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High-frequency oscillations (HFOs) in clinical epilepsy

J. Jacobs, R. Staba, E. Asano, H. Otsubo, J.Y. Wu, M. Zijlmans, I. Mohamed, P. Kahane, F. Dubeau, V. Navarro, J. Gotman
2012 Progress in Neurobiology  
EC Entorhinal cortex EEG Electroencephalogram EZ Epileptogenic zone HFO High frequency oscillation HS Hippocampal sclerosis MEG Magnetencephalogram MTLE Mesial temporal lobe epilepsy SOZ Seizure onset  ...  High-frequency oscillations (HFOs) between 80 and 500 Hz, which can be recorded with EEG, may be novel markers of the epileptogenic zone.  ...  Acknowledgments This publication is the outcome of the workshop "High Frequency Oscillations in Epilepsy and Cognition" held at the Montreal Neurological Institute on June 2-4, 2011.  ... 
doi:10.1016/j.pneurobio.2012.03.001 pmid:22480752 pmcid:PMC3674884 fatcat:svii4mhjrvdqjm37yzrxyp6auu

High-frequency oscillations and other electrophysiological biomarkers of epilepsy: clinical studies

Greg Worrell, Jean Gotman
2011 Biomarkers in Medicine  
Keywords epilepsy surgery; epileptogenic zone; fast ripple; high-frequency oscillation; ripple; seizure onset zone; wide bandwidth EEG Neuronal oscillations recorded from human brain span a wide range  ...  Extracellular local field potentials (LFPs) recorded from human brain range from direct current shifts to high-frequency oscillations (HFOs; ~0-1000 Hz).  ...  Acknowledgments Bibliography Papers of special note have been highlighted as:  ... 
doi:10.2217/bmm.11.74 pmid:22003904 pmcid:PMC3254091 fatcat:7hbt6iddzzen5dggsjqt4wnt7q

Recent advances in the noninvasive detection of high-frequency oscillations in the human brain

Yuying Fan, Liping Dong, Xueyan Liu, Hua Wang, Yunhui Liu
2020 Reviews in the Neurosciences  
AbstractIn recent decades, a significant body of evidence based on invasive clinical research has showed that high-frequency oscillations (HFOs) are a promising biomarker for localization of the seizure  ...  Noninvasively detected scalp HFOs have been investigated in various types of epilepsy. HFOs have also been studied noninvasively in other pathologic brain disorders, such as migraine and autism.  ...  Jing Xiang (Director of MEG center, Division of Neurology, Cincinnati Children's Medical Center, USA) very much for revising and editing the manuscript.  ... 
doi:10.1515/revneuro-2020-0073 pmid:33661582 fatcat:o3gh4nombbdb7lbrra4meyjyg4

High-frequency oscillations detected in ECoG recordings correlate with cavernous malformation and seizure-free outcome in a child with focal epilepsy: A case report

Su Liu, Michael M. Quach, Daniel J. Curry, Monika Ummat, Elaine Seto, Nuri F. Ince
2017 Epilepsia Open  
High-frequency oscillations (HFOs) in intracranial electroencephalogram (EEG) are reported as potential biomarkers of epileptogenic regions, but to our knowledge there are no data on the existence of HFOs  ...  Epilepsy associated with cavernous malformation (CM) often requires surgical resection of seizure focus to achieve seizure-free outcome.  ...  This observation needs to be investigated in studies with larger numbers of patients to explore whether the HFOs can be used as an early predictor of resection zone.  ... 
doi:10.1002/epi4.12056 pmid:29588956 pmcid:PMC5719856 fatcat:o53rrzhfqrfmbd3hhil5kzu7q4

Pitfalls in Scalp High-Frequency Oscillation Detection From Long-Term EEG Monitoring

Nathalie Gerner, Aljoscha Thomschewski, Adrian Marcu, Eugen Trinka, Yvonne Höller
2020 Frontiers in Neurology  
We aimed to investigate the applicability of high-frequency oscillation analysis to routine surface EEG obtained at an epilepsy monitoring unit.  ...  Results: We detected high-frequency oscillations in 17 out of 18 patients and in four out of six controls.  ...  We further would like to thank the team of the Epilepsy Monitoring Unit in Salzburg for their support.  ... 
doi:10.3389/fneur.2020.00432 pmid:32582002 pmcid:PMC7280487 fatcat:ox622f4oa5h5bo6jdifrsfgloi

