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Internet-enabled high-resolution brain mapping and virtual microscopy
2007
NeuroImage
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We describe a method utilizing virtual microscopy for generation of internet-enabled, high-resolution brain maps and atlases. ...
Virtual microscopy involves the conversion of histological sections mounted on glass microscope slides to high-resolution digital images. ...
Supported by Human Brain Project Grant Number MH60975 from the National Institutes of Health, United States Public Health Service. ...
doi:10.1016/j.neuroimage.2006.11.053
pmid:17229579
pmcid:PMC1890021
fatcat:zqfiqrp33zem3lgjswvfqjrb74
BrainMaps.org - Interactive High-Resolution Digital Brain Atlases and Virtual Microscopy
2008
Brains
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BrainMaps.org is an interactive high-resolution digital brain atlas and virtual microscope that is based on over 20 million megapixels of scanned images of serial sections of both primate and non-primate ...
brains and that is integrated with a high-speed database for querying and retrieving data about brain structure and function over the internet. ...
For purposes of brain mapping, current virtual microscopy scanners achieve resolutions of digitized slides of more than 100,000 dpi, enabling the generation of brain atlases at microscopic resolutions ...
pmid:19129928
pmcid:PMC2614326
fatcat:hlhafljarnfzvbytrfqprtwdiu
Multiscale Exploration of Mouse Brain Microstructures Using the Knife-Edge Scanning Microscope Brain Atlas
2011
Frontiers in Neuroinformatics
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Recent advances in high-throughput, high-resolution 3D microscopy methods have enabled the imaging of whole small animal brains at a sub-micrometer resolution, potentially opening the road to full-blown ...
(e.g., serial sectioning electron microscopy). ...
BrainMaps.org BrainMaps.org is an internet-enabled, high-resolution brain map (Mikula et al., 2007) . ...
doi:10.3389/fninf.2011.00029
pmid:22275895
pmcid:PMC3254184
fatcat:4amvlcja2fee3iavoukmihfo24
Integrating anatomy and function for zebrafish circuit analysis
2013
Frontiers in Neural Circuits
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Due to its transparency, virtually every brain structure of the larval zebrafish is accessible to light-based interrogation of circuit function. ...
To comprehensively understand circuit function, these functional maps need to be placed into the proper context of morphological features and projection patterns, neurotransmitter phenotypes, and key anatomical ...
The authors are supported by the Excellence Initiative of the German Federal and State Governments (Centre for Biological Signalling Studies EXC 294, Wolfgang Driever) and the German Research Foundation ...
doi:10.3389/fncir.2013.00074
pmid:23630469
pmcid:PMC3632786
fatcat:bio4ejsirrgo3dl2ghx43bsboy
Online histological atlas of the Göttingen minipig brain
2019
Heliyon
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One set was photographed in high resolution and labelled, the other set in low resolution (resized first set) was used for reference on the computer screen. ...
allowed magnifying of the base image (low-resolution image) up to the maximum resolution of the high-resolution image. ...
Bech and Mr. A. Meier. ...
doi:10.18154/rwth-conv-241766
fatcat:ig2z5xrzyngkvaqv2ccy4jkudq
Building retinal connectomes
2012
Current Opinion in Neurobiology
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References and annotations ...
Acknowledgments We thank the National Institutes of Health (EY02576, EY015128, and EY014800), the National Science Foundation (0941717) , the Calvin and JeNeal Hatch Presidential Endowed Chair, and Research ...
Internet-enabled high-resolution brain mapping and virtual
microscopy. Neuroimage. 2007; 35:9-15. [PubMed: 17229579]
46.
Curr Opin Neurobiol. ...
doi:10.1016/j.conb.2012.03.011
pmid:22498714
pmcid:PMC3415605
fatcat:ciigo2xprngqznvaq7rgpiwmw4
Visualization of image data from cells to organisms
2010
Nature Methods
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Second, the availability of high-throughput techniques enables experiments on a large scale, generating large sets of image data, and even though the readout of each single experiment may be easily visualized ...
By their very nature, microscopy and magnetic resonance imaging (MRI) ( Fig. 1 and Boxes 1 and 2) are dependent on data visualization. ...
Iterating this process and combining the acquired raw images yields a high-resolution image. ...
doi:10.1038/nmeth.1431
pmid:20195255
pmcid:PMC3650473
fatcat:b6nnwhe3t5fjnhxue3ghu4mjoy
Erratum: Visualization of image data from cells to organisms
2010
Nature Methods
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By their very nature, microscopy and magnetic resonance imaging (MRI) (Fig. 1 and Boxes 1 and 2) are dependent on data visualization. ...
Advances in imaging techniques and high-throughput technologies are providing scientists with unprecedented possibilities to visualize internal structures of cells, organs and organisms and to collect ...
