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An Integrated Model Combining Machine Learning and Deep Learning Algorithms for Classification of Rupture Status of IAs

Rong Chen, Xiao Mo, Zhenpeng Chen, Pujie Feng, Haiyun Li
2022 Frontiers in Neurology  
and MethodsA total of 148 (39 ruptured and 109 unruptured) IA subjects were retrospectively computed with computational fluid dynamics (CFDs), and the integrated models were proposed by combining machine  ...  BackgroundThe rupture risk assessment of intracranial aneurysms (IAs) is clinically relevant.  ...  The morphological variables were computed on the IA geometric models, and the hemodynamic clouds were obtained from computational fluid dynamic (CFD), and hemodynamic parameters were calculated on hemodynamic  ... 
doi:10.3389/fneur.2022.868395 fatcat:gf7rq42bojg55bswzatflww5pm

Computational modeling of cerebral aneurysm formation — framework for modeling the interaction between fluid dynamics, signal transduction pathways and arterial wall mechanics [chapter]

Holger Schmid, P. Watton, M. McCormick, Y. Lanir, H. Ho, C. Lloyd, P. Hunter, A. Ehret, M. Itskov
2009 International Federation for Medical and Biological Engineering Proceedings  
Here, we present a general framework for modeling the interplay of fluid dynamics, molecular signaling pathways and arterial wall mechanics.  ...  Many phenomenological models of cerebral aneurysm formation have been proposed. Such studies have focused on modeling the structural adaption of the arterial wall.  ...  ACKNOWLEDGMENT The authors would like to thank Chris Bradley from the University of Oxford for his support with regard to computational questions.  ... 
doi:10.1007/978-3-540-89208-3_451 fatcat:26ewvoopszgsbi4vpohaxhudr4

Virtual Reality Visualization of CFD Simulated Blood Flow in Cerebral Aneurysms Treated with Flow Diverter Stents

Sima Baheri Islami, Mike Wesolowski, William Revell, Xiongbiao Chen
2021 Applied Sciences  
This paper presents our study aimed at developing the VR visualization of computational fluid dynamics (CFD) simulations of cerebral aneurysms treated with flow-diverting (FD) stents.  ...  The animated flow elements rendered in the VR environment were velocity vectors, velocity contours, streamlines, particle traces, and point clouds.  ...  The distribution of velocity, pressure, and wall shear stress has been presented to assess the potential risk of aneurysm rupture [11] , evaluate the accuracy of computational fluid dynamics methods by  ... 
doi:10.3390/app11178082 fatcat:larzeja5svckznequxhg5xxuzm

Hemodynamics of Cerebral Aneurysms: Connecting Medical Imaging and Biomechanical Analysis

Vitaliy L Rayz, Aaron A Cohen-Gadol
2020 Annual Review of Biomedical Engineering  
In the last two decades, numerous studies have conducted patient-specific computations of blood flow dynamics in cerebral aneurysms and reported correlations between various hemodynamic metrics and aneurysmal  ...  It is expected that predictive models utilizing hemodynamic factors in combination with patient medical history and morphological data will outperform current risk scores and treatment guidelines.  ...  Image-Based Computational Fluid Dynamics Models in Unruptured Intracranial Aneurysm Risk Stratification and Interventional Planning As patient-specific modeling tools became more sophisticated and the  ... 
doi:10.1146/annurev-bioeng-092419-061429 pmid:32212833 fatcat:jrvzsszb5vcwjfxbwhctafqvoq

Letter from the President of WFITN

2015 Interventional Neuroradiology  
More studies are needed before it applies for evaluating aneurysm rupture risk in clinical applications.  ...  Conclusion: We demonstrated the feasibility to study leukocyte transport phenomenon inside cerebral aneurysms by an image-based patient-specific CFD analysis.  ...  Results: We examined the features on vessel site of de novo aneurysm occurred and rupture point of the aneurysm using computational fluid dynamics (CFD) technology.  ... 
doi:10.1177/1591019915618059 pmid:26547766 pmcid:PMC4757183 fatcat:fvlfbc5e3zac5l7gpae3qxtgzy

