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Can DNA fragmentation of neat or swim-up spermatozoa be used to predict pregnancy following ICSI of fertile oocyte donors?

Jaime Gosálvez, Pedro Caballero, Carmen López-Fernández, Leonor Ortega, José Andrés Guijarro, José Luís Fernández, Stephen D Johnston, Rocío Nuñez-Calonge
2013 Asian Journal of Andrology  
This suggests that a certain level of DNA damage that is not detectable using current technologies could be impacting on the relative success of assisted reproductive technology (ART) procedures.  ...  While increased levels of SDF negatively impact reproductive outcome, we have shown that a reduction in SDF following sperm selection using ICSI with proven donor oocytes is not mandatory for achieving  ...  effectiveness, effectiveness at specified levels of false positives rates and optimal diagnostic ability.  ... 
doi:10.1038/aja.2013.74 pmid:24121979 pmcid:PMC3854048 fatcat:zlfcde2fnvcxla75rn6wdgk43a

Detection of human embryo aneuploidy in the procedure of in vitro fertilization after preimplantation genetic screening using array comparative genomic hybridization

Jelena Vukosavljevic, Aleksandra Trninic-Pjevic, Artur Bjelica, Ivana Jagodic, Vesna Kopitovic, Stevan Milatovic
2017 Medicinski pregled  
Only one false positive aneuploidy is sufficient for a false positive mosaicism diagnosis.  ...  For example, assuming that genetic testing is done in one blastomere, resulting in 10% false positive diagnosis, then the analysis of 6 genetically normal blastomeres would result in 50% false positive  ... 
doi:10.2298/mpns1710325v fatcat:2e4yg5jhi5expoasx6ljlchddm

Effect of Vitamin D Supplementation on In Vitro Fertilization Outcomes: A Trial Sequential Meta-Analysis of 5 Randomized Controlled Trials

Xiaoting Zhou, Xiaomei Wu, Xi Luo, Jingyi Shao, Dongqun Guo, Bo Deng, Ze Wu
2022 Frontiers in Endocrinology  
Despite numerous studies indicating an imperative role of vitamin D for reproduction, the importance of vitamin D supplementation on in vitro fertilization (IVF) outcomes remains controversial.  ...  We therefore performed this meta-analysis to investigate the IVF outcomes of vitamin D supplementation in infertile women with vitamin D deficiency.  ...  As a result, more than 8 million babies have been born from assisted reproductive technologies (ARTs), namely, in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) worldwide (3) ;  ... 
doi:10.3389/fendo.2022.852428 pmid:35370977 pmcid:PMC8969598 fatcat:ek4szjbxzbfcvea5lybeuzivfa

Effect of Toxoplasma gondii on Ram Sperm Quality After Experimental Infection

Theofanis Fais, Nektarios Giadinis, Elias Papadopoulos, Georgia Brellou, Alexandros Theodoridis, Radu Blaga, Delphine Le Roux, Dimitra Bitchava, Aikaterini Ntemka, Constantin Boscos, Ioannis Tsakmakidis
2020 Pathogens  
Higher values were noticed in viability and functional membrane integrity in positive spermatozoa in the control group compared to other groups, level of significance p < 0.05.  ...  Abnormal sperm was higher in groups C and D vs. A and C vs. B (p < 0.05). T. gondii DNA was detected in three sperm samples of the infected rams (12.5%).  ...  Negative and positive controls were added to each set of PCRs.  ... 
doi:10.3390/pathogens9121004 pmid:33266056 pmcid:PMC7760549 fatcat:r4rfsrwpjvdjjgw2znhs46ot7i

Andrology: Consensus workshop on advanced diagnostic andrology techniques

1996 Human Reproduction  
The Workshop reviewed four areas of advanced diagnostic andrology identified in the World Health Organization's 1992 Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction  ...  These were computer-assisted sperm analysis (CASA), acrosome reaction tests, the zona-free hamster egg penetration test and sperm-zona pellucida binding tests.  ...  Acknowledgements The generous support of Hamilton-Thome Research in providing refreshments and lunch for Workshop participants is gratefully acknowledged.  ... 
doi:10.1093/oxfordjournals.humrep.a019420 fatcat:a7matmm52zgzjeqiwa7rm2vxqi

