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Investigation of sequence features of hinge-bending regions in proteins with domain movements using kernel logistic regression

Ruth Veevers, Gavin Cawley, Steven Hayward
2020 BMC Bioinformatics  
Using statistical methods and Kernel Logistic Regression (KLR) models, this data was used to determine sequence features that favour or disfavour hinge-bending regions.  ...  Hinge-bending movements in proteins comprising two or more domains form a large class of functional movements.  ...  Conclusions We have used statistical methods and machine learning methods to investigate sequence features of hinge-bending regions.  ... 
doi:10.1186/s12859-020-3464-3 pmid:32272894 fatcat:al4xgo4xyvcslm3fi65zi3bfcq

Modelling the dynamic pattern of surface area in basketball and its effects on team performance

Rodolfo Metulini, Marica Manisera, Paola Zuccolotto
2018 Journal of Quantitative Analysis in Sports (JQAS)  
Because of the advent of GPS techniques, a wide range of scientific literature on Sport Science is nowadays devoted to the analysis of players' movement in relation to team performance in the context of  ...  and analysis of a game with respect to surface areas dynamics and (ii) to investigate its influence on the points made by both the team and the opponent.  ...  We investigate research movements and trends in statistical science in the academic filed using Latent Dirichlet Allocation (LDA).  ... 
doi:10.1515/jqas-2018-0041 fatcat:b3qwsi7tqjg2vdo7gbjtiorv6m

In Silico Studies in Drug Research Against Neurodegenerative Diseases

Farahnaz Rezaei Makhouri, Jahan B. Ghasemi
2018 Current Neuropharmacology  
Results: Detailed analysis of the recently reported case studies revealed that the majority of them use a sequential combination of ligand and structure-based virtual screening techniques, with particular  ...  multiple proteins (and therefore etiologies) involved in the development of a disease is recommended in future.  ...  routine and novel feature selection methods, for example, using LDA, binary logistic regression (BLR), genetic algorithm-based neural networks, ANN.  ... 
doi:10.2174/1570159x15666170823095628 pmid:28831921 pmcid:PMC6080098 fatcat:irfiwke6crgtphyqn2iv5wtl6y

Understanding cytoskeletal avalanches using mechanical stability analysis [article]

Carlos Floyd, Herbert Levine, Christopher Jarzynski, Garegin A. Papoian
2021 arXiv   pre-print
Here, we use agent-based simulations of cytoskeletal self-organization to study fluctuations in the network's mechanical energy.  ...  The large events of energy release are found to correlate with large, collective displacements of the cytoskeletal filaments.  ...  A L2 penalty of 0.05 is used to curb overfitting. When using only U (t) as a predictor, a logistic regression model is fit using the same sample weights.  ... 
arXiv:2006.01884v4 fatcat:a34aajzvjjc4ji3xbo2hmq7a6a

Classification of knee arthropathy with accelerometer-based vibroarthrography

Dinis Moreira, Joana Silva, Miguel V Correia, Marta Massada
2016 Studies in Health Technology and Informatics  
The best classification was obtained using the k-nearest neighbors classifier with only 6 time-frequency features with an overall accuracy of 89.8% and with a precision, recall and f-measure of 88.3%,  ...  In this study, a vibration-based classification system was created using a dataset with 92 healthy and 120 arthritic segments of knee joint signals collected from 19 healthy and 20 arthritic volunteers  ...  The most commonly used non parametric classifiers are the k-Nearest Neighbors (k-NN) and the logistic regression. [83] .  ... 
pmid:27225550 fatcat:4sxa7ojcvnharbpzdeee4wxd5a

Plasmodium falciparumK76TpfcrtGene Mutations and Parasite Population Structure, Haiti, 2006–2009

Macarthur Charles, Sanchita Das, Rachel Daniels, Laura Kirkman, Glavdia G. Delva, Rodney Destine, Ananias Escalante, Leopoldo Villegas, Noah M. Daniels, Kristi Shigyo, Sarah K. Volkman, Jean W. Pape (+1 others)
2016 Emerging Infectious Diseases  
of not only each mutation but also of each domain of PfCRT in both fitness and function.  ...  Diagnostic tools used to reduce the burden of malaria in the control phase are less effective in regions undergoing programmatic reorientation toward malaria elimination.  ...  We have recently described the hinge region between domain I and II of the dengue E protein as a target of some human monoclonal antibodies that neutralize DENVs.  ... 
doi:10.3201/eid2205.150359 pmid:27089479 pmcid:PMC4861504 fatcat:vssqgctonfhyrc7k6zhwf5zhke

Program

2022 2022 International Conference on Decision Aid Sciences and Applications (DASA)  
The selected features from EEG recordings of 23 subjects (AD-12 and NC-11) are used to train and test the Leastsquare support vector machine (LS-SVM) classifier with three different kernel functions.  ...  A maximum of 92.90% classification accuracy is obtained using the features of IMF-4 with 10-fold cross-validation. The results conclude that the proposed method can detect AD patients efficiently.  ...  The headcount index was used to determine the prevalence of poverty in the selected households, and the analysis was conducted using a binary logistic regression model.  ... 
doi:10.1109/dasa54658.2022.9765271 fatcat:ttqppf4j3navnaxe653mrzmezi

