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Constituents of Ramalina capitata (Ach.) Nyl. extracts

Ivana Zrnzević, Olga Jovanović, Ivana Zlatanović, Igor Stojanović, Goran Petrović, Gordana Stojanović
2016 Figshare  
Note: RI -experimental retention indices; RL -retention indices from literature; S/Nsignal-to-noise; Eether extract; EAethyl acetate extract; DCMdichloromethane extract; a -Zrnzević et al. (2015); b -Stojanović  ... 
doi:10.6084/m9.figshare.4499048 fatcat:37btebmyofaefjnxwrpo4lvj5e

Mature Intracranial Teratoma

Irena Dimov, Desanka Tasić, Ivana Stojanović, Simonida Stojanović, Nebojša Stojanović, Ivan Stefanović, Dragan Dimov
2013 Acta Facultatis Medicae Naissensis  
Irena Dimov¹ , ², Desanka Tasić³, Ivana Stojanović³, Simonida Stojanović³, Nebojša Stojanović 4 , Ivan Stefanović 4 , Dragan Dimov³ ¹Univerzitet u Nišu, Medicinski fakultet, Srbija ²Institut za imunologiju  ... 
doi:10.2478/v10283-012-0043-1 fatcat:pwlkug6mxbdx7kkhtjgihyhrvy

Hypogymnia tubulosa extracts: chemical profile and biological activities

Gordana Stojanović, Ivana Zlatanović, Ivana Zrnzević, Miroslava Stanković, Vesna Stankov Jovanović, Bojan Zlatković
2017 Figshare  
This study reports for the first time in the chemical composition of acetone, ether, ethyl acetate and dichloromethane extracts of Hypogymnia tubulosa determined by HPLC-UV, GC-FID and GC-MS as well as effect of H. tubulosa acetone extract on micronucleus distribution on human lymphocytes and on cholinesterase activity. Additionally, antioxidant (estimated via DPPH, ABTS, TRP, CUPRAC and TPC assays) and antibacterial activity against two Gram-positive and three Gram-negative bacteria were also
more » ... etermined. The HPLC-UV analysis revealed the presence of depsidones, 3-hydroxyphysodic, 4-O-methyl physodic acid, physodic and physodalic acid together with two depsides, atranorin and chloroatranorin. GC-FID and GC-MS analyses enabled the identification of atranol, chloroatranol, atraric acid, olivetol, olivetonide and 3-hydroxyolivetonide as the main components. The results of present study show that H. tubulosa acetone extract is a promising candidate for in vivo experiments considering antioxidant activity.
doi:10.6084/m9.figshare.5401858 fatcat:v4w6k42c2bdupdy5bhe5fto4xu

From Myth to Reality: Stevan Stojanović Mokranjac and Serbian Church Music

Vesna Peno, Ivana Vesić
2018 Muzikološki Zbornik  
In this paper, we will focus on the historical reconstruction of Stevan Stojanović Mokranjac's work in the field of melography and pedagogy of Serbian church chant.  ...  In Honour of Roksanda Pejović, Ivana Perković Radak, Dragana Stojanović-Novičić eds. (Belgrade: Faculty of Music -Belgrade, 2006), 208-210. 31 Cf. Manojlović, St. St.  ...  Music Editions, 1998). 24 Biljana Milanović, ed., Stevan Stojanović Mokranjac (1856-1914).  ... 
doi:10.4312/mz.54.1.49-58 fatcat:25ugmzy3ibgp5mym43tqfj2li4

Are all performatives statements?

Ivana Stojanovic-Prelevic
2019 Theoria Beograd  
Ivana Stojanović Prelević Famous Austin's example of constatives is "The cat is on the mat''. With a constative we describe a certain state of affairs. They are either true or false.  ...  Ivana Stojanović Prelević Da li su svi performativi tvrdnje? (Apstrakt) U radu branim Ostinovu tezu da performativi nisu tvrdnje.  ... 
doi:10.2298/theo1904017s fatcat:3jgydkrizjhghgkm6fw5bjeoaa

Therapeutic potential of agmatine in the experimental autoimmune encephalomyelitis