Submitted oral presentations

2014 Advances in Animal Biosciences  
Remarkably, in bC supplemented animals (PEB+bC vs. NEB+bC), no negative effect of fasting (NEB) in bC levels in serum and FF could be detected (P>0.05).  ...  However, very little is known about the availability of bC in the follicular fluid (FF) and how oral supplementation may affect this.  ...  Tibbits (DEPI, Melbourne) for assistance with the bioinformatics analysis of the RNA-seq dataset. References  ... 
doi:10.1017/s2040470014000089 fatcat:ddt2ihvtazekpm6oy4ibnchg6q

Artificial intelligence in reproductive medicine

Renjie Wang, Wei Pan, Lei Jin, Yuehan Li, Yudi Geng, Chun Gao, Gang Chen, Hui Wang, Ding Ma, Shujie Liao
2019 Reproduction  
AI is proving to be increasingly applicable to healthcare, and multiple machine-learning techniques have been used to improve the performance of assisted reproductive technology (ART).  ...  Machine learning (ML), a subset of AI, allows computers to detect patterns from large complex datasets automatically and uses these patterns to make predictions.  ...  The naïve Bayes model finally 232 yielded the best predictions on embryo-based implantation with an accuracy of 80.4%, a 233 sensitivity of 63.7%, and a false positive rate of 17.6%.  ... 
doi:10.1530/rep-18-0523 pmid:30970326 pmcid:PMC6733338 fatcat:l7mujkpcevhnvoqpl2vn2x77d4

Follicular Metabolites-Assisted Clinical Evaluation of IVF/ICSI Outcomes

Bing Qu, Yunhe Xiong, Xiaofan Yu, Jinli Ding, Jing Weng, Xinghua Yang, Yanmin Ma, Lingyan Liu, Jing Yang, Yong Wang
2021 Evidence-Based Complementary and Alternative Medicine  
As infertility became a significant public health problem, assisted reproductive technologies (ARTs) were introduced.  ...  However, the fertilization rate of in vitro fertilization (IVF) per cycle varied, and patients needed to repeat IVF or change to intracytoplasmic sperm injection (ICSI).  ...  Acknowledgments e authors acknowledge the instrument support from the Central Laboratory of Capital Medical University, China. is work was financially supported by the National Natural Evidence-Based Complementary  ... 
doi:10.1155/2021/9999659 pmid:34122613 pmcid:PMC8189786 fatcat:ooj6hkg5zzfi5iop5mxjcofutu

Semen evaluation: methodological advancements in sperm quality-specific fertility assessment

Bereket Molla Tanga, Ahmad Yar Qamar, Sanan Raza, Seonggyu Bang, Xun Fang, Kiyoung Yoon, Jongki Cho
2021 Animal bioscience  
Accurate sperm evaluation is of paramount importance in the application of artificial insemination (AI) and assisted reproductive technology (ART).  ...  Identification of different sperm proteins and diagnosis of DNA damage has positively contributed to the existing pool of knowledge about sperm physiology and molecular anomalies associated with different  ...  along the straight line 202 between its first and last detected position.  ... 
doi:10.5713/ab.21.0072 pmid:33902175 fatcat:uu4tqm5b5rhwhomrgdscditsua

Utility of Antioxidants in the Treatment of Male Infertility: Clinical Guidelines Based on a Systematic Review and Analysis of Evidence

Ashok Agarwal, Kristian Leisegang, Ahmad Majzoub, Ralf Henkel, Renata Finelli, Manesh Kumar Panner Selvam, Nicholas Tadros, Neel Parekh, Edmund Y Ko, Chak Lam Cho, Mohamed Arafa, Marco G Alves (+3 others)
2021 The World Journal of Men's Health  
Data extracted included the type of antioxidant used, the clinical conditions under investigation, the evaluation of semen parameters and reproductive outcomes.  ...  for the use of antioxidants in the treatment of male infertility.  ...  The study was sup ported by the American Center for Reproductive Medi cine (Andrology Research Fund #500000105879).  ... 
doi:10.5534/wjmh.200196 pmid:33474843 pmcid:PMC7994666 fatcat:niwze6tz2rhf7iw6idfrsvi4vm

Oviductal Transcriptome Is Modified after Insemination during Spontaneous Ovulation in the Sow

