A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Filters
Intranasal Oxytocin Selectively Modulates Large-Scale Brain Networks in Humans
2017
Brain Connectivity
Preserved Fulltext
Yet the effects of OT over important large-scale networks involved in these processes, such as the default mode (DM), ventral attention (VA), and cingulo-opercular (CO) networks, remain unknown. ...
Overall, our data support that the modulation of functional connectivity within the VA is a basic mechanism by which OT directs attentional resources from internal to external cues, preparing the brain ...
Acknowledgments We thank the Department of Psychiatry and Psychotherapy of the University Medical Center Göttingen in supporting this work and we thank the local MRI staff for their valuable contributions ...
doi:10.1089/brain.2017.0528
pmid:28762756
pmcid:PMC5647506
fatcat:x6qhoo73ojb7ljdrdhhbyq4raq
Oxytocin modulates local topography of human functional connectome in healthy men at rest
2021
Communications Biology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
Together, our results suggest that oxytocin effects on human behaviour entail modulation of multiple levels of brain processing distributed across different systems. ...
Increases in levels of oxytocin in systemic circulation induce broad effects on the functional connectome, yet we provide indirect evidence supporting the involvement of nose-to-brain pathways in at least ...
We would also like to thank Sofia Vasilakopoulou, Jack Loveridge and Ndaba Mazibuko for their assistance in data collection and Dr Fernando Zelaya for his comments on the first draft of the manuscript. ...
doi:10.1038/s42003-020-01610-z
pmid:33452496
fatcat:o6vsrnbfvvbvxduh3rwo4x2r3e
Intranasal Oxytocin and Vasopressin Modulate Divergent Brainwide Functional Substrates
2016
Neuropsychopharmacology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
However, the large-scale functional substrates directly engaged by these peptides and their functional dynamics remain elusive. ...
The observed divergence calls for a deeper investigation of the systemslevel mechanisms by which exogenous OXT and AVP modulate brain function and exert their putative therapeutic effects. ...
DISCUSSION We used phMRI to map the large-scale functional substrates modulated by acute intranasal administration of OXT and AVP in the mouse brain and demonstrate that both neuropeptides elicit a rapid ...
doi:10.1038/npp.2016.283
pmid:27995932
pmcid:PMC5436116
fatcat:kfjfsfqmlrdxtbckoqfem6iwii
Oxytocin effects on the resting-state mentalizing brain network
[article]
2018
biorxiv/medrxiv
pre-print
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
ABSTRACTOxytocin(OT) has effects in both human behavior and in the brain, which is not limited in the specific brain area but also with the potential effect on connectivity with other brain regions. ...
Since the vital role of mentalizing in understanding others, here we proposed and tested that whether OT has a general effect on theory of mind brain network which is associated to the effect of related ...
Although it has been reported that human oxytocin could modulate both social cognition and resting state brain connectivity, how oxytocin modulates other social brain networks engaged in these social behaviors ...
doi:10.1101/465658
fatcat:zcalfbo23jhjdnqhhqj7tjo7lq
Less is more: a dose-response mechanistic account of intranasal oxytocin pharmacodynamics in the human brain
[article]
2021
bioRxiv
pre-print
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
We also demonstrate that intranasal oxytocin does not disrupt cerebrovascular reactivity, corroborating the validity of haemodynamic neuroimaging to probe its effects on the human brain. ...
We further link physiological changes with the density of the oxytocin receptor gene mRNA across brain regions, strengthening our confidence in intranasal oxytocin as a valid approach to target central ...
Regarding the first question, the most commonly used dose in studies administering intranasal oxytocin with nasal sprays (24IU) has been selected largely due to historical precedence 20 , rather than a ...
doi:10.1101/2021.01.18.427062
fatcat:4tvqmg2kzveaho2nfx5flnxeny
Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women
2017
Translational Psychiatry
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
Oxytocin may influence various human behaviors and the connectivity across subcortical and cortical networks. Previous oxytocin studies are male biased and often constrained by task-based inferences. ...
Here, we investigate the impact of oxytocin on restingstate connectivity between subcortical and cortical networks in women. ...
to compare the whole-brain component maps with large-scale automated metaanalysis maps within NeuroSynth. ...
doi:10.1038/tp.2017.72
pmid:28418398
pmcid:PMC5416709
fatcat:emzg3a2nandj3d7qpqf6ij6i7y
Neural and Molecular Contributions to Pathological Jealousy and a Potential Therapeutic Role for Intranasal Oxytocin
2021
Frontiers in Pharmacology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
However, there is increasing interest in a potential role for the neuropeptide oxytocin, which can also modulate dopaminergic and serotonin systems in the brain and has been shown to altered in other psychotic ...
Recent studies in healthy populations have reported that when oxytocin is administered intranasally it can influence the brain to promote strengthening of romantic bonds and reduce romantic jealousy in ...
In humans, the effects of administering oxytocin exogenously via an intranasal route in order to activate its widely distributed network of receptors (Quintana et al., 2019) have been widely investigated ...
doi:10.3389/fphar.2021.652473
pmid:33959017
pmcid:PMC8094533
fatcat:exltqmzgrrcgljppvy6z3agjhe
Oxytocin's effect on resting-state functional connectivity varies by age and sex
2016
Psychoneuroendocrinology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
This study provides novel evidence of age-by-sex differences in how oxytocin modulates resting-state brain connectivity, furthering our understanding of how oxytocin affects brain networks at rest. ...