Ivana Stevanovic, Milica Ninkovic, Jelena Stanojevic, Bojana Mancic, Ivana Stojanovic
2019 Vojnosanitetski Pregled  
/ Aim: Experimental autoimmune encephalomyelitis (EAE) is a model of multiple sclerosis (MS), in which we investigated the neuroprotective effect of agmatine (AGM), known as a primary amine produced via the decarboxylation of L-arginine. Methods: Dark Agouti rats were divided into groups: control (C), Complete Freund's Adjuvant (CFA), EAE rats decapitated at 13 th dpi (EAE13) and at 20 th dpi (EAE20), EAE animals applied with three (EAE+AGM13) and 10 (EAE+AGM20) doses of AGM, and healthy
more » ... administered with three/10 doses of AGM (AGM). Thiobarbituric acidreacting substances (TBARS), SH groups (SH), total glutathione (GSH), glutathione peroxidase activity (GPx), superoxide dismutase activities (tSOD, MnSOD, CuZnSOD) and nitrite/nitrate concentration (NO 2 +NO 3 ) were assessed in plasma and brain structures (whole encephalitic mass-WEM and brainstem-BS). Results: Obtained results showed that AGM treatment successfully attenuated severe clinical deficits in EAE. Applications of AGM in EAE rats induced normalized TBARS, SH, GSH, GPx and NO in WEM. In BS, AGM expressed less prominent effects, inducing normalized TBARS, GPx and NO, but no effect on SH and GSH. In both brain structures, tSOD activity lowered and normalized at the peak and in the remission phase of the disease, post-AGM treatment. The effect of AGM on the MnSOD in EAE was expressed in WEM/BS only in the remissive phase as a reduced activity. Conclusion: Milder clinical form of developed EAE in rats indicates promising therapeutic effect of AGM in MS. The activated antioxidant system and suppressed oxidative/ nitrosative stress development may denote a successful blockade of neuroinflammation initiated by EAE immunization. The study implies the capability of AGM to attenuate oxidative/ nitrosative damage in the peak of EAE by modulating antioxidative defense capacity during the time-course of the disease. Thus, AGM may be considered as an agent with a beneficial effect on neuroinflammation in EAE. Abstrakt Uvod: Eksperimentalni autoimunski encefalomijelitis (EAE) je model multiple skleroze (MS), u kome su ispitivani neuroprotektivni efekti agmatina (AGM), poznatog primarnog amina koji se dobija dekarboksilacijom L-arginina. Metode: Dark Aguti pacovi su 4 podeljeni u grupe: kontrola (C), kompletni Frojdov adjuvans (CFA), EAE pacovi dekapitovani 13 dana (EAE13) i 20 dana (EAE20) nakon imunizacije, EAE životinje sa tri (EAE+AGM13) i 10 (EAE+AGM20) doza AGM i zdrave životinje sa tri/10 doza AGM (AGM). Reaktivne supstance koje reaguju sa tiobarbiturnom kiselinom (TBARS), SH grupe (SH), koncentracija ukupnog glutationa (GSH), aktivnost glutation peroksidaze (GPx), aktivnost superoksid dizmutaza (tSOD, MnSOD, CuZnSOD) i koncentracija nitrita/nitrata (NO 2 +NO 3 ) su određivani u plazmi i moždanim strukturama (kompletna encefalitična masa-WEM i produžena moždina-BS). Rezultati: Dobijeni rezultati pokazuju da tretman sa AGM uspešno smanjuje teški klinički deficit kod EAE. Aplikacija AGM kod EAE pacova normalizuje TBARS, SH, GSH, GPx i NO u WEM. U BS, AGM dovodi do manje izraženih efekata normalizacijom TBARS, GPx i NO, ali nema efekata na SH grupe i GSH. U obe moždane strukture, tSOD je smanjena i normalizovana u piku i remisiji bolesti nakon tretmana sa AGM. Efekat AGM na MnSOD kod EAE je izražen u WEM/BS samo u toku remisije bolesti kao redukcija aktivnosti enzima. Zaključak: Blaža forma razvijenog EAE pokazuje izraženi terapijski efekat AGM kod MS. Aktivirani antioksidativni sistem i supresija razvoja oksidativnog/ nitrozativnog stresa mogu označiti uspešnu blokadu neuroinflamacije indukovanu EAE imunizacijom. Studija pokazuje sposobnost AGM da ublaži oksidativno/ nitrozativno oštećenje u piku EAE modulacijom kapaciteta antioksidativne odbrane u toku trajanja bolesti. U tom smislu, AGM se može smatrati agensom sa antioksidativnim pristupom za lečenje i prevenciju neuroinflamacije u EAE.
doi:10.2298/vsp190707145s fatcat:ekpre2arqvbivlvhqgfpvvcgom

