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Intranasal Oxytocin Selectively Modulates Large-Scale Brain Networks in Humans

Katja Brodmann, Oliver Gruber, Roberto Goya-Maldonado
2017 Brain Connectivity  
Yet the effects of OT over important large-scale networks involved in these processes, such as the default mode (DM), ventral attention (VA), and cingulo-opercular (CO) networks, remain unknown.  ...  Overall, our data support that the modulation of functional connectivity within the VA is a basic mechanism by which OT directs attentional resources from internal to external cues, preparing the brain  ...  Acknowledgments We thank the Department of Psychiatry and Psychotherapy of the University Medical Center Göttingen in supporting this work and we thank the local MRI staff for their valuable contributions  ... 
doi:10.1089/brain.2017.0528 pmid:28762756 pmcid:PMC5647506 fatcat:x6qhoo73ojb7ljdrdhhbyq4raq

Oxytocin modulates local topography of human functional connectome in healthy men at rest

Daniel Martins, Ottavia Dipasquale, Yannis Paloyelis
2021 Communications Biology  
Together, our results suggest that oxytocin effects on human behaviour entail modulation of multiple levels of brain processing distributed across different systems.  ...  Increases in levels of oxytocin in systemic circulation induce broad effects on the functional connectome, yet we provide indirect evidence supporting the involvement of nose-to-brain pathways in at least  ...  We would also like to thank Sofia Vasilakopoulou, Jack Loveridge and Ndaba Mazibuko for their assistance in data collection and Dr Fernando Zelaya for his comments on the first draft of the manuscript.  ... 
doi:10.1038/s42003-020-01610-z pmid:33452496 fatcat:o6vsrnbfvvbvxduh3rwo4x2r3e

Intranasal Oxytocin and Vasopressin Modulate Divergent Brainwide Functional Substrates

Alberto Galbusera, Alessia De Felice, Stefano Girardi, Giacomo Bassetto, Marta Maschietto, Katsuhiko Nishimori, Bice Chini, Francesco Papaleo, Stefano Vassanelli, Alessandro Gozzi
2016 Neuropsychopharmacology  
However, the large-scale functional substrates directly engaged by these peptides and their functional dynamics remain elusive.  ...  The observed divergence calls for a deeper investigation of the systemslevel mechanisms by which exogenous OXT and AVP modulate brain function and exert their putative therapeutic effects.  ...  DISCUSSION We used phMRI to map the large-scale functional substrates modulated by acute intranasal administration of OXT and AVP in the mouse brain and demonstrate that both neuropeptides elicit a rapid  ... 
doi:10.1038/npp.2016.283 pmid:27995932 pmcid:PMC5436116 fatcat:kfjfsfqmlrdxtbckoqfem6iwii

Oxytocin effects on the resting-state mentalizing brain network [article]

Haiyan Wu, Chunliang Feng, Xiaping Lu, Xun Liu, Quanying Liu
2018 biorxiv/medrxiv   pre-print
ABSTRACTOxytocin(OT) has effects in both human behavior and in the brain, which is not limited in the specific brain area but also with the potential effect on connectivity with other brain regions.  ...  Since the vital role of mentalizing in understanding others, here we proposed and tested that whether OT has a general effect on theory of mind brain network which is associated to the effect of related  ...  Although it has been reported that human oxytocin could modulate both social cognition and resting state brain connectivity, how oxytocin modulates other social brain networks engaged in these social behaviors  ... 
doi:10.1101/465658 fatcat:zcalfbo23jhjdnqhhqj7tjo7lq

Less is more: a dose-response mechanistic account of intranasal oxytocin pharmacodynamics in the human brain [article]

Daniel Martins, Katja Brodmann, Mattia Veronese, Ottavia Dipasquale, Ndaba Mazibuko, Uwe Schuschnig, Fernando Zelaya, Katarina Fotopoulou, Yannis Paloyelis
2021 bioRxiv   pre-print
We also demonstrate that intranasal oxytocin does not disrupt cerebrovascular reactivity, corroborating the validity of haemodynamic neuroimaging to probe its effects on the human brain.  ...  We further link physiological changes with the density of the oxytocin receptor gene mRNA across brain regions, strengthening our confidence in intranasal oxytocin as a valid approach to target central  ...  Regarding the first question, the most commonly used dose in studies administering intranasal oxytocin with nasal sprays (24IU) has been selected largely due to historical precedence 20 , rather than a  ... 
doi:10.1101/2021.01.18.427062 fatcat:4tvqmg2kzveaho2nfx5flnxeny

