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Intrinsic Brain Activity of Cognitively Normal Older Persons Resembles More That of Patients Both with and at Risk for Alzheimer's Disease Than That of Healthy Younger Persons

Lorenzo Pasquini, Annika Tonch, Claudia Plant, Andrew Zherdin, Marion Ortner, Alexander Kurz, Hans Förstl, Claus Zimmer, Timo Grimmer, Afra Wohlschäger, Valentin Riedl, Christian Sorg
2014 Brain Connectivity  
Our result provides evidence for larger similarity in intrinsic brain activity between healthy older persons and patients with or at-risk for AD than between older and younger ones, suggesting a significant  ...  Independently of applied methods and involved areas, healthy older persons' intrinsic brain activity was consistently more alike that of patients than that of younger controls.  ...  The authors are grateful to the participants of the study and the staff of the Department of Psychiatry and Neuroradiology for their help in recruitment and data collection.  ... 
doi:10.1089/brain.2013.0213 pmid:24689864 pmcid:PMC4064725 fatcat:vu5v7l2gx5dz7mgefgfulfssam

Sleep and Circadian Rhythm Disorders in Human Aging and Dementia [chapter]

M.V. Vitiello
2009 Encyclopedia of Neuroscience  
Both of these changes are indicative of impaired sleep maintenance and depth and contribute to the characterization of the sleep of older adults as lighter, or more fragile, than that of younger adults  ...  Aging is also associated with a tendency to both fall asleep and awaken earlier. That is, a tendency for older individuals to be larks rather than owls.  ...  See also: Aging of the Brain and Alzheimer's Disease; Alzheimer's Disease: An Overview; Alzheimer's Disease: Molecular Genetics; Alzheimer's Disease: Transgenic Mouse Models; Animal Models of Alzheimer's  ... 
doi:10.1016/b978-008045046-9.01620-x fatcat:ddoe3zl3ujdn7le5p43swvxtfy

Final Program Forty First Annual Meeting International Neuropsychological Society February 6–9, 2013 Waikoloa, Hawaii, USA

2013 Journal of the International Neuropsychological Society  
Lastly, we will provide examples of the relationship between neuroimaging phenotypes and cognitive status, as well as how particular genes may modify brain development or the aging brain, in both health  ...  to study brain development and aging 2) Discuss typical changes in neuroimaging measures across the age span 3) Incorporate cognitive studies and genetic information in the assessments of various neuroimaging  ...  Bott, Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd., MC 5719, Palo Alto, Nencki Institute, 3 Pasteur Street,  ... 
doi:10.1017/s1355617713000362 fatcat:4bgx6f2nwfhd7fwsgabtjpdr4a

Theme A: AGEING OF BIOLOGICAL SYSTEMS Session A1: Changing Pathology of Ageing Society Session A2: Molecular Basis of Ageing Session A3: Ischemic, hypoxic, hemorrhagic brain disorders & ageing Session A4: Neuroscience and Neurodegenrative Disorders and Ageing Session A5: Good Clinical Practices for the Improvement of the Age Related Diseases

2020 Liječnički vjesnik  
Although total sleep time tends to remain constant, older people spend more time in the lighter stages of sleep, sleep latency might increase, REM sleep decline,  ...  Sleep architecture and duration changes throughout the lifespan starting with dramatic changes during the first year of life, continuing to change through the childhood and finally becomes characterized  ...  There are more older people than children and more people at extreme old age than ever before.  ... 
doi:10.26800/lv-142-suppl1-2 fatcat:wwr7crnd5fh3nngeyoh5xjlwzi

Dementia syndromes: evaluation and treatment

Kevin R Scott, Anna M Barrett
2007 Expert Review of Neurotherapeutics  
Dementia (neurodegenerative) is age related, with prevalence estimated at 20% in individuals older than 85 years [201] .  ...  The Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV defines dementia as a decline in memory with impairment of at least one other cognitive function, such as skilled movements (limb apraxia  ...  Acknowledgements Anna Barrett received support for the writing of this article from The National Institutes of Health/NINDS (K02NS47099), and the Henry H. Kessler Foundation.  ... 
doi:10.1586/14737175.7.4.407 pmid:17425495 pmcid:PMC2536654 fatcat:sh3mrpwn5ver7kal5w5g7jg774