Direct Estimation of Wall Shear Stress from Aneurysmal Morphology: A Statistical Approach [chapter]

Ali Sarrami-Foroushani, Toni Lassila, Jose M. Pozo, Ali Gooya, Alejandro F. Frangi
2016 Lecture Notes in Computer Science  
Computational fluid dynamics (CFD) is a valuable tool for studying vascular diseases, but requires long computational time.  ...  The shapes and wall shear stresses are then converted to clouds of hybrid points containing both types of information.  ...  The aneurysm dataset has been provided by the European integrated project @neurIST (IST-027703).  ... 
doi:10.1007/978-3-319-46726-9_24 fatcat:b3pxxk4a2bhwbgnqm5cucajvni

Stenting as porous media in anatomically accurate geometries. A comparison of models and spatial heterogeneity

Nicolás Dazeo, Javier Dottori, Gustavo Boroni, Ana Paula Narata, Ignacio Larrabide
2020 Journal of Biomechanics  
aneurysm of 14 patients with different shapes, sizes, and locations.  ...  Modelling intracranial aneurysm blood flow after flow diverter treatment has proven to be of great scientific and clinical interest.  ...  Computational Fluid Dynamics (CFD) is a non invasive way to simulate treatment effect on local hemodynamics.  ... 
doi:10.1016/j.jbiomech.2020.109945 pmid:32827768 fatcat:jky53yqguzfidhdfxpidx6ajei

In-silico trial of intracranial flow diverters replicates and expands insights from conventional clinical trials

Ali Sarrami-Foroushani, Toni Lassila, Michael MacRaild, Joshua Asquith, Kit C. B. Roes, James V. Byrne, Alejandro F. Frangi
2021 Nature Communications  
stent, using computational fluid dynamics to quantify post-treatment flow reduction.  ...  We present the flow diverter performance assessment (FD-PASS) in-silico trial, which models the treatment of intracranial aneurysms in 164 virtual patients with 82 distinct anatomies with a flow-diverting  ...  Several groups have performed computational fluid dynamics studies of cerebral aneurysms 10,60,61 and suggested the use post-flow diversion aneurysm mean velocity as a proxy haemodynamic metric for predicting  ... 
doi:10.1038/s41467-021-23998-w pmid:34162852 fatcat:a46qpoydybgfvc3n7etjk5owva

Numerical Simulation of the Blood Flow through a Brain Vascular Aneurysm with an Artificial Stent Using the SPH Method

Leonardo Di G. Sigalotti, Jaime Klapp, Karla Pedroza, Edgar Nathal, Carlos E. Alvarado-Rodríguez
2018 Engineering  
The initial conditions for the simulations were constructed from angiographic images of a real patient with an aneurysm.  ...  We present numerical simulations of blood flow through a brain vascular aneurysm with an artificial stent using Smoothed Particle Hydrodynamics (SPH).  ...  Several studies have found that the localization, size and shape are important factors of rupture, a trial called ISUIA (International Study of Unruptured Intracranial Aneurysms).  ... 
doi:10.4236/eng.2018.1012062 fatcat:kl4hxqzeebgsbmu2alpvjubocq

Biological, Geometric and Biomechanical Factors Influencing Abdominal Aortic Aneurysm Rupture Risk: A Comprehensive Review

Samarth S. Raut, Santanu Chandra, Judy Shum, Christopher B. Washington, Satish C. Muluk, Ender A. Finol, Jose F. Rodriguez
2013 Recent Patents on Medical Imaging  
Decades of clinical evidence show that aneurysm diameter is positively associated with the probability of rupture, but that other parameters may also play a role in causing or predisposing the AAA to rupture  ...  correlated with rupture risk with a higher accuracy and sensitivity than maximum diameter alone.  ...  Estimated wall thickness distribution (in mm) in a point cloud resulting from a segmented CT dataset.  ... 
doi:10.2174/1877613211303010006 fatcat:23ovhrkutfe65h5db5obxcp57a

