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Callosal Abnormalities Across the Psychosis Dimension: Bipolar Schizophrenia Network on Intermediate Phenotypes

Alan N. Francis, Suraj S. Mothi, Ian T. Mathew, Neeraj Tandon, Brett Clementz, Godfrey D. Pearlson, John A. Sweeney, Carol A. Tamminga, Matcheri S. Keshavan
2016 Biological Psychiatry  
Background-The corpus callosum (CC) has been implicated in the pathogenesis of schizophrenia and bipolar disorder.  ...  The splenial volumes were positively but differentially correlated with aspects of cognition in the probands and their relatives.  ...  Acknowledgments Funding Source: This research was funded in part by NIMH grants MH078113, MH077945, MH077852,  ... 
doi:10.1016/j.biopsych.2015.12.026 pmid:26954565 pmcid:PMC5218825 fatcat:5tfzvyufpjhune6czucmqzpsli

Abnormal Asymmetry of Brain Connectivity in Schizophrenia

Michele Ribolsi, Zafiris J. Daskalakis, Alberto Siracusano, Giacomo Koch
2014 Frontiers in Human Neuroscience  
Finally, we hypothesize that structural deficits across the corpus callosum may contribute to the abnormal asymmetry of intra-hemispheric connectivity in schizophrenia.  ...  Recently, a growing body of data has revealed that beyond a dysfunction of connectivity among different brain areas in schizophrenia patients (SCZ), there is also an abnormal asymmetry of functional connectivity  ...  Differences in area and volume of the corpus callosum were greatest in patients whose condition was chronic relative to patients with a first episode, as well as the controls (Collinson et al., 2014)  ... 
doi:10.3389/fnhum.2014.01010 pmid:25566030 pmcid:PMC4273663 fatcat:eibhflcul5by7pgbd45t6abr6q

Poster Session II

2012 Neuropsychopharmacology  
consistently reduced in chronic and first episode schizophrenia patients, and that also shows reductions in unaffected relatives and other high-risk groups.  ...  matter integrity in this fiber tract.  ...  types, and relative to the effects of these same cues in healthy controls.  ... 
doi:10.1038/npp.2012.220 fatcat:coblfrtlujc6hdycjbnrdwzslm

ACNP 58th Annual Meeting: Panels, Mini-Panels and Study Groups

2019 Neuropsychopharmacology  
What activity patterns and molecular mechanisms govern release? What is the extent of volume transmission, and how long do peptidergic signals last?  ...  The kinetics of dynorphin signal activation, duration and spread were characterized in striatum using a combination of photorelease, sensor imaging and electrophysiology.  ...  Patients with schizophrenia and their unaffected relatives have a specific deficit in sleep spindles, a defining oscillation of Stage 2 non-rapid eye movement sleep that, in coordination with cortical  ... 
doi:10.1038/s41386-019-0544-z pmid:31801977 pmcid:PMC6957922 fatcat:hjyvf7fcpbf2fhxit6rlhsvg2y

Control of Functional Connectivity in Cerebral Cortex by Basal Ganglia Mediated Synchronization [article]

Daniel Pouzzner
2020 arXiv   pre-print
The basal ganglia also target the dopaminergic, cholinergic, and serotonergic centers of the brainstem and basal forebrain, and the reticular nucleus of the thalamus, structures broadly implicated in the  ...  In the core mechanism of the model, oscillatory patterns in cortex are selected by and routed through the basal ganglia to the thalamus phase-coherently, then circulated back to widely separated areas  ...  Schizophrenia is also typified by abnormalities of the corpus callosum, and of interhemispheric coordination (Foong 2000; Whitford et al. 2010; Hoptman et al. 2012) .  ... 
arXiv:1708.00779v2 fatcat:3mbrakwdgfewpcdggox5v6mwme

The topology of structural brain connectivity in diseases and spatio-temporal connectomics

Alessandra Griffa
communication principles on the top of the brain structural network. v Finally, we have applied developed measures and frameworks to the investigation of dysconnectivity traits in schizophrenia, 22q11  ...  First, we have contributed to the characterization of the human connectome in health and pathologies by adapting and developing network measures for the description of the brain architecture at different  ...  The majority of the work presented in this Part III is unpublished. Preliminary results can be found in (Griffa et al., 2015b) .  ... 
doi:10.5075/epfl-thesis-6586 fatcat:sf3psydfxbasdiqjvj3fpw2xj4