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Quantifying behavior to solve sensorimotor transformations: advances from worms and flies
2017
Current Opinion in Neurobiology
Preserved Fulltext
These tools permit a highly quantitative analysis of behavioral dynamics at timescales that are well matched to the timescales of neural activity. ...
genetic tools for neural activation, silencing, and recording, have already proven instrumental for illuminating underlying neural mechanisms. ...
, and the Howard Hughes Medical Institute. ...
doi:10.1016/j.conb.2017.08.006
pmid:28850885
pmcid:PMC5765764
fatcat:eaqlqhi7dzgvbdh7pucfpix3he
Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli
[article]
2021
bioRxiv
pre-print
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Our results highlight a major role for the olfactory system in regulating the ongoing activity of the habenula and the forebrain, thereby altering brain's internal states. ...
SUMMARYOngoing neural activity, which represents internal brain states, is constantly modulated by the sensory information that is generated by the environment. ...
We thank Steffen Kandler and Nathalie Jurisch-Yaksi for their feedback on the manuscript. This work was funded by ...
doi:10.1101/2021.02.14.431141
fatcat:zo46fuvevfabzdf2yz7dyy3nwy
Tonic activity in lateral habenula neurons promotes disengagement from reward-seeking behavior
[article]
2021
bioRxiv
pre-print
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Neural activity in the lateral habenula (LHb) has been linked to aversion and negative valence, but its role in regulating the balance between reward-seeking and disengaged behavioral states remains unclear ...
Further, we show that LHb inhibition extends ongoing reward-seeking behavioral states but does not prompt re-engagement. ...
., and Li, J.M. (2020). Internal state dynamics shape brainwide activity and foraging behaviour. Nature 577, 239-243. Matsumoto, M., and Hikosaka, O. (2007). ...
doi:10.1101/2021.01.15.426914
fatcat:vqmbvw6uu5hldm3v4tskpwa5hy
Experience-dependent modulation of behavioral features in sensory navigation of nematodes and bats revealed by machine learning
[article]
2017
bioRxiv
pre-print
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We segmented worms' trajectories during olfactory navigation into two behavioral states, analyzed 92 features of the states, and automatically extracted 9 distinguishing features modulated by prior odor ...
In order to decipher dynamic brain functions from time-series of behavioral data, we developed a machine learning strategy that extracts distinguishing behavioral features of sensory navigation. ...
André Brown, Katsuyoshi Matsushita, Ken-ichi Hironaka, Takuma Degawa, Daisuke Yamamoto, Soh Kohatsu and the Kimura laboratory members for suggestions and comments on this work. ...
doi:10.1101/198879
fatcat:jo3acfczx5e3dduqxzobj3bztu
A distributed circuit for associating environmental context to motor choice in retrosplenial cortex
[article]
2020
bioRxiv
pre-print
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We find that mice exhibit differential pre-decision activity in RSC, and that optogenetic suppression of RSC activity impairs task performance. ...
The retrosplenial cortex (RSC) receives inputs from both visual cortex and subcortical regions required for spatial memory, and projects to motor planning regions. ...
Nitz, Abhishek Banerjee, Steffen Kandler, and Dun Mao for 760 ...
doi:10.1101/2020.12.20.423684
fatcat:5jllgjx3bnewng63h2gl7ztmcm
ACNP 59th Annual Meeting: Poster Session III
2020
Neuropsychopharmacology
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They are involved in the initiation [basolateral amygdala] and maintenance [BNST] of anxiety-like states in response to potential threat. ...
Assets are evaluated in a tiered manner, starting with in vitro functional assays to rule out opioid receptor activity and to assess in vitro abuse liability. ...
Physical activity and smartphone use were passively monitored, and emotional state was actively self-reported. ...
doi:10.1038/s41386-020-00892-5
pmid:33279936
pmcid:PMC7735201
fatcat:mip4ywutfnfwvmye4u65i6vgg4
Norepinephrine ignites local hotspots of neuronal excitation: How arousal amplifies selectivity in perception and memory
2015
Behavioral and Brain Sciences
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At these NE hotspots, local glutamate and NE release are mutually enhancing and amplify activation of prioritized representations. ...
only high enough to activate low-threshold inhibitory adrenoreceptors. ...
Such states of emotional and behavioural arousal are characterized by physiological changes in the periphery. ...
doi:10.1017/s0140525x15000667
pmid:26126507
pmcid:PMC5830137
fatcat:i52yu4chrfgmfc4icbqomz3bpq