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Bombali Ebola Virus in Mops condylurus Bat, Kenya

Kristian M. Forbes, Paul W. Webala, Anne J. Jääskeläinen, Samir Abdurahman, Joseph Ogola, Moses M. Masika, Ilkka Kivistö, Hussein Alburkat, Ilya Plyusnin, Lev Levanov, Essi M. Korhonen, Eili Huhtamo (+6 others)
2019 Emerging Infectious Diseases  
No Ebola virus-specific RNA or antibodies were detected from febrile humans in the area who reported contact with bats.  ...  Bombali virus (genus Ebolavirus) was identified in organs and excreta of an Angolan free-tailed bat (Mops condylurus) in Kenya.  ...  His research interests include the maintenance and transmission of rodentborne and batborne zoonotic pathogens in nature and the effects of anthropogenic environmental changes on these processes.  ... 
doi:10.3201/eid2505.181666 pmid:31002301 pmcid:PMC6478230 fatcat:p2phzzckdvgx3juudjbrtytxeu

Range Expansion of Bombali Virus in Mops condylurus Bats, Kenya, 2019

Lauri Kareinen, Joseph Ogola, Ilkka Kivistö, Teemu Smura, Kirsi Aaltonen, Anne J. Jääskeläinen, Sospeter Kibiwot, Moses M. Masika, Philip Nyaga, Dufton Mwaengo, Omu Anzala, Olli Vapalahti (+3 others)
2020 Emerging Infectious Diseases  
This finding supports the role of M. condylurus bats as hosts and the potential for Bombali virus circulation across the bats' range in sub-Saharan Africa.  ...  Previously identified only in Sierra Leone, Guinea, and southeastern Kenya, Bombali virus-infected Mops condylurus bats were recently found »750 km away in western Kenya.  ...  Kareinen is a veterinarian and a PhD student at the University of Helsinki. His research interests include the maintenance and circulation of zoonotic viruses in bat hosts.  ... 
doi:10.3201/eid2612.202925 pmid:33219788 pmcid:PMC7706938 fatcat:7xmxhioz5baedpb7p7cf6qxw3u

Viruses in bats and potential spillover to animals and humans

Lin-Fa Wang, Danielle E Anderson
2019 Current Opinion in Virology  
In the last two decades, several high impact zoonotic disease outbreaks have been linked to bat-borne viruses. These include SARS coronavirus, Hendra virus and Nipah virus.  ...  It is being increasingly accepted that bats are potential reservoirs of a large number of known and unknown viruses, many of which could spillover into animal and human populations.  ...  the potential of these viruses to cause disease in humans and animals is yet to be ascertained.  ... 
doi:10.1016/j.coviro.2018.12.007 pmid:30665189 pmcid:PMC7102861 fatcat:w64ym5i3zvautmmldzsqe5uyye

Filovirus-reactive antibodies in humans and bats in Northeast India imply zoonotic spillover

Pilot Dovih, Eric D. Laing, Yihui Chen, Dolyce H. W. Low, B. R. Ansil, Xinglou Yang, Zhengli Shi, Christopher C. Broder, Gavin J. D. Smith, Martin Linster, Uma Ramakrishnan, Ian H. Mendenhall (+1 others)
2019 PLoS Neglected Tropical Diseases  
High risk activities at the bat-human interface pose the threat of zoonotic virus transmission.  ...  Bats are reservoirs for several zoonotic pathogens, including filoviruses. Recent work highlights the diversity of bat borne filoviruses in Asia.  ...  The project or effort depicted was or is sponsored by the Department of the Defense, Defense Threat Reduction Agency.  ... 
doi:10.1371/journal.pntd.0007733 pmid:31671094 pmcid:PMC6822707 fatcat:vglou2zkf5h7phni4nx6ney3ty

Social and Political Dimensions of Disseminating Research Findings on Emerging Zoonotic Viruses: Our Experience in Sierra Leone

Dorothy Peprah, James Bangura, Mohamed Vandi, Harold Thomas, Monica Dea, Anton Schneider, Kendra Chittenden
2021 Global Health: Science and Practice Journal  
pointed to the tensions that can arise between discoveries of emerging viruses with zoonotic potential and their impact on the people in direct proximity to the ecosystems in which they are found as well  ...  We discuss the complexities and challenges in disseminating research findings on the discovery of a new ebolavirus in bats in Sierra Leone, particularly in light of the previous outbreaks. n This experience  ...  Brian Bird, who were instrumental in the process of disseminating research findings.  ... 
doi:10.9745/ghsp-d-20-00321 pmid:34593573 pmcid:PMC8514041 fatcat:25lbcrdkczgj3oy4kocnzjfrda