Scalp high-frequency oscillation rates are higher in younger children

Dorottya Cserpan, Ece Boran, Santo Pietro Lo Biundo, Richard Rosch, Johannes Sarnthein, Georgia Ramantani
2021 Brain Communications  
We used an automated and clinically validated high-frequency oscillation detector to determine ripple rates (80-250 Hz) in bipolar channels.  ...  EEG intervals of ≥ 10 min duration are required for reliable measurements of high-frequency oscillation rates.  ...  The funders had no role in the design or analysis of the study.  ... 
doi:10.1093/braincomms/fcab052 pmid:33870193 pmcid:PMC8042248 fatcat:ka675henanazll7bguvfej73aa

High-frequency (80–500Hz) oscillations and epileptogenesis in temporal lobe epilepsy

Maxime Lévesque, Aleksandra Bortel, Jean Gotman, Massimo Avoli
2011 Neurobiology of Disease  
and seizure onset zones.  ...  High-frequency oscillations (HFOs), termed ripples and fast ripples (250-600 Hz), are recorded in the EEG of epileptic patients and in animal epilepsy models; HFOs are thought to reect pathological activity  ...  Panuccio for helpful comments on an earlier version of the manuscript. We also thank J.-P. Acco for the artwork.  ... 
doi:10.1016/j.nbd.2011.01.007 pmid:21238589 pmcid:PMC4873283 fatcat:r4vibu22m5a4vp3h57yrkpds5q

Removing high-frequency oscillations

Julia Jacobs, Joyce Y. Wu, Piero Perucca, Rina Zelmann, Malenka Mader, Francois Dubeau, Gary W. Mathern, Andreas Schulze-Bonhage, Jean Gotman
2018 Neurology  
MORE ONLINE Glossary ECoG = electrocorticography; FR = fast ripple; HFO = high-frequency oscillation; iEEG = intracranial EEG; SOZ = seizure onset zone; UCLA = University of California Los Angeles; UF  ...  Objective To evaluate the use of interictal high-frequency oscillations (HFOs) in epilepsy surgery for prediction of postsurgical seizure outcome in a prospective multicenter trial.  ...  FR = fast ripple; HFO = high-frequency oscillation; NA = not applicable; SOZ = seizure onset zone. a Significant.  ... 
doi:10.1212/wnl.0000000000006158 pmid:30120133 pmcid:PMC6140372 fatcat:orjzcejzxjcfvjxxly4bnbbda4

High-frequency oscillations in scalp EEG mirror seizure frequency in pediatric focal epilepsy

Ece Boran, Johannes Sarnthein, Niklaus Krayenbühl, Georgia Ramantani, Tommaso Fedele
2019 Scientific Reports  
High-frequency oscillations (HFO) are promising EEG biomarkers of epileptogenicity.  ...  Scalp HFO rates showed a significant positive correlation with seizure frequency (R2 = 0.80, p < 0.001).  ...  The funders had no role in the design or analysis of the study.  ... 
doi:10.1038/s41598-019-52700-w pmid:31719543 pmcid:PMC6851354 fatcat:srceibug7rdijpeuiln3fccvn4

Neocortical Temporal Lobe Epilepsy

Eduard Bercovici, Balagobal Santosh Kumar, Seyed M. Mirsattari
2012 Epilepsy Research and Treatment  
Various studies have attempted to correctly localize the seizure focus in nTLE as patients with this disorder may benefit from surgery.  ...  Complex partial seizures (CPSs) can present with various semiologies, while mesial temporal lobe epilepsy (mTLE) is a well-recognized cause of CPS, neocortical temporal lobe epilepsy (nTLE) albeit being  ...  Jean Gotman, Montreal Neurological Institute, Canada, for the illustration on HFOs (Figure 2 ).  ... 
doi:10.1155/2012/103160 pmid:22953057 pmcid:PMC3420667 fatcat:oxuuex2m4jgp7llk5mmuzwuc3m

Neocortical temporal lobe epilepsy [chapter]

