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Hypokalemia After Rituximab Administration in Steroid-Dependent Nephrotic Syndrome: A Case Report
2020
Frontiers in Pharmacology
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Such adverse drug reactions, when mild and self-limiting, can easily be overlooked if not expected or investigated. ...
The monoclonal antibody rituximab is a commonly used steroid sparing agent for steroid-dependent idiopathic nephrotic syndrome of childhood. ...
Given the rising use of monoclonal antibodies to treat several clinical conditions, a parallel increase in hypersensitivity reactions to these drugs have been recorded in the literature, including rituximab ...
doi:10.3389/fphar.2020.00915
pmid:32625098
pmcid:PMC7311762
fatcat:obfwn2qgajam7l3zthzbvujziu
Ontologies in Medicinal Chemistry: Current Status and Future Challenges
2013
Current Topics in Medicinal Chemistry
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Beyond glossaries or thesauri, ontologies facilitate communication between experts and allow the application of computational techniques to extract useful information from available data. ...
Reaction Terms
Adverse drug
reactions
1995
1,641
DDI [90]
Drug Discovery
Investigations
Drug discovery
research
0.9
645
EXPO and LABORS
[92, 93]
EXPO and LABORS
Scientific experiments ...
Acronym
Name
Main scope
Version
Terms
AERO [106]
Adverse Event Reporting
Ontology
Adverse event reports 12/18/2012
388
ARM [102]
Adverse Reactions and
Mechanisms
Adverse drug
reactions ...
doi:10.2174/1568026611313050003
pmid:23548021
fatcat:6hyje3smivfldn2svxvnhtsw6i
Results of an early access treatment protocol of daratumumab in United States patients with relapsed or refractory multiple myeloma
2018
Cancer
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Patients received daratumumab 16 mg/kg weekly for 8 weeks, every other week for 16 weeks, and monthly until they developed disease progression, unacceptable toxicity, or 60 days after the drug gained US ...
Treatment-emergent grade ≥3 adverse events (AEs), serious AEs, and AEs of special interest were collected. ...
TABLE 3 . 3 Most Frequently Reported Grade 3 or 4
Adverse Events: Daratumumab, N = 348 a
Adverse Event
No. of Patients (%)
Grade 3 or 4 adverse event
175 (50)
Drug-related
85 (24)
Thrombocytopenia ...
doi:10.1002/cncr.31706
pmid:30395359
pmcid:PMC6587745
fatcat:heopjvcz4fbk7chyy3bmsk7mra
Lessons to be Learnt from Real-World Studies on Immune-Related Adverse Events with Checkpoint Inhibitors: A Clinical Perspective from Pharmacovigilance
2020
Targeted oncology
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As of February 2020, 30 real-world postmarketing studies have characterized multiple irAEs through international spontaneous reporting systems, namely WHO Vigibase and the US FDA Adverse Event Reporting ...
This review aims to summarize and critically appraise the current landscape of pharmacovigilance studies, thus deriving take-home messages for oncologists. ...
Frequent use of multiple therapeutic regimens makes it difficult to disentangle the adverse effects of individual drugs versus drug-drug interactions versus 'innocent bystander' effects [21, 22] . ...
doi:10.1007/s11523-020-00738-6
pmid:32725437
fatcat:u2qnhx7o4fe7rldh57ebipcpki
Emerging Therapies in Hereditary Angioedema
2017
Immunology and allergy clinics of North America
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The burden of treatment must also be addressed with regard to medication administration difficulties, treatment complications, and adverse side effects. ...
Multiple new therapies with novel mechanisms of action are currently being investigated and may offer potential solutions to these challenges faced by patients and physicians. ...
Overall, the drug was well tolerated with no drug-related serious adverse events reported. ...
doi:10.1016/j.iac.2017.03.003
pmid:28687111
pmcid:PMC5585075
fatcat:okeaot6rzjbojbzqbr4p6qgvju
T cell mediated hypersensitivity to previously tolerated iodinated contrast media precipitated by introduction of atezolizumab
2021
Journal for ImmunoTherapy of Cancer
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Many adverse reactions associated with immune checkpoint inhibitor (ICI) treatments are immunologically driven and may necessitate discontinuation of the ICI. ...
Our findings highlight the importance of considering all concomitant medications in patients on ICIs who develop immune-mediated adverse reactions. ...
Contributors SH and AO-B conceptualized the study with their PhD supervisors MP and DJN. AO-B, SH, JG, PT, CJ and LR conducted laboratory experiments. ...
doi:10.1136/jitc-2021-002521
pmid:34049931
pmcid:PMC8166637
fatcat:y6ququikobhxjfwxmf33q5fg3e
TTN/OBSCN 'Double-Hit' predicts favourable prognosis, 'immune-hot' subtype and potentially better immunotherapeutic efficacy in colorectal cancer
2021
Journal of Cellular and Molecular Medicine
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Using two-independent cohorts, we found the common frequently mutated genes TTN and OBSCN had the significant correlation with higher tumour mutation burden (TMB) and favourable overall survival. ...
Libo Wang: Conceptualization (supporting); Formal analysis (supporting); Investigation (equal); Software (equal); Supervision (equalDechao Jiao: Conceptualization (equal); Funding acquisition (lead); Investigation ...
AUTH O R CO NTR I B UTI O N S Zaoqu Liu: Conceptualization (lead); Data curation (lead); Formal analysis (lead); Investigation (lead); Methodology (lead); Project administration (lead); Resources (lead ...
doi:10.1111/jcmm.16393
pmid:33624434
fatcat:pp4o3ja2crapxfbk7sg546zk7e
Pharmacogenomic network analysis of the gene-drug interaction landscape underlying drug disposition
2019
Computational and Structural Biotechnology Journal
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To visualize the gene-drug interaction landscape, we use multidimensional scaling to collapse this similarity matrix into a two-dimensional network. ...
