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Investigating the metabolic capabilities of Mycobacterium tuberculosis H37Rv using the in silico strain iNJ661 and proposing alternative drug targets
2007
BMC Systems Biology
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Many of the drugs used for treatment of tuberculosis target metabolic enzymes. ...
Finally, by considering the HCR sets in the context of known drug targets for tuberculosis treatment we proposed new alternative, but equivalent drug targets. ...
Acknowledgements This work was supported in part by an NIH Training Grant. We also thank Mr. Scott Becker and Mr. Adam Feist for helpful comments and feedback. ...
doi:10.1186/1752-0509-1-26
pmid:17555602
pmcid:PMC1925256
fatcat:6bl4byhfijgwnfp2z3q3asm6ai
Genome-Scale Metabolic Modeling for Unraveling Molecular Mechanisms of High Threat Pathogens
2020
Frontiers in Cell and Developmental Biology
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The genes or enzymes responsible for the essential metabolic reactions in pathogen growth are regarded as potential drug targets, as a priori guide to researchers in the pharmaceutical field. ...
Along with essential metabolic reactions, alternate pathways and fluxes are predicted by performing computational flux analyses for the growth of pathogens in a very short time. ...
Genome annotation of M. tuberculosis H37Rv was used as the starting point in iNJ661 model reconstruction (Cole et al., 1998) . ...
doi:10.3389/fcell.2020.566702
pmid:33251208
pmcid:PMC7673413
fatcat:bzxpxhdfibe5voxtahevqniqi4
Model-based integration of genomics and metabolomics reveals SNP functionality in Mycobacterium tuberculosis
[article]
2019
bioRxiv
pre-print
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Human tuberculosis is caused by members of the Mycobacterium tuberculosis complex (MTBC) and presents variable disease outcomes. ...
Here, we used metabolomics to unravel the potential role of genetic variations in conferring strain-specific adaptive capacity and vulnerability. ...
Hans-Michael Kaltenbach, and Charlotte Ramon for helpful contributions to the analysis. ...
doi:10.1101/555763
fatcat:jhfqyenmkvc6nctvk5pbb26u3u
Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction
2011
BMC Systems Biology
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of disease infection and identifying potential drug targets. ...
The model iKF1028 captures important metabolic capabilities of B. cenocepacia J2315 with a particular focus on the biosyntheses of key metabolic virulence factors to assist in understanding the mechanism ...
Acknowledgements and Funding ...
doi:10.1186/1752-0509-5-83
pmid:21609491
pmcid:PMC3123600
fatcat:mprzuat3fzfdfdsjzr3sq2nohu
Probabilistic integrative modeling of genome-scale metabolic and regulatory networks inEscherichia coliandMycobacterium tuberculosis
2010
Proceedings of the National Academy of Sciences of the United States of America
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Prediction of metabolic changes that result from genetic or environmental perturbations has several important applications, including diagnosing metabolic disorders and discovering novel drug targets. ...
After validating the approach, we used PROM to build a genome-scale integrated metabolic-regulatory model for Mycobacterium tuberculosis, a critically important human pathogen. ...
This work was supported by a National Institutes of Health/National Cancer Institute Howard Temin Pathway to Independence Award in Cancer Research, a Young Investigator Grant from the Roy J. ...
doi:10.1073/pnas.1005139107
pmid:20876091
pmcid:PMC2955152
fatcat:zh7slr2mgvd4hle2k3vtbk5bwq