A Ebner
2008 Textbook of Epilepsy Surgery  
Various studies have attempted to correctly localize the seizure focus in nTLE as patients with this disorder may benefit from surgery.  ...  Complex partial seizures (CPSs) can present with various semiologies, while mesial temporal lobe epilepsy (mTLE) is a wellrecognized cause of CPS, neocortical temporal lobe epilepsy (nTLE) albeit being  ...  Jean Gotman, Montreal Neurological Institute, Canada, for the illustration on HFOs (Figure 2 ).  ... 
doi:10.3109/9780203091708-41 fatcat:qrxyyn2f2bfldeql6b4w6oudba

Presurgical diagnosis of epilepsies – concepts and diagnostic tools

Heinz Gregor Wieser
2016 Journal of Epileptology  
Potential modern surrogate markers of epileptogenicity, such as High frequency oscillations, Ictal slow waves/DC shifts, Magnetic resonance spectroscopy, Functional MRI, the use of Magnetized nanoparticles  ...  The definitions of the various cortical zones have been conceptualized in the presurgical evaluation of candidates for epilepsy surgery: the seizure onset zone versus the epileptogenic zone, the symptomatogenic  ...  Potential modern surrogate markers of epileptogenesis and epileptogenicity High Frequency Oscillations (HFOs - figure 10 ) has emerged as a new biomarker for epileptogenic tissue, which holds the promise  ... 
doi:10.1515/joepi-2016-0014 fatcat:4clma3n6fjbfrnhzm5752rahdm

Ictal Occurrence of High-Frequency Oscillations Correlates With Seizure Severity in a Rat Model of Temporal Lobe Epilepsy

Nadja Birk, Jan Schönberger, Karin Helene Somerlik-Fuchs, Andreas Schulze-Bonhage, Julia Jacobs
2021 Frontiers in Human Neuroscience  
High-frequency oscillations (HFOs, ripples 80–250 Hz, fast ripples 250–500 Hz) are biomarkers of epileptic tissue.  ...  Overall results provide additional evidence that HFOs can be used as biomarkers for measuring seizure severity in epilepsy.  ...  INTRODUCTION High-frequency oscillations (HFOs) between 80 and 500 Hz are biomarkers for epileptic tissue.  ... 
doi:10.3389/fnhum.2021.624620 pmid:34168542 pmcid:PMC8217452 fatcat:cv7auuoidbbjzccng4zesttdvq

Microscale dynamics of electrophysiological markers of epilepsy [article]

Jimmy C Yang, Angelique C Paulk, Sang Heon Lee, Mehran Ganji, Daniel J Soper, Pariya Salami, Daniel Cleary, Mirela Simon, Douglas Maus, Jong Woo Lee, Brian Nahed, Pamela Jones (+7 others)
2020 medRxiv   pre-print
Objective: Interictal discharges (IIDs) and high frequency oscillations (HFOs) are neurophysiologic biomarkers of epilepsy.  ...  Conclusions: Overall, these data suggest micro-domains of irritable cortex that form part of an underlying pathologic architecture that contributes to the seizure network.  ...  The views and conclusions contained in this document are those of the authors and do not represent the official policies, either expressed or implied, of the funding sources.  ... 
doi:10.1101/2020.10.14.20211649 fatcat:nnmfsttv6vd35lwxzauiaja6cm

Stereo-Encephalographic Presurgical Evaluation of Temporal Lobe Epilepsy: An Evolving Science

Elma Paredes-Aragon, Norah A. AlKhaldi, Daniel Ballesteros-Herrera, Seyed M. Mirsattari
2022 Frontiers in Neurology  
Drug-resistant epilepsy is present in nearly 30% of patients. Resection of the epileptogenic zone has been found to be the most effective in achieving seizure freedom.  ...  Select cases present more complexity involving bilateral clinical or electrographic manifestations, have contradicting information, or may involve deeper structures as a part of the epileptogenic zone.  ...  Greydon Gilmore for the images of the robotic insertion illustrations at London Health Sciences Centre, London, Ontario.  ... 
doi:10.3389/fneur.2022.867458 pmid:35720095 pmcid:PMC9197919 fatcat:jz3fviro5rcwhmlt6c7mzoy65i
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