Agmatine prevents acute chlorpromazine-induced neurotoxicity in rats

Bratislav Dejanović, Milica Ninković, Ivana Stojanović, Irena Lavrnja, Tatjana Radičević, Ivana Stevanović
2015 Arhiv za farmaciju  
Ovа studijа se bavi ispitivanjem potencijаlno zaštitinih efekata аgmаtina (AGM) nа razvoj oksidаtivnog/nitrozativnog stresa u selektivno osetljivim strukturama mozga pacova nakon davanja hlorpromаzina (HPZ). Sve ispitivane supstance aplikovane su u pojedinačnoj dozi intraperitonealno (i.p.). Životinje su podeljene na kontrolnu (K, 0.9 % fiziološki rastvor), HPZ (HPZ, 38.7 mg/kg TM), HPZ+AGM (AGM, 75 mg/kg TM odmah nakon HPZ, 38.7 mg/kg TM i.p.) i AGM (AGM, 75 mg/kg TM) grupu i žrtvovane
more » ... cijom 24 h nakon odgovarajućeg tretmana. Rezultаti pokаzuju dа primena HPZ sa AGM značajno smanjuje koncentraciju leka u mozgu pacova u poređenju sа HPZ-životinjаmа (p<0.05). Aplikacija HPZ povećava lipidnu peroksidaciju (p<0.001 u korteksu, strijatumu i hipokampusu), koncentraciju nitrita i nitrata (p<0.001 u sva tri ispitivana regiona mozga) i stvaranje superoksidnog anjon radikala (p<0.05 u sve tri moždane strukture) u odnosu na odgovarajuću kontrolu, dok istovremeno utiče na oštećenje enzimskog antioksidativnog sistema (superoksid dizmutaza u korteksu i strijatumu p<0.05, odnosno hipokampusu p<0.001; glutation reduktaza u kori mozga i strijatumu p<0.001, odnosno hipokampusu p<0.05; katalaza u korteksu p<0.001, odnosno
doi:10.5937/arhfarm1506329d fatcat:3krzcqqaobfcbnju4pyo3tlvse

Protective effect of agmatine in acute chlorpromazine hepatotoxicity in rats

Bratislav Dejanovic, Ivana Stevanovic, Milica Ninkovic, Ivana Stojanovic, Vesna Vukovic-Dejanovic
2014 Acta Veterinaria Brno  
The present study focused on potentially beneficial effects of agmatine on oxidative stress development in the liver during chlorpromazine treatment in rats. We wanted to examine the role of reactive oxygen species and efficiency of antioxidant protection through the determination of malondylaldehyde and total glutathione concentrations in rat liver homogenate, as well as plasma concentrations of malonylaldehyde and sulfhydryl groups after the treatment. Also, liver tissue sections were
more » ... to follow histological changes. Chlorpromazine was applied intraperitoneally at a single dose of 38.7 mg/kg b.w. The second group was treated with both chlorpromazine (at a single dose of 38.7 mg/kg b.w.) and agmatine (at a single dose of 75 mg/kg b.w.). Agmatine was applied immediately after the chlorpromazine. The control group was treated with 0.9% saline solution in the same manner. Rats were sacrificed by decapitation 24 h after the treatment and biochemical and immunohistochemical examinations were performed. Analysis of data showed that treatment with agmatine significantly attenuated the oxidative stress indicators as evidenced by lowering malonylaldehyde concentrations in the liver and in plasma while not affecting liver concentrations of total glutathione and plasma concentration of sulfhydryl groups. Additionally, histological evaluation revealed the improvement of liver damage in this respect. The presented data indicated that intraperitoneally administered agmatine protects against chlorpromazine-induced liver disease in rats.
doi:10.2754/avb201483040305 fatcat:ssyydlgntvathgjc3maceim3um