Intranasal oxytocin enhances intrinsic corticostriatal functional connectivity in women

R A I Bethlehem, M V Lombardo, M-C Lai, B Auyeung, S K Crockford, J Deakin, S Soubramanian, A Sule, P Kundu, V Voon, S Baron-Cohen
2017 Translational Psychiatry  
Oxytocin may influence various human behaviors and the connectivity across subcortical and cortical networks. Previous oxytocin studies are male biased and often constrained by task-based inferences.  ...  Here, we investigate the impact of oxytocin on restingstate connectivity between subcortical and cortical networks in women.  ...  to compare the whole-brain component maps with large-scale automated metaanalysis maps within NeuroSynth.  ... 
doi:10.1038/tp.2017.72 pmid:28418398 pmcid:PMC5416709 fatcat:emzg3a2nandj3d7qpqf6ij6i7y

Neural and Molecular Contributions to Pathological Jealousy and a Potential Therapeutic Role for Intranasal Oxytocin

Xiaoxiao Zheng, Keith M. Kendrick
2021 Frontiers in Pharmacology  
However, there is increasing interest in a potential role for the neuropeptide oxytocin, which can also modulate dopaminergic and serotonin systems in the brain and has been shown to altered in other psychotic  ...  Recent studies in healthy populations have reported that when oxytocin is administered intranasally it can influence the brain to promote strengthening of romantic bonds and reduce romantic jealousy in  ...  In humans, the effects of administering oxytocin exogenously via an intranasal route in order to activate its widely distributed network of receptors (Quintana et al., 2019) have been widely investigated  ... 
doi:10.3389/fphar.2021.652473 pmid:33959017 pmcid:PMC8094533 fatcat:exltqmzgrrcgljppvy6z3agjhe

Oxytocin's effect on resting-state functional connectivity varies by age and sex

Natalie C. Ebner, Huaihou Chen, Eric Porges, Tian Lin, Håkan Fischer, David Feifel, Ronald A. Cohen
2016 Psychoneuroendocrinology  
This study provides novel evidence of age-by-sex differences in how oxytocin modulates resting-state brain connectivity, furthering our understanding of how oxytocin affects brain networks at rest.  ...  In a double-blind design, 79 participants were randomly assigned to self-administer either intranasal oxytocin or placebo before undergoing resting-state functional magnetic resonance imaging.  ...  The nasal spray was formulated as stated in DF's IND 100,860.  ... 
doi:10.1016/j.psyneuen.2016.03.013 pmid:27032063 pmcid:PMC4942126 fatcat:no2to64ll5hojb4ik3nbctws6q

Integrative Approaches Utilizing Oxytocin to Enhance Prosocial Behavior: From Animal and Human Social Behavior to Autistic Social Dysfunction

H. Yamasue, J. R. Yee, R. Hurlemann, J. K. Rilling, F. S. Chen, A. Meyer-Lindenberg, H. Tost
2012 Journal of Neuroscience  
subjects ranging from animal models to humans suffering from autism for the purpose of promoting further study for developing the clinical use of oxytocin in treating ASD.  ...  Instead, we wish to share the newest findings on the effects of oxytocin on social behavior, the brain, and the social dysfunction of ASD at the molecular, genetic, systemic, and behavior levels, in varied  ...  Prairie voles, in particular, have been useful in revealing OT's role in human sociality largely because they share with humans the tendency toward forming selective preferences for familiar conspecifics  ... 
doi:10.1523/jneurosci.3327-12.2012 pmid:23055480 pmcid:PMC6622380 fatcat:fjxsfye4vjhjrfiocbzv5kvtva

Effects of Intranasal Oxytocin on the Blood Oxygenation Level-Dependent Signal in Food Motivation and Cognitive Control Pathways in Overweight and Obese Men

Franziska Plessow, Dean A Marengi, Sylvia K Perry, Julia M Felicione, Rachel Franklin, Tara M Holmes, Laura M Holsen, Nikolaos Makris, Thilo Deckersbach, Elizabeth A Lawson
2017 Neuropsychopharmacology  
Oxytocin administration reduces the BOLD signal in reward-related food motivation brain regions, providing a potential neurobiological mechanism for the anorexigenic oxytocin effects in humans.  ...  However, the mechanisms underlying the anorexigenic effects of oxytocin in humans are unknown and critical to study to consider oxytocin as a neurohormonal weight loss treatment.  ...  food motivation arises from a widespread network of brain regions known to be involved in reward processing.  ... 
doi:10.1038/npp.2017.226 pmid:28930284 fatcat:wywe5qll2rewjnfgdhik6fohhe

