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Investigating resting-state functional connectivity in the cervical spinal cord at 3 T

Falk Eippert, Yazhuo Kong, Anderson M. Winkler, Jesper L. Andersson, Jürgen Finsterbusch, Christian Büchel, Jonathan C.W. Brooks, Irene Tracey
2017 NeuroImage  
In a reanalysis of a sample of 20 healthy human participants who underwent a resting-state fMRI acquisition of the cervical spinal cord, we were able to observe significant dorsal horn connectivity as  ...  more prevalent field strength of 3 T.  ...  Acknowledgements AMW received support from the National Research Council of Brazil (CNPq; 211534/2013-7). CB is supported by the DFG (FOR 1328 and SFB 936) and ERC (2010-AdG_20100407).  ... 
doi:10.1016/j.neuroimage.2016.12.072 pmid:28027960 pmcid:PMC5315056 fatcat:th7z56ca25b33p63aslm7hh6uq

Intrinsic Resting-State Functional Connectivity in the Human Spinal Cord at 3.0 T

Oscar San Emeterio Nateras, Fang Yu, Eric R. Muir, Carlos Bazan, Crystal G. Franklin, Wei Li, Jinqi Li, Jack L. Lancaster, Timothy Q. Duong
2016 Radiology  
Resting-state functional MR imaging was performed to map functional connectivity of the human cervical spinal cord from C1 to C4 at 1 × 1 × 3-mm resolution with a 3.0-T clinical MR imaging unit.  ...  Purpose-To apply resting-state functional magnetic resonance (MR) imaging to map functional connectivity of the human spinal cord.  ...  Building on these previous works, we investigated intrinsic functional connectivity by using a clinical 3.0-T MR imaging unit at 1 × 1 × 3-mm resolution.  ... 
doi:10.1148/radiol.2015150768 pmid:26505923 pmcid:PMC5425154 fatcat:fo5p2sawwzdh7nfpphgudlyhiu

Amplitude of Low Frequency Fluctuation (ALFF) in the Cervical Spinal Cord with Stenosis: A Resting State fMRI Study

Xiaojia Liu, Wenshu Qian, Richu Jin, Xiang Li, Keith DK Luk, Ed. X. Wu, Yong Hu, Giovanni Grasso
2016 PLoS ONE  
Cervical spondylotic myelopathy (CSM) is a common spinal cord dysfunction disease with complex symptoms in clinical presentation.  ...  Resting state fMRI (rsfMRI) has been introduced to study the mechanism of neural development of CSM.  ...  Acknowledgments The authors thank all those participants for their contribution to this project. Author Contributions Conceptualization: YH KDKL EXW. Data curation: X. Liu.  ... 
doi:10.1371/journal.pone.0167279 pmid:27907060 pmcid:PMC5132295 fatcat:rh7ahibhgffwfo2mea6ytxbama

Investigating resting-state functional connectivity in the cervical spinal cord at 3T [article]

Falk Eippert, Yazhuo Kong, Anderson M Winkler, Jesper L Andersson, Jurgen Finsterbusch, Christian Buchel, Jonathan CW Brooks, Irene Tracey
2016 bioRxiv   pre-print
In a reanalysis of a sample of 20 healthy human participants who underwent a resting-state fMRI acquisition of the cervical spinal cord, we were able to observe significant dorsal horn connectivity as  ...  Two ultra-high field functional magnetic resonance imaging (fMRI) studies in humans have provided evidence for reproducible resting-state connectivity between the dorsal horns as well as between the ventral  ...  IT is supported by a Wellcome Trust Strategic Award and the NIHR Oxford Biomedical Research Centre. JCWB was supported by the Medical Research Council UK (G0700238).  ... 
doi:10.1101/073569 fatcat:vgakckmz3rconhhsvdufkh5wwu

Alterations in Cortical Sensorimotor Connectivity following Complete Cervical Spinal Cord Injury: A Prospective Resting-State fMRI Study