Seroprevalence of Ebola virus infection in Bombali District, Sierra Leone

Nadege Goumkwa Mafopa, Gianluca Russo, Raoul Emeric Guetiya Wadoum, Emmanuel Iwerima, Vincent Batwala, Marta Giovanetti, Antonella Minutolo, Patrick Turay, Thomas B. Turay, Brima Kargbo, Massimo Amicosante, Mattei Maurizio (+2 others)
2017 Journal of Public Health in Africa  
A serosurvey of anti-Ebola Zaire virus nucleoprotein IgG prevalence was carried out among Ebola virus disease survivors and their Community Contacts in Bombali District, Sierra Leone.  ...  Our data suggest that the specie of Ebola virus (Zaire) responsible of the 2013-2016 epidemic in West Africa may cause mild or asymptomatic infection in a proportion of cases, possibly due to an efficient  ...  Acknowledgments: the data presented here were obtained with the financial support of the Italian Episcopal Conference (Camillian Task Force), the Italian Cooperation (Dokita ONG) and the Italian Geographical  ... 
doi:10.4081/jphia.2017.732 pmid:29456826 pmcid:PMC5812302 fatcat:p7ntyd7ouvhxrbxp7avqv57yve

The virome hunters

Charles Schmidt
2018 Nature Biotechnology  
Once it is established that a novel virus infects human cells, animal models will have to be established to study pathogenicity.  ...  Dubbed Bombali after the district where the bats were captured, this new species is the first Ebola virus to have its initial identification in an animal host rather than from a sick person.  ... 
doi:10.1038/nbt.4268 pmid:30307913 fatcat:cpeoqeslbvaefggzzp33ypku7i

Coronaviruses Detected in Bats in Close Contact with Humans in Rwanda

Julius Nziza, Tracey Goldstein, Mike Cranfield, Paul Webala, Olivier Nsengimana, Thierry Nyatanyi, Antoine Mudakikwa, Alexandre Tremeau-Bravard, Dennis Byarugaba, Jean Claude Tumushime, Ivan Emil Mwikarago, Isidore Gafarasi (+2 others)
2019 EcoHealth  
Bats living in close contact with people in Rwanda were tested for evidence of infection with viruses of zoonotic potential.  ...  Known coronaviruses detected included the betacorona viruses: Kenya bat coronaviruses, Eidolon bat coronavirus, and Bat coronavirus HKU9, as well as an alphacoronavirus, Chaerephon Bat coronavirus.  ...  In conclusion, bats in Rwanda carry novel and known coronaviruses, a family of viruses from which novel viruses have caused human pandemics.  ... 
doi:10.1007/s10393-019-01458-8 pmid:31811597 fatcat:oumtodgpxfe45lhmxyulix75vq

Ebola Virus Neutralizing Antibodies in Dogs from Sierra Leone, 2017

Kerstin Fischer, Roland Suluku, Sarah Katharina Fehling, Juliet Jabaty, Bashiru Koroma, Thomas Strecker, Martin H. Groschup, Sandra Diederich
2020 Emerging Infectious Diseases  
Ebola virus (EBOV) is a highly pathogenic zoonotic virus for which the reservoir host has not been identified.  ...  To study the role of dogs as potential hosts, we screened 300 serum samples from dogs in Sierra Leone and found EBOV neutralizing antibodies in 12, suggesting their susceptibility to natural infection.  ...  Her research focuses on highly pathogenic ebolaviruses and henipaviruses, their virus-host interactions, and the epidemiologic role of domestic animals and livestock in their ecology.  ... 
doi:10.3201/eid2604.190802 pmid:32186496 fatcat:vtjmmhawdnhqjgnpv63tdfeo5y

Human antibody cocktail deploys multiple functions to confer pan-ebolavirus protection [article]