Super-resolution fluorescence microscopy groups several recently developed methods in light microscopy capable of significantly increasing resolution and visualizing details at the nanometer scale. ...
doi:10.1038/nmeth0610-479a
fatcat:mimxo5gqnrf6zpu2uhfh7iinxm
The OptIPuter: high-performance, QoS-guaranteed network service for emerging E-science applications
2006
IEEE Communications Magazine
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Emerging large-scale scientific applications have a critical need for high bandwidth and predictableperformance network service. ...
These private optical paths are set up on-demand, and combined with end resources to form a Distributed Virtual Computer (DVC). ...
from NIH/NCRR for the National Center for Microscopy and Imaging Research (P41RR004050) and BIRN (U24 RR019701). ...
doi:10.1109/mcom.2006.1637945
fatcat:uoxx42zccfeutbu3vmkisq7xmy
Stereo Pseudo 3D Rendering for Web-based Display of Scientific Volumetric Data
[article]
2008
International Workshop on Volume Graphics, Proceedings of the
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Advancement in high-throughput microscopy technology such as the Knife-Edge Scanning Microscopy (KESM) is enabling the production of massive amounts of high-resolution volumetric data of biological microstructures ...
Google Maps and Google Maps-like interfaces such as Brainmaps.org allow users to pan and zoom 2D images efficiently. ...
Mayerich, and J. Kwon for KESM data acquisition, and J. Keyser for valuable feedback. ...
doi:10.2312/vg/vg-pbg08/073-080
fatcat:mngnd7zxonbqxn3pconmqcn3vu
Visible rodent brain-wide networks at single-neuron resolution
2015
Frontiers in Neuroanatomy
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of neuron and vessels and tracing long-distant circuit at axonal resolution in the whole brain of mammals. ...
In this review, we summarize brain-wide optical tomography techniques, review the progress on visible brain neuronal/vascular networks benefit from these novel techniques, and prospect the future technical ...
Acknowledgments We appreciate Jie Peng, Congdi Guo, Benyi Xiong and Hang Lu for image processing, Prof. Tonghui Xu for valuable discussion, and the financial supports from the Science ...
doi:10.3389/fnana.2015.00070
pmid:26074784
pmcid:PMC4446545
fatcat:ha7wxtug3nhzvbopailzptt5ju
Conneconomics: The Economics of Dense, Large-Scale, High-Resolution Neural Connectomics
[article]
2013
bioRxiv
pre-print
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An optical approach to whole mouse brain connectomics may be achievable for less than $10 million and could be enabled by emerging technologies to sequence nucleic acids in-situ in fixed tissue via fluorescent ...
microscopy. ...
We focus here on techniques for dense, cellular-resolution circuit mapping of individual brains: we do not consider sparse mapping (e.g., viral tracers), low-resolution mapping (e.g., diffusion MRI) or ...
doi:10.1101/001214
fatcat:qlpnmobhkjeulauwlggt7tn474
Virtual microscopy enhances the reliability and validity in histopathology curriculum: Practical guidelines [Version 2]
2019
MedEdPublish
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The new technology of virtual microscopy is a proven reliable and valid pedagogy method for histopathology learning objectives, and assessments. ...
This paper emphasises the practical tips and guidelines for cost-effective implementation and the successful use of Virtual Microscope technology to enhance the histopathology curriculum in a medical school ...
Virtual/Digital microscopy is the computerized conversion of light microscopic images in full resolution and their presentation over a computer network. ...
doi:10.15694/mep.2019.000028.2
fatcat:vji6cakyw5cmpem6ov6nb2mofq
Automated generation of massive image knowledge collections using Microsoft Live Labs Pivot to promote neuroimaging and translational research
2011
Journal of Clinical Bioinformatics
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The metadata along with high-resolution images were automatically extracted using the Allen Brain Atlas API. ...
, explore or analyze the massive image data sets of high-resolution images and their associated meta information, such as neuro-imaging databases from the Allen Brain Atlas. ...
All authors read and approved the final manuscript. ...
doi:10.1186/2043-9113-1-18
pmid:21884637
pmcid:PMC3164611
fatcat:5ai2eszqkrc4fotpnxcp7xwq5q
LIFE SCIENCE TECHNOLOGIES: This Is Your Brain: Mapping the Connectome
2013
Science
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Neuroscientists would like to navigate the brain in virtual space as modern travelers do on the Internet: by zooming in and out and panning at will, from entire brain regions down to individual cells and ...
Wedeen invented and uses one form of diffusion MRI, called diffusion spectrum imaging (DSI); the WashU and Minnesota teams use HARDI, or high-angular resolution diffusion imaging. ...
doi:10.1126/science.339.6117.350
fatcat:3kbcladsojb4tbjma46ovzrzk4
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