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Inverse inbreeding coefficient problems with an application to linkage analysis of recessive diseases in inbred populations

Richa Agarwala, Leslie G. Biesecker, Alejandro A. Schäffer
2000 Discrete Applied Mathematics  
The problem of choosing a pedigree is particularly interesting for diseases inherited in an autosomal recessive pattern in inbred populations because there are many possible paths of inheritance to choose  ...  We call such a problem an inverse inbreeding coe cient problem.  ...  Our work is also applicable to more large-scale epidemiology studies of inbred populations.  ... 
doi:10.1016/s0166-218x(00)00193-1 fatcat:3jwtouym5negnj2ivsgmufyg2q

An overview on quantitative and genomic tools for utilising dominance genetic variation in improving animal production

2008 Agricultural and Food Science  
One possibility is the use of genomic tools in assessing populations for crossbreeding and in searching for major genes mediating dominance variation.  ...  Maximisation of heterosis can be done only on a temporary basis as a continued exploitation leads to stagnation in the overall genetic progress.  ...  Wall et al. (2005) found that the difference between a noninbred animal and an animal with an inbreeding coefficient of 10% had a 2.8 d increase in calving interval, a 1.7 d increase in days to first  ... 
doi:10.2137/145960607782219337 fatcat:us5fr6eztjao5m6hhr35chbpuu

Quantitative Genetics of Inbreeding in a Synthetic Maize Population

Jode W. Edwards, Kendall R. Lamkey
2002 Crop science  
The observed provided some quantitative genetic analysis of the efvariance of inbred individuals in our study was 1.18 times the variance fects of inbreeding on genetic variability in maize.  ...  By con-studies found that dominance deviations of inbred inditrast, variance of dominance deviations of inbred individuals ranged viduals became negatively correlated with their breedfrom 1.6 to 3.3 times  ...  These which is applicable to any reference population: components are the mixed linear model equivalents of genotype x environment interaction in analysis-of-variance models. d ϭ Ί 2 2 D* 2 A* ϭ Ί 2 D  ... 
doi:10.2135/cropsci2002.1094 fatcat:xbqaolp6a5e7tkzydfn64klmma

Page 7602 of Mathematical Reviews Vol. , Issue 2001J [page]

2001 Mathematical Reviews  
analysis of recessive diseases in inbred populations.  ...  , Richa (1-NIH-HG; Bethesda, MD); Biesecker, Leslie G. (1-NIH-HGG; Bethesda, MD); Schaffer, Alejandro A. (1-NIH-HID; Bethesda, MD) Inverse inbreeding coefficient problems with an application to linkage  ... 

Genomic descriptors of biodiversity – A review

Gábor Mészáros
2018 Die Bodenkultur  
Both LD and relatedness are of interest on their own, as well as in their follow-up applications deriving overall measures of effective population size.  ...  The assessment of relatedness is also pivotal to construct meaningful mating plans and to avoid the negative consequences of inbreeding depression that might be detrimental especially in small, endangered  ...  The analysis of dense marker data is based on the assumption that SNPs are in sufficient linkage disequilibrium to regions of interests.  ... 
doi:10.2478/boku-2018-0007 fatcat:dt4vrs7lpjdljinpcbkvzbrcum

Quantitative Genetics and Plant Breeding [chapter]

John W. Dudley
1997 Advances in Agronomy  
Choice of Parents to Form Base Populations Conceptually, the problem of developing improved inbreds for use in hybrids is one of adding favorable alleles from a donor source to an elite inbred without  ...  Choice of Parents to Form Base Populations Conceptually, the problem of developing improved inbreds for use in hybrids is one of adding favorable alleles from a donor source to an elite inbred without  ... 
doi:10.1016/s0065-2113(08)60051-6 fatcat:lyyslqoh2fbx7oj53xmxrb3ufy

Quantifying realized inbreeding in wild and captive animal populations

U Knief, G Hemmrich-Stanisak, M Wittig, A Franke, S C Griffith, B Kempenaers, W Forstmeier
2015 Heredity  
This allowed us to determine whether any of these four regions was completely homozygous within an individual, which indicates IBD with high confidence.  ...  The inbreeding coefficient F Ped obtained from pedigrees is a valuable estimator of IBD, but pedigrees are not always available, and cannot capture inbreeding loops that reach back in time further than  ...  This study was funded by the Max Planck Society (BK), with the zebra finch study at Fowler's Gap funded by support to SCG from the Australian Research Council.  ... 
doi:10.1038/hdy.2014.116 pmid:25585923 pmcid:PMC4359978 fatcat:gokaie6utvdmxpbqwyrbdrvk2a


1965 American Journal of Human Genetics  
Franklin Schneider for their co-operation in contacting patients and their families; and to the Roman Catholic chanceries of Wisconsin for permission to use their marriage records for population inbreeding  ...  ACKNOWLEDGMENT We are indebted to Dr. Harry Waisman for visiting the Wisconsin colonies with us; to Mr. John Garstecki, Mr. Harvey Stevens, Mr. A. C. Nelson, and Mr.  ...  , c is the proportion of probands in simplex families, F, is the mean inbreeding coefficient of isolated probands, FF the mean inbreeding coefficient of familial probands, and a the mean inbreeding coefficient  ... 
pmid:14295493 pmcid:PMC1932604 fatcat:pi2nwmxndzfx3oh55semg6hrky