Brain-Specific Biomarkers as Mortality Predictors after Aneurysmal Subarachnoid Haemorrhage

Jaroslaw Kedziora, Malgorzata Burzynska, Waldemar Gozdzik, Andrzej Kübler, Agnieszka Uryga, Magdalena Kasprowicz, Barbara Adamik
2020 Journal of Clinical Medicine  
Aneurysmal subarachnoid haemorrhage (aSAH) is a serious condition with a high mortality and high permanent disability rate for those who survive the initial haemorrhage.  ...  In patients with an external ventricular drain, enolase, S100B, and GFAP levels were measured in the blood and cerebrospinal fluid (CSF) on days 1, 2, and 3 after aSAH.  ...  Aneurysmal subarachnoid haemorrhage (aSAH), which is subarachnoid bleeding resulting from an intracranial aneurysm, is a serious condition with a high mortality rate and high permanent disability rate  ... 
doi:10.3390/jcm9124117 pmid:33419282 fatcat:walbjg4zj5dkzglptcln6sbojy

Implementation of computer simulation to assess flow diversion treatment outcomes: systematic review and meta-analysis

Mingzi Zhang, Simon Tupin, Hitomi Anzai, Yutaro Kohata, Masaaki Shojima, Kosuke Suzuki, Yoshihiro Okamoto, Katsuhiro Tanaka, Takanobu Yagi, Soichiro Fujimura, Makoto Ohta
2020 Journal of NeuroInterventional Surgery  
with clinical outcomes.  ...  IntroductionDespite a decade of research into virtual stent deployment and the post-stenting aneurysmal hemodynamics, the hemodynamic factors which correlate with successful treatment remain inconclusive  ...  INTRODUCTION Computational fluid dynamics has been used for over a decade to assess the hemodynamics of intracranial aneurysms after flow diversion treatment.  ... 
doi:10.1136/neurintsurg-2020-016724 pmid:33097626 fatcat:mtpd34qy3jb4pflpqo2ibsyfsy

Primary intracerebral and subarachnoid hemorrhage an approach to diagnosis and therapy

Marc Fisher
1991 Arquivos de Neuro-Psiquiatria  
The prognosis for both disorders remains dismal and the mortality rate is substantially higher than that observed with ischemic stroke.  ...  The diagnosis of primary intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH) has become easier with the advent of modern imaging techniques.  ...  Usefulness of computed tomography in predicting outcome after aneurysmal subarachnoid hemorrhage. Neurology 1985, 35 : 1263-1267. 3. Adams HP, Kassell NF, Torner JC, Sahs A L .  ... 
doi:10.1590/s0004-282x1991000300001 pmid:1807220 fatcat:zuy46z3uufaqpd5cpmrkibclti

Trends in monitoring patients with aneurysmal subarachnoid haemorrhage

J.B. Springborg, H.-J. Frederiksen, V. Eskesen, N.V. Olsen
2005 British Journal of Anaesthesia  
In the last 30 yr the incidence of spontaneous subarachnoid haemorrhage (SAH), mostly from rupture of intracranial aneurysms, has remained at around 6-10 per 100 000 persons per year. 79 SAH accounts  ...  dynamics.  ... 
doi:10.1093/bja/aei004 pmid:15516355 fatcat:hs6t24hafvgpzi5ayl2ikztgxa

ABC of diseases of liver, pancreas, and biliary system: Acute pancreatitis

I J Beckingham
2001 BMJ (Clinical Research Edition)  
It is often associated with nausea and vomiting. Severe attacks often mimic other abdominal catastrophes such as perforated or ischaemic bowel and ruptured aortic aneurysm.  ...  Although we knew that the intracranial pressure would continue to rise, no one could predict when Richard could be declared brain dead.  ... 
doi:10.1136/bmj.322.7286.595 pmid:11238158 pmcid:PMC1119789 fatcat:kpmitaw57rhije5uara3jpf2pa
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