Akinwunmi Oni-Orisan, Mayank Kaushal, Wenjun Li, Jack Leschke, B. Douglas Ward, Aditya Vedantam, Benjamin Kalinosky, Matthew D. Budde, Brian D. Schmit, Shi-Jiang Li, Vaishnavi Muqeet, Shekar N. Kurpad (+1 others)
2016 PLoS ONE  
However, the effect of SCI on brain resting-state connectivity patterns remains unclear.  ...  Functional magnetic resonance imaging (fMRI) studies have demonstrated alterations during task-induced brain activation in spinal cord injury (SCI) patients.  ...  Introduction Spinal cord injury (SCI) is a serious problem in the United States and worldwide.  ... 
doi:10.1371/journal.pone.0150351 pmid:26954693 pmcid:PMC4783046 fatcat:ixodgyzlvfccbkua35tiscjxni

Resting-state brain and spinal cord networks in humans are functionally integrated

Shahabeddin Vahdat, Ali Khatibi, Ovidiu Lungu, Jürgen Finsterbusch, Christian Büchel, Julien Cohen-Adad, Veronique Marchand-Pauvert, Julien Doyon, Ed T. Bullmore
2020 PLoS Biology  
However, whether such resting-state networks (RSNs) are interconnected across the brain and spinal cord is unclear.  ...  Thus, our findings reveal a unified functional organisation of sensorimotor networks in the entire central nervous system (CNS) at rest.  ...  Furthermore, we investigated brain functional connectivity associated with the grey commissure in the cervical cord.  ... 
doi:10.1371/journal.pbio.3000789 pmid:32614823 fatcat:rm4eu3ctpbhppmgmqygfsgw2pu

Resting-State Functional Magnetic Resonance Imaging Connectivity of the Brain Is Associated with Altered Sensorimotor Function in Patients with Cervical Spondylosis

Davis C. Woodworth, Langston T. Holly, Noriko Salamon, Benjamin M. Ellingson
2018 World Neurosurgery  
Objectives: To determine the relationship between functional connectivity using resting-state fMRI and neurological impairment in patients with cervical spondylosis and healthy controls.  ...  Results: Increased functional connectivity was observed with increasing neurological impairment in patients with cervical stenosis within sensorimotor areas, including precentral gyrus, postcentral gyrus  ...  Acknowledgments Research Support: Funding was received through the following NIH/NINDS grants: no. 1R21NS065419-01A1 (to LTH and NS), 1R01NS078494-01A1 (to LTH, NS, and BME), and 2R01NS078494-06 (to LTH  ... 
doi:10.1016/j.wneu.2018.07.257 pmid:30092474 pmcid:PMC6200587 fatcat:kzkywtrn7fc73pf3zphjkq6wla

Resting state functional connectivity in the human spinal cord

Robert L Barry, Seth A Smith, Adrienne N Dula, John C Gore
2014 eLife  
However, to date there have been no previous substantiated reports of resting state correlations in the spinal cord.  ...  Numerous studies have measured how low-frequency BOLD signal fluctuations from the brain are correlated between voxels in a resting state, and have exploited these signals to infer functional connectivity  ...  The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Additional information  ... 
doi:10.7554/elife.02812 pmid:25097248 pmcid:PMC4120419 fatcat:jsjw57m57ndrbpjdph7fvpmeqy

Characterizing Thalamocortical Disturbances in Cervical Spondylotic Myelopathy: Revealed by Functional Connectivity under Two Slow Frequency Bands

Fuqing Zhou, Lin Wu, Xiaojia Liu, Honghan Gong, Keith Dip-Kei Luk, Yong Hu, Nader N. Pouratian
2015 PLoS ONE  
in the slow-4 band, and were associated with higher fractional anisotropy values in the cervical cord, corresponding to mild spinal cord structural injury.  ...  Results Decreased functional connectivity was found in the thalamo-motor, -somatosensory, and -temporal circuits in the slow-5 band, indicating impairment of thalamo-cortical circuit degeneration or axon  ...  cervical spinal cord, suggesting more enhanced connectivity occur in the minor spinal cord structural injury.  ... 
doi:10.1371/journal.pone.0125913 pmid:26053316 pmcid:PMC4460123 fatcat:k52ifcc5y5a55bp3yk5hp5rqu4

Intrinsic Functional Plasticity of the Sensory-Motor Network in Patients with Cervical Spondylotic Myelopathy