Premature or pathological aging: longevity

Valdemiro Carlos Sgarbieri, Maria Teresa Bertoldo Pacheco
2017 Brazilian Journal of Food Technology  
Unfamiliarity with these factors leads to chronic and/or degenerative diseases that compromise quality of life and longevity.  ...  The factors that act on premature aging processes are essentially the same as those of natural or healthy aging, but in a more intense and uncontrolled manner.  ...  In blood testing for E4 allele, 20 control patients (healthy older individuals), 41 patients with Alzheimer's and 21 with mild cognitive impairment (MCI) were analyzed.  ... 
doi:10.1590/1981-6723.19416 fatcat:lf7vol4ozzhctekan53oyjclim

Impact of diabetes on cognitive function and brain structure

Amir Moheet, Silvia Mangia, Elizabeth R. Seaquist
2015 Annals of the New York Academy of Sciences  
Other alterations of brain functional connectivity have been reported in T2DM 84 which resemble those observed in individuals at risk for Alzheimer's disease, 79 (including a reduced resting-state connectivity  ...  , requiring more assistance with personal care and increased risk of hospitalization. 98 More research is needed to develop specific diagnostic criteria or severity scores to identify people who are at  ...  Other alterations of brain functional connectivity have been reported in T2DM 84 which resemble those observed in individuals at risk for Alzheimer's disease, 79 (including a reduced resting-state connectivity  ... 
doi:10.1111/nyas.12807 pmid:26132277 pmcid:PMC4837888 fatcat:zwuilgiilnclvoim643gml4k4u

From Onset and Prodromal Stage to a Life-Long Course of Schizophrenia and Its Symptom Dimensions: How Sex, Age, and Other Risk Factors Influence Incidence and Course of Illness

Heinz Häfner
2019 Psychiatry Journal  
They occur at the early stages of various brain diseases, too. Psychosis seems to be a preformed pattern of response of the human brain.  ...  The lifetime risk seems to be the same for both sexes. The lower incidence in premenopausal women is accounted for by the downregulating effect of oestrogen on dopamine receptors.  ...  Sonderforschungsbereich) 258 at the Central Institute of Mental Health from January 1, 1987, to December 30, 1998, and from January 1, 1999, to May 31, 2012, as an independent project.  ... 
doi:10.1155/2019/9804836 pmid:31139639 pmcid:PMC6500669 fatcat:kzqocl65v5cx5lpi5ggyzrgzeu

Final Program The 2013 International Neuropsychological Society Mid–Year Meeting July 10–13, 2013 Amsterdam, The Netherlands

2013 Journal of the International Neuropsychological Society  
the person with Alzheimer's disease.  ...  Alzheimer's Disease patients showed a greater underestimation of time than older adults but both populations showed the same reduction in retrospective time evaluation.  ...  The aim of the current study was to investigate brain activation during self-reflection in a sample with an ultra-high risk (UHR) for psychosis.  ... 
doi:10.1017/s1355617713001033 fatcat:55ykcdrjcrffplpcaebwtrcew4

Final Program, Abstracts Presented at the Thirty–Fifth Annual International Neuropsychological Society Conference, February 7–10, Portland, Oregon, USA

2007 Journal of the International Neuropsychological Society  
The role of disease variables, age, and depression proneness in predicting depression in MS patients.  ...  Stepwise regression analysis predicting CMDI score with illness variables, age, and depression proneness showed that the only signficant predictor of depression was depression proneness.  ...  that occur in normal aging, in Alzheimer's disease (AD) and in those individuals at particular risk for Alzheimer's disease.  ... 
doi:10.1017/s1355617707079969 fatcat:hyqc3ut5ybg3rnk6shatuylham