ACNP 55th Annual Meeting: Panels, Mini-Panels and Study Groups

2016 Neuropsychopharmacology  
and synaptic proteins have been associated with both regional and general encephalitic syndromes that produce either movement or psychiatric disorders.  ...  A logistic regression revealed that the severity of the alcohol use disorder, neuroticism, and a life time history of affective disorders explained most of the variance in "dark side" symptoms.  ...  However, the ability of ketamine to produce a rapid and long-lasting antidepressant response in patients with depression provides a unique opportunity for investigation of mechanisms that mediate these  ... 
doi:10.1038/npp.2016.239 fatcat:wg7pyurlzvhp7bvlmlbxtkunl4

Modern Applied Science, Vol. 3, No. 1, January 2009, all in one file

Editor MAS
2008 Modern Applied Science  
Yamin, Universiti Kebangsaan Malaysia for helping in doing microanalysis; as well as Desy Anggraini, Chandra Rini P. and Arif Dwi R. who help us in the preparation of the samples.  ...  provide fund for this project to be undertaken through Hibah Bersaing XVI/1 Research Grant Scheme 2008 with contract number of 010/SP2H/PP/DP2M/III/2008, 6 March 2008.  ...  in the region, n = number of segments in the sample.  ... 
doi:10.5539/mas.v3n1p0 fatcat:jovqztw2qre4ra46ggzarwfatu

A binaural advantage in the subjective modulation transfer function with simple impulse responses

Eric R. Thompson, Torsten Dau
2008 Journal of the Acoustical Society of America  
Extraction of green fluorescent proteins with sonoporation. 2pBBb3. Blood-brain barrier disruption using a diagnostic scanner and Definity in mice.  ...  In general, simulated results of C 80 and G are found to be in good agreement with regression models.  ...  Using this model, we found some common"different features in the perception of expressive speech.  ... 
doi:10.1121/1.2933699 fatcat:4nc5pg4ysbhgrjcatwhr7fh77q

On determination of microphone response and other parameters by a hybrid experimental and numerical method

Salvador Barrera‐Figueroa, Finn Jacobsen, Knud Rasmussen
2008 Journal of the Acoustical Society of America  
Extraction of green fluorescent proteins with sonoporation. 2pBBb3. Blood-brain barrier disruption using a diagnostic scanner and Definity in mice.  ...  In general, simulated results of C 80 and G are found to be in good agreement with regression models.  ...  Using this model, we found some common"different features in the perception of expressive speech.  ... 
doi:10.1121/1.2933455 fatcat:gl6kkwih6rbkriigc7g6ghdlnq

The importance of bass clarity in pop and rock venues

Niels W. Adelman‐Larsen, Eric R. Thompson
2008 Journal of the Acoustical Society of America  
Extraction of green fluorescent proteins with sonoporation. 2pBBb3. Blood-brain barrier disruption using a diagnostic scanner and Definity in mice.  ...  In general, simulated results of C 80 and G are found to be in good agreement with regression models.  ...  Using this model, we found some common"different features in the perception of expressive speech.  ... 
doi:10.1121/1.2932922 fatcat:fvtlbt6x5vgelp5p67x53qtvgi

From the Editor-in-Chief

Kimon P. Valavanis
2018 Journal of Intelligent and Robotic Systems  
Acknowledgement We thank Mrs Christiane Gauvin for secretarial assistance, Acknowledgement The author is indebted to many colleagues and friends for the active discussions and exchanges both in the  ...  As Y111H missense mutation is located in the highly conserved region of the adiponectin gene -at the hinge between the collagen and globular domains, it was previously suggested that this mutation may  ...  HBV-DNA quantification In order to detect HBV-DNA sequences in sera of the patients the conventional PCR method with conserved pre-S/S region primers was used.  ... 
doi:10.1007/s10846-018-0847-z fatcat:zg6ye677mbgxvfxhlqw35n7ega

Leveraging novel information for coarse-grained prediction of protein motion

Ines Putz, Technische Universität Berlin, Technische Universität Berlin, Oliver Brock
2018
Information that is specific to the problem domain, i.e. protein motion in our case, usually results in better models.  ...  Proteins are involved in almost all functions in our cells due to their ability to combine conformational motion with chemical specificity.  ...  Acknowledgments We designed features specific to our problem domain, as well as reuse or extend features used in previous work from our group (Schneider and Brock, 2014) .  ... 
doi:10.14279/depositonce-7660 fatcat:lg7knsmpgrdh7ag5il35rnztxu

XXIInd Congress of the European Society for Stereotactic and Functional Neurosurgery. Madrid, Spain,September 28-October 1, 2016: Abstracts

2016 Stereotactic and Functional Neurosurgery  
Therefore, detection of increased (over the 50 percentile) beta band activity (22-28 Hz) was used to trigger the stimulation in the adaptive condition.  ...  images with 1 mm slice thickness.  ...  The fibrosis limited the movement of the neck and during head rotations, it caused pain in the scalp, especially around the scars above Stimlocks.  ... 
doi:10.1159/000448961 pmid:27676399 fatcat:wlmdt6rwsbdmha6vtkin6ywbou
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