F. Q. Zhou, Y. M. Tan, L. Wu, Y. Zhuang, L. C. He, H. H. Gong
2015 Scientific Reports  
Comparatively, CSM not only showed significantly decreased FCS in the operculum-integrated regions, which exhibited reduced resting-state functional connectivity (rsFC) around the Rolandic sulcus, but  ...  scores and that the rsFC pattern was influenced by cervical cord micro-structural damage at the C2 level.  ...  the cervical spinal cord.  ... 
doi:10.1038/srep09975 pmid:25897648 pmcid:PMC4404678 fatcat:7rml6xptyzbflhj6a56sidyx5y

Increased Low-Frequency Oscillation Amplitude of Sensorimotor Cortex Associated with the Severity of Structural Impairment in Cervical Myelopathy

Fuqing Zhou, Honghan Gong, Xiaojia Liu, Lin Wu, Keith Dip-Kei Luk, Yong Hu, Michael Fehlings
2014 PLoS ONE  
However, the nature of intrinsic neuronal activity in the SMC, and the relationship between cerebral function and structural damage of the spinal cord in patients with CM are not fully understood.  ...  neuronal activity in the SMC corresponding to the structural impairment in the spinal cord of patients with CM.  ...  Sagittal and axial conventional T 1 W, T 2 W and T 2 -FLAIR images were acquired in the brain and cervical spinal cord for diagnosis in each subject.  ... 
doi:10.1371/journal.pone.0104442 pmid:25111566 pmcid:PMC4128667 fatcat:mjh6yzahsnetter6lcqpps4nmm

Coordinated Human Brainstem and Spinal Cord Networks during the Expectation of Pain Have Elements Unique from Resting-State Effects

Gabriela Ioachim, Jocelyn M. Powers, Howard J. M. Warren, Patrick W. Stroman
2020 Brain Sciences  
Functional magnetic resonance imaging (fMRI) research on the human brainstem (BS) and spinal cord (SC) has identified extensive BS/SC resting-state networks (RSNs) by showing spontaneous coordinated blood  ...  In each study, BOLD fMRI data were obtained from the cervical SC and brainstem in healthy participants at 3 tesla using a T2-weighted single-shot fast spin-echo imaging method.  ...  Acknowledgments: We would like to thank Don Brien and Janet Myrtle for their help with acquiring the data. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/brainsci10090568 pmid:32824896 fatcat:cbtg3tqwyffj3baimofm7wt4vi

Abnormal intrinsic functional activity in patients with cervical spondylotic myelopathy a resting state fMRI study

Cuili Kuang, Yunfei Zha
2019 Neuropsychiatric Disease and Treatment  
We employed resting-state fMRI analyses to reveal central functional reorganization in the brains of patients with cervical spondylotic myelopathy (CSM) and to provide complementary evidence of cortex  ...  Then, we calculated Pearson's correlation coefficients between the resting-state time courses of each seed and the time series of the rest of the brain.  ...  This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.  ... 
doi:10.2147/ndt.s209952 pmid:31686821 pmcid:PMC6708884 fatcat:maheg4m4vzgupbkghgwmvgbdqy

Ten Key Insights into the Use of Spinal Cord fMRI

Jocelyn Powers, Gabriela Ioachim, Patrick Stroman
2018 Brain Sciences  
Although it is newly emerging, complex connectivity and network analysis is not only possible, but has also been shown to be reliable and reproducible in the spinal cord for both task-based and resting-state  ...  A comprehensive review of the literature-to-date on functional magnetic resonance imaging (fMRI) of the spinal cord is presented.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/brainsci8090173 pmid:30201938 pmcid:PMC6162663 fatcat:yln4g5xk4vdv5lh22dofobyuqu

Reproducibility of resting state spinal cord networks in healthy volunteers at 7 Tesla

Robert L. Barry, Baxter P. Rogers, Benjamin N. Conrad, Seth A. Smith, John C. Gore
2016 NeuroImage  
We recently reported our findings of resting state functional connectivity in the human spinal cord: in a cohort of healthy volunteers we observed robust functional connectivity between left and right  ...  Our results suggest that frequencies above 0.08 Hz may enhance the detectability of these resting state networks, which would be beneficial for practical studies of spinal cord functional connectivity.  ...  The project was also supported by the National Center for Research Resources, grant UL1RR024975-01, which is now at the National Center for Advancing Translational Sciences, grant 2UL1TR000445-06.  ... 
doi:10.1016/j.neuroimage.2016.02.058 pmid:26924285 pmcid:PMC4889527 fatcat:6jiiiruogbawvlygp66n65o5la
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