IgM, we used the pIgM, and Igk or Igl vectors [24] , with expression in HEK293T cells that stably express the Ig J-chain, as previously described [24] .  ...  Murine B-1 clones also more frequently have gene rearrangements without N-insertions in the V-D and D-J junctions [44] suggesting that they arise before birth in the fetal liver that lacks expression  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0095999">doi:10.1371/journal.pone.0095999</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24760047">pmid:24760047</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3997490/">pmcid:PMC3997490</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/v4qj7633hffzzkefo5ggv3h43i">fatcat:v4qj7633hffzzkefo5ggv3h43i</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171010000414/http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0095999&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/78/7c/787c6df838f87d9b4929c09d514c80302e70c803.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0095999"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997490" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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