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Investigating the metabolic capabilities of Mycobacterium tuberculosis H37Rv using the in silico strain iNJ661 and proposing alternative drug targets

Neema Jamshidi, Bernhard Ø Palsson
2007 BMC Systems Biology  
Many of the drugs used for treatment of tuberculosis target metabolic enzymes.  ...  Finally, by considering the HCR sets in the context of known drug targets for tuberculosis treatment we proposed new alternative, but equivalent drug targets.  ...  Acknowledgements This work was supported in part by an NIH Training Grant. We also thank Mr. Scott Becker and Mr. Adam Feist for helpful comments and feedback.  ... 
doi:10.1186/1752-0509-1-26 pmid:17555602 pmcid:PMC1925256 fatcat:6bl4byhfijgwnfp2z3q3asm6ai

Genome-Scale Metabolic Modeling for Unraveling Molecular Mechanisms of High Threat Pathogens

Mustafa Sertbas, Kutlu O. Ulgen
2020 Frontiers in Cell and Developmental Biology  
The genes or enzymes responsible for the essential metabolic reactions in pathogen growth are regarded as potential drug targets, as a priori guide to researchers in the pharmaceutical field.  ...  Along with essential metabolic reactions, alternate pathways and fluxes are predicted by performing computational flux analyses for the growth of pathogens in a very short time.  ...  Genome annotation of M. tuberculosis H37Rv was used as the starting point in iNJ661 model reconstruction (Cole et al., 1998) .  ... 
doi:10.3389/fcell.2020.566702 pmid:33251208 pmcid:PMC7673413 fatcat:bzxpxhdfibe5voxtahevqniqi4

Model-based integration of genomics and metabolomics reveals SNP functionality in Mycobacterium tuberculosis [article]

Ove Oeyas, Sonia Borrel, Andrej Trauner, Michael Zimmermann, Julia Feldmann, Sebastien Gagneux, Joerg Stelling, Uwe Sauer, Mattia Zampieri
2019 bioRxiv   pre-print
Human tuberculosis is caused by members of the Mycobacterium tuberculosis complex (MTBC) and presents variable disease outcomes.  ...  Here, we used metabolomics to unravel the potential role of genetic variations in conferring strain-specific adaptive capacity and vulnerability.  ...  Hans-Michael Kaltenbach, and Charlotte Ramon for helpful contributions to the analysis.  ... 
doi:10.1101/555763 fatcat:jhfqyenmkvc6nctvk5pbb26u3u

Exploring the metabolic network of the epidemic pathogen Burkholderia cenocepacia J2315 via genome-scale reconstruction

Kechi Fang, Hansheng Zhao, Changyue Sun, Carolyn M C Lam, Suhua Chang, Kunlin Zhang, Gurudutta Panda, Miguel Godinho, Vítor A P Martins dos Santos, Jing Wang
2011 BMC Systems Biology  
of disease infection and identifying potential drug targets.  ...  The model iKF1028 captures important metabolic capabilities of B. cenocepacia J2315 with a particular focus on the biosyntheses of key metabolic virulence factors to assist in understanding the mechanism  ...  Acknowledgements and Funding  ... 
doi:10.1186/1752-0509-5-83 pmid:21609491 pmcid:PMC3123600 fatcat:mprzuat3fzfdfdsjzr3sq2nohu

Probabilistic integrative modeling of genome-scale metabolic and regulatory networks inEscherichia coliandMycobacterium tuberculosis

Sriram Chandrasekaran, Nathan D. Price
2010 Proceedings of the National Academy of Sciences of the United States of America  
Prediction of metabolic changes that result from genetic or environmental perturbations has several important applications, including diagnosing metabolic disorders and discovering novel drug targets.  ...  After validating the approach, we used PROM to build a genome-scale integrated metabolic-regulatory model for Mycobacterium tuberculosis, a critically important human pathogen.  ...  This work was supported by a National Institutes of Health/National Cancer Institute Howard Temin Pathway to Independence Award in Cancer Research, a Young Investigator Grant from the Roy J.  ... 
doi:10.1073/pnas.1005139107 pmid:20876091 pmcid:PMC2955152 fatcat:zh7slr2mgvd4hle2k3vtbk5bwq