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Australian Schizophrenia Research Bank: a database of comprehensive clinical, endophenotypic and genetic data for aetiological studies of schizophrenia

Carmel Loughland, Daren Draganic, Kathryn McCabe, Jacqueline Richards, Aslam Nasir, Joanne Allen, Stanley Catts, Assen Jablensky, Frans Henskens, Patricia Michie, Bryan Mowry, Christos Pantelis (+4 others)
2010 Australian and New Zealand journal of psychiatry (Print)  
This article describes the establishment of the Australian Schizophrenia Research Bank (ASRB), which operates to collect, store and distribute linked clinical, cognitive, neuroimaging and genetic data  ...  The ASRB is a valuable and accessible schizophrenia research facility for use by approved scientific investigators.  ...  Declaration of interest : The Australian Schizophrenia  ... 
doi:10.3109/00048674.2010.501758 pmid:21034186 fatcat:beqlvu6jmvdarifxybcs4ggd7q

The Importance of Brain Banks for Molecular Neuropathological Research: The New South Wales Tissue Resource Centre Experience

Irina Dedova, Antony Harding, Donna Sheedy, Therese Garrick, Nina Sundqvist, Clare Hunt, Juliette Gillies, Clive Harper
2009 International Journal of Molecular Sciences  
The focus of this tissue collection is on schizophrenia and allied disorders, alcohol use disorders and controls.  ...  The New South Wales Tissue Resource Centre (TRC) at The University of Sydney has grown from a small tissue collection into one of the leading international brain banking facilities, which operates with  ...  The Australian Brain Donor Programs NSW Tissue Resource Centre is supported by The University of Sydney, National Health and Medical Research Council of Australia, Schizophrenia Research Institute, National  ... 
doi:10.3390/ijms10010366 pmid:19333451 pmcid:PMC2662458 fatcat:hlecpmgaencexk7cbtznhh27i4

Association of NOS1AP variants and depression phenotypes in schizophrenia

Sern-Yih Cheah, Bruce R. Lawford, Ross McD. Young, C. Phillip Morris, Joanne Voisey
2015 Journal of Affective Disorders  
The nitric oxide synthase 1 adaptor protein gene (NOS1AP) has previously been recognised as a schizophrenia susceptibility gene due to its role in glutamate neurotransmission.  ...  Methods: Nine NOS1AP SNPs, rs1415259, rs1415263, rs1858232, rs386231, rs4531275, rs4656355, rs4657178, rs6683968 and rs6704393 were genotyped in 235 schizophrenia subjects screened for various phenotypes  ...  Acknowledgements This study was supported by a Post-graduate Research Award scholarship provided by the Queensland University of Technology, and the Australian Schizophrenia Research Bank (ASRB), which  ... 
doi:10.1016/j.jad.2015.08.069 pmid:26384012 fatcat:dhku5p4idrdjbcoxviavtr77me

Reduced integrity of the left arcuate fasciculus is specifically associated with auditory verbal hallucinations in schizophrenia

Simon McCarthy-Jones, Lena K.L. Oestreich, Thomas J. Whitford
2015 Schizophrenia Research  
Method: Diffusion tensor imaging scans and clinical data were obtained from the Australian Schizophrenia Research Bank for 39 schizophrenia patients with lifetime AVH (18 current, 21 remitted), 74 schizophrenia  ...  Evidence was found for a non-linear relation between fractional anisotropy in the AF L and state AVH.  ...  This study was supported by the Schizophrenia Research Institute using data from the Australian Schizophrenia Research Bank, funded by NHMRC Enabling Grant (No. 386500) held by V Carr, U Schall, R Scott  ... 
doi:10.1016/j.schres.2014.12.041 pmid:25631452 fatcat:aoxq55dvnjazhhn2i2n5ocxeym

Dysbindin (DTNBP1) variants are associated with hallucinations in schizophrenia

S.-Y. Cheah, B.R. Lawford, R.M. Young, C.P. Morris, J. Voisey
2015 European psychiatry  
The gene is known to be associated with cognitive deficit phenotypes within schizophrenia.  ...  Methods: Five DTNBP1 SNPs, rs17470454, rs1997679, rs4236167, rs9370822 and rs9370823 were genotyped in 235 schizophrenia subjects screened for various phenotypes in the domains of depression, mania, hallucinations  ...  Acknowledgements This study was supported by the Post-graduate Research Award scholarship provided by the Queensland University of Technology, and the Australian Schizophrenia Research Bank (ASRB), which  ... 
doi:10.1016/j.eurpsy.2015.01.008 pmid:25697573 fatcat:bsdk6bvuoza4lotrwqbv3jrp4a