Specifically, we analyzed the landscape of drug metabolizing enzymes and transporters for 100 top selling drugs as well as all compounds with pharmacogenetic germline labels or dosing guidelines. ...
Furthermore, epidemiological data from the US shows that adverse drug reactions (ADRs) cause 8.25% and 19.2% increase of hospital stay length and death rate, respectively, and severe ADRs are estimated ...
doi:10.1016/j.csbj.2019.11.010
pmid:31890144
pmcid:PMC6921140
fatcat:6ssp44x57jbivgkqow73k5vhzy
Newer therapeutics for hepatitis C
2016
Annals of Translational Medicine
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Until recently, treatment for hepatitis C included use of pegylated interferon-α (IFN-α) and ribavirin, which resulted in modest cure rates, despite having significant dose limiting adverse reactions ( ...
Hence, a similar trial should use CCZ in addition to approved DAA regimens to reduce duration of HCV therapy. If proven this approach will change the landscape of HCV therapy world-wide. ...
Until recently, treatment for hepatitis C included use of pegylated interferon-α (IFN-α) and ribavirin, which resulted in modest cure rates, despite having significant dose limiting adverse reactions ...
doi:10.3978/j.issn.2305-5839.2015.10.06
pmid:26889484
pmcid:PMC4731604
fatcat:pndboot63jaf7hktqdlcgvl4qm
Reverse translation of adverse event reports paves the way for de-risking preclinical off-targets
2017
eLife
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The Food and Drug Administration Adverse Event Reporting System (FAERS) remains the primary source for post-marketing pharmacovigilance. ...
To address these problems, we mapped drugs to their ingredients and used natural language processing to classify and correlate drug events. ...
The work of BKS was supported by US National Institutes of Health Grant R01 GM71896 and by R35 GM122481. We thank Dr Duncan Armstrong for his comments and advice on the manuscript. ...
doi:10.7554/elife.25818
pmid:28786378
pmcid:PMC5548487
fatcat:bwncooqaerbalku7uybrcugv5m
Disease-Modifying Drugs and Breastfeeding in Multiple Sclerosis: A Narrative Literature Review
2022
Frontiers in Neurology
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The use of most DMTs is unlicensed during breastfeeding mainly due to the limited data available on the excretion in human milk and on the effects on infants' exposure. ...
Pregnancy-related issues in women with multiple sclerosis (MS) have been receiving increasing attention, with particular interest for the use of disease-modifying therapies (DMTs) before conception, during ...
and GQ: conceptualization and reviewing. VD and EFe: conceptualization, supervision, and reviewing. EFa, AC, and LD: methodology and reviewing. ...
doi:10.3389/fneur.2022.851413
pmid:35493841
pmcid:PMC9051389
fatcat:dzmwnqyn2ng3vfwo4ccfuzw7s4
Omalizumab and mepolizumab in the landscape of biological therapy for severe asthma in children: how to choose?
2019
Italian Journal of Pediatrics
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Moreover, research on biological drugs for the treatment of severe asthma is expanding rapidly, with some molecules currently used in adult patients that could be registered also for pediatric use and ...
However, mepolizumab will likely be accessible soon globally for clinical use. ...
Even if the vast majority of adverse reactions are represented by mild reactions manageable with a pharmacological treatment of the specific signs and symptoms, severe reactions such as a systemic one ...
doi:10.1186/s13052-019-0737-4
pmid:31779657
pmcid:PMC6883618
fatcat:5xw3gfss6jggle65oopr26gnxm
Multimorbidity and Quaternary Prevention (P4)
2015
Revista Brasileira de Medicina de Família e Comunidade
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This approach has led to the current 'epidemic' in morbidity and mortality from adverse drug reactions that now outstrip the target diseases as a cause of death. ...
The siloed approach to treatment decision making has led inevitably to polypharmacy, and the current 'epidemic' in morbidity and mortality from adverse drug reactions that now outstrips the target diseases ...
With multimorbidity in particular, this increases vulnerability to excessive investigation and treatment offering no overall benefits, and adding morbidity due to drug interactions and adverse effects. ...
doi:10.5712/rbmfc10(35)1069
fatcat:323yrf5zhbg6dmxoqsxtugrjxa
Cell sensitivity, non-linearity and inverse effects
2015
Homeopathy
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Here we review hypotheses about homeopathic drug action at cellular and molecular levels, and present a new conceptual model of the principle of similarity based on allosteric drug action. ...
Low doses or high dilutions of a drug interact only with the enhanced sensitivities of regulatory systems, functioning as minute harmful stimuli to trigger specific compensatory healing reactions. ...
This is also connected with the use of very small doses of drugs in homeopathy. ...
doi:10.1016/j.homp.2015.02.002
pmid:25869978
fatcat:kbvpe2mhabeylg2nejepe35nj4
Comparison of Anticancer Drug Toxicities: Paradigm Shift in Adverse Effect Profile
2021
Life
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The differences in drug disposition and interaction with human basal pathways contribute to this paradigm shift in adverse effect profile. ...
In this review, we summarized the general mechanisms and adverse effects of small and large molecule anticancer drugs that would further our understanding on the toxicity patterns of chemotherapeutic regimens ...
Author Contributions: Conceptualization, S.D.; methodology, S.D., D.B.; software, S.D.; investigation, S.A., Y.D., D.B.; resources, S.D., D.B.; data curation, D.B., S.A., Y.D.; writing-original draft preparation ...
doi:10.3390/life12010048
pmid:35054441
pmcid:PMC8777973
fatcat:jgh2z3fxdndvnehrld5vjmlnpi
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