The role of NUPR1 in lymphocyte proliferation and apoptosis

Milica Vujicic, Bobana Vasic, Ivana Nikolic, Tamara Saksida, Ivana Stojanovic
2017 Archives of Biological Sciences  
Nuclear protein 1 (NUPR1) is a transcription cofactor that senses stressful conditions and modulates cellular response by promoting or inhibiting apoptosis. NUPR1 is usually highly expressed in tumor cells where it enables them to adapt and resist environmental stress or chemotherapeutic compounds. NUPR1 can be involved in cell proliferation. Data about the involvement of NUPR1 in the proliferation and apoptosis of lymphocytes are scarce. Therefore, in this study we focused on the role of NUPR1
more » ... in lymphocyte physiology and found that NUPR1 might be involved in the initiation of their proliferation. Lymphocytes were isolated from the cervical lymph nodes of C57BL/6 mice. NUPR1 expression subsided 24 h after the induction of proliferation by a mitogen. Also, stressful conditions after cell isolation led to increased NUPR1 mRNA and protein expression in vitro that coincided with cell apoptosis. Similarly, apoptosis induction by staurosporine, a broadrange protein kinase inhibitor, led to increased NUPR1 expression. In addition, NUPR1 inhibition by small-interfering RNA prevented the staurosporine-induced apoptosis (judging from decreased caspase activity) in the whole cell population of cervical lymph nodes. However, NUPR1 absence was irrelevant to the induction of apoptosis in CD3 + T lymphocytes, suggesting that NUPR1 is probably a mediator of apoptosis in other immune cell populations within the lymph node, such as B lymphocytes. In conclusion, our results suggest that NUPR1 is important for the initiation of lymphocyte cell division and for the apoptotic process of non-T cells during stressful conditions.
doi:10.2298/abs160707096v fatcat:42sieiszejaqxfsow3thoqqwva

Folic Acid Effect on Arginase Activity in Human Colostrum and Mature Milk

Ljiljana Bjelakovic, Gordana Kocic, Ivana Stojanovic, Tatjana Jevtovic-Stoimenov, Stevo Najman, Dusan Sokolovic, Svetlana Stojanovic, Gordana Kocic
2012 Pteridines  
Folic acid, or folates are available from a large variety of sources, such as green leafy vegetables (spinach, beans) and liver. The importance of folates is based on their requirement as coenzymes in the transfer and utilization of one-carbon units in a variety of biosynthetic reactions. Folate is an essential cofactor for the de novo biosynthesis of purine nucleotides and thymine, thus influencing RNA and DNA synthesis. Therefore, during periods of rapid cell regeneration and growth, such as
more » ... regnancy and infancy, increased amounts of folate are required. Folate has the roles in the prevention of neural tube defects, an important cause of infant mortality and disability. The periconceptional folic acid intake reduces the risk of neural tube defects. Arginase, as part of the urea cycle, detoxifies human body from ammonia. Its activity is important in the production of ornithine, subsequently leading to the production of polyamines (spermine and spermidine), glutamate or proline, and nitric oxide. Arginase is normally present in mother's milk. In the present study, the effect of folic acid supplementation during pregnancy on the dynamics of arginase activity and malondialdehyde concentration in human colostrum and mature milk was studied. The obtained results suggest that in breastfeeding mothers' colostrum and mature human milk samples, supplemented with folic acid during pregnancy (400µg/daily periconceptionaly), the arginase activity increases compared with the enzyme activity in milk samples taken from mothers who did not take folic acid. At the same time, the supplementation with folic acid causes malondialdehyde decrease in colostrum and mature milk.
doi:10.1515/pteridines.2012.23.1.33 fatcat:btu5imwjgvcgjmxydxwwcooqkm

5`-Nukleotidase and adenosine deaminase in patients with rheumatoid arthritis

Nela Zivkovic, Boris Djindjic, Sonja Stojanovic, Ivana Krstic, Ivana Ciric, Tomislav Kostic, Gordana Kocic
2017 Vojnosanitetski Pregled  
Svetlani Stojanović, for their unselfish help.  ... 
doi:10.2298/vsp151125267z fatcat:4qel2wxsang65bpiuzm4u6tzdu