In a double-blind design, 79 participants were randomly assigned to self-administer either intranasal oxytocin or placebo before undergoing resting-state functional magnetic resonance imaging. ...
The nasal spray was formulated as stated in DF's IND 100,860. ...
doi:10.1016/j.psyneuen.2016.03.013
pmid:27032063
pmcid:PMC4942126
fatcat:no2to64ll5hojb4ik3nbctws6q
Integrative Approaches Utilizing Oxytocin to Enhance Prosocial Behavior: From Animal and Human Social Behavior to Autistic Social Dysfunction
2012
Journal of Neuroscience
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
subjects ranging from animal models to humans suffering from autism for the purpose of promoting further study for developing the clinical use of oxytocin in treating ASD. ...
Instead, we wish to share the newest findings on the effects of oxytocin on social behavior, the brain, and the social dysfunction of ASD at the molecular, genetic, systemic, and behavior levels, in varied ...
Prairie voles, in particular, have been useful in revealing OT's role in human sociality largely because they share with humans the tendency toward forming selective preferences for familiar conspecifics ...
doi:10.1523/jneurosci.3327-12.2012
pmid:23055480
pmcid:PMC6622380
fatcat:fjxsfye4vjhjrfiocbzv5kvtva
Effects of Intranasal Oxytocin on the Blood Oxygenation Level-Dependent Signal in Food Motivation and Cognitive Control Pathways in Overweight and Obese Men
2017
Neuropsychopharmacology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Oxytocin administration reduces the BOLD signal in reward-related food motivation brain regions, providing a potential neurobiological mechanism for the anorexigenic oxytocin effects in humans. ...
However, the mechanisms underlying the anorexigenic effects of oxytocin in humans are unknown and critical to study to consider oxytocin as a neurohormonal weight loss treatment. ...
food motivation arises from a widespread network of brain regions known to be involved in reward processing. ...
doi:10.1038/npp.2017.226
pmid:28930284
fatcat:wywe5qll2rewjnfgdhik6fohhe
Oxytocin, brain physiology, and functional connectivity: A review of intranasal oxytocin fMRI studies
2013
Psychoneuroendocrinology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
In recent years the neuropeptide oxytocin (OT) has become one of the most studied peptides of the human neuroendocrine system. ...
In light of the increasing knowledge of the behavioural effects of OT in humans, studies of the effects of OT administration on brain function can contribute to our understanding of the neural networks ...
How this results in a specific behaviour will depend on the interaction between context and oxytocin modulation of the neural network. ...
doi:10.1016/j.psyneuen.2012.10.011
pmid:23159011
fatcat:4cagoaibpng2zjdyg6osfiyzyi
The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders
2016
CNS and Neurological Disorders - Drug Targets
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Examination of changes in the neural underpinnings of social behavior and simultaneous oxytocin levels in blood or cerebrospinal fluid could prove important in elucidating the pharmacokinetics of intranasal ...
In addition to doubts about the efficacy of particular methods of administration, questions remain about the mechanism of action of intranasal oxytocin on the central nervous system. ...
This work was partly funded by the Grants-in-Aid for Scientific Research from the JSPS (15K08093). ...
doi:10.2174/1871527315666160413120845
pmid:27071789
pmcid:PMC5080861
fatcat:lxtxxtfokjbhfp723sydftflwe
Oxytocin enhances intrinsic corticostriatal functional connectivity in women
[article]
2016
bioRxiv
pre-print
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Oxytocin may influence various human behaviors and the connectivity across subcortical and cortical networks. Previous oxytocin studies are male-biased and often constrained by task-based inferences. ...
An independent analysis of oxytocin receptor (OXTR) gene expression in human subcortical and cortical areas was carried out to determine plausibility of direct oxytocin effects on OXTR. ...
to compare the whole-brain component maps with large-scale automated meta-analysis maps within NeuroSynth. ...
doi:10.1101/068585
fatcat:op2gnn35tbhmhd2d3ol5zwy3tq
Pain modulation by intranasal oxytocin and emotional picture viewing — a randomized double-blind fMRI study
2016
Scientific Reports
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf.
No corresponding changes in whole-brain correlates of heat intensity processing were found. ...
This randomized, placebo-controlled, double-blind, crossover study explored whether intranasal oxytocin and emotional context can affect heat pain perception in 30 healthy male volunteers. ...
This investigator initiated research project received no other specific grant from any funding agency in the public, commercial, or not-for-profit sectors. ...
doi:10.1038/srep31606
pmid:27546446
pmcid:PMC4992880
fatcat:zluucllke5ekxdcqrg7ibj7w4u
411. Dose-Dependent Social-Cognitive Effects of Intranasal Oxytocin Delivered with Novel Breath Powered Device in Adults with Autism Spectrum Disorder: A Randomized Placebo-Controlled Double-Blind Crossover Trial
2017
Biological Psychiatry
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
We examined two doses of oxytocin delivered using a novel Breath Powered intranasal delivery device designed to improve direct nose-to-brain activity in a double-blind, crossover, randomized, placebo-controlled ...
To our knowledge, this is the first trial to assess the dose-dependent effects of a single oxytocin administration in autism, with results indicating that a low dose of oxytocin can significantly modulate ...
brain rather than across the blood-brain barrier via circulating blood, this has not been directly tested in humans. ...
doi:10.1016/j.biopsych.2017.02.428
fatcat:vo4r2mpo75chlb4a2jjcckwxiy
« Previous
Showing results 1 — 15 out of 475 results