Oxytocin, brain physiology, and functional connectivity: A review of intranasal oxytocin fMRI studies

Richard A.I. Bethlehem, Jack van Honk, Bonnie Auyeung, Simon Baron-Cohen
2013 Psychoneuroendocrinology  
In recent years the neuropeptide oxytocin (OT) has become one of the most studied peptides of the human neuroendocrine system.  ...  In light of the increasing knowledge of the behavioural effects of OT in humans, studies of the effects of OT administration on brain function can contribute to our understanding of the neural networks  ...  How this results in a specific behaviour will depend on the interaction between context and oxytocin modulation of the neural network.  ... 
doi:10.1016/j.psyneuen.2012.10.011 pmid:23159011 fatcat:4cagoaibpng2zjdyg6osfiyzyi

The Potential of Nasal Oxytocin Administration for Remediation of Autism Spectrum Disorders

Yuko Okamoto, Makoto Ishitobi, Yuji Wada, Hirotaka Kosaka
2016 CNS and Neurological Disorders - Drug Targets  
Examination of changes in the neural underpinnings of social behavior and simultaneous oxytocin levels in blood or cerebrospinal fluid could prove important in elucidating the pharmacokinetics of intranasal  ...  In addition to doubts about the efficacy of particular methods of administration, questions remain about the mechanism of action of intranasal oxytocin on the central nervous system.  ...  This work was partly funded by the Grants-in-Aid for Scientific Research from the JSPS (15K08093).  ... 
doi:10.2174/1871527315666160413120845 pmid:27071789 pmcid:PMC5080861 fatcat:lxtxxtfokjbhfp723sydftflwe

Oxytocin enhances intrinsic corticostriatal functional connectivity in women [article]

Richard Alexander Ingmar Bethlehem, Michael V. Lombardo, Meng-Chuan Lai, Bonnie Auyeung, Sarah Crockford, Julia Deakin, Sentil Soubramanian, Akeem Sule, Prantik Kundu, Valerie Voon, Simon Baron-Cohen
2016 bioRxiv   pre-print
Oxytocin may influence various human behaviors and the connectivity across subcortical and cortical networks. Previous oxytocin studies are male-biased and often constrained by task-based inferences.  ...  An independent analysis of oxytocin receptor (OXTR) gene expression in human subcortical and cortical areas was carried out to determine plausibility of direct oxytocin effects on OXTR.  ...  to compare the whole-brain component maps with large-scale automated meta-analysis maps within NeuroSynth.  ... 
doi:10.1101/068585 fatcat:op2gnn35tbhmhd2d3ol5zwy3tq

Pain modulation by intranasal oxytocin and emotional picture viewing — a randomized double-blind fMRI study

Matthias Zunhammer, Sandra Geis, Volker Busch, Peter Eichhammer, Mark W. Greenlee
2016 Scientific Reports  
No corresponding changes in whole-brain correlates of heat intensity processing were found.  ...  This randomized, placebo-controlled, double-blind, crossover study explored whether intranasal oxytocin and emotional context can affect heat pain perception in 30 healthy male volunteers.  ...  This investigator initiated research project received no other specific grant from any funding agency in the public, commercial, or not-for-profit sectors.  ... 
doi:10.1038/srep31606 pmid:27546446 pmcid:PMC4992880 fatcat:zluucllke5ekxdcqrg7ibj7w4u

411. Dose-Dependent Social-Cognitive Effects of Intranasal Oxytocin Delivered with Novel Breath Powered Device in Adults with Autism Spectrum Disorder: A Randomized Placebo-Controlled Double-Blind Crossover Trial

Daniel Quintana, Lars Westlye, Sigrun Hope, Terje Nærland, Knut Smerud, Ramy Mahmoud, Per Djupesland, Ole Andreassen
2017 Biological Psychiatry  
We examined two doses of oxytocin delivered using a novel Breath Powered intranasal delivery device designed to improve direct nose-to-brain activity in a double-blind, crossover, randomized, placebo-controlled  ...  To our knowledge, this is the first trial to assess the dose-dependent effects of a single oxytocin administration in autism, with results indicating that a low dose of oxytocin can significantly modulate  ...  brain rather than across the blood-brain barrier via circulating blood, this has not been directly tested in humans.  ... 
doi:10.1016/j.biopsych.2017.02.428 fatcat:vo4r2mpo75chlb4a2jjcckwxiy
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