Rebeca López-Úbeda, Francisco A. García-Vázquez, Raquel Romar, Joaquín Gadea, Marta Muñoz, Ronald H. F. Hunter, Pilar Coy, Joël R Drevet
2015 PLoS ONE  
Some of the genes in network 1 had been previously detected in the oviduct of human and animals, where they were over-expressed in the presence of spermatozoa or pre-implantation embryos (C3, IGHG1, ITIH4  ...  We used an in vivo model approaching the study from a physiological point of view in which no hormonal treatment (animals were in natural oestrus) and no artificial sperm selection (selection was performed  ...  Acknowledgments The authors thank to Juan Antonio Carvajal and Soledad Rodriguez for technical support; Luis Vieira for helping with the surgical arrangements; Octavio López Albors for collaborating in  ... 
doi:10.1371/journal.pone.0130128 pmid:26098421 pmcid:PMC4476686 fatcat:xrju7eg3t5dbjpnug325lggs4y

Single-center thorough evaluation and targeted treatment of globozoospermic men

Stephanie Cheung, Alessandra Parrella, Danielle Tavares, Derek Keating, Philip Xie, Zev Rosenwaks, Gianpiero D Palermo
2021 Journal of Assisted Reproduction and Genetics  
PLCZ1 was both mutated and underexpressed in these CG patients, regardless of reproductive outcome.  ...  PLCζ assessment failed to detect OASCF for 8 CG patients who underwent 9 subsequent ICSI cycles with AGT, yielding a remarkable improvement of fertilization (39/97; 40.2%) (P = 0.00001).  ...  Acknowledgements We would like to thank the clinicians, scientists, embryologists, and nursing staff of the Ronald O. Perelman & Claudia Cohen Center for Reproductive Medicine.  ... 
doi:10.1007/s10815-021-02191-4 pmid:33877510 pmcid:PMC8417186 fatcat:yb6kwlyv3rfsjbtrsfqswuqyce

Proteomics Reveals Novel Drosophila Seminal Fluid Proteins Transferred at Mating

Geoffrey D Findlay, Xianhua Yi, Michael J MacCoss, Willie J Swanson, Mohamed A. F Noor
2008 PLoS Biology  
Such reproductive proteins often evolve under positive selection between species; because of this rapid divergence, Sfps are hypothesized to play a role in speciation by contributing to reproductive isolation  ...  We identified 63 proteins, which were previously unknown to function in reproduction, and confirmed the transfer of dozens of predicted Sfps.  ...  Hsieh for assistance with MS experiments and data processing and M. Dean, three anonymous reviewers, and the Swanson Lab for comments on the manuscript. C. Berg, M. Wolfner, H.  ... 
doi:10.1371/journal.pbio.0060178 pmid:18666829 pmcid:PMC2486302 fatcat:6wb5h5h5b5bf7pmfntnxoy2cau

Proteomic analysis reveals Topoisomerase 2A is associated with defective sperm head morphology

Jacob K Netherton, Rachel A Ogle, Louise Hetherington, Ana Izabel Silva Balbin Villaverde, Hubert Hondermarck, Mark A Baker
2019 Molecular & Cellular Proteomics  
Although in some cases the etiology of the condition is well understood, for at least 50% of men, the underlying cause is yet to be classified.  ...  We demonstrate that the presence of Topoisomerase 2A in the sperm head is highly correlated to poor head morphology.  ...  Although solutions are available through a variety of assisted reproductive technologies (ART), there are many drawbacks.  ... 
doi:10.1074/mcp.ra119.001626 pmid:31848259 pmcid:PMC7050105 fatcat:2wt6ouowefft5pvzso46rbv2wm

Dysregulation of an X-linked primate-specific epididymal microRNA cluster in unexplained asthenozoospermia

Xingrong Qing, Jian Shi, Tingting Dong, Chunlin Wu, Lian Hu, Honggang Li
2017 OncoTarget  
Functions and pathways of predicted target genes of this cluster suggested its role in sperm maturation. Dysregulation of this miRNA cluster might be an epigenetic basis for some patients with UA.  ...  This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided  ...  This work is funded by the grant 31271249 from the National Natural Science Foundation of China and Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College, HUST.  ... 
doi:10.18632/oncotarget.18076 pmid:28915635 pmcid:PMC5593606 fatcat:x676qov67baxnfm2lgyjjpnsqu
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