Youthful Memory Capacity in Old Brains: Anatomic and Genetic Clues from the Northwestern SuperAging Project

Emily J. Rogalski, Tamar Gefen, Junzi Shi, Mehrnoosh Samimi, Eileen Bigio, Sandra Weintraub, Changiz Geula, M.-Marsel Mesulam
2013 Journal of Cognitive Neuroscience  
SuperAgers also displayed a patch of ACC where cortical thickness was higher than in 50-to 60-year-old younger cognitively healthy adults.  ...  They also offer clues to potential biological factors that may promote resistance to age-related involutional changes in the structure and function of the brain.  ...  Acknowledgments This project was supported by a grant from The Davee Foundation and the Northwestern University Alzheimer's Disease Care Center grant from the National Institute on Aging (AG13854).  ... 
doi:10.1162/jocn_a_00300 pmid:23198888 pmcid:PMC3541673 fatcat:lkqgngja4fadzdcrxy6yhaxtlq

XI Convegno Nazionale: Firenze, 17–19 marzo 2016, Palazzo dei Congressi – Villa Vittoria

M. Musicco, P. Caffarra, M. Bozzali, A.C. Bruni, B. Nacmias, L. Pantoni, G. Sorrentino, A. Venneri
2016 Journal of Alzheimer's Disease  
Conclusions: Relative to PD no-ICD, PD-ICD patients are characterized by a more severe involvement of frontal, meso-limbic and motor circuits.  ...  Furthermore, in PD-ICD, the lack of increased functional connectivity within the sensorimotor-network together with their cortical thinning in the same regions, suggest a greater disconnection among these  ...  Conclusions: The role of genomic SNPs still represented a challenge for the genetics of SAD, having an effects in increasing the risk for SAD, if any, much smaller than those of APOE.  ... 
doi:10.3233/jad-169001 pmid:27232541 fatcat:ld4yvhhabbdrzeok5ghvddevze

VI Sindem MEETING: Italian Association for the Study of Dementia linked to the Italian Neurological Society (SIN)

Vincenzo Bonavita, Carlo Caltagirone, Claudio Mariani, Alessandro Padovani, Elio Scarpini, Sandro Sorbi, Vincenzo Bonavita, Carlo Caltagirone, Claudio Mariani, Alessandro Padovani, Elio Scarpini, Sandro Sorbi
2011 Journal of Alzheimer's Disease  
in 13 patients with Alzheimer's disease (AD) and 12 patients with amnestic mild cognitive impairment (aMCI) relative to 13 healthy controls.  ...  They were also older at disease onset, and showed more widesperad atrophy and major frontal plus minor occipital involvement at neuroimaging.  ...  The second patient showed clinical Alzheimer's disease with deficits in all cortical functions and normal temporo-mesial structures by MRI scan.  ... 
doi:10.3233/jad-2010-1433 fatcat:owgslmgl4rdinpovt26xcvnkwe

Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors

Chanung Wang, David M. Holtzman
2019 Neuropsychopharmacology  
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before memory and other cognitive deficits are reported.  ...  As the disease progresses and cognitive changes ensue, sleep disturbances become even more debilitating.  ...  of the manuscript.  ... 
doi:10.1038/s41386-019-0478-5 pmid:31408876 pmcid:PMC6879647 fatcat:wxr6g5pjjzbr5kdr5i25w4nfoi

Age-related decline in brain resources magnifies genetic effects on cognitive functioning

Ulman Lindenberger
2008 Frontiers in Neuroscience  
We hypothesize that losses in neurochemical and anatomical brain resources in normal aging modulate the effects of common genetic variations on cognitive functioning.  ...  in old age and interacted with the Brain-Derived Neurotrophic Factor (BDNF) gene.  ...  The apolipoprotein E gene (APOE) is the most clearly established genetic risk factor for Alzheimer's disease (AD).  ... 
doi:10.3389/neuro.01.039.2008 pmid:19225597 pmcid:PMC2622748 fatcat:hfh2wmwnmzeg3p4fnv3an76cqe
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