Brain donation for schizophrenia research: gift, consent, and meaning

M Boyes
2003 Journal of Medical Ethics  
research into schizophrenia.  ...  Organ donation for purposes of research differs from transplant donation in a number of ways, most notably the absence of a single recipient.  ...  their brain when they die for research into schizophrenia.  ... 
doi:10.1136/jme.29.3.165 pmid:12796437 pmcid:PMC1733720 fatcat:euf27l7k2jddzmh65qon4ozdqm

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Barbara Franke, Jason L Stein, Stephan Ripke, Verneri Anttila, Derrek P Hibar, Kimm J E van Hulzen, Alejandro Arias-Vasquez, Jordan W Smoller, Thomas E Nichols, Michael C Neale, Andrew M McIntosh, Phil Lee (+22 others)
2016 Nature Neuroscience  
We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant Franke et al. genetic architecture or for single genetic markers  ...  The current study provides proof-of-concept (albeit based on a limited set of structural brain measures), and defines a roadmap for future studies investigating the genetic covariance between structural  ...  The expected proportion under the null is 0.5. Nat Neurosci. Author manuscript; available in PMC 2016 August 01.  ... 
doi:10.1038/nn.4228 pmid:26854805 pmcid:PMC4852730 fatcat:d2celhhusravto6fr7g3fxvfqi

Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells

Erin J. Gardiner, Murray J. Cairns, Bing Liu, Natalie J. Beveridge, Vaughan Carr, Brian Kelly, Rodney J. Scott, Paul A. Tooney
2013 Journal of Psychiatric Research  
controls from the Australian Schizophrenia Research Bank (ASRB).  ...  Peripheral blood mononuclear cells (PBMCs) represent an accessible tissue source for gene expression profiling in schizophrenia that could provide insight into the molecular basis of the disorder.  ...  using the Australian Schizophrenia Research Bank (ASRB).  ... 
doi:10.1016/j.jpsychires.2012.11.007 pmid:23218666 pmcid:PMC7094548 fatcat:pbxhgr5rivbyjgbnhy477x5a4i

Psychosis prevalence and physical, metabolic and cognitive co-morbidity: data from the second Australian national survey of psychosis

V. A. Morgan, J. J. McGrath, A. Jablensky, J. C. Badcock, A. Waterreus, R. Bush, V. Carr, D. Castle, M. Cohen, C. Galletly, C. Harvey, B. Hocking (+6 others)
2013 Psychological Medicine  
., 44 The full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes  ...  2014) 'Psychosis prevalence and physical, metabolic and cognitive co-morbidity : data from the second Australian national survey of psychosis.  ...  Declaration of Interest D.C. has received grant monies for research from Eli Lilly, Janssen Cilag, Roche, Allergen, Bristol-Myers Squibb, Pfizer, Lundbeck, AstraZeneca and Hospira; travel support and honoraria  ... 
doi:10.1017/s0033291713002973 pmid:24365456 pmcid:PMC4045165 fatcat:yw5bauc7zbhfthyfnp7bprfwgi

Detecting motion signals of intent in schizophrenia

Robyn Langdon, Jillian McMillan, Tao Gao
2014 Psychiatry Research  
Perceiving intent was generally intact in patients, despite the well-known difficulties with inferring intentional mental states in schizophrenia.  ...  Compared to controls, patients had relatively higher hit rates for less direct compared to more direct chasing trials.  ...  Recruitment was facilitated by the Australian Schizophrenia Research Bank (supported by the National Health and Medical Research Council of Australia), Pratt Foundation, Ramsay Health Care, Viertel Charitable  ... 
doi:10.1016/j.psychres.2014.06.012 pmid:25048755 fatcat:vios33qafvdftir6kkrzbpx77a

Genetic variants in Nogo receptor signaling pathways may be associated with early life adversity in schizophrenia susceptibility

