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Investigating the role of interleukin-1 beta and glutamate in inflammatory bowel disease and epilepsy using discovery browsing

Thomas C. Rindflesch, Catherine L. Blake, Michael J. Cairelli, Marcelo Fiszman, Caroline J. Zeiss, Halil Kilicoglu
2018 Journal of Biomedical Semantics  
For drug development and better understanding of biomedical phenomena, such correlations need to be supported by viable hypotheses about the mechanisms involved, which can then form the basis of experimental  ...  investigations.  ...  Availability of data and materials SemMedDB data used in this study is publicly available at https://skr3.nlm.nih. gov/SemMedDB/download/download.html.  ... 
doi:10.1186/s13326-018-0192-y pmid:30587224 pmcid:PMC6307110 fatcat:yfqje3qfazbzrk35lr7hevm2zq

ESICM LIVES 2021: Part 2

2021 Intensive Care Medicine Experimental  
We aimed to investigate the prevalence of SSD, the association between SSD and clinical outcomes and understanding if SSD is an independent entity or precedes delirium. Methods.  ...  A daily evaluation of delirium and SSD was done with Intensive Care Delirium Screening Checklist (ICDSC) and Confusion Assessment Method-ICU (CAM-ICU). Scales  ...  SARS CoV-2 infection causes sepsis, which leads to the release of inflammatory cytokines such as interleukin-2 (IL-2) and interleukin-6 (IL-6).  ... 
doi:10.1186/s40635-021-00415-6 pmid:34633571 fatcat:ef5ksbl2gnf6nbh2b2hd4njr6q

Hypertension: recent concepts and developmentsWhat Should You Tell Patients with MS About Their Risk of Developing Dementia? WORLD EXCLUSIVE

Alexandra Sinclair, Jason Warren, Jonathon O'brien -A
unpublished
to human disease; IL23R as a protective factor in inflammatory bowel disease?  ...  Only three of these have been linked to human disease; IL23R as a protective factor in inflammatory bowel disease, and biallelic mutations in RPE65 and CTH as causes of Leber congenital amaurosis and cystothionuria  ...  This receptor is normally involved in the immune response of the organism to bacterial infections, and works through the release of inflammatory mediators such as interleukin 1 beta.  ... 
fatcat:yuyf4uoh6rbojo372t7zfork2i

Informational Space of Meaning for Scientific Texts [article]

Neslihan Suzen, Evgeny M. Mirkes, Alexander N. Gorban
2020 arXiv   pre-print
Analysis of the Meaning Space provides us with a tool to further explore quantifying the meaning of a text using more complex and context-dependent meaning models that use co-occurrence of words and their  ...  The Meaning Space is described and statistically analysed for the LSC with the LScDC. The usefulness of the proposed representation model is evaluated through top-ranked words in each category.  ...  The distribution indicates words used in texts of each category and the most frequently used words can be sorted in categories.  ... 
arXiv:2004.13717v1 fatcat:jhhwyxgb2zcmpelaovrprgbkqi

Characterization of environmental and genetic factors in multiple-case lymphoid cancer families

Samantha Jean Jones
2020
Lymphoid cancers, the fifth most common cancer type in Canada, comprise a clinically and biologically heterogeneous group of neoplasms.  ...  The hygiene hypothesis, according to which a relative lack of infectious exposure during early childhood may cause aberrant immune development and subsequent adult-onset immune-related diseases, including  ...  Oxidative stress: Reactive oxygen species are implicated in several inflammatory conditions (e.g., inflammatory bowel disease) and in cancer risk (386, 398) .  ... 
doi:10.14288/1.0390430 fatcat:5bxsgq4djrd45otyfv5icfs3iu