Genetic Equilibrium and Selection

W B Kemp
1929 Genetics  
increase in the proportion (T) in which the detrimental recessive occurs in the population a t equilibrium, and also with decrease in vigor ( W ) of the recessive.  ...  In an inbred form producing many descendants per parent, natural selection is intense; therefore a small proportion of the population is apt to engage in reproduction.  ...  The more inportant formulas for a random-fertilized population follow: Formulas for finding F,+1 from F,,  ... 
pmid:17246570 pmcid:PMC1201026 fatcat:vwiegxeknngnxa6lb3baq4t2va

Reconciling Differences in Pool-GWAS Between Populations: A Case Study of Female Abdominal Pigmentation in Drosophila melanogaster

L. Endler, A. J. Betancourt, V. Nolte, C. Schlotterer
2015 Genetics  
The degree of concordance between populations in the genetic architecture of a given trait is an important issue in medical and evolutionary genetics.  ...  Here, we address this problem, using a replicated pooled genome-wide association study approach (Pool-GWAS) to compare the genetic basis of variation in abdominal pigmentation in female European and South  ...  In the analysis of the European population, the SNPs within a group show strong linkage disequilibrium, resulting in almost identical allele frequency change.  ... 
doi:10.1534/genetics.115.183376 pmid:26715669 pmcid:PMC4788253 fatcat:zkxhc4dhfzezddzv7h67jw5krm

Genetic Disorders in Qatar [chapter]

Ahmad S. Teebi, Tawfeg Ben-Omran
2010 Genetic Disorders Among Arab Populations  
Linkage analysis showed there was no evidence for genetic linkage to any of mutant loci implicated in EDS.  ...  in breast, skin, thyroid and female genital cancer groups (with the coefficient of inbreeding 0.014, 0.012, 0.008, and 0.014).  ... 
doi:10.1007/978-3-642-05080-0_18 fatcat:csmxwkvhbvfnnmbi7rkzrowi7u

Analytic review: some current problems of human population genetics

L L Cavalli-Sforza
1973 American Journal of Human Genetics  
The inbreeding coefficient of an individual is identical with the kinship of his parents.  ...  Under some conditions it can be equated to FST, an inbreeding coefficient defined by S.  ... 
pmid:4567614 pmcid:PMC1762215 fatcat:r2eadettqrb5nmtmtcmu7zufpy

Heritability and segregation analysis of osteosarcoma in the Scottish deerhound

Jeffrey C. Phillips, Betty Stephenson, Marlene Hauck, John Dillberger
2007 Genomics  
The Scottish deerhound is a breed of dog with a N 15% incidence of osteosarcoma and represents an excellent spontaneously occurring large-animal model of the human disease.  ...  Inheritance of the putative high-risk allele was thus associated with N 75% risk of disease occurrence compared to the b5% baseline risk.  ...  Also, thanks to Arnold Saxton (University of Tennessee) for his thorough review of the manuscript, to Sandy Hasstedt (University of Utah) for her help with the jPAP software, and finally to Matthew Breen  ... 
doi:10.1016/j.ygeno.2007.05.001 pmid:17628392 fatcat:jpmufkxk3fdrhfmmx727fnre2y

AUDACITY: a comprehensive approach for the detection and classification of Runs of Homozygosity in medical and population genomics

Alberto Magi, Tania Giangregorio, Roberto Semeraro, Giulia Carangelo, Flavia Palombo, Giovanni Romeo, Marco Seri, Tommaso Pippucci
2020 Computational and Structural Biotechnology Journal  
Simulations and analysis of real exomes/genomes show its potential to foster future RoH studies in medical and population genomics.  ...  Runs of Homozygosity (RoHs) are popular among geneticists as the footprint of demographic processes, evolutionary forces and inbreeding in shaping our genome, and are known to confer risk of Mendelian  ...  Estimation of inbreeding coefficient F We estimated the inbreeding coefficient (F) of the simulated 1C, 2C, 3C index offspring using FSuite [11] with default options, creating 100 random submaps with  ... 
doi:10.1016/j.csbj.2020.07.003 pmid:32774790 pmcid:PMC7394861 fatcat:i265hqqoszghhetbhajewa6ziq

One Hundred Years of Coat Colour Influences on Genetic Diversity in the Process of Development of a Composite Horse Breed

Carmen Marín Navas, Juan Vicente Delgado Bermejo, Amy Katherine McLean, José Manuel León Jurado, Antonio Rodríguez de la Borbolla y Ruiberriz de Torres, Francisco Javier Navas González
2022 Veterinary Sciences  
Inbreeding levels ranged from 1.81% in smokey cream horses to 8.80 for white horses.  ...  Genetic diversity and demographic parameters were computed to evaluate the historic effects of coat colour segregation in the process of configuration of the Hispano-Arabian horse (Há).  ...  Acknowledgments: The authors thank the Unión Española de Ganaderos de Pura Raza Hispano-Árabe or Spanish Union of Purebred Hispano-Arabian Horses Breeders (UEGHá) for providing the data used in this study  ... 
doi:10.3390/vetsci9020068 pmid:35202321 pmcid:PMC8879117 fatcat:a3us7yechzadho5xjqf7v7st4q
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