Anna Z Wec, Zachary A Bornholdt, Shihua He, Andrew S Herbert, Eileen Goodwin, Ariel S Wirchnianski, Bronwyn M Gunn, Zirui Zhang, Wenjun Zhu, Guodong Liu, Dafna M Abelson, Crystal L Moyer (+18 others)
2018 bioRxiv   pre-print
During the unprecedented 2013-2016 Ebola virus disease (EVD) epidemic in Western Africa and in its aftermath, the passive administration of monoclonal antibodies (mAbs) emerged as a promising treatment  ...  One component of this cocktail is a pan-ebolavirus neutralizing mAb, ADI-15878, isolated from a human EVD survivor.  ...  This work is supported by NIH grants AI1332204 and AI132256 (to K.C.) and U19AI109762 (to KC., J.M.D., and L.Z.), and by  ... 
doi:10.1101/395525 fatcat:6wzulhrecvavpceix5sw2ogeiq

Ebola Virus L Polymerase RdRp Sequence and Phylogenetic Analysis

Mohamed El gohary, Amir Eissa, Abdo Elfiky, Amr Desouky
2019 Egyptian Journal of Biomedical Engineering and Biophysics  
Inhibition of the viral polymerase succeeded is in stopping the infection of other viruses such as Hepatitis C Virus (HCV).  ...  E BOLA Virus (EBOV) infection affects humans beings in the last four decades with the deadliest outbreak at 2015 in West Africa, leaving more than 10,000 deaths.  ...  Introduction Ebola virus is stand out amongst the most harmful pathogens known to contaminate people. 1 The first recognized Ebola outbreak occurred at 1976, near Ebola River in Zaire (now Democratic  ... 
doi:10.21608/ejbbe.2019.17450.1027 fatcat:4mldxmnoyzd2zneqntydlliv2e

Recombinant Vesicular Stomatitis Virus Vector Vaccines for WHO Blueprint Priority Pathogens

Anahita Fathi, Christine Dahlke, Marylyn M. Addo
2019 Human Vaccines & Immunotherapeutics  
The devastating Ebola virus (EBOV) outbreak in West Africa in 2013-2016 has flagged the need for the timely development of vaccines for high-threat pathogens.  ...  To this end, the detailed characterization of vaccine platforms is needed.  ...  Disclosure of potential conflicts of interest The authors declare no conflict of interest.  ... 
doi:10.1080/21645515.2019.1649532 pmid:31368826 pmcid:PMC6816421 fatcat:4522a2sxtjgexk4igjrvxpusj4

In This Issue

2020 EcoHealth  
RIFT VALLEY FEVER VIRUS IN NIGERIA Rift Valley Fever (RVF) is a fatal arboviral zoonoses affecting domestic, wild ruminants and humans in Africa and the Middle-East.  ...  VIRUS TRANSMISSION RISKS IN NEPAL Wolking et al. conducted surveillance for viruses in small mammals and assessed potential risks for virus transmission to people in urban settlements along rivers in Kathmandu  ... 
doi:10.1007/s10393-020-01505-9 pmid:33237501 fatcat:fiuvrfsrvndoxeq5s5v3msqflm

Shedding of soluble glycoprotein 1 detected during acute Lassa virus infection in human subjects

Luis M Branco, Jessica N Grove, Lina M Moses, Augustine Goba, Mohammed Fullah, Mambu Momoh, Randal J Schoepp, Daniel G Bausch, Robert F Garry
2010 Virology Journal  
by a secreted glycoprotein component in filoviruses, another class of hemorrhagic fever-causing viruses.  ...  With a high rate of infection that may lead to morbidity and mortality, understanding how the virus interacts with the host's immune system is of great importance for generating vaccines and therapeutics  ...  Normal human sera used in these studies were collected in the Bombali district of Northern Province, Sierra Leone, and designated BOM.  ... 
doi:10.1186/1743-422x-7-306 pmid:21062490 pmcid:PMC2993672 fatcat:rz5g2bkoajfulaueku4vzvlso4

The Utility of Human Immune System Mice for High-Containment Viral Hemorrhagic Fever Research

David M. Wozniak, Kerry J. Lavender, Joseph Prescott, Jessica R. Spengler
2020 Vaccines  
Viral hemorrhagic fevers (VHFs) cause severe disease in humans, typically with high case fatality rates.  ...  HIS mouse studies have been performed to investigate the pathogenesis and immune responses to VHFs that must be handled in high-containment laboratory facilities.  ...  Acknowledgments: The authors thank Tatyana Klimova for assistance in editing the manuscript. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/vaccines8010098 pmid:32098330 fatcat:5lwrlphycved3bzwxxratmi7om
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