Jessica L. Andrews, Francesca Fernandez-Enright
2015 BBA Clinical  
Conclusions: Despite the lack of positive findings in our population after correction for multiple testing, previous gene expression and association studies in schizophrenia suggest the implication of  ...  Nogo signaling is responsible for central nervous system myelin regulation and neurite outgrowth during neurodevelopment, and plasticity in the mature brain.  ...  This study was supported by the Australian Schizophrenia Research Bank, which is supported by the National Health and Medical Research Council of Australia, the Pratt Foundation, Ramsay Health Care, the  ... 
doi:10.1016/j.bbacli.2014.11.008 pmid:26673096 pmcid:PMC4661513 fatcat:3oyoottxfzgfvkpqwv73laxbf4

An Australian Brain Bank: a critical investment with a high return!

D. Sheedy, T. Garrick, I. Dedova, C. Hunt, R. Miller, N. Sundqvist, C. Harper
2008 Cell and Tissue Banking  
Community support for this program is strong with over 2,000 people  ...  The New South Wales Tissue Resource Centre (TRC) in the University of Sydney (Australia) is a human brain bank that can provide tissues to the neuroscience research community studying alcohol-related brain  ...  The NSW TRC is supported by The University of Sydney, Schizophrenia Research Institute (SRI), National Institutes on Alcohol Abuse and Alcoholism (NIAAA-grant no: R01AAA01272508), Sydney South Western  ... 
doi:10.1007/s10561-008-9076-1 pmid:18543078 pmcid:PMC3391553 fatcat:t3gflhbhnfcifneymiru5bvzqm

The NSW brain tissue resource centre: Banking for alcohol and major neuropsychiatric disorders research

G.T. Sutherland, D. Sheedy, J. Stevens, T. McCrossin, C.C. Smith, M. van Roijen, J.J. Kril
2016 Alcohol  
The New South Wales Brain Tissue Resource Centre (NSWBTRC) at the University of Sydney (Australia) is an established human brain bank providing tissue to the neuroscience research community for investigations  ...  The NSWBTRC relies on wide community engagement to encourage those with and without neuropsychiatric illness to consent to donation through its allied research programs.  ...  Acknowledgments The New South Wales Brain Tissue Resource Centre at the University of Sydney is supported by The University of Sydney and the Schizophrenia Research Institute.  ... 
doi:10.1016/j.alcohol.2016.02.005 pmid:27139235 pmcid:PMC4855871 fatcat:eat7nj6gtffyhmjisgndy6e2ci

BDNF SNPs Are Implicated in Comorbid Alcohol Dependence in Schizophrenia But Not in Alcohol-Dependent Patients Without Schizophrenia

Sern-Yih Cheah, Bruce R. Lawford, Ross McD. Young, Jason P. Connor, C. Phillip Morris, Joanne Voisey
2014 Alcohol and Alcoholism  
Comorbid alcohol dependence has a high prevalence in schizophrenia so we investigated the role of rs6265 in alcohol dependence in Australian populations of schizophrenia and alcohol-dependent patients.  ...  When these SNPs were tested in the non-schizophrenia alcohol-dependent group we were unable to detect association.  ...  Acknowledgements -This study was supported by the Australian Schizophrenia Research Bank (ASRB), which is supported by the National Health and Medical Research Council of Australia, the Pratt Foundation  ... 
doi:10.1093/alcalc/agu040 pmid:24993285 fatcat:t6zundggpvb3jb2cgyas6ueueq

White matter alterations between brain network hubs underlie processing speed impairment in patients with schizophrenia

Paul Klauser, Vanessa L Cropley, Philipp S Baumann, Jinglei Lv, Pascal Steullet, Daniella Dwir, Yasser Aleman, Meritxell Bach Cuadra, Michel Cuenod, Kim Do, Philippe Conus, Christos Pantelis (+3 others)
2021 Schizophrenia Bulletin Open  
from the Australian Schizophrenia Research Bank.  ...  Processing speed (PS) impairment is one of the most severe and common cognitive deficits in schizophrenia.  ...  Acknowledgements We would like to acknowledge Jason Bridge for the management of data from the Australian Schizophrenia Research Bank.  ... 
doi:10.1093/schizbullopen/sgab033 pmid:34901867 pmcid:PMC8650074 fatcat:hcwrs3nczza4lc2vn4jkrpltoy
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