MOGUĆNOSTI DRUŠTVENIH MEDIJA U OSTVARIVANJU MARKETINŠKIH CILJEVA PREDUZEĆA

Goran Dašić, Ivana Stojanović
2017 ZBORNIK MES  
Zadovoljni i lojalni potrošači cilj su svakog preduzeća. Međutim, taj cilj u savremenim uslovima poslovanja, koje karakterišu dinamične promene u okruženju, globalizacija i tehnološki razvoj, veoma je teško ostvariti. Svi navedeni faktori utiču na povećanje konkurentnosti i veću informisanost potrošača, što rezultira instinktivnim kupovnim ponašanjem i odsustvom lojalnosti. Internet, kao mreža svih mreža, za relativno kratko vreme je napravila pravu revoluciju koja ima veliki uticaj kako na
more » ... dinca, tako i na poslovni svet, odnosno način poslovanja preduzeća. Faza u razvoju interneta poznatija kao Web 2.0 izbacila je u prvi plan društvene mreže koje vrlo brzo ovladavaju virtuelnim svetom o čemu svedoči veliki broj aktivnih korisnika. U ovom radu će upravo biti reči o društvenim mrežama kao mediju koji ima višestruki uticaj na marketinške ciljeve preduzeća.
doi:10.7251/mfp1701258d fatcat:ofujnhhkw5bipa7xs7zx7bqwca

SELFIES, PERFORMATIVITY, AND INDIVIDUALISM

Ivana Stojanovic Prelevic
2021 Facta Universitatis Series Visual Arts and Music  
We can identify the use of these selfies with the propaganda technique called the "technique of innocence" (Stojanović Prelević, 2019, 167) .  ...  Yet some theorists think that the first selfie appeared in New York in 1920 (Stojanović Prelević, 2020) . What are the similarities and differences between a self-portrait and a selfie?  ... 
doi:10.22190/fuvam2002137s fatcat:xtbdavuq6vfxteoiffo7pli2ey

Effect of L-NAME on AlCl3-induced toxicity in rat brain

Stevanovic Ivana, Jovanovic Marina, Jelenkovic Ankica, Bokonjic D., Colic M., Stojanovic Ivana, Ninkovic Milica
2009 Acta Veterinaria  
Stevanovi} Ivana et al.:Effect of L-NAME on AlCl 3 -induced toxicity in rat brain Acta Veterinaria (Beograd), Vol. 59. No. 2-3, 133-146, 2009. Stevanovi} Ivana et al.  ...  Stevanovi} Ivana et al.: Effect of L-NAME on AlCl 3 -induced toxicity in rat brain Figure 2A,B.  ... 
doi:10.2298/avb0903133s fatcat:s3dsdp6a5bfypnnrhejz3okm6q

Multidimensional aspects of pain in myotonic dystrophies

Marina Peric, Stojan Peric, Nada Rapajic, Valerija Dobricic, Dusanka Savic-Pavicevic, Ivana Nesic, Svetlana Radojicic, Ivana Novakovic, Dragana Lavrnic, Vidosava Rakocevic-Stojanovic
2015 Acta myologica  
To analyze the frequency and intensity of pain and its association with different characteristics of patients with myotonic dystrophy type 1 (DM1) and type 2 (DM2), 52 adult genetically confirmed DM1 and 44 DM2 patients completed the Brief Pain Inventory questionnaire (BPI). Frequency and average intensity of pain on numerical rating scale (0-10) were similar in DM1 and DM2 (88% vs. 86% and 4.6 ± 2.3 vs. 4.2 ± 1.8, respectively, p > 0.05). In DM1, average pain intensity showed strong
more » ... with longer duration of disease and inverse relation with cognition. In DM2, average pain intensity showed association with female gender and emotions. Average pain intensity correlated with Individualized Neuromuscular Quality of Life (INQoL) total score in both DM1 (rho = +0.30, p < 0.05) and DM2 patients (rho = +0.61, p < 0.01). In conclusion, the majority of DM1 and DM2 patients have mild to moderate pain. Our results open new opportunities for behavioral and cognitive interventions.
pmid:27199540 pmcid:PMC4859081 fatcat:gvw43lg6ufbexdshmdx5ztotby
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